Geriatrics

P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Senior Fellow of the Center for the Study of Aging and Human Development
Affiliate in the Duke Center for Applied Genomics and Precision Medicine
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Scott, Jan, Samuel Hockey, Laura Ospina-Pinillos, P Murali Doraiswamy, Mario Alvarez-Jimenez, and Ian Hickie. “Research to Clinical Practice-Youth seeking mental health information online and its impact on the first steps in the patient journey.” Acta Psychiatr Scand 145, no. 3 (March 2022): 301–14. https://doi.org/10.1111/acps.13390.

PMID
34923619
Full Text

Califf, Robert M., Celeste Wong, P Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega, and Jessica L. Baseline Study Group. “Biological and clinical correlates of the patient health questionnaire-9: exploratory cross-sectional analyses of the baseline health study.” Bmj Open 12, no. 1 (January 4, 2022): e054741. https://doi.org/10.1136/bmjopen-2021-054741.

PMID
34983769
Full Text

Prescott, Jeffrey W., P Murali Doraiswamy, Dragan Gamberger, Tammie Benzinger, Jeffrey R. Petrella, and Jeffrey R. Dominantly Inherited Alzheimer Network. “Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort.” Radiology 302, no. 1 (January 2022): 143–50. https://doi.org/10.1148/radiol.2021210383.

PMID
34636637
Full Text

Shuren, J., and P. M. Doraiswamy. “Digital Therapeutics for MCI and Alzheimer's disease: A Regulatory Perspective - Highlights From The Clinical Trials on Alzheimer's Disease conference (CTAD).” J Prev Alzheimers Dis 9, no. 2 (2022): 236–40. https://doi.org/10.14283/jpad.2022.28.

PMID
35542995
Full Text

Motter, Jeffrey N., Seonjoo Lee, Joel R. Sneed, P Murali Doraiswamy, Gregory H. Pelton, Jeffrey R. Petrella, and D. P. Devanand. “Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.” J Affect Disord 295 (December 1, 2021): 438–45. https://doi.org/10.1016/j.jad.2021.08.062.

PMID
34507224
Full Text

Wang, QuanQiu, Pamela B. Davis, Xin Qi, Shu G. Chen, Mark E. Gurney, George Perry, P Murali Doraiswamy, and Rong Xu. “Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.” Alzheimers Res Ther 13, no. 1 (October 20, 2021): 177. https://doi.org/10.1186/s13195-021-00917-1.

PMID
34670619
Full Text

Grzesiak, Emilia, Brinnae Bent, Micah T. McClain, Christopher W. Woods, Ephraim L. Tsalik, Bradly P. Nicholson, Timothy Veldman, et al. “Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.” Jama Netw Open 4, no. 9 (September 1, 2021): e2128534. https://doi.org/10.1001/jamanetworkopen.2021.28534.

PMID
34586364
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Occhipinti, Jo-An, Adam Skinner, P Murali Doraiswamy, Cameron Fox, Helen Herrman, Shekhar Saxena, Elisha London, Yun Ju Christine Song, and Ian B. Hickie. “Mental health: build predictive models to steer policy.” Nature 597, no. 7878 (September 2021): 633–36. https://doi.org/10.1038/d41586-021-02581-9.

PMID
34565800
Full Text

Califf, Robert M., Celeste Wong, P Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega, and Jessica L. Baseline Study Group. “Importance of Social Determinants in Screening for Depression.” J Gen Intern Med, August 17, 2021. https://doi.org/10.1007/s11606-021-06957-5.

PMID
34405346
Full Text

James, Olga G., Alexandra R. Linares, Caroline Hellegers, P Murali Doraiswamy, and Terence Z. Wong. “Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.” Clin Nucl Med 46, no. 7 (July 1, 2021): 605–8. https://doi.org/10.1097/RLU.0000000000003493.

PMID
33443955
Full Text

Pages