Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993


Smith, PJ, Blumenthal, JA, Trulock, EP, Freedland, KE, Carney, RM, Davis, RD, Hoffman, BM, and Palmer, SM. "Psychosocial Predictors of Mortality Following Lung Transplantation." AMERICAN JOURNAL OF TRANSPLANTATION 16, no. 1 (January 2016): 271-277.

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Brass, DM, Gwinn, WM, Valente, A, Kelly, FL, Brinkley, C, Nagler, A, Moseley, A, Morgan, DL, Palmer, SM, and Foster, MW. "Artificial Butter Flavoring Exposure Causes An Extracellular Matrix Reorganizing Proteomic Signature In Primary Human Airway Epithelial Cells." 2016.


Brass, DM, Kelly, FL, Gwinn, WM, Brinkley, C, Nagler, A, Morgan, DL, Foster, MW, and Palmer, SM. "Synthesis Of A Cross-Linked Hyaluronan Matrix By The Airway Epithelium In Experimental Bronchiolitis Obliterans." 2016.


Foster, MW, Gwinn, WM, Kelly, FL, Brass, DM, Thompson, JW, Moseley, MA, Morgan, DL, and Palmer, SM. "Proteomic Analysis Reveals Significant Epithelial Remodeling After In Vitro Exposure To Diacetyl Vapor." 2016.


Foster, MW, Thompson, JW, Brass, DM, Moseley, MA, Morgan, DL, and Palmer, SM. "Plasma Metabolomics Analysis Identifies Candidate Biomarkers Of Flavoring-Induced Bronchiolitis Obliterans." 2016.


O'Brien, EC, Shrader, P, Durheim, MT, Snyder, LD, Todd, JL, Gamerman, V, Anstrom, KJ, Belperio, JA, Culver, DA, De Andrade, JAM, Roman, J, Whelan, TPM, Conoscenti, CS, and Palmer, SM. "Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients." 2016.


Podolanczuk, A, Oelsner, EC, Barr, RG, Hoffman, EA, Armstrong, HF, Austin, JHM, Basner, RC, Bartels, MN, Christie, JD, Enright, PL, Gochuico, B, Stukovsky, KH, Kaufman, J, Nath, H, Newell, JD, Palmer, SM, Rabinowitz, D, Raghu, G, Sell, J, Sieren, JP, Sonavane, SK, Tracy, RP, Watts, JR, Williams, K, Kawut, SM, and Lederer, DJ. "High Attenuation Areas On Computed Tomography, Subclinical Interstitial Lung Disease, And Mortality In Community Dwelling Adults." 2016.


International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), . "Design and Implementation of the International Genetics and Translational Research in Transplantation Network." Transplantation 99, no. 11 (November 2015): 2401-2412.

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Castleberry, AW, Englum, BR, Snyder, LD, Worni, M, Osho, AA, Gulack, BC, Palmer, SM, Davis, RD, and Hartwig, MG. "The utility of preoperative six-minute-walk distance in lung transplantation." American journal of respiratory and critical care medicine 192, no. 7 (October 2015): 843-852.

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Shah, RJ, Diamond, JM, Cantu, E, Flesch, J, Lee, JC, Lederer, DJ, Lama, VN, Orens, J, Weinacker, A, Wilkes, DS, Roe, D, Bhorade, S, Wille, KM, Ware, LB, Palmer, SM, Crespo, M, Demissie, E, Sonnet, J, Shah, A, Kawut, SM, Bellamy, SL, Localio, AR, and Christie, JD. "Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2188-2196.

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