Nephrology

Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Professor of Medicine
Chief of Nephrology
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York at Brooklyn, 1996

Grants

Publications

Kolak, M, Bradley, M, Block, DR, Pool, L, Garg, G, Toman, CK, Boatright, K, Lipiszko, D, Koschinsky, J, Kershaw, K, Carnethon, M, Isakova, T, and Wolf, M. "Urban foodscape trends: Disparities in healthy food access in Chicago, 2007-2014." Health & Place 52 (July 9, 2018): 231-239.

PMID
30015180
Full Text

Gerber, C, Cai, X, Lee, J, Craven, T, Scialla, J, Souma, N, Srivastava, A, Mehta, R, Paluch, A, Hodakowski, A, Frazier, R, Carnethon, MR, Wolf, MS, and Isakova, T. "Incidence and Progression of Chronic Kidney Disease in Black and White Individuals with Type 2 Diabetes." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 6 (June 2018): 884-892.

PMID
29798889
Full Text

Isakova, T, Cai, X, Lee, J, Xie, D, Wang, X, Mehta, R, Allen, NB, Scialla, JJ, Pencina, MJ, Anderson, AH, Talierco, J, Chen, J, Fischer, MJ, Steigerwalt, SP, Leonard, MB, Hsu, C-Y, de Boer, IH, Kusek, JW, Feldman, HI, Wolf, M, and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, . "Longitudinal FGF23 Trajectories and Mortality in Patients with CKD." Journal of the American Society of Nephrology : Jasn 29, no. 2 (February 2018): 579-590.

PMID
29167351
Full Text

Mitsnefes, MM, Betoko, A, Schneider, MF, Salusky, IB, Wolf, MS, Jüppner, H, Warady, BA, Furth, SL, and Portale, AA. "FGF23 and Left Ventricular Hypertrophy in Children with CKD." Clinical journal of the American Society of Nephrology : CJASN 13, no. 1 (January 2018): 45-52.

PMID
29025789
Full Text

Batacchi, Z, Robinson-Cohen, C, Hoofnagle, AN, Isakova, T, Kestenbaum, B, Martin, KJ, Wolf, MS, and de Boer, IH. "Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD." Clinical Journal of the American Society of Nephrology : Cjasn 12, no. 9 (September 2017): 1498-1506.

PMID
28768705
Full Text

Kim, S-J, Cheresh, P, Eren, M, Jablonski, RP, Yeldandi, A, Ridge, KM, Budinger, GRS, Kim, D-H, Wolf, M, Vaughan, DE, and Kamp, DW. "Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis." American journal of physiology. Lung cellular and molecular physiology 313, no. 1 (July 2017): L16-L26.

PMID
28428174
Full Text

Munoz Mendoza, J, Isakova, T, Cai, X, Bayes, LY, Faul, C, Scialla, JJ, Lash, JP, Chen, J, He, J, Navaneethan, S, Negrea, L, Rosas, SE, Kretzler, M, Nessel, L, Xie, D, Anderson, AH, Raj, DS, Wolf, M, and CRIC Study Investigators, . "Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease." Kidney International 91, no. 3 (March 2017): 711-719.

PMID
28017325
Full Text

Yuen, SN, Kramer, H, Luke, A, Bovet, P, Plange-Rhule, J, Forrester, T, Lambert, V, Wolf, M, Camacho, P, Harders, R, Dugas, L, Cooper, R, and Durazo-Arvizu, R. "Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization." The Journal of Clinical Endocrinology & Metabolism 101, no. 5 (May 2016): 2246-2253.

Full Text

Ali, FN, Josefson, J, Mendez, AJ, Mestan, K, and Wolf, M. "Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates." The Journal of Clinical Endocrinology & Metabolism 101, no. 4 (April 2016): 1673-1679.

Full Text

Leaf, DE, Christov, M, Jüppner, H, Siew, E, Ikizler, TA, Bian, A, Chen, G, Sabbisetti, VS, Bonventre, JV, Cai, X, Wolf, M, and Waikar, SS. "Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery." Kidney International 89, no. 4 (April 2016): 939-948.

Full Text

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