Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Kim, Victor, Huaqing Zhao, Elizabeth Regan, MeiLan K. Han, Barry J. Make, James D. Crapo, Paul W. Jones, et al. “The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition..” Chest, May 15, 2019. https://doi.org/10.1016/j.chest.2019.03.041.

PMID
31047955
Full Text

Miller, Andrew G., Kyle J. Rehder, Ira M. Cheifetz, and Neil R. MacIntyre. “Optoacoustic Evaluation of Endotracheal Tube Depth in Pediatrics..” Respir Care 63, no. 12 (December 2018): 1575–76. https://doi.org/10.4187/respcare.06687.

PMID
30467228
Full Text

"2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung." Brian L. Graham, Vito Brusasco, Felip Burgos, Brendan G. Cooper, Robert Jensen, Adrian Kendrick, Neil R. MacIntyre, Bruce R. Thompson and Jack Wanger. Eur Respir J 2017; 49: 1600016..” Eur Respir J 52, no. 5 (November 2018). https://doi.org/10.1183/13993003.50016-2016.

PMID
30467174
Full Text

Coates, Allan, Bruce Culver, Donald Cockcroft, Teal Hallstrand, Jeffrey Haynes, David Kaminsky, Neil MacIntyre, and Jack Wanger. “Characterizing Nebulizer Performance for Methacholine Challenge Tests..” Am J Respir Crit Care Med 198, no. 8 (October 15, 2018): 988–90. https://doi.org/10.1164/rccm.201805-0942ED.

PMID
30160985
Full Text

Culver, Bruce H., Brian L. Graham, Neil R. MacIntyre, Meredith McCormack, David A. Kaminsky, Allan L. Coates, Daniel J. Weiner, Margaret Rosenfeld, Jack Wanger, and Jack ATS Committee on Proficiency Standards for Pulmonary Function Laboratories. “Reply to Johnson: Improve Pulmonary Function Test Reporting..” Am J Respir Crit Care Med 198, no. 1 (July 1, 2018): 138–39. https://doi.org/10.1164/rccm.201802-0280LE.

PMID
29533673
Full Text

Yun, Jeong H., Andrew Lamb, Robert Chase, Dave Singh, Margaret M. Parker, Aabida Saferali, Jørgen Vestbo, et al. “Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease..” J Allergy Clin Immunol 141, no. 6 (June 2018): 2037-2047.e10. https://doi.org/10.1016/j.jaci.2018.04.010.

PMID
29709670
Full Text

Ekström, Magnus, Anna Bornefalk-Hermansson, Nicholas Wysham, David C. Currow, and Neil MacIntyre. “Spirometric Volumes and Breathlessness Across Levels of Airflow Limitation: The COPDGene Study..” Am J Respir Crit Care Med, April 27, 2018. https://doi.org/10.1164/rccm.201803-0594LE.

PMID
29702011
Full Text

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