
My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.
For more information see http://ed-media.mc.duke.edu/BMT.nsf
Education and Training
- Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
- Medical Resident, Medicine, Stanford University, 1981 - 1984
- M.D., Yale University, 1981
Grants
- Centers for Medical Countermeasures against Radiation Consortium
- A Randomized Phase 2 Trial to Evaluate Prebiotic Intervention in Allogeneic Hematopoietic Stem Cell Transplantation
- Home-based Autologous Hematopoietic Stem Cell Transplantation to Improve Outcomes and Decrease Costs
- Advanced Immunobiology Traning Program for Surgeons
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG)
- Duke CTSA (TL1) Year 5
- Cabinet Radiation Therapy System for Small Animals
- Home Transplant to Preserve the Microbiota and Decrease GVHD
- Minimizing the risk of therapy-related myeloid neoplasms by inhibiting genotoxic stress-induced expansion of leukemia-initiating cells
- RITN 2022
- Translational Research in Surgical Oncology
- T32 UNC - Duke Immunotherapy Training Program
- Image-Guided Radiation Therapy System for Small Animals
- Characterization of CMV-specific T cell responses in immunocompromised hosts
- Smartphone Enabled Point-of-Care Detection of Serum Markers of Liver Cancer
- Postdoctoral Training in Genomic Medicine Research
- U01 RPPR: Mitigators of Radiation-Induced Endovascular Injury: Targeting Tie2 and Thrombocytopenia