Geriatrics

P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Senior Fellow of the Center for the Study of Aging and Human Development
Affiliate in the Duke Center for Applied Genomics and Precision Medicine
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Bernath, Megan M., Sudeepa Bhattacharyya, Kwangsik Nho, Dinesh Kumar Barupal, Oliver Fiehn, Rebecca Baillie, Shannon L. Risacher, et al. “Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers.” Neurology 94, no. 20 (May 19, 2020): e2088–98. https://doi.org/10.1212/WNL.0000000000009436.

PMID
32358220
Full Text

Arnold, Matthias, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, et al. “Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.” Nat Commun 11, no. 1 (March 2, 2020): 1148. https://doi.org/10.1038/s41467-020-14959-w.

PMID
32123170
Full Text

Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, P Murali Doraiswamy, et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc 68, no. 3 (March 2020): 559–68. https://doi.org/10.1111/jgs.16252.

PMID
31755550
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Sabbagh, M. N., M. Boada, S. Borson, P. M. Doraiswamy, B. Dubois, J. Ingram, A. Iwata, et al. “Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting.” J Prev Alzheimers Dis 7, no. 3 (2020): 171–78. https://doi.org/10.14283/jpad.2020.22.

PMID
32463070
Full Text

Sabbagh, M. N., M. Boada, S. Borson, M. Chilukuri, P. M. Doraiswamy, B. Dubois, J. Ingram, et al. “Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies.” J Prev Alzheimers Dis 7, no. 3 (2020): 158–64. https://doi.org/10.14283/jpad.2020.19.

PMID
32463068
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Horgusluoglu-Moloch, Emrin, Shannon L. Risacher, Paul K. Crane, Derrek Hibar, Paul M. Thompson, Andrew J. Saykin, Kwangsik Nho, and Kwangsik Alzheimer’s Disease Neuroimaging Initiative (ADNI). “Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.” Sci Rep 9, no. 1 (October 10, 2019): 14498. https://doi.org/10.1038/s41598-019-50507-3.

PMID
31601890
Full Text

Nho, Kwangsik, Alexandra Kueider-Paisley, Shahzad Ahmad, Siamak MahmoudianDehkordi, Matthias Arnold, Shannon L. Risacher, Gregory Louie, et al. “Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.” Jama Netw Open 2, no. 7 (July 3, 2019): e197978. https://doi.org/10.1001/jamanetworkopen.2019.7978.

PMID
31365104
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Pontecorvo, Michael J., Michael D. Devous, Ian Kennedy, Michael Navitsky, Ming Lu, Nicholas Galante, Stephen Salloway, et al. “A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia.” Brain 142, no. 6 (June 1, 2019): 1723–35. https://doi.org/10.1093/brain/awz090.

PMID
31009046
Full Text

Goudey, Benjamin, Bowen J. Fung, Christine Schieber, Noel G. Faux, Noel G. Alzheimer’s Disease Metabolomics Consortium, and Noel G. Alzheimer’s Disease Neuroimaging Initiative. “A blood-based signature of cerebrospinal fluid Aβ1-42 status.” Sci Rep 9, no. 1 (March 11, 2019): 4163. https://doi.org/10.1038/s41598-018-37149-7.

PMID
30853713
Full Text

Nho, Kwangsik, Alexandra Kueider-Paisley, Siamak MahmoudianDehkordi, Matthias Arnold, Shannon L. Risacher, Gregory Louie, Colette Blach, et al. “Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.” Alzheimers Dement 15, no. 2 (February 2019): 232–44. https://doi.org/10.1016/j.jalz.2018.08.012.

PMID
30337152
Full Text

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