Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Grants

Publications

Gharahkhani, P, Burdon, KP, Cooke Bailey, JN, Hewitt, AW, Law, MH, Pasquale, LR, Kang, JH, Haines, JL, Souzeau, E, Zhou, T, Siggs, OM, Landers, J, Awadalla, M, Sharma, S, Mills, RA, Ridge, B, Lynn, D, Casson, R, Graham, SL, Goldberg, I, White, A, Healey, PR, Grigg, J, Lawlor, M, Mitchell, P, Ruddle, J, Coote, M, Walland, M, Best, S, Vincent, A, Gale, J, RadfordSmith, G, Whiteman, DC, Montgomery, GW, Martin, NG, Mackey, DA, Wiggs, JL, MacGregor, S, and Craig, JE. "Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma." Scientific Reports 8, no. 1 (December 2018).

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Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc Workgroup, , Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, and Logue, MW. "Traumatic stress and accelerated DNA methylation age: A meta-analysis." Psychoneuroendocrinology 92 (June 2018): 123-134.

PMID
29452766
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Khaled, ML, Bykhovskaya, Y, Yablonski, SER, Li, H, Drewry, MD, Aboobakar, IF, Estes, A, Gao, XR, Stamer, WD, Xu, H, Allingham, RR, Hauser, MA, Rabinowitz, YS, and Liu, Y. "Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas." Investigative Ophthalmology & Visual Science 59, no. 7 (June 2018): 2717-2728.

PMID
29860458
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Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE, Li, X, Yazar, S, Nag, A, Khawaja, AP, Polašek, O, Siscovick, D, Mitchell, P, Tham, YC, Haines, JL, Kearns, LS, Hayward, C, Shi, Y, van Leeuwen, EM, Taylor, KD, Blue Mountains Eye Study—GWAS group, , Bonnemaijer, P, Rotter, JI, Martin, NG, Zeller, T, Mills, RA, Souzeau, E, Staffieri, SE, Jonas, JB, Schmidtmann, I, Boutin, T, Kang, JH, Lucas, SEM, Wong, TY, Beutel, ME, Wilson, JF, NEIGHBORHOOD Consortium, , Wellcome Trust Case Control Consortium 2 (WTCCC2), , Uitterlinden, AG, Vithana, EN, Foster, PJ, Hysi, PG, Hewitt, AW, Khor, CC, Pasquale, LR, Montgomery, GW, Klaver, CCW, Aung, T, Pfeiffer, N, Mackey, DA, Hammond, CJ, Cheng, C-Y, Craig, JE, Rabinowitz, YS, Wiggs, JL, Burdon, KP, van Duijn, CM, and MacGregor, S. "Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases." Nature Communications 9, no. 1 (May 14, 2018): 1864-null.

PMID
29760442
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Nievergelt, CM, Ashley-Koch, AE, Dalvie, S, Hauser, MA, Morey, RA, Smith, AK, and Uddin, M. "Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative." Biological Psychiatry 83, no. 10 (May 2018): 831-839. (Review)

PMID
29555185
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Shiga, Y, Akiyama, M, Nishiguchi, KM, Sato, K, Shimozawa, N, Takahashi, A, Momozawa, Y, Hirata, M, Matsuda, K, Yamaji, T, Iwasaki, M, Tsugane, S, Oze, I, Mikami, H, Naito, M, Wakai, K, Yoshikawa, M, Miyake, M, Yamashiro, K, Japan Glaucoma Society Omics Group (JGS-OG), , Kashiwagi, K, Iwata, T, Mabuchi, F, Takamoto, M, Ozaki, M, Kawase, K, Aihara, M, Araie, M, Yamamoto, T, Kiuchi, Y, Nakamura, M, Ikeda, Y, Sonoda, K-H, Ishibashi, T, Nitta, K, Iwase, A, Shirato, S, Oka, Y, Satoh, M, Sasaki, M, Fuse, N, Suzuki, Y, Cheng, C-Y, Khor, CC, Baskaran, M, Perera, S, Aung, T, Vithana, EN, Cooke Bailey, JN, Kang, JH, Pasquale, LR, Haines, JL, NEIGHBORHOOD Consortium, , Wiggs, JL, Burdon, KP, Gharahkhani, P, Hewitt, AW, Mackey, DA, MacGregor, S, Craig, JE, Allingham, RR, Hauser, M, Ashaye, A, Budenz, DL, Akafo, S, Williams, SEI, Kamatani, Y, Nakazawa, T, and Kubo, M. "Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma." Human Molecular Genetics 27, no. 8 (April 2018): 1486-1496.

PMID
29452408
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Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, Uddin, M, Ursano, RJ, Wildman, DE, Yehuda, R, Zhao, H, Daly, MJ, Liberzon, I, Ressler, KJ, Nievergelt, CM, and Koenen, KC. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular Psychiatry 23, no. 3 (March 2018): 666-673.

PMID
28439101
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Johnson, WM, Finnegan, LK, Hauser, MA, and Stamer, WD. "lncRNAs, DNA Methylation, and the Pathobiology of Exfoliation Glaucoma." Journal of Glaucoma 27, no. 3 (March 2018): 202-209.

PMID
28671923
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Carnes, MU, Allingham, RR, Ashley-Koch, A, and Hauser, MA. "Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing." Experimental Eye Research 167 (February 2018): 91-99.

PMID
27914989
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Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Vollrath, D, Zack, DJ, Medeiros, F, Vajaranant, TS, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Craig, JE, Burdon, KP, Hewitt, AW, Mackey, DA, Haines, JL, MacGregor, S, Wiggs, JL, Pasquale, LR, and Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium, . "Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets." Investigative Ophthalmology & Visual Science 59, no. 2 (February 2018): 629-636.

PMID
29392307
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