Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

MacIntyre, NR, Gentile, M, Davies, J, Bergin, S, Rackley, C, and Mathews, A. "Airway pressure release ventilation: a step forward?." Intensive care medicine 44, no. 2 (February 2018): 272-. (Letter)

PMID
29230522
Full Text

Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.

PMID
29297435
Full Text

Yusen, RD, Criner, GJ, Sternberg, AL, Au, DH, Fuhlbrigge, AL, Albert, RK, Casaburi, R, Stoller, JK, Harrington, KF, Cooper, JAD, Diaz, P, Gay, S, Kanner, R, MacIntyre, N, Martinez, FJ, Piantadosi, S, Sciurba, F, Shade, D, Stibolt, T, Tonascia, J, Wise, R, Bailey, WC, Bailey, WC, Fuhlbrigge, AL, Sampong, E, Sloan, K, Wagner, A, Anderson, S, Moy, M, Okunbor, O, Stoller, JK, Marlow, S, Meli, Y, Rice, R, Aboussouan, LS, Castele, R, Parambil, J, Khatri, S, Pande, A, Zein, J, Olbrych, T, and Alkins, S et al. "The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned." Annals of the American Thoracic Society 15, no. 1 (January 2018): 89-101.

Full Text

MacIntyre, NR. "Humidified High-Flow Nasal Cannula Oxygen-More Than Just Supplemental Oxygen." Critical care medicine 45, no. 12 (December 2017): 2103-2104.

PMID
29148988
Full Text

Culver, BH, Graham, BL, Coates, AL, Wanger, J, Berry, CE, Clarke, PK, Hallstrand, TS, Hankinson, JL, Kaminsky, DA, MacIntyre, NR, McCormack, MC, Rosenfeld, M, Stanojevic, S, Weiner, DJ, and ATS Committee on Proficiency Standards for Pulmonary Function Laboratories, . "Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement." American journal of respiratory and critical care medicine 196, no. 11 (December 2017): 1463-1472.

PMID
29192835
Full Text

Giovacchini, CX, Mathews, AM, Lawlor, BR, and MacIntyre, NR. "Titrating Oxygen Requirements During Exercise: Evaluation of a Standardized Single Walk Test Protocol." Chest (November 20, 2017).

PMID
29170035
Full Text

Schoenberg, NC, Barker, AF, Bernardo, J, Deterding, RR, Ellner, JJ, Hess, DR, MacIntyre, NR, Martinez, FJ, and Wilson, KC. "A Comparative Analysis of Pulmonary and Critical Care Medicine Guideline Development Methodologies." September 2017.

PMID
28731387
Full Text

Boueiz, A, Chang, Y, Cho, MH, Washko, GR, San José Estépar, R, Bowler, RP, Crapo, JD, DeMeo, DL, Dy, JG, Silverman, EK, Castaldi, PJ, Crapo, J, Silverman, E, Make, B, Regan, E, Beaty, T, Laird, N, Lange, C, Cho, MH, Santorico, S, Hokanson, J, DeMeo, D, Hansel, N, Hersh, C, Castaldi, P, McDonald, M-L, Wan, E, Hardin, M, Hetmanski, J, Parker, M, Foreman, M, Hobbs, B, Busch, R, Boueiz, A, Castaldi, P, Hardin, M, Qiao, D, Regan, E, Halper-Stromberg, E, Begum, F, Won, S, Lutz, S, and Lynch, DA et al. "Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression." Chest (September 2017).

Full Text

Morris, TA, Gay, PC, MacIntyre, NR, Hess, DR, Hanneman, SK, Lamberti, JP, Doherty, DE, Chang, L, and Seckel, MA. "Respiratory Compromise as a New Paradigm for the Care of Vulnerable Hospitalized Patients." Respiratory care 62, no. 4 (April 2017): 497-512.

PMID
28341777
Full Text

Miller, AG, and MacIntyre, NR. "Initial Ventilator Settings in the Emergency Department." Annals of emergency medicine 69, no. 2 (February 2017): 266-267. (Letter)

PMID
28126128
Full Text

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