Nephrology

Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Distinguished Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York, Brooklyn, 1996

Grants

Publications

Hofacker, Samuel A., Matthew E. Dupre, Kimberly Vellano, Bryan McNally, Monique Anderson Starks, Myles Wolf, Laura P. Svetkey, and Patrick H. Pun. “Association between patient race and staff resuscitation efforts after cardiac arrest in outpatient dialysis clinics: A study from the CARES surveillance group.” Resuscitation 156 (November 2020): 42–50. https://doi.org/10.1016/j.resuscitation.2020.07.036.

PMID
32860854
Full Text

Florenzano, Pablo, Macarena Jimenez, Carlos R. Ferreira, Galina Nesterova, Mary Scott Roberts, Sri Harsha Tella, Luis Fernandez de Castro, et al. “Nephropathic Cystinosis: A Distinct Form of CKD-Mineral and Bone Disorder that Provides Novel Insights into the Regulation of FGF23.” J Am Soc Nephrol 31, no. 9 (September 2020): 2184–92. https://doi.org/10.1681/ASN.2019111172.

PMID
32631973
Full Text

Edmonston, Daniel L., Matthew T. Roe, Geoffrey Block, Paul T. Conway, Laura M. Dember, Peter M. DiBattiste, Tom Greene, et al. “Drug Development in Kidney Disease: Proceedings From a Multistakeholder Conference.” Am J Kidney Dis, August 5, 2020. https://doi.org/10.1053/j.ajkd.2020.05.026.

PMID
32768631
Full Text

Ishigami, Junichi, Jonathan T. Taliercio, Harold I. Feldman, Anand Srivastava, Raymond R. Townsend, Debbie L. Cohen, Edward J. Horwitz, et al. “Fibroblast Growth Factor 23 and Risk of Hospitalization with Infection in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study.” J Am Soc Nephrol 31, no. 8 (August 2020): 1836–46. https://doi.org/10.1681/ASN.2019101106.

PMID
32576601
Full Text

Frazier, Rebecca, Alexander Hodakowski, Xuan Cai, Jungwha Lee, Anaadriana Zakarija, Brady Stein, Valentin David, Myles Wolf, Tamara Isakova, and Rupal Mehta. “Effects of ferric carboxymaltose on markers of mineral and bone metabolism: A single-center prospective observational study of women with iron deficiency.” Bone 141 (July 28, 2020): 115559. https://doi.org/10.1016/j.bone.2020.115559.

PMID
32730929
Full Text

Perelló, Joan, Miquel D. Ferrer, Maria Del Mar Pérez, Nadine Kaesler, Vincent M. Brandenburg, Geert J. Behets, Patrick C. D’Haese, et al. “Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis.” Br J Pharmacol, June 18, 2020. https://doi.org/10.1111/bph.15163.

PMID
32557649
Full Text

Lentz, Trevor A., Lesley H. Curtis, Frank W. Rockhold, David Martin, Tomas L. G. Andersson, Carolyn Arias, Jesse A. Berlin, et al. “Designing, Conducting, Monitoring, and Analyzing Data from Pragmatic Randomized Clinical Trials: Proceedings from a Multi-stakeholder Think Tank Meeting.” Ther Innov Regul Sci, June 8, 2020. https://doi.org/10.1007/s43441-020-00175-7.

PMID
32514736
Full Text

Srivastava, Anand, Xuan Cai, Jungwha Lee, Wei Li, Brett Larive, Cynthia Kendrick, Jennifer J. Gassman, et al. “Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD.” Clin J Am Soc Nephrol 15, no. 6 (June 8, 2020): 776–83. https://doi.org/10.2215/CJN.13201019.

PMID
32345747
Full Text

Mehta, Rupal, Xuan Cai, Jungwha Lee, Dawei Xie, Xue Wang, Julia Scialla, Amanda H. Anderson, et al. “Serial Fibroblast Growth Factor 23 Measurements and Risk of Requirement for Kidney Replacement Therapy: The CRIC (Chronic Renal Insufficiency Cohort) Study.” Am J Kidney Dis 75, no. 6 (June 2020): 908–18. https://doi.org/10.1053/j.ajkd.2019.09.009.

PMID
31864822
Full Text

Ishigami, Junichi, Jonathan Taliercio, Harold I Feldman, Anand Srivastava, Raymond Townsend, Debbie L Cohen, Edward Horwitz, et al. “Inflammatory Markers and Incidence of Hospitalization With Infection in Chronic Kidney Disease.” Am J Epidemiol 189, no. 5 (May 5, 2020): 433–44. https://doi.org/10.1093/aje/kwz246.

PMID
31673705
Full Text

Pages