Nephrology

Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Distinguished Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York at Brooklyn, 1996

Grants

Publications

Isakova, Tamara, Xuan Cai, Jungwha Lee, Rupal Mehta, Xiaoming Zhang, Wei Yang, Lisa Nessel, et al. “Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.” Am J Kidney Dis 75, no. 2 (February 2020): 235–44. https://doi.org/10.1053/j.ajkd.2019.07.022.

PMID
31668375
Full Text

Pool, L. R., K. N. Kershaw, P. Gordon-Larsen, O. M. Gutiérrez, J. P. Reis, T. Isakova, M. Wolf, and M. R. Carnethon. “Racial Differences in the Associations Between Food Insecurity and Fibroblast Growth Factor 23 in the Coronary Artery Risk Development in Young Adults Study.” Journal of Renal Nutrition, January 1, 2020. https://doi.org/10.1053/j.jrn.2020.01.020.

Full Text

Raphael, Kalani L., Tamara Isakova, Joachim H. Ix, Dominic S. Raj, Myles Wolf, Linda F. Fried, Jennifer J. Gassman, et al. “A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial.” J Am Soc Nephrol 31, no. 1 (January 2020): 161–74. https://doi.org/10.1681/ASN.2019030287.

PMID
31848294
Full Text

Willey, Joshua Z., Yeseon Park Moon, S Ali Husain, Mitchell S. V. Elkind, Ralph L. Sacco, Myles Wolf, Ken Cheung, Clinton B. Wright, and Sumit Mohan. “Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: The Northern Manhattan Study.” Plos One 15, no. 1 (2020): e0226509. https://doi.org/10.1371/journal.pone.0226509.

PMID
31940363
Full Text

Mehta, Rupal, Xuan Cai, Jungwha Lee, Dawei Xie, Xue Wang, Julia Scialla, Amanda H. Anderson, et al. “Serial Fibroblast Growth Factor 23 Measurements and Risk of Requirement for Kidney Replacement Therapy: The CRIC (Chronic Renal Insufficiency Cohort) Study.” Am J Kidney Dis, December 18, 2019. https://doi.org/10.1053/j.ajkd.2019.09.009.

PMID
31864822
Full Text

Edmonston, Daniel, Daniel Wojdyla, Rupal Mehta, Xuan Cai, Claudia Lora, Debbie Cohen, Raymond R. Townsend, et al. “Single Measurements of Carboxy-Terminal Fibroblast Growth Factor 23 and Clinical Risk Prediction of Adverse Outcomes in CKD.” Am J Kidney Dis 74, no. 6 (December 2019): 771–81. https://doi.org/10.1053/j.ajkd.2019.05.026.

PMID
31445926
Full Text

Francis, Connor, Guillaume Courbon, Claire Gerber, Samantha Neuburg, Xueyan Wang, Corey Dussold, Maralee Capella, et al. “Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease.” Kidney Int 96, no. 6 (December 2019): 1346–58. https://doi.org/10.1016/j.kint.2019.07.026.

PMID
31668632
Full Text

Emrich, Insa E., Juliane Dederer, Angelika Kircher, Verena Klemis, Claudia S. Lennartz, Kathrin Untersteller, Stefan Wagenpfeil, Danilo Fliser, Myles Wolf, and Gunnar H. Heine. “Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet?” Nutr Metab Cardiovasc Dis 29, no. 12 (December 2019): 1361–67. https://doi.org/10.1016/j.numecd.2019.09.002.

PMID
31653518
Full Text

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