Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Piryani, SO, Jiao, Y, Kam, AYF, Liu, Y, Vo-Dinh, T, Chen, BJ, Chao, NJ, and Doan, PL. "Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury." International Journal of Radiation Oncology, Biology, Physics (February 11, 2019).

PMID
30763662
Full Text

Zheng, J, Sha, Y, Roof, L, Foreman, O, Lazarchick, J, Venkta, JK, Kozlowski, C, Gasparetto, C, Chao, N, Ebens, A, Hu, J, and Kang, Y. "Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade." Cancer Letters 440-441 (January 2019): 1-10.

PMID
30312729
Full Text

Jacobs, AR, Guyon, T, Headley, V, Nair, M, Ricketts, W, Gray, G, Wong, JYC, Chao, N, and Terbrueggen, R. "Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident." International Journal of Radiation Biology (December 3, 2018): 1-9.

PMID
30507310
Full Text

Jauhari, S, and Chao, N. "Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease." Current Stem Cell Reports 4, no. 4 (December 1, 2018): 318-326. (Review)

Full Text

Iversen, ES, McCarthy, JM, Bell Burdett, K, Lipton, G, Phillips, G, Dressman, H, Ross, J, and Chao, N. "Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans." International Journal of Radiation Biology (October 29, 2018): 1-10.

PMID
30371121
Full Text

Poe, JC, Jia, W, Di Paolo, JA, Reyes, NJ, Kim, JY, Su, H, Sundy, JS, Cardones, AR, Perez, VL, Chen, BJ, Chao, NJ, Cardona, DM, Saban, DR, and Sarantopoulos, S. "SYK inhibitor entospletinib prevents ocular and skin GVHD in mice." Jci Insight 3, no. 19 (October 4, 2018).

PMID
30282825
Full Text

Rein, LAM, Yang, H, and Chao, NJ. "Applications of Gene Editing Technologies to Cellular Therapies." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 8 (August 2018): 1537-1545. (Review)

PMID
29601858
Full Text

Sivaraj, D, Green, MM, Kang, Y, Long, GD, Rizzieri, DA, Li, Z, Garrett, AH, McIntyre, JL, Chao, NJ, and Gasparetto, C. "Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma." Blood Cancer Journal 8, no. 8 (July 31, 2018): 71-null. (Letter)

PMID
30065277
Full Text

Turcotte, LM, Wang, T, Hemmer, MT, Spellman, SR, Arora, M, Couriel, D, Alousi, A, Pidala, J, Abdel-Azim, H, Ahmed, I, Beitinjaneh, A, Buchbinder, D, Byrne, M, Callander, N, Chao, N, Choi, SW, DeFilipp, Z, Gadalla, SM, Gale, RP, Gergis, U, Hashmi, S, Hematti, P, Holmberg, L, Inamoto, Y, Kamble, RT, Lehmann, L, MacMillan, MA, McIver, Z, Nishihori, T, Norkin, M, O'Brien, T, Olsson, RF, Reshef, R, Saad, A, Savani, BN, Schouten, HC, Seo, S, Solh, M, Verdonck, L, Vij, R, Wirk, B, Yared, J, Horowitz, MM, Knight, JM, and Verneris, MR. "Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation." Bone Marrow Transplantation 53, no. 7 (July 2018): 932-937. (Letter)

PMID
29382954
Full Text

Ai, H-S, Guo, M, and Chao, NJ. "Study Limitations in HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia-Reply." Jama Oncology 4, no. 6 (June 2018): 891-null.

PMID
29710175
Full Text

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