Redford B. Williams, MD

Professor of Psychiatry and Behavioral Sciences
Professor of Psychology and Neuroscience
Professor of Medicine
Campus mail 905 W. Main Street, Suite 22 (2nd Floor), Durham, NC 27701
Phone (919) 684-3863
Email address redfordw@duke.edu

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Education and Training

  • M.D., Yale University, 1967

Publications

Haberstick, Brett C., Andrew Smolen, Redford B. Williams, George D. Bishop, Vangie A. Foshee, Terence P. Thornberry, Rand Conger, et al. “Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa.” Behav Genet 45, no. 2 (March 2015): 255–61. https://doi.org/10.1007/s10519-014-9703-5.

PMID
25564228
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Boyle, Stephen H., Anastasia Georgiades, Beverly H. Brummett, John C. Barefoot, Ilene C. Siegler, Wayne R. Matson, Cynthia M. Kuhn, et al. “Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.” Ann Behav Med 49, no. 1 (February 2015): 49–57. https://doi.org/10.1007/s12160-014-9626-7.

PMID
24806470
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Jiang, W., S. H. Boyle, T. L. Ortel, Z. Samad, E. J. Velazquez, R. W. Harrison, J. Wilson, et al. “Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.” American Heart Journal 169, no. 4 (January 1, 2015): 496-507.e1. https://doi.org/10.1016/j.ahj.2014.12.002.

Full Text

Brummett, Beverly H., Michael A. Babyak, Cynthia M. Kuhn, Ilene C. Siegler, and Redford B. Williams. “A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.” Biol Psychol 103 (December 2014): 317–21. https://doi.org/10.1016/j.biopsycho.2014.10.006.

PMID
25457638
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Samad, Zainab, Stephen Boyle, Mads Ersboll, Amit N. Vora, Ye Zhang, Richard C. Becker, Redford Williams, et al. “Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study.” J Am Coll Cardiol 64, no. 16 (October 21, 2014): 1669–78. https://doi.org/10.1016/j.jacc.2014.04.087.

PMID
25323254
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Proeschold-Bell, R. J., R. Swift, H. E. Moore, G. Bennett, X. F. Li, R. Blouin, V. P. Williams, R. B. Williams, and D. Toole. “Corrigendum to Use of a randomized multiple baseline design: Rationale and design of the Spirited Life holistic health intervention study [Contemp Clin Trials 35 (2013) 138-152].” Contemporary Clinical Trials 37, no. 1 (January 1, 2014). https://doi.org/10.1016/j.cct.2013.09.013.

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Haberstick, Brett C., Jeffrey M. Lessem, John K. Hewitt, Andrew Smolen, Christian J. Hopfer, Carolyn T. Halpern, Ley A. Killeya-Jones, et al. “MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors.” Biol Psychiatry 75, no. 1 (January 1, 2014): 25–30. https://doi.org/10.1016/j.biopsych.2013.03.028.

PMID
23726513
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Brummett, Beverly H., Michael A. Babyak, Redford B. Williams, Kathleen Mullan Harris, Rong Jiang, William E. Kraus, Abanish Singh, Paul T. Costa, Anastasia Georgiades, and Ilene C. Siegler. “A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.” Plos One 9, no. 12 (2014): e114451. https://doi.org/10.1371/journal.pone.0114451.

PMID
25514629
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Pages