Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Wilson, Kevin C., David A. Kaminsky, Gaetane Michaud, Sunil Sharma, Linda Nici, Rodney J. Folz, Igor Barjaktarevic, et al. “Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens. From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force.” Ann Am Thorac Soc 17, no. 11 (November 2020): 1343–51. https://doi.org/10.1513/AnnalsATS.202005-514ST.

PMID
32663071
Full Text

Leitao Filho, Fernando Sergio, Andre Mattman, Robert Schellenberg, Gerard J. Criner, Prescott Woodruff, Stephen C. Lazarus, Richard K. Albert, et al. “Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-analysis.” Chest 158, no. 4 (October 2020): 1420–30. https://doi.org/10.1016/j.chest.2020.04.058.

PMID
32439504
Full Text

Mathews, Anne M., Nicholas G. Wysham, Jichun Xie, Xiaodi Qin, Coral X. Giovacchini, Magnus Ekström, and Neil R. MacIntyre. “Hypercapnia in Advanced Chronic Obstructive Pulmonary Disease: A Secondary Analysis of the National Emphysema Treatment Trial.” Chronic Obstr Pulm Dis 7, no. 4 (October 2020): 336–45. https://doi.org/10.15326/jcopdf.7.4.2020.0176.

PMID
32877962
Full Text

Bedoya, Armando D., Nrupen A. Bhavsar, Bhargav Adagarla, Courtney B. Page, Benjamin A. Goldstein, and Neil R. MacIntyre. “Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.” Respir Care 65, no. 9 (September 2020): 1233–40. https://doi.org/10.4187/respcare.07438.

PMID
32156789
Full Text

Criner, Rachel N., Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, et al. “Relationship between diffusion capacity and small airway abnormality in COPDGene.” In Respir Res, 20:269, 2019. https://doi.org/10.1186/s12931-019-1237-1.

PMID
31791337
Full Text

Balasubramanian, Aparna, Neil R. MacIntyre, Robert J. Henderson, Robert L. Jensen, Gregory Kinney, William W. Stringer, Craig P. Hersh, et al. “Diffusing Capacity of Carbon Monoxide in Assessment of COPD.” Chest 156, no. 6 (December 2019): 1111–19. https://doi.org/10.1016/j.chest.2019.06.035.

PMID
31352035
Full Text

Kim, Victor, Huaqing Zhao, Elizabeth Regan, MeiLan K. Han, Barry J. Make, James D. Crapo, Paul W. Jones, et al. “The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition.” Chest 156, no. 4 (October 2019): 685–95. https://doi.org/10.1016/j.chest.2019.03.041.

PMID
31047955
Full Text

Pages