Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Culver, BH, Graham, BL, MacIntyre, NR, McCormack, M, Kaminsky, DA, Coates, AL, Weiner, DJ, Rosenfeld, M, Wanger, J, and ATS Committee on Proficiency Standards for Pulmonary Function Laboratories, . "Reply to Johnson: Improve Pulmonary Function Test Reporting." American Journal of Respiratory and Critical Care Medicine 198, no. 1 (July 2018): 138-139.

PMID
29533673
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Yun, JH, Lamb, A, Chase, R, Singh, D, Parker, MM, Saferali, A, Vestbo, J, Tal-Singer, R, Castaldi, PJ, Silverman, EK, Hersh, CP, Crapo, JD, Make, BJ, Regan, EA, Beaty, T, Begum, F, Busch, R, Cho, M, DeMeo, DL, Boueiz, AR, Foreman, MG, Halper-Stromberg, E, Hansel, NN, Hardin, ME, Hayden, LP, Hetmanski, J, Hobbs, BD, Hokanson, JE, Laird, N, Lange, C, Lutz, SM, McDonald, M-L, Qiao, D, Santorico, S, Wan, ES, Won, S, Al Qaisi, M, Coxson, HO, Gray, T, Han, MK, Hoffman, EA, Humphries, S, Jacobson, FL, Judy, PF, Kazerooni, EA, Kluiber, A, Lynch, DA, Newell, JD, Ross, JC, San Jose Estepar, R, Schroeder, J, Sieren, J, Stinson, D, Stoel, BC, Tschirren, J, Van Beek, E, van Ginneken, B, van Rikxoort, E, Washko, G, Wilson, CG, Jensen, R, Everett, D, Crooks, J, Moore, C, Strand, M, Hughes, J, Kinney, G, Pratte, K, Young, KA, Curtis, JL, Martinez, CH, Pernicano, PG, Hanania, N, Alapat, P, Atik, M, Bandi, V, Boriek, A, Guntupalli, K, Guy, E, Nachiappan, A, Parulekar, A, Hersh, C, Barr, RG, Austin, J, D'Souza, B, Pearson, GDN, Rozenshtein, A, Thomashow, B, MacIntyre, N, McAdams, HP, Washington, L, McEvoy, C, Tashjian, J, Wise, R, Brown, R, Horton, K, Lambert, A, Putcha, N, Casaburi, R, Adami, A, Budoff, M, Fischer, H, Porszasz, J, Rossiter, H, Stringer, W, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Berkowitz, E, Westney, G, Bowler, R, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, G, Desai, P, Jacobs, M, Kelsen, S, Kim, V, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, ME, Dransfield, M, Bailey, W, Bhatt, S, Iyer, A, Nath, H, Wells, JM, Ramsdell, J, Friedman, P, Soler, X, Yen, A, Comellas, AP, Newell, J, Thompson, B, Kazerooni, E, Billings, J, Begnaud, A, Allen, T, Sciurba, F, Bon, J, Chandra, D, Fuhrman, C, Weissfeld, J, Anzueto, A, Adams, S, Maselli-Caceres, D, Ruiz, ME, Ivanov, Y, Kostov, K, Bourbeau, J, Fitzgerald, M, Hernandez, P, Killian, K, Levy, R, Maltais, F, O'Donnell, D, Krepelka, J, Vestbo, J, Wouters, E, Quinn, D, Bakke, P, Kosnik, M, Agusti, A, Sauleda, J, de Mallorca, P, Feschenko, Y, Gavrisyuk, V, Kiev, LY, Monogarova, N, Calverley, P, Lomas, D, MacNee, W, Singh, D, Wedzicha, J, Anzueto, A, Braman, S, Casaburi, R, Celli, B, Giessel, G, Gotfried, M, Greenwald, G, Hanania, N, Mahler, D, Make, B, Rennard, S, Rochester, C, Scanlon, P, Schuller, D, Sciurba, F, Sharafkhaneh, A, Siler, T, Silverman, E, Wanner, A, Wise, R, ZuWallack, R, Coxson, H, Crim, C, Edwards, L, Singer, RT, Yates, J, Miller, B, and Tal-Singer, R. "Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease." Journal of Allergy and Clinical Immunology 141, no. 6 (June 2018): 2037-2047.e10.

Full Text

MacIntyre, NR, Gentile, M, Davies, J, Bergin, S, Rackley, C, and Mathews, A. "Airway pressure release ventilation: a step forward?." Intensive Care Medicine 44, no. 2 (February 2018): 272-null. (Letter)

PMID
29230522
Full Text

MacIntyre, N. "Rebuttal From Dr MacIntyre(Accepted)." Chest (January 1, 2018).

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MacIntyre, N. "COUNTERPOINT: Should Computerized Protocols Replace Physicians for Managing Mechanical Ventilation? No(Accepted)." Chest (January 1, 2018).

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Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.

PMID
29297435
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MacIntyre, NR, Miller, AG, Gentile, MA, and Davies, JD. "Airway Pressure Release Ventilation Letter-Reply." Respiratory Care 63, no. 1 (January 2018): 128-129.

PMID
29237871
Full Text

Yusen, RD, Criner, GJ, Sternberg, AL, Au, DH, Fuhlbrigge, AL, Albert, RK, Casaburi, R, Stoller, JK, Harrington, KF, Cooper, JAD, Diaz, P, Gay, S, Kanner, R, MacIntyre, N, Martinez, FJ, Piantadosi, S, Sciurba, F, Shade, D, Stibolt, T, Tonascia, J, Wise, R, Bailey, WC, Bailey, WC, Fuhlbrigge, AL, Sampong, E, Sloan, K, Wagner, A, Anderson, S, Moy, M, Okunbor, O, Stoller, JK, Marlow, S, Meli, Y, Rice, R, Aboussouan, LS, Castele, R, Parambil, J, Khatri, S, Pande, A, Zein, J, Olbrych, T, and Alkins, S et al. "The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned." Annals of the American Thoracic Society 15, no. 1 (January 2018): 89-101.

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MacIntyre, NR. "Humidified High-Flow Nasal Cannula Oxygen-More Than Just Supplemental Oxygen." Critical care medicine 45, no. 12 (December 2017): 2103-2104.

PMID
29148988
Full Text

Culver, BH, Graham, BL, Coates, AL, Wanger, J, Berry, CE, Clarke, PK, Hallstrand, TS, Hankinson, JL, Kaminsky, DA, MacIntyre, NR, McCormack, MC, Rosenfeld, M, Stanojevic, S, Weiner, DJ, and ATS Committee on Proficiency Standards for Pulmonary Function Laboratories, . "Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement." American Journal of Respiratory and Critical Care Medicine 196, no. 11 (December 2017): 1463-1472.

PMID
29192835
Full Text

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