Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Percival, Mary-Elizabeth, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark Litzow, Partow Kebriaei, et al. “Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.” Bone Marrow Transplant 56, no. 9 (September 2021): 2108–17. https://doi.org/10.1038/s41409-021-01261-6.

PMID
33864019
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Percival, Mary-Elizabeth, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark Litzow, Partow Kebriaei, et al. “Correction to: Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.” Bone Marrow Transplant 56, no. 9 (September 2021): 2319. https://doi.org/10.1038/s41409-021-01353-3.

PMID
34017072
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Islam, Prioty, Helen Tang, Haesu Jin, Felicia Cao, Lauren M. Bohannon, Yi Ren, Nelson J. Chao, et al. “Female Sex Is Associated with Improved Long-Term Survival Following Allogeneic Hematopoietic Stem Cell Transplantation.” Transplantation and Cellular Therapy 27, no. 9 (September 2021): 784.e1-784.e7. https://doi.org/10.1016/j.jtct.2021.06.012.

PMID
34146734
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Liu, JoAnn, Deborah Hutch Allen, Martha Lassiter, Felicia Cao, Anthony D. Sung, and Nelson J. Chao. “Homecare Encounters: An Organizational Response to Innovative Care for Patients Undergoing Hematopoietic Stem Cell Transplantation During COVID-19.” Clin J Oncol Nurs 25, no. 4 (August 1, 2021): 457–64. https://doi.org/10.1188/21.CJON.457-464.

PMID
34269347
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Bohannon, Lauren, Helen Tang, Kristin Page, Yi Ren, Sin-Ho Jung, Alexandra Artica, Anne Britt, et al. “Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies.” Transplant Cell Ther 27, no. 8 (August 2021): 669.e1-669.e8. https://doi.org/10.1016/j.jtct.2021.05.002.

PMID
33991725
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Pabon, Cindy M., Zhiguo Li, Therese Hennig, Carlos de Castro, Jadee L. Neff, Mitchell E. Horwitz, Thomas W. LeBlanc, et al. “Morphologic leukemia-free state in acute myeloid leukemia is sufficient for successful allogeneic hematopoietic stem cell transplant.” Blood Cancer J 11, no. 5 (May 16, 2021): 92. https://doi.org/10.1038/s41408-021-00481-9.

PMID
33994546
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Jia, Wei, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, et al. “BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.” Blood 137, no. 18 (May 6, 2021): 2544–57. https://doi.org/10.1182/blood.2020008040.

PMID
33534893
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Cardones, Adela R., Russell P. Hall, Keith M. Sullivan, Joanna Hooten, Seung Yun Lee, Beiyu Liu, Cynthia L. Green, et al. “Quantifying Skin Stiffness in Graft-Versus-Host Disease, Morphea, and Systemic Sclerosis Using Acoustic Radiation Force Impulse Imaging and Shear Wave Elastography.” The Journal of Investigative Dermatology 141, no. 4 (April 2021): 924-927.e2. https://doi.org/10.1016/j.jid.2020.07.031.

PMID
32950506
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Khan, Niloufer, Sarah Lindner, Antonio L. C. Gomes, Sean M. Devlin, Gunjan L. Shah, Anthony D. Sung, Craig S. Sauter, et al. “Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.” Blood 137, no. 11 (March 18, 2021): 1527–37. https://doi.org/10.1182/blood.2020006923.

PMID
33512409
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Giri, Vinay K., Kristin G. Kegerreis, Yi Ren, Lauren M. Bohannon, Erica Lobaugh-Jin, Julia A. Messina, Anita Matthews, et al. “Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.” Transplant Cell Ther 27, no. 3 (March 2021): 262.e1-262.e11. https://doi.org/10.1016/j.jtct.2021.01.004.

PMID
33781532
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Pages