Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Sung, Anthony D., Syed Hassan, Diana M. Cardona, Daniel Wild, Krista Rowe Nichols, Hossein Mehdikhani, Bryan Balmadrid, et al. “Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults.” Biol Blood Marrow Transplant 24, no. 4 (April 2018): 734–40. https://doi.org/10.1016/j.bbmt.2017.12.772.

PMID
29246821
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Somers, Tamara J., Sarah A. Kelleher, Caroline S. Dorfman, Rebecca A. Shelby, Hannah M. Fisher, Krista Rowe Nichols, Keith M. Sullivan, et al. “An mHealth Pain Coping Skills Training Intervention for Hematopoietic Stem Cell Transplantation Patients: Development and Pilot Randomized Controlled Trial.” Jmir Mhealth Uhealth 6, no. 3 (March 19, 2018): e66. https://doi.org/10.2196/mhealth.8565.

PMID
29555620
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Zheng, Zhihong, Shengjun Fan, Jing Zheng, Wei Huang, Cristina Gasparetto, Nelson J. Chao, Jianda Hu, and Yubin Kang. “Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma.” J Hematol Oncol 11, no. 1 (February 27, 2018): 29. https://doi.org/10.1186/s13045-018-0575-7.

PMID
29482577
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Piryani, Sadhna O., Angel Y. F. Kam, Evelyna G. Kliassov, Benny J. Chen, Neil L. Spector, John P. Chute, David S. Hsu, Nelson J. Chao, and Phuong L. Doan. “Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.” Stem Cells 36, no. 2 (February 2018): 252–64. https://doi.org/10.1002/stem.2731.

PMID
29086459
Full Text

Richardson, Paul G., Brandon M. Triplett, Vincent T. Ho, Nelson Chao, Fiona L. Dignan, Michelle Maglio, and Mohamad Mohty. “Defibrotide sodium for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome.” Expert Rev Clin Pharmacol 11, no. 2 (February 2018): 113–24. https://doi.org/10.1080/17512433.2018.1421943.

PMID
29301447
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Guo, Mei, Nelson J. Chao, Jian-Yong Li, David A. Rizzieri, Qi-Yun Sun, Ann Mohrbacher, Elizabeth F. Krakow, et al. “HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group.” Jama Oncol 4, no. 1 (January 1, 2018): 54–62. https://doi.org/10.1001/jamaoncol.2017.2656.

PMID
28910431
Full Text

Sivaraj, D., W. Bacon, G. D. Long, D. A. Rizzieri, M. E. Horwitz, K. M. Sullivan, Y. Kang, Z. Li, N. J. Chao, and C. Gasparetto. “High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma.” Bone Marrow Transplant 53, no. 1 (January 2018): 34–38. https://doi.org/10.1038/bmt.2017.208.

PMID
29084203
Full Text

Huang, Wei, and Nelson J. Chao. “Memory T cells: A helpful guard for allogeneic hematopoietic stem cell transplantation without causing graft-versus-host disease.” Hematol Oncol Stem Cell Ther 10, no. 4 (December 2017): 211–19. https://doi.org/10.1016/j.hemonc.2017.05.006.

PMID
28636890
Full Text

Coleman, C Norman, Miles A. Pomper, Nelson Chao, Ferenc Dalnoki-Veress, and David A. Pistenmaa. “Treatment, Not Terror: Time for Unique Problem-Solving Partnerships for Cancer Care in Resource-Challenged Environments.” J Glob Oncol 3, no. 6 (December 2017): 687–91. https://doi.org/10.1200/JGO.2016.007591.

PMID
29244981
Full Text

Huang, Li-Wen, Wendi Bacon, Constance Cirrincione, Bercedis Peterson, Gwynn Long, David Rizzieri, Keith M. Sullivan, et al. “Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma.” Hematol Oncol 35, no. 4 (December 2017): 752–59. https://doi.org/10.1002/hon.2379.

PMID
28105753
Full Text

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