Hematology

Murat Osman Arcasoy, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Duke Box 3912, Durham, NC 27710
Phone (919) 684-5350
Email address arcas001@mc.duke.edu

Dr. Arcasoy's research interests include 1)The role of cytokines and cytokine receptors in hematopoietic commitment and lineage-specific differentiation 2) Mechanisms of tissue-specific expression of erythropoietin receptor (EPOR) gene and its role in lineage commitment and lineage-specific differentiation 3) Studies of the molecular basis of familial and congenital myeloproliferative disorders.4). Isolation of novel hematopoietic cytokine-responsive genes and study of their function and regulation 5). Characterization of novel non-hematopoietic functions of EPOR signaling

Dr. Arcasoy's laboratory has been studying the expression, regulation and function of the EPOR gene focusing on the function of naturally occuring mutations of the EPOR gene that result in primary familial and congenital polycythemia as well as the non-hematopoietic expression and functions of EPOR in vascular endothelium, macrophages, cardiac myocytes and cancer cells. We have also been studying global gene expression in erythroid cells from patients with polycythemia vera to better characterize the molecular signature of the disorder and develop new diagnostic tools.

Education and Training

  • Fellow in Medical Oncology, Medicine, Yale University, 1997 - 1998
  • Hematology Fellow, Medicine, Yale University, 1992 - 1993
  • Chief Medical Resident, Medicine, State University of New York at Brooklyn, 1991 - 1992
  • Medical Resident, Medicine, State University of New York at Brooklyn, 1988 - 1991
  • M.D., Aegean University School of Medicine (Turkey), 1987

Grants

Publications

Mascarenhas, J., H. Kosiorek, J. Prchal, A. Yacoub, D. Berenzon, M. R. Baer, E. Ritchie, et al. “A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis.” Leukemia 33, no. 12 (December 2019): 2974–78. https://doi.org/10.1038/s41375-019-0524-7.

PMID
31363161
Full Text

Yacoub, Abdulraheem, John Mascarenhas, Heidi Kosiorek, Josef T. Prchal, Dmitry Berenzon, Maria R. Baer, Ellen Ritchie, et al. “Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea.” Blood 134, no. 18 (October 31, 2019): 1498–1509. https://doi.org/10.1182/blood.2019000428.

PMID
31515250
Full Text

Gable, Dustin L., Valeriya Gaysinskaya, Christine C. Atik, C Conover Talbot, Byunghak Kang, Susan E. Stanley, Elizabeth W. Pugh, et al. “ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.” Genes Dev 33, no. 19–20 (October 1, 2019): 1381–96. https://doi.org/10.1101/gad.326785.119.

PMID
31488579
Full Text

Grainger, Brian T., Murat O. Arcasoy, and Christopher A. Kenedi. “Feasibility of myelosuppressive chemotherapy in psychiatric patients on clozapine: A systematic review of the literature.” Eur J Haematol 103, no. 4 (October 2019): 277–86. https://doi.org/10.1111/ejh.13285.

PMID
31257631
Full Text

Diep, Robert T., Kristin Corey, and Murat O. Arcasoy. “A novel nucleotide substitution in the 5' untranslated region of ANKRD26 gene is associated with inherited thrombocytopenia: a report of two new families.” Ann Hematol 98, no. 7 (July 2019): 1789–91. https://doi.org/10.1007/s00277-019-03632-y.

PMID
30747248
Full Text

Verstovsek, Srdan, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, et al. “Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial.” J Hematol Oncol 10, no. 1 (February 22, 2017): 55. https://doi.org/10.1186/s13045-017-0417-z.

PMID
28228106
Full Text

Abril, Maria K., Adam S. Barnett, Kara Wegermann, Eric Fountain, Andrew Strand, Benjamin M. Heyman, Britton A. Blough, et al. “Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.” Open Forum Infect Dis 3, no. 3 (September 2016): ofw144. https://doi.org/10.1093/ofid/ofw144.

PMID
27704003
Full Text

Shanavas, Mohamed, Uday Popat, Laura C. Michaelis, Veena Fauble, Donal McLornan, Rebecca Klisovic, John Mascarenhas, et al. “Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis with Prior Exposure to Janus Kinase 1/2 Inhibitors.” Biol Blood Marrow Transplant 22, no. 3 (March 2016): 432–40. https://doi.org/10.1016/j.bbmt.2015.10.005.

PMID
26493563
Full Text

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