Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Schoenberg, NC, Barker, AF, Bernardo, J, Deterding, RR, Ellner, JJ, Hess, DR, MacIntyre, NR, Martinez, FJ, and Wilson, KC. "A Comparative Analysis of Pulmonary and Critical Care Medicine Guideline Development Methodologies." September 2017.

PMID
28731387
Full Text

Morris, TA, Gay, PC, MacIntyre, NR, Hess, DR, Hanneman, SK, Lamberti, JP, Doherty, DE, Chang, L, and Seckel, MA. "Respiratory Compromise as a New Paradigm for the Care of Vulnerable Hospitalized Patients." Respiratory care 62, no. 4 (April 2017): 497-512.

PMID
28341777
Full Text

Miller, AG, and MacIntyre, NR. "Initial Ventilator Settings in the Emergency Department." Annals of emergency medicine 69, no. 2 (February 2017): 266-267. (Letter)

PMID
28126128
Full Text

Graham, BL, Brusasco, V, Burgos, F, Cooper, BG, Jensen, R, Kendrick, A, MacIntyre, NR, Thompson, BR, and Wanger, J. "2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung." The European respiratory journal 49, no. 1 (January 3, 2017).

PMID
28049168
Full Text

Graham, BL, Brusasco, V, Burgos, F, Cooper, BG, Jensen, R, Kendrick, A, MacIntyre, NR, Thompson, BR, and Wanger, J. "Executive Summary: 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung." The European respiratory journal 49, no. 1 (January 3, 2017).

PMID
28049167
Full Text

MacIntyre, N. "Design Features of Modern Mechanical Ventilators." Clinics in chest medicine 37, no. 4 (December 2016): 607-613. (Review)

PMID
27842742
Full Text

MacIntyre, N. "Evolving Concepts in Mechanical Ventilation." Clinics in chest medicine 37, no. 4 (December 2016): xiii-.

PMID
27842756
Full Text

Long-Term Oxygen Treatment Trial Research Group, , Albert, RK, Au, DH, Blackford, AL, Casaburi, R, Cooper, JA, Criner, GJ, Diaz, P, Fuhlbrigge, AL, Gay, SE, Kanner, RE, MacIntyre, N, Martinez, FJ, Panos, RJ, Piantadosi, S, Sciurba, F, Shade, D, Stibolt, T, Stoller, JK, Wise, R, Yusen, RD, Tonascia, J, Sternberg, AL, and Bailey, W. "A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation." The New England journal of medicine 375, no. 17 (October 2016): 1617-1627.

PMID
27783918
Full Text

Sun, W, Kechris, K, Jacobson, S, Drummond, MB, Hawkins, GA, Yang, J, Chen, T-H, Quibrera, PM, Anderson, W, Barr, RG, Basta, PV, Bleecker, ER, Beaty, T, Casaburi, R, Castaldi, P, Cho, MH, Comellas, A, Crapo, JD, Criner, G, Demeo, D, Christenson, SA, Couper, DJ, Curtis, JL, Doerschuk, CM, Freeman, CM, Gouskova, NA, Han, MK, Hanania, NA, Hansel, NN, Hersh, CP, Hoffman, EA, Kaner, RJ, Kanner, RE, Kleerup, EC, Lutz, S, Martinez, FJ, Meyers, DA, Peters, SP, Regan, EA, Rennard, SI, and Scholand, MB et al. "Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD." PLoS genetics 12, no. 8 (August 17, 2016): e1006011-.

PMID
27532455
Full Text

Macintyre, N. "Spontaneous breathing during mechanical ventilation: A two-edged sword." Critical Care Medicine 44, no. 8 (August 1, 2016): 1625-1626.

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