Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Distinguished Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York, Brooklyn, 1996

Publications

Mehta, Rupal, Xuan Cai, Jungwha Lee, Dawei Xie, Xue Wang, Julia Scialla, Amanda H. Anderson, et al. “Serial Fibroblast Growth Factor 23 Measurements and Risk of Requirement for Kidney Replacement Therapy: The CRIC (Chronic Renal Insufficiency Cohort) Study.” Am J Kidney Dis 75, no. 6 (June 2020): 908–18. https://doi.org/10.1053/j.ajkd.2019.09.009.

PMID
31864822
Full Text

Ishigami, Junichi, Jonathan Taliercio, Harold I Feldman, Anand Srivastava, Raymond Townsend, Debbie L Cohen, Edward Horwitz, et al. “Inflammatory Markers and Incidence of Hospitalization With Infection in Chronic Kidney Disease.” Am J Epidemiol 189, no. 5 (May 5, 2020): 433–44. https://doi.org/10.1093/aje/kwz246.

PMID
31673705
Full Text

Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD.” Am J Kidney Dis 75, no. 5 (May 2020): 713–24. https://doi.org/10.1053/j.ajkd.2019.08.027.

PMID
31732231
Full Text

Nelson, Adam J., Paolo Raggi, Myles Wolf, Alexander M. Gold, Glenn M. Chertow, and Matthew T. Roe. “Targeting Vascular Calcification in Chronic Kidney Disease.” Jacc: Basic to Translational Science 5, no. 4 (April 27, 2020): 398–412. https://doi.org/10.1016/j.jacbts.2020.02.002.

PMID
32368697
Full Text

Isakova, Tamara, Xuan Cai, Jungwha Lee, Rupal Mehta, Xiaoming Zhang, Wei Yang, Lisa Nessel, et al. “Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.” Am J Kidney Dis 75, no. 2 (February 2020): 235–44. https://doi.org/10.1053/j.ajkd.2019.07.022.

PMID
31668375
Full Text

Wolf, Myles, Geoffrey A. Block, Glenn M. Chertow, Kerry Cooper, Bruno Fouqueray, Sharon M. Moe, Yan Sun, Holly Tomlin, Marc Vervloet, and Rainer Oberbauer. “Effects of etelcalcetide on fibroblast growth factor 23 in patients with secondary hyperparathyroidism receiving hemodialysis.” Clin Kidney J 13, no. 1 (February 2020): 75–84. https://doi.org/10.1093/ckj/sfz034.

PMID
32082556
Full Text

Raphael, Kalani L., Tamara Isakova, Joachim H. Ix, Dominic S. Raj, Myles Wolf, Linda F. Fried, Jennifer J. Gassman, et al. “A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial.” J Am Soc Nephrol 31, no. 1 (January 2020): 161–74. https://doi.org/10.1681/ASN.2019030287.

PMID
31848294
Full Text

Pages