Patrick Hank Pun, MD

Associate Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail Duke Box 17969, Durham, NC 27705
Phone (919) 668-8529

My current research interest is in understanding the mechanisms of cardiovascular disease among patients with chronic kidney disease, with a particular focus on the epidemic of sudden cardiac death. The ultimate goal is to reduce the impact of sudden death through improved risk stratification and novel risk mitigation therapies. Current investigations are focused on identifying novel genetic and biomarker risk factors among CKD patients, understanding the interplay of hemodialysis-specific exposures in the development of arrhythmias, and examining the risks and benefits of implantable cardioverter defibrillators among CKD patients using clinical trial and registry data.

Education and Training

  • Fellow in Nephrology, Medicine, Duke University, 2004 - 2007
  • Medical Resident, Medicine, Duke University, 2001 - 2004
  • M.D., Vanderbilt University, 2001

Publications

Surana, Sikander P., Patrick H. Pun, Sai Ram Keithi-Reddy, Steven M. Spiegel, John P. Middleton, and Ajay K. Singh. “Sudden cardiac arrest in ESRD patients.” Clin Nephrol 81, no. 2 (February 2014): 121–31. https://doi.org/10.5414/CN107667.

PMID
23149247
Full Text

Tyson, Crystal C., Maragatha Kuchibhatla, Uptal D. Patel, Patrick H. Pun, Alex Chang, Chinazo Nwankwo, Michael A. Joseph, and Laura P. Svetkey. “Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.” J Hypertens (Los Angel) 3 (2014). https://doi.org/10.4172/2167-1095.1000168.

PMID
26380159
Full Text

Pun, Patrick H., John R. Horton, and John P. Middleton. “Dialysate calcium concentration and the risk of sudden cardiac arrest in hemodialysis patients.” Clin J Am Soc Nephrol 8, no. 5 (May 2013): 797–803. https://doi.org/10.2215/CJN.10000912.

PMID
23371957
Full Text

Pun, Patrick Hank, Sana M. Al-Khatib, Rex Edwards, Gust Bardy, J Thomas Bigger, Alfred Buxton, Arthur Moss, et al. “INFLUENCE OF CHRONIC KIDNEY DISEASE ON THE EFFICACY OF PRIMARY PREVENTION IMPLANTABLE CARDIOVERTER DEFIBRILLATORS: A META-ANALYSIS OF THREE RANDOMIZED TRIALS.” In Journal of the American College of Cardiology, 61:E393–E393. Elsevier BV, 2013. https://doi.org/10.1016/s0735-1097(13)60393-9.

Full Text

Pun, Patrick H., Debra Schumm, Gillian D. Sanders, Deborah Hickey, John P. Middleton, Nancy Clapp-Channing, and Sana M. Al-Khatib. “A pilot study using an implantable device to characterize cardiac arrhythmias in hemodialysis patients: implications for future research.” Ann Noninvasive Electrocardiol 17, no. 2 (April 2012): 159. https://doi.org/10.1111/j.1542-474X.2012.00491.x.

PMID
22537338
Full Text

Pun, Patrick H., Charles A. Herzog, and John P. Middleton. “Improving ascertainment of sudden cardiac death in patients with end stage renal disease.” Clin J Am Soc Nephrol 7, no. 1 (January 2012): 116–22. https://doi.org/10.2215/CJN.02820311.

PMID
22076878
Full Text

Pun, Patrick H., and John P. Middleton. “Sudden cardiac death in hemodialysis patients: a comprehensive care approach to reduce risk.” Blood Purif 33, no. 1–3 (2012): 183–89. https://doi.org/10.1159/000334154.

PMID
22269796
Full Text

Herzog, Charles A., Richard W. Asinger, Alan K. Berger, David M. Charytan, Javier Díez, Robert G. Hart, Kai-Uwe Eckardt, et al. “Cardiovascular disease in chronic kidney disease. A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO).” Kidney Int 80, no. 6 (September 2011): 572–86. https://doi.org/10.1038/ki.2011.223.

PMID
21750584
Full Text

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