Nephrology

Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York at Brooklyn, 1996

Grants

Publications

Brown, Landon, Alison Luciano, Jane Pendergast, Pascale Khairallah, Cheryl A. M. Anderson, James Sondheimer, L Lee Hamm, et al. “Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study..” Am J Kidney Dis 74, no. 2 (August 2019): 203–12. https://doi.org/10.1053/j.ajkd.2018.12.043.

PMID
30910373
Full Text

Rope, R., J. Perl, S. Anand, K. Kalantar-Zadeh, A. Levin, A. Fogo, A. Cheung, et al. “Global Health Training Opportunities in North American Nephrology Fellowships.” Kidney International Reports 4, no. 7 (July 1, 2019): 904–7. https://doi.org/10.1016/j.ekir.2019.04.019.

Full Text

Paluch, Amanda E., Lindsay R. Pool, Tamara Isakova, Cora E. Lewis, Rupal Mehta, Pamela J. Schreiner, Stephen Sidney, Myles Wolf, and Mercedes R. Carnethon. “Association of Fitness With Racial Differences in Chronic Kidney Disease..” Am J Prev Med 57, no. 1 (July 2019): 68–76. https://doi.org/10.1016/j.amepre.2019.02.016.

PMID
31122794
Full Text

Yokoyama, Keitaro, Masafumi Fukagawa, Takashi Akiba, Masaaki Nakayama, Kyoko Ito, Koji Hanaki, Myles Wolf, and Hideki Hirakata. “Randomised clinical trial of ferric citrate hydrate on anaemia management in haemodialysis patients with hyperphosphataemia: ASTRIO study..” Sci Rep 9, no. 1 (June 20, 2019). https://doi.org/10.1038/s41598-019-45335-4.

PMID
31222044
Full Text

Lunyera, Joseph, Clemontina A. Davenport, Jane Pendergast, Solomon K. Musani, Nrupen A. Bhavsar, Mario Sims, Stanford Mwasongwe, et al. “Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study.,” June 1, 2019. https://doi.org/10.1210/jc.2018-01747.

PMID
30668751
Full Text

Bundy, Joshua D., Xuan Cai, Julia J. Scialla, Mirela A. Dobre, Jing Chen, Chi-Yuan Hsu, Mary B. Leonard, et al. “Serum Calcification Propensity and Coronary Artery Calcification Among Patients With CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study..” Am J Kidney Dis 73, no. 6 (June 2019): 806–14. https://doi.org/10.1053/j.ajkd.2019.01.024.

PMID
30935773
Full Text

Ix, Joachim H., Tamara Isakova, Brett Larive, Kalani L. Raphael, Dominic S. Raj, Alfred K. Cheung, Stuart M. Sprague, et al. “Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in CKD: The COMBINE Trial..” J Am Soc Nephrol 30, no. 6 (June 2019): 1096–1108. https://doi.org/10.1681/ASN.2018101058.

PMID
31085679
Full Text

Amdur, Richard L., Harold I. Feldman, Elizabeth A. Dominic, Amanda H. Anderson, Srinivasan Beddhu, Mahboob Rahman, Myles Wolf, et al. “Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study..” Am J Kidney Dis 73, no. 3 (March 2019): 344–53. https://doi.org/10.1053/j.ajkd.2018.09.012.

PMID
30545708
Full Text

Block, Geoffrey A., David P. Rosenbaum, Andrew Yan, Peter J. Greasley, Glenn M. Chertow, and Myles Wolf. “The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia..” Nephrol Dial Transplant 34, no. 2 (February 1, 2019): 339–46. https://doi.org/10.1093/ndt/gfy061.

PMID
29617976
Full Text

Pages