Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Aschard, H, Kang, JH, Iglesias, AI, Hysi, P, Cooke Bailey, JN, Khawaja, AP, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Haven, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Cheng, C-Y, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, and Hauser, MA et al. "Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis." European journal of human genetics : EJHG 25, no. 11 (November 2017): 1261-1267.

PMID
28853718
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Teotia, P, Van Hook, MJ, Wichman, CS, Allingham, RR, Hauser, MA, and Ahmad, I. "Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities." Stem cells (Dayton, Ohio) 35, no. 11 (November 2017): 2239-2252.

PMID
28792678
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Ratanatharathorn, A, Boks, MP, Maihofer, AX, Aiello, AE, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bromet, E, Dennis, M, Garrett, ME, Geuze, E, Guffanti, G, Hauser, MA, Kilaru, V, Kimbrel, NA, Koenen, KC, Kuan, P-F, Logue, MW, Luft, BJ, Miller, MW, Mitchell, C, Nugent, NR, Ressler, KJ, Rutten, BPF, Stein, MB, Vermetten, E, Vinkers, CH, Youssef, NA, VA Mid-Atlantic MIRECC Workgroup, , PGC PTSD Epigenetics Workgroup, , Uddin, M, Nievergelt, CM, and Smith, AK. "Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 174, no. 6 (September 2017): 619-630.

PMID
28691784
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Aung, T, Ozaki, M, Lee, MC, Schlötzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RP, Haripriya, A, Williams, SE, Astakhov, YS, Orr, AC, Burdon, KP, Nakano, S, Mori, K, Abu-Amero, K, Hauser, M, Li, Z, Prakadeeswari, G, Bailey, JNC, Cherecheanu, AP, Kang, JH, Nelson, S, Hayashi, K, Manabe, S-I, Kazama, S, Zarnowski, T, Inoue, K, Irkec, M, Coca-Prados, M, Sugiyama, K, Järvelä, I, Schlottmann, P, Lerner, SF, Lamari, H, Nilgün, Y, Bikbov, M, Park, KH, Cha, SC, Yamashiro, K, and Zenteno, JC et al. "Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci." Nature genetics 49, no. 7 (July 2017): 993-1004.

PMID
28553957
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Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, and Uddin, M et al. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular psychiatry (April 25, 2017).

PMID
28439101
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Grassmann, F, Kiel, C, Zimmermann, ME, Gorski, M, Grassmann, V, Stark, K, International AMD Genomics Consortium (IAMDGC), , Heid, IM, and Weber, BHF. "Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits." Genome medicine 9, no. 1 (March 27, 2017): 29-.

PMID
28347358
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Pasquale, LR, Aschard, H, Kang, JH, Bailey, JNC, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, J, Budenz, DL, Realini, T, Gaasterland, T, Gaasterland, D, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Havens, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Haines, JL, and Wiggs, JL. "Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample." Menopause (New York, N.Y.) 24, no. 2 (February 2017): 150-156.

PMID
27760082
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Grassmann, F, Heid, IM, Weber, BHF, and International AMD Genomics Consortium (IAMDGC), . "Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration." Genetics 205, no. 2 (February 2017): 919-924.

Full Text

Hauser, MA, Garrett, ME, Liu, Y, Dennis, MF, Kimbrel, NA, Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, , Beckham, JC, and Ashley-Koch, AE. "Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder." Journal of psychiatric research 84 (January 2017): 59-61.

PMID
27701011
Full Text

Aboobakar, IF, Johnson, WM, Stamer, WD, Hauser, MA, and Allingham, RR. "Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology." Experimental eye research 154 (January 2017): 88-103. (Review)

PMID
27845061
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