Richard Frothingham, MD

Associate Professor of Medicine
Assistant Professor in Molecular Genetics and Microbiology
Member of the Duke Human Vaccine Institute
Campus mail 2424 Erwin Rd, Hock Plaza Room 9089, Durham, NC 27710
Phone (919) 684-5455
Email address richard.frothingham@duke.edu

Dr. Frothingham is the principal investigator of a research laboratory which studies Mycobacterium tuberculosis, the cause of tuberculosis, and Mycobacterium avium, a closely related bacterium causing serious infections in AIDS patients. We are pursuing two current projects.

The first project aims to develop vaccines against M. avium and M. tuberculosis. We inject mice with candidate plasmid DNA vaccines which produce bacterial proteins in mouse muscle. We use a variety of DNA adjuvants to modify the immune response. We hope to use DNA vaccination to protect against new infections and to modify the course of existing infections. We also hope to identify correlates of vaccine-induced protective immunity.

The second project uses variations in bacterial DNA sequences to identify species and strains. Dr. Frothingham was part of a team of four Duke scientists who used DNA sequence analysis to identify the cause of Whipple's disease. He also identified used DNA sequence to identify a particular group of M. avium strains which cause disseminated infections in AIDS patients. We recently developed a new tuberculosis typing method using variable numbers of tandem DNA repeats. We are applying this new typing method in national and international collaborations.

Dr. Frothingham does not currently conduct clinical trials.

Special areas of expertise include tuberculosis, mycobacteria, strain differentiation, DNA vaccination, and pyrazinamide.

Key words: tuberculosis, mycobacteria, Mycobacterium tuberculosis, Mycobacterium avium, DNA vaccines, tandem repeat DNA, pyrazinamide, mouse

Education and Training

  • Medicine and Pediatrics Resident, Medicine, University of Rochester, 1982 - 1986
  • M.D., Duke University, 1981

Publications

Owens, Robert C., and Paul G. Ambrose. “Torsades de pointes associated with fluoroquinolones..” Pharmacotherapy 22, no. 5 (May 2002): 663–68.

PMID
12013370
Scholars@Duke

Mathema, Barun, Pablo J. Bifani, Jeffrey Driscoll, Lauren Steinlein, Natalia Kurepina, Soraya L. Moghazeh, Elena Shashkina, et al. “Identification and evolution of an IS6110 low-copy-number Mycobacterium tuberculosis cluster..” J Infect Dis 185, no. 5 (March 1, 2002): 641–49. https://doi.org/10.1086/339345.

PMID
11865421
Full Text

Frothingham, R. “Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin..” Pharmacotherapy 21, no. 12 (December 2001): 1468–72.

PMID
11765299
Scholars@Duke

Goodman, L. A., M. P. Salyers, K. T. Mueser, S. D. Rosenberg, M. Swartz, S. M. Essock, F. C. Osher, M. I. Butterfield, J. Swanson, and J. 5 Site Health and Risk Study Research Committee. “Recent victimization in women and men with severe mental illness: prevalence and correlates..” J Trauma Stress 14, no. 4 (October 2001): 615–32. https://doi.org/10.1023/A:1013026318450.

PMID
11776413
Full Text

Bifani, P., B. Mathema, M. Campo, S. Moghazeh, B. Nivin, E. Shashkina, J. Driscoll, S. S. Munsiff, R. Frothingham, and B. N. Kreiswirth. “Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain..” Emerg Infect Dis 7, no. 5 (September 2001): 842–48. https://doi.org/10.3201/eid0705.010512.

PMID
11747697
Full Text

Frothingham, R. “Mortality rates in comparative trials of formulations of amphotericin B..” Clin Infect Dis 33, no. 4 (August 15, 2001): 582–83. https://doi.org/10.1086/321906.

PMID
11462201
Full Text

Gascoyne-Binzi, D. M., R. E. Barlow, R. Frothingham, G. Robinson, T. A. Collyns, R. Gelletlie, and P. M. Hawkey. “Rapid identification of laboratory contamination with Mycobacterium tuberculosis using variable number tandem repeat analysis..” J Clin Microbiol 39, no. 1 (January 2001): 69–74. https://doi.org/10.1128/JCM.39.1.69-74.2001.

PMID
11136751
Full Text

Bifani, P. J., B. Shopsin, P. Alcabes, B. Mathema, B. N. Kreiswirth, Z. Liu, J. Driscoll, R. Frothingham, and J. M. Musser. “Molecular epidemiology and tuberculosis control.” Jama 284, no. 3 (July 19, 2000): 305–7.

PMID
10891955
Scholars@Duke

Bifani, P. J., B. Shopsin, P. Alcabes, B. Mathema, B. N. Kreiswirth, Z. Y. Liu, J. Driscoll, R. Frothingham, and J. M. Musser. “Molecular epidemiology and tuberculosis control - Reply.” Jama Journal of the American Medical Association 284, no. 3 (July 19, 2000): 306–7.

Scholars@Duke

Pages