Geriatrics

P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Senior Fellow of the Center for the Study of Aging and Human Development
Affiliate in the Duke Center for Applied Genomics and Precision Medicine
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Blumenthal, James A., Michael A. Babyak, Wade Edward Craighead, Jonathan Davidson, Alan Hinderliter, Benson Hoffman, Pudugramam Murali Doraiswamy, and Andrew Sherwood. “The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.” Depress Anxiety 38, no. 2 (February 2021): 124–33. https://doi.org/10.1002/da.23088.

PMID
32790020
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Lu, M., M. J. Pontecorvo, M. D. Devous, A. K. Arora, N. Galante, A. McGeehan, C. Devadanam, et al. “Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results from 2 Phase III Clinical Trials.” Jama Neurology, January 1, 2021. https://doi.org/10.1001/jamaneurol.2020.5505.

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Baloni, Priyanka, Cory C. Funk, Jingwen Yan, James T. Yurkovich, Alexandra Kueider-Paisley, Kwangsik Nho, Almut Heinken, et al. “Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.” Cell Rep Med 1, no. 8 (November 17, 2020): 100138. https://doi.org/10.1016/j.xcrm.2020.100138.

PMID
33294859
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Franzmeier, Nicolai, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, et al. “Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.” Mol Neurodegener 15, no. 1 (October 8, 2020): 57. https://doi.org/10.1186/s13024-020-00407-2.

PMID
33032659
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Bernath, Megan M., Sudeepa Bhattacharyya, Kwangsik Nho, Dinesh Kumar Barupal, Oliver Fiehn, Rebecca Baillie, Shannon L. Risacher, et al. “Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers.” Neurology 94, no. 20 (May 2020): e2088–98. https://doi.org/10.1212/wnl.0000000000009436.

PMID
32358220
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Arnold, Matthias, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, et al. “Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.” Nat Commun 11, no. 1 (March 2, 2020): 1148. https://doi.org/10.1038/s41467-020-14959-w.

PMID
32123170
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Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, P Murali Doraiswamy, et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc 68, no. 3 (March 2020): 559–68. https://doi.org/10.1111/jgs.16252.

PMID
31755550
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Sabbagh, M. N., M. Boada, S. Borson, M. Chilukuri, P. M. Doraiswamy, B. Dubois, J. Ingram, et al. “Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies.” J Prev Alzheimers Dis 7, no. 3 (2020): 158–64. https://doi.org/10.14283/jpad.2020.19.

PMID
32463068
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Smith, Patrick J., Stephanie M. Mabe, Andrew Sherwood, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, James R. Burke, William E. Kraus, et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.” J Alzheimers Dis 77, no. 4 (2020): 1793–1803. https://doi.org/10.3233/JAD-200374.

PMID
32925039
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Bodner, Kaylee A., Terry E. Goldberg, D. P. Devanand, and P Murali Doraiswamy. “Advancing Computerized Cognitive Training for MCI and Alzheimer's Disease in a Pandemic and Post-pandemic World.” Front Psychiatry 11 (2020): 557571. https://doi.org/10.3389/fpsyt.2020.557571.

PMID
33329097
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