P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy is a doctor and scientist at Duke University where he directs a clinical trials unit developing novel technologies and treatments for enhancing brain health.  He has served as an advisor to leading businesses, government agencies and patient advocacy groups. 

Murali is a health advisor for Men's Health magazine and AARP Magazine, and is a co-author of a popular book, The Alzheimer's Action Plan.  His research has been featured in media outlets such as The New York Times, Oprah, Dr Oz Show, CBS Morning, Discovery, BBC, USA Today, NPR, and BBC.   

Dr. Doraiswamy is a member of the World Economic Forum's Global Future Councils.    

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Publications

Varma, VR, Oommen, AM, Varma, S, Casanova, R, An, Y, Andrews, RM, O'Brien, R, Pletnikova, O, Troncoso, JC, Toledo, J, Baillie, R, Arnold, M, Kastenmueller, G, Nho, K, Doraiswamy, PM, Saykin, AJ, Kaddurah-Daouk, R, Legido-Quigley, C, and Thambisetty, M. "Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study." PLoS medicine 15, no. 1 (January 25, 2018): e1002482-.

PMID
29370177
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Gamberger, D, Lavrač, N, Srivatsa, S, Tanzi, RE, and Doraiswamy, PM. "Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease." Scientific Reports 7, no. 1 (December 2017).

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Singanamalli, A, Wang, H, and Madabhushi, A. "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features." Scientific Reports 7, no. 1 (December 2017).

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Padmanabhan, K, Shpanskaya, K, Bello, G, Doraiswamy, PM, and Samatova, NF. "Toward Personalized Network Biomarkers in Alzheimer's Disease: Computing Individualized Genomic and Protein Crosstalk Maps." Frontiers in Aging Neuroscience 9 (September 26, 2017).

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Toledo, JB, Arnold, M, Kastenmüller, G, Chang, R, Baillie, RA, Han, X, Thambisetty, M, Tenenbaum, JD, Suhre, K, Thompson, JW, John-Williams, LS, MahmoudianDehkordi, S, Rotroff, DM, Jack, JR, Motsinger-Reif, A, Risacher, SL, Blach, C, Lucas, JE, Massaro, T, Louie, G, Zhu, H, Dallmann, G, Klavins, K, Koal, T, Kim, S, Nho, K, Shen, L, Casanova, R, Varma, S, Legido-Quigley, C, Moseley, MA, Zhu, K, Henrion, MYR, van der Lee, SJ, Harms, AC, Demirkan, A, Hankemeier, T, van Duijn, CM, and Trojanowski, JQ et al. "Metabolic network failures in Alzheimer's disease: A biochemical road map." Alzheimer's & dementia : the journal of the Alzheimer's Association 13, no. 9 (September 2017): 965-984.

PMID
28341160
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Padmanabhan, K, Nudelman, K, Harenberg, S, Bello, G, Sohn, D, Shpanskaya, K, Tiwari Dikshit, P, Yerramsetty, P, Tanzi, R, Saykin, A, Petrella, J, Doraiswamy, P, Samatova, N, and Alzheimer’s Disease Neuroimaging Initiative, . "Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach." Processes 5, no. 3 (September 2017): 47-47.

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Blumenthal, JA, Smith, PJ, Mabe, S, Hinderliter, A, Welsh-Bohmer, K, Browndyke, JN, Lin, P-H, Kraus, W, Doraiswamy, PM, Burke, J, and Sherwood, A. "Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment." Psychosomatic medicine 79, no. 6 (July 2017): 719-727.

PMID
28437380
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Mattsson, N, Andreasson, U, Zetterberg, H, Blennow, K, and Alzheimer’s Disease Neuroimaging Initiative, . "Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease." JAMA neurology 74, no. 5 (May 2017): 557-566.

PMID
28346578
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Lin, KA, Rundel, C, Doraiswamy, PM, and Alzheimer’s Disease Neuroimaging Initiative, . "Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment." Journal of Alzheimer's disease : JAD 55, no. 3 (January 2017): 1123-1130.

PMID
27767986
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Lee, E, Giovanello, KS, Saykin, AJ, Xie, F, Kong, D, Wang, Y, Yang, L, Ibrahim, JG, Doraiswamy, PM, and Zhu, H. "Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients." Alzheimer's & dementia (Amsterdam, Netherlands) 8 (January 2017): 86-95.

PMID
28560309
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