Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Jagasia, M, Arora, M, Flowers, MED, Chao, NJ, McCarthy, PL, Cutler, CS, Urbano-Ispizua, A, Pavletic, SZ, Haagenson, MD, Zhang, M-J, Antin, JH, Bolwell, BJ, Bredeson, C, Cahn, J-Y, Cairo, M, Gale, RP, Gupta, V, Lee, SJ, Litzow, M, Weisdorf, DJ, Horowitz, MM, and Hahn, T. "Risk factors for acute GVHD and survival after hematopoietic cell transplantation." Blood 119, no. 1 (2012): 296-307.

PMID
22010102
Full Text

Confer, DL, Weisdorf, D, Weinstock, D, Case, C, and Chao, N. "Radiation Disasters: Role of the BMT Team." Biology of Blood and Marrow Transplantation 18, no. 1 SUPPL. (2012): S189-S192.

PMID
22226106
Full Text

Lee, HR, Park, JS, Shin, S, Roh, EY, Yoon, JH, Han, KS, Kim, BJ, Storms, RW, and Chao, NJ. "Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: An analysis of neonatal innate factors in the Korean population." Transfusion 52, no. 1 (2012): 76-81.

PMID
21790633
Full Text

Himburg, HA, Harris, JR, Ito, T, Daher, P, Russell, JL, Quarmyne, M, Doan, PL, Helms, K, Nakamura, M, Fixsen, E, Herradon, G, Reya, T, Chao, NJ, Harroch, S, and Chute, JP. "Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche." Cell Reports 2, no. 6 (2012): 1774--.

Full Text

Coleman, CN, Adams, S, Adrianopoli, C, Ansari, A, Bader, JL, Buddemeier, B, Caro, JJ, Casagrande, R, Case, C, Caspary, K, Chang, AS, Chang, HF, Chao, N, Cliffer, KD, Confer, D, Deitchman, S, Derenzo, EG, Dobbs, A, Dodgen, D, Donnelly, EH, Gorman, S, Grace, MB, Hatchett, R, Hick, JL, Hrdina, C, Jones, R, Kane, E, Knebel, A, Koerner, JF, Laffan, AM, Larson, L, Livinski, A, MacKinney, J, Maidment, BW, Manning, R, Marinissen, MJ, Martin, C, Michael, G, Murrain-Hill, P, Nemhauser, JB, and Norwood, AE et al. "Medical planning and response for a nuclear detonation: A practical guide." Biosecurity and Bioterrorism 10, no. 4 (2012): 346-371.

PMID
23244500
Full Text

Kang, Y, and Chao, NJ. "Strategies to enhance hematopoietic stem cell engraftment following transplantation." In Novel Developments in Stem Cell Mobilization: Focus on CXCR4, 439-456. January 1, 2012.

Full Text

Chao, N. "You Cannot Improve What You Do Not Measure." Biology of Blood and Marrow Transplantation 18, no. 10 (2012): 1467-1468.

PMID
22771840
Full Text

Chao, N. "Control of GVHD: It's in our DNA!." Blood 119, no. 5 (2012): 1102-1103.

Full Text

Kelsey, CR, Horwitz, ME, Chino, JP, Craciunescu, O, Steffey, B, Folz, RJ, Chao, NJ, Rizzieri, DA, and Marks, LB. "Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors." Int J Radiat Oncol Biol Phys 81, no. 3 (November 1, 2011): 812-818.

PMID
20932682
Full Text

Klymenko, SV, Belyi, DA, Ross, JR, Owzar, K, Jiang, C, Li, Z, N Minchenko, J, N Kovalenko, A, Bebeshko, VG, and J Chao, N. "Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident." Int J Radiat Biol 87, no. 8 (August 2011): 846-850.

PMID
21406047
Full Text

Pages