Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Ferrara, J. L., R. Levy, and N. J. Chao. “Pathophysiologic mechanisms of acute graft-vs.-host disease..” Biol Blood Marrow Transplant 5, no. 6 (1999): 347–56.

PMID
10595812
Scholars@Duke

Laughlin, M. J., D. S. McGaughey, J. R. Crews, N. J. Chao, D. Rizzieri, M. Ross, J. Gockerman, et al. “Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant..” J Clin Oncol 16, no. 3 (March 1998): 1008–12. https://doi.org/10.1200/JCO.1998.16.3.1008.

PMID
9508184
Full Text

Long, G. D., M. D. Amylon, K. E. Stockerl-Goldstein, R. S. Negrin, N. J. Chao, W. W. Hu, A. P. Nademanee, et al. “Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies..” Biol Blood Marrow Transplant 3, no. 6 (December 1997): 324–30.

PMID
9502300
Scholars@Duke

Kohler, S., M. R. Hendrickson, N. J. Chao, and B. R. Smoller. “Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease..” Am J Surg Pathol 21, no. 9 (September 1997): 988–96.

PMID
9298874
Scholars@Duke

Rizzieri, D. A., and N. J. Chao. “Treatment of non-Hodgkin's lymphoma with high-dose therapy and hematopoietic stem cell support..” Curr Opin Oncol 9, no. 5 (September 1997): 420–27.

PMID
9327219
Scholars@Duke

Lee, P. P., D. Zeng, A. E. McCaulay, Y. F. Chen, C. Geiler, D. T. Umetsu, and N. J. Chao. “T helper 2-dominant antilymphoma immune response is associated with fatal outcome..” Blood 90, no. 4 (August 15, 1997): 1611–17.

PMID
9269780
Scholars@Duke

Aharoni, R., P. G. Schlegel, D. Teitelbaum, O. Roikhel-Karpov, Y. Chen, R. Arnon, M. Sela, and N. J. Chao. “Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease..” Immunol Lett 58, no. 2 (July 1997): 79–87.

PMID
9271317
Scholars@Duke

Chao, N. J. “Graft-versus-host disease: the viewpoint from the donor T cell..” Biol Blood Marrow Transplant 3, no. 1 (April 1997): 1–10.

PMID
9209735
Scholars@Duke

Chen, Y., P. G. Schlegel, N. Tran, D. Thompson, J. L. Zehnder, and N. J. Chao. “Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease..” Blood 89, no. 4 (February 15, 1997): 1452–59.

PMID
9028970
Scholars@Duke

Horning, S. J., N. J. Chao, R. S. Negrin, R. T. Hoppe, G. D. Long, W. W. Hu, R. M. Wong, B. W. Brown, and K. G. Blume. “High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin's disease: analysis of the Stanford University results and prognostic indices..” Blood 89, no. 3 (February 1, 1997): 801–13.

PMID
9028311
Scholars@Duke

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