Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). In collaboration with Dr. Rand Allingham at the Duke Eye Center, and Dr. Yutao Liu in the Center for Human Genetics, Dr. Hauser is currently conducting an admixture screen to identify susceptibility genes for glaucoma in African Americans and other individuals of African descent. These investigations include large datasets collected in Ghana and Nigeria. A collection of patients from South Africa are being used to dissect the genetics of exfoliation glaucoma.

Dr. Hauser also has an extensive research interest in muscular dystrophy. He has identified mutations in the myotilin gene as the cause of limb girdle muscular dystrophy 1A (LGMD1A), and constructed mouse models that recapitulate many of the pathological features of human LGMD1A. This model system will help clarify the role of the myotilin protein in normal muscle function, and will be used to develop and test possible therapeutic strategies. Dr. Hauser has recently received fundingfrom the Muscular Dystrophy Association of America to use whole exome sequencing and functional testing in zebrafish to identify novel mutations that cause muscular dystrophy.

Dr. Hauser is also involved in collaborative investigations into the genetic etiology of post-tramatic stress disorder and amylotrophic lateral sclerosis in US veterans, and non-alcoholic fatty liver disease.

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Li, YJ, Minear, MA, Qin, X, Rimmler, J, Hauser, MA, Allingham, RR, Igo, RP, Lass, JH, Iyengar, SK, Klintworth, GK, Afshari, NA, and Gregory, SG. "Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy." Investigative ophthalmology & visual science 55, no. 7 (July 2014): 4577-4584.

PMID
24917144
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Kang, JH, Loomis, SJ, Yaspan, BL, Bailey, JC, Weinreb, RN, Lee, RK, Lichter, PR, Budenz, DL, Liu, Y, Realini, T, Gaasterland, D, Gaasterland, T, Friedman, DS, McCarty, CA, Moroi, SE, Olson, L, Schuman, JS, Singh, K, Vollrath, D, Wollstein, G, Zack, DJ, Brilliant, M, Sit, AJ, Christen, WG, Fingert, J, Forman, JP, Buys, ES, Kraft, P, Zhang, K, Allingham, RR, Pericak-Vance, MA, Richards, JE, Hauser, MA, Haines, JL, Wiggs, JL, and Pasquale, LR. "Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma." Eye (London, England) 28, no. 6 (June 2014): 662-671.

PMID
24603425
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Nongpiur, ME, Khor, CC, Jia, H, Cornes, BK, Chen, LJ, Qiao, C, Nair, KS, Cheng, CY, Xu, L, George, R, Tan, D, Abu-Amero, K, Perera, SA, Ozaki, M, Mizoguchi, T, Kurimoto, Y, Low, S, Tajudin, LS, Ho, CL, Tham, CC, Soto, I, Chew, PT, Wong, HT, Shantha, B, Kuroda, M, Osman, EA, Tang, G, Fan, S, Meng, H, Wang, H, Feng, B, Yong, VH, Ting, SM, Li, Y, Wang, YX, Li, Z, Lavanya, R, Wu, RY, Zheng, YF, Su, DH, Loon, SC, Yong, VK, Allingham, RR, Hauser, MA, Soumittra, N, Ramprasad, VL, Waseem, N, Yaakub, A, Chia, KS, Kumaramanickavel, G, Wong, TT, How, AC, Chau, TN, Simmons, CP, Bei, JX, Zeng, YX, Bhattacharya, SS, Zhang, M, Tan, DT, Teo, YY, Al-Obeidan, SA, Hon, DN, Tai, ES, Saw, SM, Foster, PJ, Vijaya, L, Jonas, JB, Wong, TY, John, SW, Pang, CP, Vithana, EN, Wang, N, and Aung, T. "ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma." PLoS genetics 10, no. 3 (March 2014): e1004089-.

PMID
24603532
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Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482.

PMID
23913408
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Loomis, SJ, Kang, J, Weinréb, RN, Yaspan, BL, Cooke Bailey, JN, Gaasterland, DE, Gaasterland, TM, Lee, R, Lichter, PR, Budenz, DL, Liu, Y, Realini, TD, Friedman, DS, McCarty, CA, Moroi, S, Olson, LM, Schuman, JS, Singh, K, Vollrath, D, Wollstein, G, Zack, DJ, Brilliant, MH, Sit, A, Christen, WG, Fingert, JH, Kraft, PL, Zhang, K, Allingham, RR, Peričak-Vance, MAS, Richards, JE, Hauser, MA, Haines, JL, Pasquale, LR, and Wiggs, JL. "Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss." Ophthalmology 121, no. 2 (February 1, 2014): 508-516.

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Özel, AB, Moroi, S, Reed, DM, Nika, M, Schmidt, CM, Akbari, S, Scott, KL, Rozsa, FW, Pawar, HS, Musch, DC, Lichter, PR, Gaasterland, DE, Branham, KEH, Gilbert, JE, Garnai, SJ, Chén, W, Othman, MI, Heckenlively, JR, Swaroop, A, Abeçasis, GR, Friedman, DS, Zack, DJ, Ashley-Koch, AE, Ulmer, M, Kang, J, Liu, Y, Yaspan, BL, Haines, JL, Allingham, RR, Hauser, MA, Pasquale, LR, Wiggs, JL, Richards, JE, and Li, J. "Genome-wide association study and meta-analysis of intraocular pressure." Human Genetics 133, no. 1 (January 1, 2014): 41-57.

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Ozel, AB, Moroi, SE, Reed, DM, Nika, M, Schmidt, CM, Akbari, S, Scott, K, Rozsa, F, Pawar, H, Musch, DC, Lichter, PR, Gaasterland, D, Branham, K, Gilbert, J, Garnai, SJ, Chen, W, Othman, M, Heckenlively, J, Swaroop, A, Abecasis, G, Friedman, DS, Zack, D, Ashley-Koch, A, Ulmer, M, Kang, JH, NEIGHBOR Consortium, , Liu, Y, Yaspan, BL, Haines, J, Allingham, RR, Hauser, MA, Pasquale, L, Wiggs, J, Richards, JE, and Li, JZ. "Genome-wide association study and meta-analysis of intraocular pressure." Hum Genet 133, no. 1 (January 2014): 41-57.

PMID
24002674
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Carnes, MU, Liu, YP, Allingham, RR, Whigham, BT, Havens, S, Garrett, ME, Qiao, C, Katsanis, N, Wiggs, JL, Pasquale, LR, Ashley-Koch, A, Oh, EC, and Hauser, MA. "Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma." PLoS genetics 10, no. 5 (2014): e1004372-.

PMID
24875647
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Dietz, JA, Maes, ME, Huang, S, Yandell, BS, Schlamp, CL, Montgomery, AD, Allingham, RR, Hauser, MA, and Nickells, RW. "Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage." PloS one 9, no. 4 (2014): e93564-.

PMID
24699552
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Maselli, RA, Arredondo, J, Nguyen, J, Lara, M, Ng, F, Ngo, M, Pham, JM, Yi, Q, Stajich, JM, Mcdonald, K, Hauser, MA, and Wollmann, RL. "Exome sequencing detection of two untranslated GFPT1 mutations in a family with limb-girdle myasthenia." Clinical Genetics 85, no. 2 (2014): 166-171.

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