Hematologic Malignancies and Cellular Therapy

Mitchell Eric Horwitz, MD

Professor of Medicine
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address mitchell.horwitz@duke.edu

Allogeneic stem cell transplantation using umbilical cord blood grafts; Allogenic stem cell transplantation for Sickle Cell Disease; Prevention of acute graft versus host disease through donor stem cell graft manipulation; Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation or third party thymus transplantation.

In Their Words

Education and Training

  • Medical Resident, Medicine, Northwestern University, 1992 - 1995
  • M.D., Rush University, 1992

Grants

Publications

Cardones, Adela R., Keith M. Sullivan, Cindy Green, Nelson J. Chao, Krista Rowe-Nichols, Lionel L. Bañez, Claude S. Burton, et al. “Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease..” Jama Dermatol 155, no. 7 (July 1, 2019): 833–37. https://doi.org/10.1001/jamadermatol.2018.5459.

PMID
30994873
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Maung, Ko K., and Mitchell E. Horwitz. “Current and future perspectives on allogeneic transplantation using ex vivo expansion or manipulation of umbilical cord blood cells..” Int J Hematol 110, no. 1 (July 2019): 50–58. https://doi.org/10.1007/s12185-019-02670-6.

PMID
31123927
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Chen, Yi-Bin, Jennifer Le-Rademacher, Ruta Brazauskas, Deidre M. Kiefer, Mehdi Hamadani, John F. DiPersio, Mark R. Litzow, et al. “Plerixafor alone for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells..” Blood Adv 3, no. 6 (March 26, 2019): 875–83. https://doi.org/10.1182/bloodadvances.2018027599.

PMID
30890544
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Horwitz, Mitchell E., Stephen Wease, Beth Blackwell, David Valcarcel, Francesco Frassoni, Jaap Jan Boelens, Stefan Nierkens, et al. “Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide..” J Clin Oncol 37, no. 5 (February 10, 2019): 367–74. https://doi.org/10.1200/JCO.18.00053.

PMID
30523748
Full Text

Foster, Yevgeniya, Michael J. Grant, Samantha M. Thomas, Blake Cameron, Doug Raiff, Kelly Corbet, Christopher Ferreri, and Mitchell E. Horwitz. “Treatment with Foscarnet after Allogenic Hematopoietic-Cell Transplant (AlloHCT) Is Associated with Long-Term Loss of Renal Function.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-113189.

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Boelens, Jaap Jan, Coco de Koning, Mitchell E. Horwitz, Guillermo Sanz, Madan Jagasia, John E. Wagner, Patrick J. Stiff, Rabi Hanna, Daniela Cilloni, and Stefan Nierkens. “Rapid and Robust CD4+and CD8+T-, NK-, B- and Monocyte Cell Reconstitution after Nicotinamide-Expanded Cord Blood Transplantation.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-116700.

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Leventhal, Joseph R., John P. Galvin, James Mathew, Lorenzo Gallon, Kadiyala Ravindra, Mitchell E. Horwitz, Michael Abecassis, and Suzanne T. Ildstad. “Use of a Processed Hematopoietic Stem Cell Product (FCRx) in Unmatched Related and Unrelated Donor - Recipient Pairs Is Associated with High Levels of Donor Chimerism and Donor-Specific Tolerance to Kidney Allografts.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-118832.

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Spellecy, Ryan, Sergey Tarima, Ellen Denzen, Heather Moore, Sunil Abhyankar, Peter Dawson, Amy Foley, et al. “Easy-to-Read Informed Consent Form for Hematopoietic Cell Transplantation Clinical Trials: Results from the Blood and Marrow Transplant Clinical Trials Network 1205 Study..” Biol Blood Marrow Transplant 24, no. 10 (October 2018): 2145–51. https://doi.org/10.1016/j.bbmt.2018.04.014.

PMID
29679770
Full Text

Micallef, Ivana N., Patrick J. Stiff, Auayporn P. Nademanee, Richard T. Maziarz, Mitchell E. Horwitz, Edward A. Stadtmauer, Jonathan L. Kaufman, et al. “Plerixafor Plus Granulocyte Colony-Stimulating Factor for Patients with Non-Hodgkin Lymphoma and Multiple Myeloma: Long-Term Follow-Up Report..” Biol Blood Marrow Transplant 24, no. 6 (June 2018): 1187–95. https://doi.org/10.1016/j.bbmt.2018.01.039.

PMID
29410180
Full Text

Pages