Geriatrics

P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy is a doctor and translational scientist at Duke University where he directs a clinical trials unit developing novel technologies and treatments for enhancing brain health.  He has served as an advisor to leading businesses, government agencies and patient advocacy groups. 

Murali has been a health advisor for Men's Health magazine and AARP Magazine, and is a co-author of a popular book, The Alzheimer's Action Plan.  His research has been featured in media outlets such as The New York Times, Oprah, Dr Oz Show, CBS Morning, Discovery, BBC, USA Today, NPR, and BBC.   

Dr. Doraiswamy is a member of the World Economic Forum's Global Future Councils.    

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Arnold, Matthias, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, et al. “Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.” Nat Commun 11, no. 1 (March 2, 2020): 1148. https://doi.org/10.1038/s41467-020-14959-w.

PMID
32123170
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Horgusluoglu-Moloch, Emrin, Shannon L. Risacher, Paul K. Crane, Derrek Hibar, Paul M. Thompson, Andrew J. Saykin, Kwangsik Nho, and Kwangsik Alzheimer’s Disease Neuroimaging Initiative (ADNI). “Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.” Sci Rep 9, no. 1 (October 10, 2019): 14498. https://doi.org/10.1038/s41598-019-50507-3.

PMID
31601890
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Goudey, Benjamin, Bowen J. Fung, Christine Schieber, Noel G. Faux, Noel G. Alzheimer’s Disease Metabolomics Consortium, and Noel G. Alzheimer’s Disease Neuroimaging Initiative. “A blood-based signature of cerebrospinal fluid Aβ1-42 status.” Sci Rep 9, no. 1 (March 11, 2019): 4163. https://doi.org/10.1038/s41598-018-37149-7.

PMID
30853713
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Nho, Kwangsik, Alexandra Kueider-Paisley, Siamak MahmoudianDehkordi, Matthias Arnold, Shannon L. Risacher, Gregory Louie, Colette Blach, et al. “Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.” Alzheimers Dement 15, no. 2 (February 2019): 232–44. https://doi.org/10.1016/j.jalz.2018.08.012.

PMID
30337152
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MahmoudianDehkordi, Siamak, Matthias Arnold, Kwangsik Nho, Shahzad Ahmad, Wei Jia, Guoxiang Xie, Gregory Louie, et al. “Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.” Alzheimers Dement 15, no. 1 (January 2019): 76–92. https://doi.org/10.1016/j.jalz.2018.07.217.

PMID
30337151
Full Text

Petrella, Jeffrey R., Wenrui Hao, Adithi Rao, and P Murali Doraiswamy. “Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.” Comput Math Methods Med 2019 (2019): 6216530. https://doi.org/10.1155/2019/6216530.

PMID
30863455
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Sohn, Dongwha, Katie Shpanskaya, Joseph E. Lucas, Jeffrey R. Petrella, Andrew J. Saykin, Rudolph E. Tanzi, Nagiza F. Samatova, and P Murali Doraiswamy. “Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.” Sci Rep 8, no. 1 (May 10, 2018): 7490. https://doi.org/10.1038/s41598-018-25377-w.

PMID
29748598
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Lu, Donghuan, Karteek Popuri, Gavin Weiguang Ding, Rakesh Balachandar, Mirza Faisal Beg, and Mirza Faisal Alzheimer’s Disease Neuroimaging Initiative. “Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.” Sci Rep 8, no. 1 (April 9, 2018): 5697. https://doi.org/10.1038/s41598-018-22871-z.

PMID
29632364
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Mills, Paul J., Christine Tara Peterson, Meredith A. Pung, Sheila Patel, Lizabeth Weiss, Kathleen L. Wilson, P Murali Doraiswamy, Jeffery A. Martin, Rudolph E. Tanzi, and Deepak Chopra. “Change in Sense of Nondual Awareness and Spiritual Awakening in Response to a Multidimensional Well-Being Program.” J Altern Complement Med 24, no. 4 (April 2018): 343–51. https://doi.org/10.1089/acm.2017.0160.

PMID
29216441
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Mahjoub, Ines, Mohamed Ali Mahjoub, Islem Rekik, and Islem Alzheimer’s Disease Neuroimaging Initiative. “Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.” Sci Rep 8, no. 1 (March 7, 2018): 4103. https://doi.org/10.1038/s41598-018-21568-7.

PMID
29515158
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Pages