Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Coates, A, Culver, B, Cockcroft, D, Hallstrand, T, Haynes, J, Kaminsky, D, MacIntyre, N, and Wanger, J. "Characterizing Nebulizer Performance for Methacholine Challenge Tests." American Journal of Respiratory and Critical Care Medicine 198, no. 8 (October 2018): 988-990.

PMID
30160985
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MacIntyre, N. "Rebuttal From Dr MacIntyre." Chest 154, no. 3 (September 1, 2018): 485-486.

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MacIntyre, N. "COUNTERPOINT: Should Computerized Protocols Replace Physicians for Managing Mechanical Ventilation? No." Chest 154, no. 3 (September 1, 2018): 481-484.

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Culver, BH, Graham, BL, MacIntyre, NR, McCormack, M, Kaminsky, DA, Coates, AL, Weiner, DJ, Rosenfeld, M, Wanger, J, and ATS Committee on Proficiency Standards for Pulmonary Function Laboratories, . "Reply to Johnson: Improve Pulmonary Function Test Reporting." American Journal of Respiratory and Critical Care Medicine 198, no. 1 (July 2018): 138-139.

PMID
29533673
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Yun, JH, Lamb, A, Chase, R, Singh, D, Parker, MM, Saferali, A, Vestbo, J, Tal-Singer, R, Castaldi, PJ, Silverman, EK, Hersh, CP, Crapo, JD, Make, BJ, Regan, EA, Beaty, T, Begum, F, Busch, R, Cho, M, DeMeo, DL, Boueiz, AR, Foreman, MG, Halper-Stromberg, E, Hansel, NN, Hardin, ME, Hayden, LP, Hetmanski, J, Hobbs, BD, Hokanson, JE, Laird, N, Lange, C, Lutz, SM, McDonald, M-L, Qiao, D, Santorico, S, Wan, ES, Won, S, Al Qaisi, M, Coxson, HO, Gray, T, Han, MK, Hoffman, EA, Humphries, S, Jacobson, FL, Judy, PF, Kazerooni, EA, Kluiber, A, Lynch, DA, Newell, JD, Ross, JC, San Jose Estepar, R, Schroeder, J, Sieren, J, Stinson, D, Stoel, BC, Tschirren, J, Van Beek, E, van Ginneken, B, van Rikxoort, E, Washko, G, Wilson, CG, Jensen, R, Everett, D, Crooks, J, Moore, C, Strand, M, Hughes, J, Kinney, G, Pratte, K, Young, KA, Curtis, JL, Martinez, CH, Pernicano, PG, Hanania, N, Alapat, P, Atik, M, Bandi, V, Boriek, A, Guntupalli, K, Guy, E, Nachiappan, A, Parulekar, A, Hersh, C, Barr, RG, Austin, J, D'Souza, B, Pearson, GDN, Rozenshtein, A, Thomashow, B, MacIntyre, N, McAdams, HP, Washington, L, McEvoy, C, Tashjian, J, Wise, R, Brown, R, Horton, K, Lambert, A, Putcha, N, Casaburi, R, Adami, A, Budoff, M, Fischer, H, Porszasz, J, Rossiter, H, Stringer, W, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Berkowitz, E, Westney, G, Bowler, R, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, G, Desai, P, Jacobs, M, Kelsen, S, Kim, V, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, ME, Dransfield, M, Bailey, W, Bhatt, S, Iyer, A, Nath, H, Wells, JM, Ramsdell, J, Friedman, P, Soler, X, Yen, A, Comellas, AP, Newell, J, Thompson, B, Kazerooni, E, Billings, J, Begnaud, A, Allen, T, Sciurba, F, Bon, J, Chandra, D, Fuhrman, C, Weissfeld, J, Anzueto, A, Adams, S, Maselli-Caceres, D, Ruiz, ME, Ivanov, Y, Kostov, K, Bourbeau, J, Fitzgerald, M, Hernandez, P, Killian, K, Levy, R, Maltais, F, O'Donnell, D, Krepelka, J, Vestbo, J, Wouters, E, Quinn, D, Bakke, P, Kosnik, M, Agusti, A, Sauleda, J, de Mallorca, P, Feschenko, Y, Gavrisyuk, V, Kiev, LY, Monogarova, N, Calverley, P, Lomas, D, MacNee, W, Singh, D, Wedzicha, J, Anzueto, A, Braman, S, Casaburi, R, Celli, B, Giessel, G, Gotfried, M, Greenwald, G, Hanania, N, Mahler, D, Make, B, Rennard, S, Rochester, C, Scanlon, P, Schuller, D, Sciurba, F, Sharafkhaneh, A, Siler, T, Silverman, E, Wanner, A, Wise, R, ZuWallack, R, Coxson, H, Crim, C, Edwards, L, Singer, RT, Yates, J, Miller, B, and Tal-Singer, R. "Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease." Journal of Allergy and Clinical Immunology 141, no. 6 (June 2018): 2037-2047.e10.

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Ekström, M, Bornefalk-Hermansson, A, Wysham, N, Currow, DC, and MacIntyre, N. "Spirometric Volumes and Breathlessness Across Levels of Airflow Limitation: The COPDGene Study." American Journal of Respiratory and Critical Care Medicine (April 27, 2018).

PMID
29702011
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Zapol, WM, Charles, HC, Martin, AR, Sá, RC, Yu, B, Ichinose, F, MacIntyre, N, Mammarappallil, J, Moon, R, Chen, JZ, Geier, ET, Darquenne, C, Prisk, GK, and Katz, I. "Pulmonary Delivery of Therapeutic and Diagnostic Gases." Journal of Aerosol Medicine and Pulmonary Drug Delivery 31, no. 2 (April 2018): 78-87.

PMID
29451844
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MacIntyre, NR, Gentile, M, Davies, J, Bergin, S, Rackley, C, and Mathews, A. "Airway pressure release ventilation: a step forward?." Intensive Care Medicine 44, no. 2 (February 2018): 272-null. (Letter)

PMID
29230522
Full Text

Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The International Journal of Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.

PMID
29297435
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MacIntyre, NR, Miller, AG, Gentile, MA, and Davies, JD. "Airway Pressure Release Ventilation Letter-Reply." Respiratory Care 63, no. 1 (January 2018): 128-129.

PMID
29237871
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