Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Kusnierz-Glaz, C. R., P. G. Schlegel, R. M. Wong, J. R. Schriber, N. J. Chao, M. D. Amylon, W. W. Hu, et al. “Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies..” J Clin Oncol 15, no. 1 (January 1997): 18–25. https://doi.org/10.1200/JCO.1997.15.1.18.

PMID
8996120
Full Text

Long, G. D., N. J. Chao, W. W. Hu, R. S. Negrin, R. M. Wong, and K. G. Blume. “High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma..” Cancer 78, no. 12 (December 15, 1996): 2502–9. https://doi.org/10.1002/(sici)1097-0142(19961215)78:12<2502::aid-cncr9>3.0.co;2-l.

PMID
8952558
Full Text

Geiler, C. R., J. Baker, S. Wells, P. G. Schlegel, and N. J. Chao. “Purging peripheral blood progenitor cells with 4-hydroperoxycyclophosphamide (4-HC).” Cancer Research Therapy and Control 5, no. 1 (December 1, 1996): 23–27.

Scholars@Duke

Schlegel, P. G., and N. J. Chao. “Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease..” Leuk Lymphoma 23, no. 1–2 (September 1996): 11–16. https://doi.org/10.3109/10428199609054796.

PMID
9021680
Full Text

Parker, P., N. J. Chao, J. Ben-Ezra, N. Slatkin, H. Openshaw, J. C. Niland, C. A. Linker, et al. “Polymyositis as a manifestation of chronic graft-versus-host disease..” Medicine (Baltimore) 75, no. 5 (September 1996): 279–85. https://doi.org/10.1097/00005792-199609000-00004.

PMID
8862349
Full Text

Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo..” Proc Natl Acad Sci U S A 93, no. 10 (May 14, 1996): 5061–66. https://doi.org/10.1073/pnas.93.10.5061.

PMID
8643529
Full Text

Chao, N. J., P. M. Parker, J. C. Niland, R. M. Wong, A. Dagis, G. D. Long, A. P. Nademanee, et al. “Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease..” Biol Blood Marrow Transplant 2, no. 2 (May 1996): 86–92.

PMID
9118303
Scholars@Duke

Stockerl-Goldstein, K. E., S. J. Horning, R. S. Negrin, N. J. Chao, W. W. Hu, G. D. Long, R. T. Hoppe, et al. “Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma..” Biol Blood Marrow Transplant 2, no. 2 (May 1996): 76–85.

PMID
9118302
Scholars@Duke

Behar, E., N. J. Chao, D. D. Hiraki, S. Krishnaswamy, B. W. Brown, J. L. Zehnder, and F. C. Grumet. “Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease..” N Engl J Med 334, no. 5 (February 1, 1996): 286–91. https://doi.org/10.1056/NEJM199602013340502.

PMID
8532023
Full Text

Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “Erratum: A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules (Proceedings of the National Academy of Science of the United States of America (May 14, 1996) 93:10 (5061-5066)).” Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (January 1, 1996).

Scholars@Duke

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