Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Member of the Duke Cancer Institute
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

Education and Training

  • Fellow In Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Himburg, HA, Yan, X, Doan, PL, Quarmyne, M, Micewicz, E, McBride, W, Chao, NJ, Slamon, DJ, and Chute, JP. "Pleiotrophin mediates hematopoietic regeneration via activation of RAS." The Journal of clinical investigation 124, no. 11 (November 2014): 4753-4758.

PMID
25250571
Full Text

Wang, C, Belley, MD, Chao, NJ, Dewhirst, MW, and Yoshizumi, T. "Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators." Medical physics 41, no. 8 (August 2014): 084101-.

PMID
25086562
Full Text

Horwitz, ME, Chao, NJ, Rizzieri, DA, Long, GD, Sullivan, KM, Gasparetto, C, Chute, JP, Morris, A, McDonald, C, Waters-Pick, B, Stiff, P, Wease, S, Peled, A, Snyder, D, Cohen, EG, Shoham, H, Landau, E, Friend, E, Peleg, I, Aschengrau, D, Yackoubov, D, Kurtzberg, J, and Peled, T. "Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment." The Journal of clinical investigation 124, no. 7 (July 2014): 3121-3128.

PMID
24911148
Full Text

Chao, N. "How I treat sinusoidal obstruction syndrome." Blood 123, no. 26 (June 26, 2014): 4023-4026.

Full Text

Lee, CL, Lento, WE, Castle, KD, Chao, NJ, and Kirsch, DG. "Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice." Radiation research 181, no. 5 (May 2014): 445-451.

PMID
24720754
Full Text

Lento, W, Ito, T, Zhao, C, Harris, JR, Huang, W, Jiang, C, Owzar, K, Piryani, S, Racioppi, L, Chao, N, and Reya, T. "Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration." Genes & development 28, no. 9 (May 2014): 995-1004.

PMID
24788518
Full Text

Allen, JL, Tata, PV, Fore, MS, Wooten, J, Rudra, S, Deal, AM, Sharf, A, Hoffert, T, Roehrs, PA, Shea, TC, Serody, JS, Richards, KL, Jagasia, M, Lee, SJ, Rizzieri, D, Horwitz, ME, Chao, NJ, and Sarantopoulos, S. "Increased BCR responsiveness in B cells from patients with chronic GVHD." Blood 123, no. 13 (March 2014): 2108-2115.

PMID
24532806
Full Text

Belley, MD, Wang, C, Nguyen, G, Gunasingha, R, Chao, NJ, Chen, BJ, Dewhirst, MW, and Yoshizumi, TT. "Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators." Medical physics 41, no. 3 (March 2014): 034101-.

PMID
24593746
Full Text

Rein, LAM, and Chao, NJ. "WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy." Expert Opinion on Investigational Drugs 23, no. 3 (March 2014): 417-426.

Full Text

Kanda, J, Long, GD, Gasparetto, C, Horwitz, ME, Sullivan, KM, Chute, JP, Morris, A, Shafique, M, Li, Z, Chao, NJ, and Rizzieri, DA. "Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies." Biol Blood Marrow Transplant 20, no. 2 (February 2014): 257-263.

PMID
24269380
Full Text

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