Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Grants

Publications

Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Chiea Chuen, Michael A. Hauser, R Rand Allingham, Tin Aung, Carly J. Van Der Heide, Kent D. Taylor, Jerome I. Rotter, et al. “Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.” Jama 322, no. 17 (November 5, 2019): 1682–91. https://doi.org/10.1001/jama.2019.16161.

PMID
31688885
Full Text

Nievergelt, Caroline M., Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, et al. “International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.” Nat Commun 10, no. 1 (October 8, 2019): 4558. https://doi.org/10.1038/s41467-019-12576-w.

PMID
31594949
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Laville, Vincent, Jae H. Kang, Clara C. Cousins, Adriana I. Iglesias, Réka Nagy, Jessica N. Cooke Bailey, Robert P. Igo, et al. “Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.” Am J Ophthalmol 206 (October 2019): 245–55. https://doi.org/10.1016/j.ajo.2019.05.015.

PMID
31121135
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Bonnemaijer, Pieter W. M., Elisabeth M van Leeuwen, Adriana I. Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P. Khawaja, Mark Simcoe, et al. “Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.” Commun Biol 2 (2019): 435. https://doi.org/10.1038/s42003-019-0634-9.

PMID
31798171
Full Text

Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Michelle F. VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Michael A. Hauser, Allison E. Ashley-Koch, and Jean C. Beckham. “A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.” Psychiatry Res 269 (November 2018): 64–69. https://doi.org/10.1016/j.psychres.2018.07.017.

PMID
30145303
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Bonnemaijer, Pieter W. M., Adriana I. Iglesias, Girish N. Nadkarni, Anna J. Sanyiwa, Hassan G. Hassan, Colin Cook, Colin GIGA Study Group, et al. “Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.” In Hum Genet, 137:847–62, 2018. https://doi.org/10.1007/s00439-018-1943-7.

PMID
30317457
Full Text

Khawaja, Anthony P., Michelle P. Y. Chan, Jennifer L. Y. Yip, David C. Broadway, David F. Garway-Heath, Ananth C. Viswanathan, Robert Luben, et al. “A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population: The EPIC-Norfolk Eye Study.” J Glaucoma 27, no. 9 (September 2018): 743–49. https://doi.org/10.1097/IJG.0000000000001026.

PMID
30005032
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Khaled, Mariam Lofty, Yelena Bykhovskaya, Sarah E. R. Yablonski, Hanzhou Li, Michelle D. Drewry, Inas F. Aboobakar, Amy Estes, et al. “Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas.” Invest Ophthalmol Vis Sci 59, no. 7 (June 1, 2018): 2717–28. https://doi.org/10.1167/iovs.18-24267.

PMID
29860458
Full Text

Wolf, Erika J., Hannah Maniates, Nicole Nugent, Adam X. Maihofer, Don Armstrong, Andrew Ratanatharathorn, Allison E. Ashley-Koch, et al. “Traumatic stress and accelerated DNA methylation age: A meta-analysis.” Psychoneuroendocrinology 92 (June 2018): 123–34. https://doi.org/10.1016/j.psyneuen.2017.12.007.

PMID
29452766
Full Text

Pages