Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Sung, Anthony D., Shekeab Jauhari, Sharareh Siamakpour-Reihani, Arati V. Rao, Janet Staats, Cliburn Chan, Everett Meyer, et al. “Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.” Am J Hematol 95, no. 6 (June 2020): 662–71. https://doi.org/10.1002/ajh.25781.

PMID
32162718
Full Text

Lazaryan, Aleksandr, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A. Kharfan-Dabaja, David I. Marks, Nelli Bejanyan, et al. “Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research.” Haematologica 105, no. 5 (May 2020): 1329–38. https://doi.org/10.3324/haematol.2019.220756.

PMID
31558669
Full Text

Peled, Jonathan U., Antonio L. C. Gomes, Sean M. Devlin, Eric R. Littmann, Ying Taur, Anthony D. Sung, Daniela Weber, et al. “Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.” N Engl J Med 382, no. 9 (February 27, 2020): 822–34. https://doi.org/10.1056/NEJMoa1900623.

PMID
32101664
Full Text

Cairo, M. S., K. R. Cooke, H. M. Lazarus, and N. Chao. “Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation.” British Journal of Haematology, January 1, 2020. https://doi.org/10.1111/bjh.16557.

Full Text

Hildebrandt, G. C., and N. Chao. “Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation.” British Journal of Haematology, January 1, 2020. https://doi.org/10.1111/bjh.16621.

Full Text

Iversen, Edwin S., Janice M. McCarthy, Kirsten Bell Burdett, Gary Lipton, Gary Phillips, Holly Dressman, Joel Ross, and Nelson Chao. “Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans.” Int J Radiat Biol 96, no. 1 (January 2020): 47–56. https://doi.org/10.1080/09553002.2018.1532614.

PMID
30371121
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Jacobs, Aviva R., Timothy Guyon, Violetta Headley, Mahalakshmi Nair, William Ricketts, Gerry Gray, Jeffery Y. C. Wong, Nelson Chao, and Robert Terbrueggen. “Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident.” Int J Radiat Biol 96, no. 1 (January 2020): 57–66. https://doi.org/10.1080/09553002.2018.1532615.

PMID
30507310
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Chao, Nelson J. “Transplantation without pretransplant therapy: Is this a possibility? Insights into providing transplantation at diagnosis for patients with acute leukemia.” Best Pract Res Clin Haematol 32, no. 4 (December 2019): 101108. https://doi.org/10.1016/j.beha.2019.101108.

PMID
31779981
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Stein-Thoeringer, C. K., K. B. Nichols, A. Lazrak, M. D. Docampo, A. E. Slingerland, J. B. Slingerland, A. G. Clurman, et al. “Lactose drives Enterococcus expansion to promote graft-versus-host disease.” Science 366, no. 6469 (November 29, 2019): 1143–49. https://doi.org/10.1126/science.aax3760.

PMID
31780560
Full Text

Panea, Razvan I., Cassandra L. Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann M. Moormann, Juliana A. Otieno, et al. “The whole-genome landscape of Burkitt lymphoma subtypes.” Blood 134, no. 19 (November 7, 2019): 1598–1607. https://doi.org/10.1182/blood.2019001880.

PMID
31558468
Full Text

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