Patty J Lee, MD

Professor of Medicine
Professor of Cell Biology
Campus mail 3110 MSRB 3, 3 Genome Court, Durham, NC 27710
Phone (919) 684-0928
Email address patty.lee@duke.edu

My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system.  Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.

Education and Training

  • Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine, 1994 - 1998
  • Internal Medicine Residency, Johns Hopkins University School of Medicine, 1991 - 1994
  • M.D., Brown University, 1991

Publications

Yuan, Qianying, Abdul Basit, Wenhua Liang, Rihao Qu, Yi Luan, Chunguang Ren, Ao Li, et al. “Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.” Sci Transl Med 13, no. 591 (April 28, 2021). https://doi.org/10.1126/scitranslmed.abc2499.

PMID
33910977
Full Text

Zhang, Yi, Guoying Yu, Naftali Kaminski, and Patty Lee. “PINK1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-induced Lung Injury.” Am J Physiol Lung Cell Mol Physiol, April 14, 2021. https://doi.org/10.1152/ajplung.00598.2020.

PMID
33851544
Full Text

Chun, Hyung J., Elias Coutavas, Alexander Pine, Alfred I. Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, et al. “Immuno-fibrotic drivers of impaired lung function in post-COVID-19 syndrome.” Medrxiv, February 6, 2021. https://doi.org/10.1101/2021.01.31.21250870.

PMID
33564789
Full Text

Nouws, Jessica, Feng Wan, Eric Finnemore, Willy Roque, So-Jin Kim, Isabel Bazan, Chuan-Xing Li, et al. “MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.” Jci Insight 6, no. 2 (January 25, 2021). https://doi.org/10.1172/jci.insight.134218.

PMID
33290275
Full Text

Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.

PMID
33128895
Full Text

Clapham, Katharine R., Youlan Rao, Sandeep Sahay, Maor Sauler, Patty J. Lee, Mitchell A. Psotka, Wassim H. Fares, and Tariq Ahmad. “PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension.” Am J Cardiol 127 (July 15, 2020): 198–99. https://doi.org/10.1016/j.amjcard.2020.04.031.

PMID
32430164
Full Text

Kim, S., F. Wan, X. Zhang, Y. Zhang, E. Ifedigbo, L. Leng, R. Bucala, P. Lee, and M. Sauler. “MIF-CD74 Signaling Protects Against Endothelial Senescence in Chronic Obstructive Pulmonary Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Kim, So-Jin, Peiying Shan, Cheol Hwangbo, Yi Zhang, Jin-Na Min, Xuchen Zhang, Taylor Ardito, et al. “Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.” Aging Cell 18, no. 3 (June 2019): e12914. https://doi.org/10.1111/acel.12914.

PMID
30790400
Full Text

Lindow, Janet C., Elsio A. Wunder, Stephen J. Popper, Jin-Na Min, Praveen Mannam, Anup Srivastava, Yi Yao, et al. “Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.” Plos Pathog 12, no. 11 (November 2016): e1005943. https://doi.org/10.1371/journal.ppat.1005943.

PMID
27812211
Full Text

Ingram, Jennifer L., Aurita Antao-Menezes, James B. Mangum, Otis Lyght, Patty J. Lee, Jack A. Elias, and James C. Bonner. “Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.” J Immunol 177, no. 6 (September 15, 2006): 4141–48. https://doi.org/10.4049/jimmunol.177.6.4141.

PMID
16951379
Full Text

Pages