Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Andrlová, Hana, Oriana Miltiadous, Anastasia I. Kousa, Anqi Dai, Susan DeWolf, Sara Violante, Hee-Yon Park, et al. “MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.” Sci Transl Med 14, no. 646 (May 25, 2022): eabj2829. https://doi.org/10.1126/scitranslmed.abj2829.

PMID
35613281
Full Text

Ison, Michael G., Francisco M. Marty, Nelson Chao, Seung Hyun Moon, Zhiji Zhang, and Aastha Chandak. “Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States.” Transpl Infect Dis, May 22, 2022, e13866. https://doi.org/10.1111/tid.13866.

PMID
35598293
Full Text

Sung, Anthony D., Vinay K. Giri, Helen Tang, Krista Rowe Nichols, Meagan V. Lew, Lauren Bohannon, Yi Ren, et al. “Home-Based Hematopoietic Cell Transplantation in the United States.” Transplant Cell Ther 28, no. 4 (April 2022): 207.e1-207.e8. https://doi.org/10.1016/j.jtct.2022.01.015.

PMID
35066211
Full Text

Heston, Sarah M., Rebecca R. Young, John S. Tanaka, Kirsten Jenkins, Richard Vinesett, Frances M. Saccoccio, Paul L. Martin, Nelson J. Chao, and Matthew S. Kelly. “Risk Factors for CMV Viremia and Treatment-Associated Adverse Events Among Pediatric Hematopoietic Stem Cell Transplant Recipients.” Open Forum Infect Dis 9, no. 2 (February 2022): ofab639. https://doi.org/10.1093/ofid/ofab639.

PMID
35111869
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Wieduwilt, Matthew J., Leland Metheny, Mei-Jie Zhang, Hai-Lin Wang, Noel Estrada-Merly, David I. Marks, A Samer Al-Homsi, et al. “Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.” Blood Adv 6, no. 1 (January 11, 2022): 339–57. https://doi.org/10.1182/bloodadvances.2021004916.

PMID
34547770
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Smith, Patrick J., Meagan Lew, Yen Lowder, Kristi Romero, Jillian C. Thompson, Lauren Bohannon, Alyssa Pittman, et al. “Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation.” In Bone Marrow Transplant, 57:89–94, 2022. https://doi.org/10.1038/s41409-021-01470-z.

PMID
34667271
Full Text

Huang, Ying, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, et al. “Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.” Front Immunol 13 (2022): 751296. https://doi.org/10.3389/fimmu.2022.751296.

PMID
35296079
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Thompson, Jillian C., Yi Ren, Kristi Romero, Meagan Lew, Amy T. Bush, Julia A. Messina, Sin-Ho Jung, et al. “Financial incentives to increase stool collection rates for microbiome studies in adult bone marrow transplant patients.” Plos One 17, no. 5 (2022): e0267974. https://doi.org/10.1371/journal.pone.0267974.

PMID
35507633
Full Text

Richardson, Paul G., Marta Palomo, Nancy A. Kernan, Gerhard C. Hildebrandt, Nelson Chao, and Enric Carreras. “The importance of endothelial protection: the emerging role of defibrotide in reversing endothelial injury and its sequelae.” Bone Marrow Transplantation 56, no. 12 (December 2021): 2889–96. https://doi.org/10.1038/s41409-021-01383-x.

PMID
34584241
Full Text

Percival, Mary-Elizabeth, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark Litzow, Partow Kebriaei, et al. “Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.” Bone Marrow Transplant 56, no. 9 (September 2021): 2108–17. https://doi.org/10.1038/s41409-021-01261-6.

PMID
33864019
Full Text

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