Nishad Jayasundara, PhD

Assistant Professor of Environmental Toxicology and Health
Assistant Research Professor of Global Health
Assistant Professor in Medicine
Email address nj58@duke.edu

Dr. Jayasundara studies adverse ecological and human health outcomes of anthropogenic environmental change. Specifically, Dr. Jayasundara focuses on various teleost fish species (e.g., zebrafish Danio rerio  and Atlantic killifish Fundulus heteroclitus) and conduct field and laboratory studies that integrate functional genomics analyses, in vitro and in vivo physiological and biochemical assays, and mathematical modeling approaches. Ongoing projects aim to:

1. Determine interactive effects of metals and pesticides on kidney mitochondrial function in the context of chronic kidney disease epidemic in agricultural communities based on environmental epidemiology and mechanistic toxicology studies.

2. Examine mitochondrial responses to acute and chronic exposure to heat stress during organismal development and linking to later-life metabolic consequences 

3. Elucidate the role of genetic, epigenetic, and gut microbiome shifts in evolved resistance to chemical pollutants.  

4. Assess rural water quality through citizen science and community engagement in Maine and Sri Lanka

Education and Training

  • Ph.D., Stanford University, 2012

Publications

Pitt, Jordan A., Jordan S. Kozal, Nishad Jayasundara, Andrey Massarsky, Rafael Trevisan, Nick Geitner, Mark Wiesner, Edward D. Levin, and Richard T. Di Giulio. “Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio).” Aquat Toxicol 194 (January 2018): 185–94. https://doi.org/10.1016/j.aquatox.2017.11.017.

PMID
29197232
Full Text

Gearhart-Serna, Larisa M., Nishad Jayasundara, Moises Tacam, Richard Di Giulio, and Gayathri R. Devi. “Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations.” J Environ Public Health 2018 (2018): 5610462. https://doi.org/10.1155/2018/5610462.

PMID
30327676
Full Text

Jayasundara, Nishad, Pani W. Fernando, Joshua S. Osterberg, Kristina M. Cammen, Thomas F. Schultz, and Richard T. Di Giulio. “Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus.” Environmental Science & Technology 51, no. 15 (August 2017): 8763–72. https://doi.org/10.1021/acs.est.7b01913.

PMID
28682633
Full Text

Lindberg, C. D., N. Jayasundara, J. S. Kozal, T. C. Leuthner, and R. T. Di Giulio. “Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus.” Ecotoxicology (London, England) 26, no. 3 (April 2017): 435–48. https://doi.org/10.1007/s10646-017-1775-6.

PMID
28213827
Full Text

Raftery, Tara D., Nishad Jayasundara, and Richard T. Di Giulio. “A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae.” Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp 192 (February 2017): 23–32. https://doi.org/10.1016/j.cbpc.2016.12.001.

PMID
27939721
Full Text

Moore, David W., Pieter Booth, Anne Alix, Sabine E. Apitz, David Forrow, Elisabeth Huber-Sannwald, and Nishad Jayasundara. “Application of ecosystem services in natural resource management decision making.” Integrated Environmental Assessment and Management 13, no. 1 (January 2017): 74–84. https://doi.org/10.1002/ieam.1838.

PMID
27474860
Full Text

Massarsky, Andrey, Nishad Jayasundara, Jordan M. Bailey, Anthony N. Oliveri, Edward D. Levin, G. L. Prasad, and Richard T. Di Giulio. “Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.” Neurotoxicol Teratol 51 (September 2015): 77–88. https://doi.org/10.1016/j.ntt.2015.09.006.

PMID
26391568
Full Text

Madigan, Daniel J., Aaron B. Carlisle, Luke D. Gardner, Nishad Jayasundara, Fiorenza Micheli, Kurt M. Schaefer, Daniel W. Fuller, and Barbara A. Block. “Assessing niche width of endothermic fish from genes to ecosystem.” Proceedings of the National Academy of Sciences of the United States of America 112, no. 27 (July 2015): 8350–55. https://doi.org/10.1073/pnas.1500524112.

PMID
26100889
Full Text

Beers, Jody M., and Nishad Jayasundara. “Antarctic notothenioid fish: what are the future consequences of 'losses' and 'gains' acquired during long-term evolution at cold and stable temperatures?” The Journal of Experimental Biology 218, no. Pt 12 (June 2015): 1834–45. https://doi.org/10.1242/jeb.116129.

PMID
26085661
Full Text

Pages