Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@mc.duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebannon), 1993

Publications

Al-Khatib, Sana M., and Sean D. Pokorney. “Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: Diminishing Returns With Advancing Age?.” Circulation 136, no. 19 (November 7, 2017): 1781–83. https://doi.org/10.1161/CIRCULATIONAHA.117.030935.

PMID
29109194
Full Text

Al-Khatib, Sana M., Gregg C. Fonarow, and Gillian D. Sanders. “Implantable Cardioverter Defibrillators for Nonischemic Cardiomyopathy-Reply..” Jama Cardiol 2, no. 11 (November 1, 2017): 1283–84. https://doi.org/10.1001/jamacardio.2017.3221.

PMID
28975189
Full Text

Zeitler, Emily P., Sana M. Al-Khatib, Daniel J. Friedman, Joo Yoon Han, Jeanne E. Poole, Gust H. Bardy, J Thomas Bigger, et al. “Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II..” In J Cardiovasc Electrophysiol, 28:1345–51, 2017. https://doi.org/10.1111/jce.13307.

PMID
28744959
Full Text

Zeitler, Emily P., Daniel J. Friedman, James P. Daubert, Sana M. Al-Khatib, Scott D. Solomon, Yitschak Biton, Scott McNitt, Wojciech Zareba, Arthur J. Moss, and Valentina Kutyifa. “Reply: The Benefit of Cardiac Resynchronization Therapy Is Not Hindered by the Number of Comorbidities..” J Am Coll Cardiol 70, no. 16 (October 17, 2017): 2097–98. https://doi.org/10.1016/j.jacc.2017.07.795.

PMID
29025566
Full Text

Pokorney, Sean D., Xiaojuan Mi, Robert K. Lewis, Melissa Greiner, Laurence M. Epstein, Roger G. Carrillo, Emily P. Zeitler, Sana M. Al-Khatib, Donald D. Hegland, and Jonathan P. Piccini. “Outcomes Associated With Extraction Versus Capping and Abandoning Pacing and Defibrillator Leads..” Circulation 136, no. 15 (October 10, 2017): 1387–95. https://doi.org/10.1161/CIRCULATIONAHA.117.027636.

PMID
28830879
Full Text

Al-Khatib, S. M., D. J. Friedman, P. L. Hess, P. H. Pun, and G. D. Sanders. “Do Implantable Cardioverter-Defibrillators Lower the Risk of Sudden Death and Total Mortality in Patients with End-Stage Renal Disease?.” Current Cardiovascular Risk Reports 11, no. 9 (September 1, 2017). https://doi.org/10.1007/s12170-017-0551-8.

Full Text

Friedman, Daniel J., Sana M. Al-Khatib, Emily P. Zeitler, JooYoon Han, Gust H. Bardy, Jeanne E. Poole, J Thomas Bigger, et al. “New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials..” In Am Heart J, 191:21–29, 2017. https://doi.org/10.1016/j.ahj.2017.06.002.

PMID
28888266
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Hess, Paul L., Hussein R. Al-Khalidi, Daniel J. Friedman, Hillary Mulder, Anna Kucharska-Newton, Wayne R. Rosamond, Renato D. Lopes, et al. “The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study..” J Am Heart Assoc 6, no. 8 (August 23, 2017). https://doi.org/10.1161/JAHA.117.006103.

PMID
28835363
Full Text

Varosy, Paul D., Lin Y. Chen, Amy L. Miller, Peter A. Noseworthy, David J. Slotwiner, and Venkatesh Thiruganasambandamoorthy. “Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society..” J Am Coll Cardiol 70, no. 5 (August 1, 2017): 664–79. https://doi.org/10.1016/j.jacc.2017.03.004.

PMID
28286220
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Shen, Win-Kuang, Robert S. Sheldon, David G. Benditt, Mitchell I. Cohen, Daniel E. Forman, Zachary D. Goldberger, Blair P. Grubb, et al. “2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society..” J Am Coll Cardiol 70, no. 5 (August 1, 2017): 620–63. https://doi.org/10.1016/j.jacc.2017.03.002.

PMID
28286222
Full Text

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