My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system. Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.
Education and Training
- Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine, 1994 - 1998
- Internal Medicine Residency, Johns Hopkins University School of Medicine, 1991 - 1994
- M.D., Brown University, 1991