Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Grants

Publications

Gharahkhani, P, Burdon, KP, Cooke Bailey, JN, Hewitt, AW, Law, MH, Pasquale, LR, Kang, JH, Haines, JL, Souzeau, E, Zhou, T, Siggs, OM, Landers, J, Awadalla, M, Sharma, S, Mills, RA, Ridge, B, Lynn, D, Casson, R, Graham, SL, Goldberg, I, White, A, Healey, PR, Grigg, J, Lawlor, M, Mitchell, P, Ruddle, J, Coote, M, Walland, M, Best, S, Vincent, A, Gale, J, Radfordsmith, G, Whiteman, DC, Montgomery, GW, Martin, NG, MacKey, DA, Wiggs, JL, MacGregor, S, Craig, JE, Allingham, RR, and Brilliant, M et al. "Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma (Accepted)." Scientific Reports 8, no. 1 (December 1, 2018).

Full Text

Nievergelt, CM, Ashley-Koch, AE, Dalvie, S, Hauser, MA, Morey, RA, Smith, AK, and Uddin, M. "Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. (Accepted)" Biological psychiatry 83, no. 10 (May 2018): 831-839. (Review)

PMID
29555185
Full Text

Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, and Uddin, M et al. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular psychiatry 23, no. 3 (March 2018): 666-673.

PMID
28439101
Full Text

Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Vollrath, D, Zack, DJ, Medeiros, F, Vajaranant, TS, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Craig, JE, and Burdon, KP et al. "Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets." Investigative ophthalmology & visual science 59, no. 2 (February 2018): 629-636.

PMID
29392307
Full Text

King, R, Struebing, FL, Li, Y, Wang, J, Koch, AA, Cooke Bailey, JN, Gharahkhani, P, International Glaucoma Genetics Consortium, , NEIGHBORHOOD Consortium, , MacGregor, S, Allingham, RR, Hauser, MA, Wiggs, JL, and Geisert, EE. "Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma." PLoS genetics 14, no. 1 (January 25, 2018): e1007145-.

PMID
29370175
Full Text

Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc Workgroup, , Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, and Logue, MW. "Traumatic stress and accelerated DNA methylation age: A meta-analysis." Psychoneuroendocrinology (December 27, 2017).

PMID
29452766
Full Text

Chintalapudi, SR, Maria, D, Di Wang, X, Bailey, JNC, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, JL, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, LR, Pericak-Vance, M, Realini, A, Rhee, D, Richards, JR, Ritch, R, Schuman, J, Scott, WK, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, CY, Craig, J, Van Duijn, C, Gharahkhani, P, and Iglesias Gonzalez, A et al. "Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility." Nature Communications 8, no. 1 (December 1, 2017).

Full Text

Morey, RA, Davis, SL, Garrett, ME, Haswell, CC, Mid-Atlantic MIRECC Workgroup, , Marx, CE, Beckham, JC, McCarthy, G, Hauser, MA, and Ashley-Koch, AE. "Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls." Translational psychiatry 7, no. 11 (November 30, 2017): 1265-.

PMID
29187748
Full Text

Polimanti, R, Amstadter, AB, Stein, MB, Almli, LM, Baker, DG, Bierut, LJ, Bradley, B, Farrer, LA, Johnson, EO, King, A, Kranzler, HR, Maihofer, AX, Rice, JP, Roberts, AL, Saccone, NL, Zhao, H, Liberzon, I, Nievergelt, CM, Koenen, KC, Gelernter, J, Duncan, LE, Chen, CY, Ratanatharathorn, A, Aiello, AE, Ashley-Koch, AE, Garrett, ME, Hauser, MA, Beckham, JC, Kimbrel, NA, Bisson, J, Dalvie, S, Galea, S, Gelernter, JE, Guffanti, G, Ressler, KJ, Kessler, RC, Koen, N, Stein, DJ, Logue, MW, and Miller, MW et al. "A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder." Genome Medicine 9, no. 1 (November 27, 2017).

Full Text

Teotia, P, Van Hook, MJ, Wichman, CS, Allingham, RR, Hauser, MA, and Ahmad, I. "Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities." Stem cells (Dayton, Ohio) 35, no. 11 (November 2017): 2239-2252.

PMID
28792678
Full Text

Pages