Patty J Lee, MD

Professor of Medicine
Professor of Cell Biology
Professor in Pathology
Campus mail 3110 MSRB 3, 3 Genome Court, Durham, NC 27710
Phone (919) 684-0928
Email address patty.lee@duke.edu

My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system.  Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.

Education and Training

  • Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine, 1994 - 1998
  • Internal Medicine Residency, Johns Hopkins University School of Medicine, 1991 - 1994
  • M.D., Brown University, 1991

Publications

Bazan, Isabel S., So-Jin Kim, Taylor A. Ardito, Yi Zhang, Peiying Shan, Maor Sauler, and Patty J. Lee. “Sex differences and altered mitophagy in experimental pulmonary hypertension.” Am J Physiol Lung Cell Mol Physiol 322, no. 5 (May 1, 2022): L761–69. https://doi.org/10.1152/ajplung.00019.2020.

PMID
35137625
Full Text

Chun, Hyung J., Elias Coutavas, Alexander B. Pine, Alfred I. Lee, Vanessa L. Yu, Marcus K. Shallow, Coral X. Giovacchini, et al. “Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.” Jci Insight 6, no. 14 (July 22, 2021). https://doi.org/10.1172/jci.insight.148476.

PMID
34111030
Full Text

Zhang, Yi, Guoying Yu, Naftali Kaminski, and Patty J. Lee. “PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury.” Am J Physiol Lung Cell Mol Physiol 320, no. 6 (June 1, 2021): L1118–25. https://doi.org/10.1152/ajplung.00598.2020.

PMID
33851544
Full Text

Kim, S., C. Zhou, E. Coutavas, and P. Lee. “Effect of Toll-Like Receptor 4 on Tom70 Expression and Its Role in Mitochondria.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Scholars@Duke

Kim, S., C. Hwangbo, P. Shan, Y. Zhang, L. Macadlo, J. Ou, P. Tata, E. Coutavas, and P. Lee. “Epigenetic Alterations in Cigarette Smoke-Induced Endothelial Cell Senescence.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Scholars@Duke

Yuan, Qianying, Abdul Basit, Wenhua Liang, Rihao Qu, Yi Luan, Chunguang Ren, Ao Li, et al. “Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.” Sci Transl Med 13, no. 591 (April 28, 2021). https://doi.org/10.1126/scitranslmed.abc2499.

PMID
33910977
Full Text

Chun, Hyung J., Elias Coutavas, Alexander Pine, Alfred I. Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, et al. “Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC).” Medrxiv, April 21, 2021. https://doi.org/10.1101/2021.01.31.21250870.

PMID
33564789
Full Text

Nouws, Jessica, Feng Wan, Eric Finnemore, Willy Roque, So-Jin Kim, Isabel Bazan, Chuan-Xing Li, et al. “MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.” Jci Insight 6, no. 2 (January 25, 2021). https://doi.org/10.1172/jci.insight.134218.

PMID
33290275
Full Text

Giri, Paresh C., Anand M. Chowdhury, Armando Bedoya, Hengji Chen, Hyun Suk Lee, Patty Lee, Craig Henriquez, Neil R. MacIntyre, and Yuh-Chin T. Huang. “Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?” Front Physiol 12 (2021): 678540. https://doi.org/10.3389/fphys.2021.678540.

PMID
34248665
Full Text

Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.

PMID
33128895
Full Text

Pages