Myles Selig Wolf, MD

Professor of Medicine
Charles Johnson, M.D. Distinguished Professor of Medicine
Chief of Nephrology
Professor in Population Health Sciences
Member of the Duke Clinical Research Institute
Email address myles.wolf@duke.edu
Fax: 919-684-3011

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Education and Training

  • Research Fellowship in Nephrology, Massachusetts General Hospital, 2000 - 2001
  • Clinical Fellowship in Nephrology, Brigham and Women's Hospital, 1999 - 2000
  • Internal Medicine Residency, Massachusetts General Hospital, 1996 - 1999
  • M.Med.Sc., Harvard Medical School, 2002
  • M.D., State University of New York, Brooklyn, 1996

Publications

Schaefer, Benedikt, Moritz Tobiasch, André Viveiros, Herbert Tilg, Nicholas A. Kennedy, Myles Wolf, and Heinz Zoller. “Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside-a systematic review and meta-analysis.” Br J Clin Pharmacol 87, no. 5 (May 2021): 2256–73. https://doi.org/10.1111/bcp.14643.

PMID
33188534
Full Text

Gitomer, Berenice, Renata Pereira, Isidro B. Salusky, Jason W. Stoneback, Tamara Isakova, Xuan Cai, Lorien S. Dalrymple, et al. “Mineral bone disease in autosomal dominant polycystic kidney disease.” Kidney Int 99, no. 4 (April 2021): 977–85. https://doi.org/10.1016/j.kint.2020.07.041.

PMID
32926884
Full Text

Ghuman, Jasleen, Xuan Cai, Ravi B. Patel, Sadiya S. Khan, Jonathan Hecktman, Margaret M. Redfield, Gregory Lewis, et al. “Fibroblast Growth Factor 23 and Exercise Capacity in Heart Failure with Preserved Ejection Fraction.” J Card Fail 27, no. 3 (March 2021): 309–17. https://doi.org/10.1016/j.cardfail.2020.09.477.

PMID
33035687
Full Text

Bhandari, Sunil, Philip A. Kalra, Mario Berkowitz, Diogo Belo, Lars L. Thomsen, and Myles Wolf. “Safety and efficacy of iron isomaltoside 1000/ferric derisomaltose versus iron sucrose in patients with chronic kidney disease: the FERWON-NEPHRO randomized, open-label, comparative trial.” Nephrol Dial Transplant 36, no. 1 (January 1, 2021): 111–20. https://doi.org/10.1093/ndt/gfaa011.

PMID
32049331
Full Text

Anderson, Amanda H., Dawei Xie, Xue Wang, Robin L. Baudier, Paula Orlandi, Lawrence J. Appel, Laura M. Dember, et al. “Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.” Am J Kidney Dis 77, no. 1 (January 2021): 56-73.e1. https://doi.org/10.1053/j.ajkd.2020.07.011.

PMID
32866540
Full Text

Wolf, Myles, Michael Auerbach, Philip A. Kalra, John Glaspy, Lars L. Thomsen, and Sunil Bhandari. “Safety of ferric derisomaltose and iron sucrose in patients with iron deficiency anemia: The FERWON-IDA/NEPHRO trials.” Am J Hematol 96, no. 1 (January 2021): E11–15. https://doi.org/10.1002/ajh.26015.

PMID
33027541
Full Text

Frazier, Rebecca, Alexander Hodakowski, Xuan Cai, Jungwha Lee, Anaadriana Zakarija, Brady Stein, Valentin David, Myles Wolf, Tamara Isakova, and Rupal Mehta. “Effects of ferric carboxymaltose on markers of mineral and bone metabolism: A single-center prospective observational study of women with iron deficiency.” Bone 141 (December 2020): 115559. https://doi.org/10.1016/j.bone.2020.115559.

PMID
32730929
Full Text

Edmonston, Daniel L., Matthew T. Roe, Geoffrey Block, Paul T. Conway, Laura M. Dember, Peter M. DiBattiste, Tom Greene, et al. “Drug Development in Kidney Disease: Proceedings From a Multistakeholder Conference.” Am J Kidney Dis 76, no. 6 (December 2020): 842–50. https://doi.org/10.1053/j.ajkd.2020.05.026.

PMID
32768631
Full Text

Pool, Lindsay R., Kiarri N. Kershaw, Penny Gordon-Larsen, Orlando M. Gutiérrez, Jared P. Reis, Tamara Isakova, Myles Wolf, and Mercedes R. Carnethon. “Racial Differences in the Associations Between Food Insecurity and Fibroblast Growth Factor 23 in the Coronary Artery Risk Development in Young Adults Study.” J Ren Nutr 30, no. 6 (November 2020): 509–17. https://doi.org/10.1053/j.jrn.2020.01.020.

PMID
32147284
Full Text

Pages