Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address palme002@mc.duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Foster, MW, Gwinn, WM, Kelly, FL, Brass, DM, Thompson, JW, Moseley, MA, Morgan, DL, and Palmer, SM. "Proteomic Analysis Reveals Significant Epithelial Remodeling After In Vitro Exposure To Diacetyl Vapor." 2016.

Scholars@Duke

Foster, MW, Thompson, JW, Brass, DM, Moseley, MA, Morgan, DL, and Palmer, SM. "Plasma Metabolomics Analysis Identifies Candidate Biomarkers Of Flavoring-Induced Bronchiolitis Obliterans." 2016.

Scholars@Duke

O'Brien, EC, Shrader, P, Durheim, MT, Snyder, LD, Todd, JL, Gamerman, V, Anstrom, KJ, Belperio, JA, Culver, DA, De Andrade, JAM, Roman, J, Whelan, TPM, Conoscenti, CS, and Palmer, SM. "Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients." 2016.

Scholars@Duke

Podolanczuk, A, Oelsner, EC, Barr, RG, Hoffman, EA, Armstrong, HF, Austin, JHM, Basner, RC, Bartels, MN, Christie, JD, Enright, PL, Gochuico, B, Stukovsky, KH, Kaufman, J, Nath, H, Newell, JD, Palmer, SM, Rabinowitz, D, Raghu, G, Sell, J, Sieren, JP, Sonavane, SK, Tracy, RP, Watts, JR, Williams, K, Kawut, SM, and Lederer, DJ. "High Attenuation Areas On Computed Tomography, Subclinical Interstitial Lung Disease, And Mortality In Community Dwelling Adults." 2016.

Scholars@Duke

International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), . "Design and Implementation of the International Genetics and Translational Research in Transplantation Network." Transplantation 99, no. 11 (November 2015): 2401-2412.

PMID
26479416
Full Text

Castleberry, AW, Englum, BR, Snyder, LD, Worni, M, Osho, AA, Gulack, BC, Palmer, SM, Davis, RD, and Hartwig, MG. "The utility of preoperative six-minute-walk distance in lung transplantation." American journal of respiratory and critical care medicine 192, no. 7 (October 2015): 843-852.

PMID
26067395
Full Text

Hoffman, BM, Stonerock, GL, Smith, PJ, O'Hayer, CVF, Palmer, S, Davis, RD, Kurita, K, Carney, RM, Freeland, K, and Blumenthal, JA. "Development and psychometric properties of the Pulmonary-specific Quality-of-Life Scale in lung transplant patients." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 34, no. 8 (August 2015): 1058-1065.

PMID
25980570
Full Text

Verleden, SE, Todd, JL, Sato, M, Palmer, SM, Martinu, T, Pavlisko, EN, Vos, R, Neyrinck, A, Van Raemdonck, D, Saito, T, Oishi, H, Keshavjee, S, Greer, M, Warnecke, G, Gottlieb, J, and Haverich, A. "Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2223-2230.

PMID
25940517
Full Text

Shah, RJ, Diamond, JM, Cantu, E, Flesch, J, Lee, JC, Lederer, DJ, Lama, VN, Orens, J, Weinacker, A, Wilkes, DS, Roe, D, Bhorade, S, Wille, KM, Ware, LB, Palmer, SM, Crespo, M, Demissie, E, Sonnet, J, Shah, A, Kawut, SM, Bellamy, SL, Localio, AR, and Christie, JD. "Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2188-2196.

PMID
25877792
Full Text

Durheim, MT, Collard, HR, Roberts, RS, Brown, KK, Flaherty, KR, King, TE, Palmer, SM, Raghu, G, Snyder, LD, Anstrom, KJ, Martinez, FJ, and IPFnet investigators, . "Association of hospital admission and forced vital capacity endpoints with survival in patients with idiopathic pulmonary fibrosis: analysis of a pooled cohort from three clinical trials." The Lancet. Respiratory medicine 3, no. 5 (May 2015): 388-396.

PMID
25890798
Full Text

Pages