Medical Oncology

Nicholas Christian DeVito, MD

Medical Instructor in the Department of Medicine
Member of the Duke Cancer Institute
Campus mail DUMC Box 3052, Durham, NC 27710
Email address nicholas.devito@duke.edu

I am an instructor of Medical Oncology who primarily treats patients with gastrointestinal malignancies. My laboratory and translational research is focused on tumor immune evasion and immunotherapy, with a specific interest in dendritic cell tolerance.

Education and Training

  • Hematology-Oncology Fellowship, Medicine, Duke University School of Medicine, 2015 - 2018
  • Internal Medicine Internship and Residency, Tufts University School of Medicine, 2012 - 2015
  • M.D., University of South Florida College of Medicine, 2012

Grants

Publications

Theivanthiran, Balamayooran, Kathy Evans, Nicholas DeVito, Michael Plebanek, Michael Sturdivant, Alisha Holtzhausen, Luke Wachsmuth, et al. “A tumor PD-L1-NLRP3 inflammasome signaling axis drives adaptive resistance to anti-PD-1 immunotherapy.” In Journal for Immunotherapy of Cancer, Vol. 7. BMC, 2019.

Scholars@Duke

DeVito, Nicholas C., Michael P. Plebanek, Bala Theivanthiran, and Brent A. Hanks. “Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.02876.

PMID
31921140
Full Text

Zhao, Fei, Kathy Evans, Christine Xiao, Nicholas DeVito, Balamayooran Theivanthiran, Alisha Holtzhausen, Peter J. Siska, Gerard C. Blobe, and Brent A. Hanks. “Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma..” Cancer Immunol Res 6, no. 12 (December 2018): 1459–71. https://doi.org/10.1158/2326-6066.CIR-18-0086.

PMID
30209062
Full Text

Grant, Michael J., Nicholas DeVito, and April K. S. Salama. “Checkpoint inhibitor use in two heart transplant patients with metastatic melanoma and review of high-risk populations..” Melanoma Manag 5, no. 4 (December 2018). https://doi.org/10.2217/mmt-2018-0004.

PMID
30459942
Full Text

Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization..” Immunity 48, no. 1 (January 16, 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.

PMID
29343435
Full Text

Theivanthiran, Bala, Nicholas C. DeVito, Kathy Evans, Fei Zhao, Christine Xiao, Benjamin S. Goldschmidt, Rob Edgar, et al. “A HSP-TLR-Wnt5a paracrine signaling axis drives CXCR2 ligand recruitment of myeloid-derived suppressor cells and represents a novel adaptive resistance mechanism to anti-PD-1 antibody therapy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.

Scholars@Duke

Kinsey, E. N., N. DeVito, W. Barrow, S. A. Myers, and A. K. S. Salama. “Paraneoplastic Production of Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in a Case of Rapidly Progressing Cutaneous Squamous Cell Carcinoma.” Clinical Skin Cancer 1, no. 1 (January 1, 2016): 20–22. https://doi.org/10.1016/j.clsc.2016.11.004.

Full Text

DeVito, Nicholas, Evita Henderson, Gang Han, Damon Reed, Marilyn M. Bui, Robert Lavey, Lary Robinson, et al. “Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience..” Plos One 10, no. 10 (2015). https://doi.org/10.1371/journal.pone.0140362.

PMID
26469269
Full Text

DeVito, Nicholas, Kit Mui, Yasir Jassam, Lynne Taylor, Monika Pilichowska, and Furha Cossor. “Small lymphocytic lymphoma presenting as a paraneoplastic syndrome with acute central nervous system demyelination..” Clin Lymphoma Myeloma Leuk 14, no. 4 (August 2014): e131–35. https://doi.org/10.1016/j.clml.2014.02.006.

PMID
24630921
Full Text

DeVito, Nicholas. “LITTLE KNOWN LYMPHOMA: SMALL LYMPHOCYTIC LYMPHOMA PRESENTING AS A PARANEOPLASTIC SYNDROME WITH ACUTE CNS DEMYELINATION.” In Journal of General Internal Medicine, 29:S384–S384. SPRINGER, 2014.

Scholars@Duke

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