Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Racioppi, Luigi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, et al. “CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer..” Nat Commun 10, no. 1 (June 4, 2019). https://doi.org/10.1038/s41467-019-10424-5.

PMID
31164648
Full Text

Piryani, Sadhna O., Yiqun Jiao, Angel Y. F. Kam, Yang Liu, Tuan Vo-Dinh, Benny J. Chen, Nelson J. Chao, and Phuong L. Doan. “Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury..” Int J Radiat Oncol Biol Phys 104, no. 2 (June 1, 2019): 291–301. https://doi.org/10.1016/j.ijrobp.2019.02.008.

PMID
30763662
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Blanchard, S. K., K. M. Sullivan, J. N. Hooten, Z. E. Holcomb, K. R. Nichols, M. A. Selim, C. L. Rao, R. P. Hall, N. J. Chao, and A. R. Cardones. “High dose intravenous immunoglobulin as adjuvant treatment for grade IV acute cutaneous graft versus host disease..” Br J Dermatol, April 24, 2019. https://doi.org/10.1111/bjd.18028.

PMID
31017659
Full Text

Cardones, Adela R., Keith M. Sullivan, Cindy Green, Nelson J. Chao, Krista Rowe-Nichols, Lionel L. Bañez, Claude S. Burton, et al. “Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease..” Jama Dermatol, April 17, 2019. https://doi.org/10.1001/jamadermatol.2018.5459.

PMID
30994873
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Zheng, Jing, Yonggang Sha, Logan Roof, Oded Foreman, John Lazarchick, Jagadish Kummetha Venkta, Cleopatra Kozlowski, et al. “Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade..” Cancer Lett 440–441 (January 2019): 1–10. https://doi.org/10.1016/j.canlet.2018.10.003.

PMID
30312729
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Huang, Wei, Wenjian Mo, Jieling Jiang, Nelson J. Chao, and Benny J. Chen. “Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.00624.

PMID
31001254
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Jacobs, Aviva R., Timothy Guyon, Violetta Headley, Mahalakshmi Nair, William Ricketts, Gerry Gray, Jeffery Y. C. Wong, Nelson Chao, and Robert Terbrueggen. “Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident..” Int J Radiat Biol, December 3, 2018, 1–9. https://doi.org/10.1080/09553002.2018.1532615.

PMID
30507310
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Jauhari, S., and N. Chao. “Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease.” Current Stem Cell Reports 4, no. 4 (December 1, 2018): 318–26. https://doi.org/10.1007/s40778-018-0146-4.

Full Text

Iversen, Edwin S., Janice M. McCarthy, Kirsten Bell Burdett, Gary Lipton, Gary Phillips, Holly Dressman, Joel Ross, and Nelson Chao. “Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans..” Int J Radiat Biol, October 29, 2018, 1–10. https://doi.org/10.1080/09553002.2018.1532614.

PMID
30371121
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Poe, Jonathan C., Wei Jia, Julie A. Di Paolo, Nancy J. Reyes, Ji Yun Kim, Hsuan Su, John S. Sundy, et al. “SYK inhibitor entospletinib prevents ocular and skin GVHD in mice..” Jci Insight 3, no. 19 (October 4, 2018). https://doi.org/10.1172/jci.insight.122430.

PMID
30282825
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