Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Rein, LAM, and Chao, NJ. "WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy." Expert opinion on investigational drugs 23, no. 3 (March 2014): 417-426. (Review)

PMID
24521058
Full Text

Kanda, J, Long, GD, Gasparetto, C, Horwitz, ME, Sullivan, KM, Chute, JP, Morris, A, Shafique, M, Li, Z, Chao, NJ, and Rizzieri, DA. "Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 20, no. 2 (February 2014): 257-263.

PMID
24269380
Full Text

Lucas, J, Dressman, HK, Suchindran, S, Nakamura, M, Chao, NJ, Himburg, H, Minor, K, Phillips, G, Ross, J, Abedi, M, Terbrueggen, R, and Chute, JP. "A translatable predictor of human radiation exposure." PLoS ONE 9, no. 9 (January 2014): e107897-.

PMID
25255453
Full Text

Coleman, CN, Formenti, SC, Williams, TR, Petereit, DG, Soo, KC, Wong, J, Chao, N, Shulman, LN, Grover, S, Magrath, I, Hahn, S, Liu, F-F, DeWeese, T, Khleif, SN, Steinberg, M, Roth, L, Pistenmaa, DA, Love, RR, Mohiuddin, M, and Vikram, B. "The international cancer expert corps: a unique approach for sustainable cancer care in low and lower-middle income countries." Frontiers in oncology 4 (January 2014): 333-. (Review)

PMID
25478326
Full Text

Tarrant, TK, Billard, MJ, Timoshchenko, RG, McGinnis, MW, Stephen Serafin, D, Foreman, O, Esserman, DA, Chao, NJ, Lento, WE, Lee, DM, Patel, D, and Siderovski, DP. "G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses." Journal of Leukocyte Biology 94, no. 6 (December 1, 2013): 1243-1251.

PMID
23935208
Full Text

Xiao, B, Wang, Y, Li, W, Baker, M, Guo, J, Corbet, K, Tsalik, EL, Li, Q-J, Palmer, SM, Woods, CW, Li, Z, Chao, NJ, and He, Y-W. "Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease." Blood 122, no. 19 (November 2013): 3365-3375.

PMID
24041574
Full Text

Sung, AD, Grima, DT, Bernard, LM, Brown, S, Carrum, G, Holmberg, L, Horwitz, ME, Liesveld, JL, Kanda, J, McClune, B, Shaughnessy, P, Tricot, GJ, and Chao, NJ. "Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone." Bone Marrow Transplantation 48, no. 11 (November 1, 2013): 1444-1449.

Full Text

Sung, AD, and Chao, NJ. "Acute graft-versus-host disease: are we close to bringing the bench to the bedside?." Best practice & research. Clinical haematology 26, no. 3 (September 2013): 285-292. (Review)

PMID
24309532
Full Text

Kanda, J, Kaynar, L, Kanda, Y, Prasad, VK, Parikh, SH, Lan, L, Shen, T, Rizzieri, DA, Long, GD, Sullivan, KM, Gasparetto, C, Chute, JP, Morris, A, Winkel, S, McPherson, J, Kurtzberg, J, Chao, NJ, and Horwitz, ME. "Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment." Bone Marrow Transplant 48, no. 7 (July 2013): 926-931.

PMID
23334274
Full Text

Zhou, D, Deoliveira, D, Kang, Y, Choi, SS, Li, Z, Chao, NJ, and Chen, BJ. "Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation." International Journal of Radiation Oncology, Biology, Physics 85, no. 4 (March 2013): 1141-1148.

PMID
23021438
Full Text

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