Nicholas Christian DeVito, MD

Medical Instructor in the Department of Medicine
Member of the Duke Cancer Institute
Campus mail DUMC Box 3052, Durham, NC 27710
Email address nicholas.devito@duke.edu

I am an instructor of Medical Oncology who primarily treats patients with gastrointestinal malignancies. My laboratory and translational research is focused on tumor immune evasion and immunotherapy, with a specific interest in dendritic cell tolerance.

Education and Training

  • Hematology-Oncology Fellowship, Medicine, Duke University School of Medicine, 2015 - 2018
  • Internal Medicine Internship and Residency, Tufts University School of Medicine, 2012 - 2015
  • M.D., University of South Florida, College of Medicine, 2012

Publications

Plebanek, Michael, Nicholas DeVito, Fang Liu, Balamayooran Theivanthiran, Georgia Beasley, and Brent Hanks. “657 Characterization and therapeutic targeting of a tumor-associated tolerogenic DC subpopulation driven by SREBP2 and the mevalonate metabolic pathway.” In Journal for Immunotherapy of Cancer, 9:A685–A685. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.657.

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Theivanthiran, Balamayooran, Fang Liu, Nicholas DeVito, Michael Plebanek, and Brent Hanks. “319 The tumor-intrinsic NLRP3 inflammasome establishes a pulmonary metastatic niche via type II epithelial HSP70/TLR4 signaling and facilitates disease hyperprogression in response to immunotherapy.” In Journal for Immunotherapy of Cancer, 9:A343–A343. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.319.

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DeVito, Nicholas, Michael Sturdivant, Balamayooran Theivanthiran, Y-Van Nguyen, Michael Plebanek, and Brent Hanks. “923 Hedgehog signaling drives epithelial-to-mesenchymal transition, immune evasion, and anti-PD-1 resistance through coordinated upregulation of Wnt ligands and PGE2 synthesis.” In Journal for Immunotherapy of Cancer, 9:A968–A968. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.923.

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Theivanthiran, Balamayooran, Tarek Haykal, Linda Cao, Alisha Holtzhausen, Michael Plebanek, Nicholas C. DeVito, and Brent A. Hanks. “Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis.” Cancers (Basel) 13, no. 19 (September 23, 2021). https://doi.org/10.3390/cancers13194753.

PMID
34638239
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Sammons, Sarah, Andrew Elliott, Jeremy Meyer Force, Nicholas C. DeVito, Paul Kelly Marcom, Sandra M. Swain, Antoinette R. Tan, et al. “Genomic evaluation of tumor mutational burden-high (TMB-H) versus TMB-low (TMB-L) metastatic breast cancer to reveal unique mutational features.” In Journal of Clinical Oncology, 39:1091–1091. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.1091.

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DeVito, Nicholas C., Michael Sturdivant, Balamayooran Thievanthiran, Christine Xiao, Michael P. Plebanek, April K. S. Salama, Georgia M. Beasley, et al. “Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy.” Cell Rep 35, no. 5 (May 4, 2021): 109071. https://doi.org/10.1016/j.celrep.2021.109071.

PMID
33951424
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DeVito, Nicholas C., Colm Kelleher, Kyle C. Strickland, James Abbruzzese, Carey Anders, Brent A. Hanks, Jingquan Jia, et al. “A case report of microsatellite instability (MSI)-high, HER2 amplified pancreatic adenocarcinoma with central nervous system metastasis.” Ame Case Rep 5 (2021): 14. https://doi.org/10.21037/acr-20-154.

PMID
33912803
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DeVito, Nicholas, Michael Sturdivant, Luke Wachsmuth, John Strickler, Georgia Beasley, Rami Al-Rohil, April Salama, and Brent Hanks. “425 Investigation of Wnt ligand signaling regulators as a predictor of Anti-PD-1 response in metastatic melanoma.” In Regular and Young Investigator Award Abstracts. BMJ Publishing Group Ltd, 2020. https://doi.org/10.1136/jitc-2020-sitc2020.0425.

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Plebanek, Michael P., Michael Sturdivant, Nicholas C. DeVito, and Brent A. Hanks. “Role of dendritic cell metabolic reprogramming in tumor immune evasion.” Int Immunol 32, no. 7 (June 26, 2020): 485–91. https://doi.org/10.1093/intimm/dxaa036.

PMID
32449776
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Theivanthiran, Balamayoora, Kathy S. Evans, Nicholas C. DeVito, Michael Plebanek, Michael Sturdivant, Luke P. Wachsmuth, April Ks Salama, et al. “A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.” J Clin Invest 130, no. 5 (May 1, 2020): 2570–86. https://doi.org/10.1172/JCI133055.

PMID
32017708
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Pages