Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Grants

Publications

Hauser, MA, Aboobakar, IF, Liu, Y, Miura, S, Whigham, BT, Challa, P, Wheeler, J, Williams, A, Santiago-Turla, C, Qin, X, Rautenbach, RM, Ziskind, A, Ramsay, M, Uebe, S, Song, L, Safi, A, Vithana, EN, Mizoguchi, T, Nakano, S, Kubota, T, Hayashi, K, Manabe, S, Kazama, S, Mori, Y, Miyata, K, Yoshimura, N, Reis, A, Crawford, GE, Pasutto, F, Carmichael, TR, Williams, SE, Ozaki, M, Aung, T, Khor, CC, Stamer, WD, Ashley-Koch, AE, and Allingham, RR. "Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus." Human molecular genetics 24, no. 22 (November 2015): 6552-6563.

PMID
26307087
Scholars@Duke

Cai, J, Perkumas, KM, Qin, X, Hauser, MA, Stamer, WD, and Liu, Y. "Expression Profiling of Human Schlemm's Canal Endothelial Cells From Eyes With and Without Glaucoma." Investigative ophthalmology & visual science 56, no. 11 (October 2015): 6747-6753.

PMID
26567786
Scholars@Duke

Ashley-Koch, AE, Garrett, ME, Gibson, J, Liu, Y, Dennis, MF, Kimbrel, NA, Beckham, JC, and Hauser, MA. "Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans." Journal of affective disorders 184 (September 2015): 225-234.

PMID
26114229
Scholars@Duke

Kimbrel, NA, Garrett, ME, Dennis, MF, Liu, Y, Patanam, I, Workgroup, VM, Ashley-Koch, AE, Hauser, MA, and Beckham, JC. "Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder." Psychiatry research 229, no. 1-2 (September 2015): 326-331.

PMID
26184988
Scholars@Duke

Li, Z, Allingham, RR, Nakano, M, Jia, L, Chen, Y, Ikeda, Y, Mani, B, Chen, LJ, Kee, C, Garway-Heath, DF, Sripriya, S, Fuse, N, Abu-Amero, KK, Huang, C, Namburi, P, Burdon, K, Perera, SA, Gharahkhani, P, Lin, Y, Ueno, M, Ozaki, M, Mizoguchi, T, Krishnadas, SR, Osman, EA, Lee, MC, Chan, AS, Tajudin, LS, Do, T, Goncalves, A, Reynier, P, Zhang, H, Bourne, R, Goh, D, Broadway, D, Husain, R, Negi, AK, Su, DH, Ho, CL, Blanco, AA, Leung, CK, Wong, TT, Yakub, A, Liu, Y, Nongpiur, ME, Han, JC, and Hon, DN et al. "A common variant near TGFBR3 is associated with primary open angle glaucoma." Human molecular genetics 24, no. 13 (July 2015): 3880-3892.

PMID
25861811
Scholars@Duke

Aboobakar, IF, Liang, J, Hauser, MA, Allingham, RR, and Stamer, WD. "Cyclic mechanical stress alters LOXL1 gene expression in trabecular meshwork and Schlemm's canal cells." June 2015.

Scholars@Duke

Kang, JH, Aschard, H, Hauser, MA, Haines, JL, Christen, WG, Kraft, P, Chasman, DI, Bailey, JC, Wiggs, JL, Pasquale, LR, and NEIGHBORHOOD, . "Age at menopause genetic risk score in relation to primary open-angle glaucoma in the Augmented GLAUGEN study." June 2015.

Scholars@Duke

King, R, Hauser, MA, Pasquale, LR, Wiggs, JL, Ashley-Koch, AE, Allingham, RR, and Geisert, EE. "Mouse Genomic Loci Modulating Corneal Thickness." June 2015.

Scholars@Duke

Liu, Y, Abu-Amero, K, Bykhovskaya, Y, Zimmerman, A, Al-Muammar, A, Li, X, Rotter, JI, Allingham, RR, Hauser, MA, and Rabinowitz, YS. "The Role of Rare Coding Variants in Keratoconus-associated Candidate Genes using Exome Sequencing." June 2015.

Scholars@Duke

Helwa, I, Abu-Amero, K, Al-Muammar, A, Strickland, S, Hauser, MA, Allingham, RRA, and Liu, Y. "Association between CCT-associated variants and keratoconus in a Saudi Arabian population." June 2015.

Scholars@Duke

Pages