Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Criner, Rachel N., Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, et al. “Relationship between diffusion capacity and small airway abnormality in COPDGene.” In Respir Res, 20:269, 2019. https://doi.org/10.1186/s12931-019-1237-1.

PMID
31791337
Full Text

Balasubramanian, Aparna, Neil R. MacIntyre, Robert J. Henderson, Robert L. Jensen, Gregory Kinney, William W. Stringer, Craig P. Hersh, et al. “Diffusing Capacity of Carbon Monoxide in Assessment of COPD.” Chest 156, no. 6 (December 2019): 1111–19. https://doi.org/10.1016/j.chest.2019.06.035.

PMID
31352035
Full Text

Kim, Victor, Huaqing Zhao, Elizabeth Regan, MeiLan K. Han, Barry J. Make, James D. Crapo, Paul W. Jones, et al. “The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition.” Chest 156, no. 4 (October 2019): 685–95. https://doi.org/10.1016/j.chest.2019.03.041.

PMID
31047955
Full Text

Kaminsky, David, Allan Coates, Bruce Culver, Donald Cockcroft, Teal Hallstrand, Jeffrey Haynes, Neil MacIntyre, and Jack Wanger. “Reply to Amirav and Newhouse: PC20 versus PD20: Why Change a Scientifically Well-Established and Clinically Relevant Test?” Am J Respir Crit Care Med 199, no. 8 (April 15, 2019): 1038. https://doi.org/10.1164/rccm.201811-2216LE.

PMID
30640508
Full Text

Wan, Emily S., Spyridon Fortis, Elizabeth A. Regan, John Hokanson, MeiLan K. Han, Richard Casaburi, Barry J. Make, et al. “Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.” Am J Respir Crit Care Med 198, no. 11 (December 1, 2018): 1397–1405. https://doi.org/10.1164/rccm.201804-0663OC.

PMID
29874098
Full Text

Miller, Andrew G., Kyle J. Rehder, Ira M. Cheifetz, and Neil R. MacIntyre. “Optoacoustic Evaluation of Endotracheal Tube Depth in Pediatrics.” Respir Care 63, no. 12 (December 2018): 1575–76. https://doi.org/10.4187/respcare.06687.

PMID
30467228
Full Text

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