Patty J Lee, MD

Professor of Medicine
Professor of Cell Biology
Campus mail 5140 MSRB 3, 3 Genome Court, Durham, NC 27710
Phone (919) 684-0928
Email address patty.lee@duke.edu

My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system.  Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.

Education and Training

  • Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine, 1994 - 1998
  • Internal Medicine Residency, Johns Hopkins University School of Medicine, 1991 - 1994
  • M.D., Brown University, 1991

Publications

Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.

PMID
33128895
Full Text

Clapham, Katharine R., Youlan Rao, Sandeep Sahay, Maor Sauler, Patty J. Lee, Mitchell A. Psotka, Wassim H. Fares, and Tariq Ahmad. “PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension.” Am J Cardiol 127 (July 15, 2020): 198–99. https://doi.org/10.1016/j.amjcard.2020.04.031.

PMID
32430164
Full Text

Kim, S., F. Wan, X. Zhang, Y. Zhang, E. Ifedigbo, L. Leng, R. Bucala, P. Lee, and M. Sauler. “MIF-CD74 Signaling Protects Against Endothelial Senescence in Chronic Obstructive Pulmonary Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Zhang, Xuchen, Peiying Shan, Salman Qureshi, Robert Homer, Ruslan Medzhitov, Paul W. Noble, and Patty J. Lee. “Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.” J Immunol 175, no. 8 (October 15, 2005): 4834–38. https://doi.org/10.4049/jimmunol.175.8.4834.

PMID
16210584
Full Text

Lee, Chun Geun, Soo Jung Cho, Min Jong Kang, Svetlana P. Chapoval, Patty J. Lee, Paul W. Noble, Teshome Yehualaeshet, et al. “Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.” J Exp Med 200, no. 3 (August 2, 2004): 377–89. https://doi.org/10.1084/jem.20040104.

PMID
15289506
Full Text