Nephrology

Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Distinguished Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York, Brooklyn, 1996

Grants

Publications

Cohen, Jordana B., Wei Yang, Liang Li, Xiaoming Zhang, Zihe Zheng, Paula Orlandi, Nisha Bansal, et al. “Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.” Am J Kidney Dis 79, no. 1 (January 2022): 36-44.e1. https://doi.org/10.1053/j.ajkd.2021.03.021.

PMID
34052355
Full Text

Kula, Alexander J., Ronit Katz, Leila R. Zelnick, Elsayed Soliman, Alan Go, Michael Shlipak, Rajat Deo, et al. “Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease.” Nephrol Dial Transplant 36, no. 12 (December 2, 2021): 2282–89. https://doi.org/10.1093/ndt/gfaa296.

PMID
33367652
Full Text

Mehta, Rupal C., Monique E. Cho, Xuan Cai, Jungwha Lee, Jing Chen, Jiang He, John Flack, et al. “Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease.” Kidney Int 100, no. 6 (December 2021): 1292–1302. https://doi.org/10.1016/j.kint.2021.07.013.

PMID
34339746
Full Text

Edmonston, Daniel L., Roland Matsouaka, Svati H. Shah, Sudarshan Rajagopal, and Myles Wolf. “Noninvasive Risk Score to Screen for Pulmonary Hypertension With Elevated Pulmonary Vascular Resistance in Diseases of Chronic Volume Overload.” Am J Cardiol 159 (November 15, 2021): 113–20. https://doi.org/10.1016/j.amjcard.2021.08.016.

PMID
34497006
Full Text

Hsu, Chi-Yuan, Wei Yang, Rishi V. Parikh, Amanda H. Anderson, Teresa K. Chen, Debbie L. Cohen, Jiang He, et al. “Race, Genetic Ancestry, and Estimating Kidney Function in CKD.” N Engl J Med 385, no. 19 (November 4, 2021): 1750–60. https://doi.org/10.1056/NEJMoa2103753.

PMID
34554660
Full Text

Paul, Shejuti, Mandy Wong, Ehimare Akhabue, Rupal C. Mehta, Holly Kramer, Tamara Isakova, Mercedes R. Carnethon, Myles Wolf, and Orlando M. Gutiérrez. “Fibroblast Growth Factor 23 and Incident Cardiovascular Disease and Mortality in Middle-Aged Adults.” J Am Heart Assoc 10, no. 16 (August 17, 2021): e020196. https://doi.org/10.1161/JAHA.120.020196.

PMID
34387090
Full Text

Courbon, Guillaume, Connor Francis, Claire Gerber, Samantha Neuburg, Xueyan Wang, Emily Lynch, Tamara Isakova, et al. “Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease.” Bone Res 9, no. 1 (August 2, 2021): 35. https://doi.org/10.1038/s41413-021-00154-0.

PMID
34334787
Full Text

Edmonston, Daniel L., Tamara Isakova, Laura M. Dember, Steven Brunelli, Amy Young, Rebecca Brosch, Srinivasan Beddhu, Hrishikesh Chakraborty, and Myles Wolf. “Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis.” Am J Kidney Dis 77, no. 6 (June 2021): 920-930.e1. https://doi.org/10.1053/j.ajkd.2020.10.008.

PMID
33279558
Full Text

Bansal, Nisha, Leila R. Zelnick, Elsayed Z. Soliman, Amanda Anderson, Robert Christenson, Christopher DeFilippi, Rajat Deo, et al. “Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.” Am J Kidney Dis 77, no. 6 (June 2021): 907–19. https://doi.org/10.1053/j.ajkd.2020.09.021.

PMID
33309861
Full Text

Pages