Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebanon), 1993


Melloni, Chiara, Karen P. Alexander, Angie Wu, W Schuyler Jones, Rajendra H. Mehta, Robert W. Harrison, David Kong, et al. “Type 2 Myocardial Infarction: Incidence, Risk Factors, and Outcomes Among 41,581 Patients Enrolled in 3 Large Randomized Clinical Trials.” In Circulation, Vol. 140, 2019.


Goldstein, Sarah A., Jennifer Green, Kurt Huber, Daniel M. Wojdyla, Renato D. Lopes, John H. Alexander, Dragos Vinereanu, Lars Wallentin, Christopher B. Granger, and Sana M. Al-Khatib. “Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial).” Am J Cardiol 124, no. 9 (November 1, 2019): 1406–12.

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Edmonston, Daniel L., Christina M. Wyatt, and Sana M. Al-Khatib. “Atrial fibrillation and kidney disease: stuck outside the CABANA.” Kidney Int 96, no. 5 (November 2019): 1054–55.

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Black-Maier, Eric, Alice Parish, Benjamin A. Steinberg, Cynthia L. Green, Zak Loring, Adam S. Barnett, Sana M. Al-Khatib, et al. “Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.” Pacing Clin Electrophysiol 42, no. 11 (November 2019): 1440–47.

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Ali-Ahmed, Fatima, Daniel Matlock, Emily P. Zeitler, Kevin L. Thomas, David E. Haines, and Sana M. Al-Khatib. “Physicians' perceptions of shared decision-making for implantable cardioverter-defibrillators: Results of a physician survey.” J Cardiovasc Electrophysiol 30, no. 11 (November 2019): 2420–26.

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Slotwiner, David J., Robert L. Abraham, Sana M. Al-Khatib, H Vernon Anderson, T Jared Bunch, Martha G. Ferrara, Neal Lippman, et al. “HRS White Paper on interoperability of data from cardiac implantable electronic devices (CIEDs).” Heart Rhythm 16, no. 9 (September 2019): e107–27.

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