Geriatrics

P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy is a doctor and translational scientist at Duke University where he directs a clinical trials unit developing novel technologies and treatments for enhancing brain health.  He has served as an advisor to leading businesses, government agencies and patient advocacy groups. 

Murali has been a health advisor for Men's Health magazine and AARP Magazine, and is a co-author of a popular book, The Alzheimer's Action Plan.  His research has been featured in media outlets such as The New York Times, Oprah, Dr Oz Show, CBS Morning, Discovery, BBC, USA Today, NPR, and BBC.   

Dr. Doraiswamy is a member of the World Economic Forum's Global Future Councils.    

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Nho, K, Kueider-Paisley, A, MahmoudianDehkordi, S, Arnold, M, Risacher, SL, Louie, G, Blach, C, Baillie, R, Han, X, Kastenmüller, G, Jia, W, Xie, G, Ahmad, S, Hankemeier, T, van Duijn, CM, Trojanowski, JQ, Shaw, LM, Weiner, MW, Doraiswamy, PM, Saykin, AJ, Kaddurah-Daouk, R, and Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, . "Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 15, no. 2 (February 2019): 232-244.

PMID
30337152
Full Text

MahmoudianDehkordi, S, Arnold, M, Nho, K, Ahmad, S, Jia, W, Xie, G, Louie, G, Kueider-Paisley, A, Moseley, MA, Thompson, JW, St John Williams, L, Tenenbaum, JD, Blach, C, Baillie, R, Han, X, Bhattacharyya, S, Toledo, JB, Schafferer, S, Klein, S, Koal, T, Risacher, SL, Kling, MA, Motsinger-Reif, A, Rotroff, DM, Jack, J, Hankemeier, T, Bennett, DA, De Jager, PL, Trojanowski, JQ, Shaw, LM, Weiner, MW, Doraiswamy, PM, van Duijn, CM, Saykin, AJ, Kastenmüller, G, Kaddurah-Daouk, R, and Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, . "Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 15, no. 1 (January 2019): 76-92.

PMID
30337151
Full Text

Mahjoub, I, Mahjoub, MA, Rekik, I, Weiner, M, Aisen, P, Petersen, R, Jack, C, Jagust, W, Trojanowki, J, Toga, A, Beckett, L, Green, R, Saykin, A, Morris, J, Shaw, L, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, L, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, B, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, J, Lord, J, Mason, S, Albers, C, Knopman, D, Johnson, K, Doody, R, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Bell, K, Ances, B, Carroll, M, Creech, M, Franklin, E, Mintun, M, Schneider, S, Oliver, A, Marson, D, Grifth, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Natelson Love, M, Grossman, H, Mitsis, E, Shah, R, Detoledo-Morrell, L, Duara, R, Varon, D, Greig, M, Roberts, P, Albert, M, Onyike, C, D'Agostino, D, Kielb, S, Galvin, J, Cerbone, B, Michel, C, Pogorelec, D, Rusinek, H, De Leon, M, Glodzik, L, De Santi, S, Doraiswamy, P, Petrella, J, Borges-Neto, S, Wong, T, Coleman, E, Smith, C, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Porsteinsson, A, Goldstein, B, Martin, K, Makino, K, Ismail, M, Brand, C, Mulnard, R, Thai, G, Mc-Adams-Ortiz, C, and Womack, K. "Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states." Scientific Reports 8, no. 1 (December 1, 2018).

Full Text

Sohn, D, Shpanskaya, K, Lucas, JE, Petrella, JR, Saykin, AJ, Tanzi, RE, Samatova, NF, and Doraiswamy, PM. "Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease." Scientific Reports 8, no. 1 (May 10, 2018): 7490-null.

PMID
29748598
Full Text

Mills, PJ, Peterson, CT, Pung, MA, Patel, S, Weiss, L, Wilson, KL, Doraiswamy, PM, Martin, JA, Tanzi, RE, and Chopra, D. "Change in Sense of Nondual Awareness and Spiritual Awakening in Response to a Multidimensional Well-Being Program." Journal of Alternative and Complementary Medicine (New York, N.Y.) 24, no. 4 (April 2018): 343-351.

PMID
29216441
Full Text

Privitera, GJ, Welling, D, Tejada, G, Sweazy, N, Cuifolo, KN, King-Shepard, QW, and Doraiswamy, PM. "No calorie comfort: Viewing and drawing "comfort foods" similarly augment positive mood for those with depression." Journal of Health Psychology 23, no. 4 (March 2018): 598-607.

PMID
27956477
Full Text

Varma, VR, Oommen, AM, Varma, S, Casanova, R, An, Y, Andrews, RM, O'Brien, R, Pletnikova, O, Troncoso, JC, Toledo, J, Baillie, R, Arnold, M, Kastenmueller, G, Nho, K, Doraiswamy, PM, Saykin, AJ, Kaddurah-Daouk, R, Legido-Quigley, C, and Thambisetty, M. "Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study." Plos Medicine 15, no. 1 (January 25, 2018): e1002482-null.

PMID
29370177
Full Text

Padmanabhan, K, Nudelman, K, Harenberg, S, Bello, G, Sohn, D, Shpanskaya, K, Dikshit, PT, Yerramsetty, PS, Tanzi, RE, Saykin, AJ, Petrella, JR, Doraiswamy, PM, and Samatova, NF. "Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach." Processes 5, no. 3 (September 1, 2017).

Full Text

Toledo, JB, Arnold, M, Kastenmüller, G, Chang, R, Baillie, RA, Han, X, Thambisetty, M, Tenenbaum, JD, Suhre, K, Thompson, JW, John-Williams, LS, MahmoudianDehkordi, S, Rotroff, DM, Jack, JR, Motsinger-Reif, A, Risacher, SL, Blach, C, Lucas, JE, Massaro, T, Louie, G, Zhu, H, Dallmann, G, Klavins, K, Koal, T, Kim, S, Nho, K, Shen, L, Casanova, R, Varma, S, Legido-Quigley, C, Moseley, MA, Zhu, K, Henrion, MYR, van der Lee, SJ, Harms, AC, Demirkan, A, Hankemeier, T, van Duijn, CM, Trojanowski, JQ, Shaw, LM, Saykin, AJ, Weiner, MW, Doraiswamy, PM, Kaddurah-Daouk, R, and Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium, . "Metabolic network failures in Alzheimer's disease: A biochemical road map." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 9 (September 2017): 965-984.

PMID
28341160
Full Text

Singanamalli, A, Wang, H, Madabhushi, A, and Alzheimer’s Disease Neuroimaging Initiative, . "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features." Scientific Reports 7, no. 1 (August 15, 2017): 8137-null.

PMID
28811553
Full Text

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