Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). In collaboration with Dr. Rand Allingham at the Duke Eye Center, and Dr. Yutao Liu in the Center for Human Genetics, Dr. Hauser is currently conducting an admixture screen to identify susceptibility genes for glaucoma in African Americans and other individuals of African descent. These investigations include large datasets collected in Ghana and Nigeria. A collection of patients from South Africa are being used to dissect the genetics of exfoliation glaucoma.
Dr. Hauser also has an extensive research interest in muscular dystrophy. He has identified mutations in the myotilin gene as the cause of limb girdle muscular dystrophy 1A (LGMD1A), and constructed mouse models that recapitulate many of the pathological features of human LGMD1A. This model system will help clarify the role of the myotilin protein in normal muscle function, and will be used to develop and test possible therapeutic strategies. Dr. Hauser has recently received fundingfrom the Muscular Dystrophy Association of America to use whole exome sequencing and functional testing in zebrafish to identify novel mutations that cause muscular dystrophy.
Dr. Hauser is also involved in collaborative investigations into the genetic etiology of post-tramatic stress disorder and amylotrophic lateral sclerosis in US veterans, and non-alcoholic fatty liver disease.
Education and Training
- Ph.D., Johns Hopkins University, 1990