Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Genetics of Exfoliation Syndrome Partnership, Chiea Chuen, Zheng Li, Zhenxun Wang, Mei Chin Lee, Matthias Zenkel, Esther Peh, Mineo Ozaki, et al. “Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.” Jama 325, no. 8 (February 23, 2021): 753–64. https://doi.org/10.1001/jama.2021.0507.

PMID
33620406
Full Text

Schmitt, Heather M., William M. Johnson, Inas F. Aboobakar, Shelby Strickland, María Gomez-Caraballo, Megan Parker, Laura Finnegan, et al. “Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.” Hum Mol Genet 29, no. 12 (July 29, 2020): 1986–95. https://doi.org/10.1093/hmg/ddaa021.

PMID
32037441
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Grasby, Katrina L., Neda Jahanshad, Jodie N. Painter, Lucía Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, et al. “The genetic architecture of the human cerebral cortex.” Science 367, no. 6484 (March 20, 2020). https://doi.org/10.1126/science.aay6690.

PMID
32193296
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Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Chiea Chuen, Michael A. Hauser, R Rand Allingham, Tin Aung, Carly J. Van Der Heide, Kent D. Taylor, Jerome I. Rotter, et al. “Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.” Jama 322, no. 17 (November 5, 2019): 1682–91. https://doi.org/10.1001/jama.2019.16161.

PMID
31688885
Full Text

Nievergelt, Caroline M., Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, et al. “International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.” Nat Commun 10, no. 1 (October 8, 2019): 4558. https://doi.org/10.1038/s41467-019-12576-w.

PMID
31594949
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Fan, Bao Jian, Jessica Cooke Bailey, Rob P. Igo, Jae H. Kang, Tahani Boumenna, Murray H. Brilliant, Donald L. Budenz, et al. “Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.” Jama Ophthalmol 137, no. 10 (October 1, 2019): 1190–94. https://doi.org/10.1001/jamaophthalmol.2019.3109.

PMID
31436842
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Laville, Vincent, Jae H. Kang, Clara C. Cousins, Adriana I. Iglesias, Réka Nagy, Jessica N. Cooke Bailey, Robert P. Igo, et al. “Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.” Am J Ophthalmol 206 (October 2019): 245–55. https://doi.org/10.1016/j.ajo.2019.05.015.

PMID
31121135
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Bonnemaijer, Pieter W. M., Elisabeth M van Leeuwen, Adriana I. Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P. Khawaja, Mark Simcoe, et al. “Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.” Commun Biol 2 (2019): 435. https://doi.org/10.1038/s42003-019-0634-9.

PMID
31798171
Full Text

Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Michelle F. VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Michael A. Hauser, Allison E. Ashley-Koch, and Jean C. Beckham. “A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.” Psychiatry Res 269 (November 2018): 64–69. https://doi.org/10.1016/j.psychres.2018.07.017.

PMID
30145303
Full Text

Pages