Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Core Faculty in Innovation & Entrepreneurship
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address palme002@mc.duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Durheim, MT, Collard, HR, Roberts, RS, Brown, KK, Flaherty, KR, King, TE, Palmer, SM, Raghu, G, Snyder, LD, Anstrom, KJ, and Martinez, FJ. "Associations Between Hospitalization And Forced Vital Capacity Endpoints And Survival In Idiopathic Pulmonary Fibrosis." International Conference of the American-Thoracic-Society (ATS). Denver, CO. May 15, 2015 - May 20, 2015.: AMER THORACIC SOC, January 1, 2015.

Scholars@Duke

Speicher, PJ, Ganapathi, AM, Englum, BR, Gulack, BC, Osho, AA, Hirji, SA, Castleberry, AW, Snyder, LD, Duane Davis, R, and Hartwig, MG. "Single-lung transplantation in the United States: what happens to the other lung?." January 2015.

PMID
25305097
Full Text

Gowdy, KM, Martinu, T, Nugent, JL, Manzo, ND, Zhang, HL, Kelly, FL, Holtzman, MJ, and Palmer, SM. "Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection." Transplant Immunology 32, no. 1 (January 2015): 51-60.

PMID
25446809
Full Text

Morgan, DL, Merrick, BA, Gerrish, KE, Stockton, PS, Wang, Y, Foley, JF, Gwinn, WM, Kelly, FL, Palmer, SM, Ton, T-VT, and Flake, GP. "Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats." PloS one 10, no. 2 (January 2015): e0118459-.

PMID
25710175
Full Text

Hoffman, BM, Stonerock, GL, Smith, PJ, O'Hayer, CVF, Palmer, S, Davis, RD, Kurita, K, Carney, RM, Freeland, K, and Blumenthal, JA. "Development and psychometric properties of the Pulmonary-specific Quality-of-Life Scale in lung transplant patients." Journal of Heart and Lung Transplantation 34, no. 8 (2015): 1058-1065.

Full Text

Durheim, MT, Cyr, DD, Al-Khatib, SM, Thomas, LE, Lopes, RD, Gersh, BJ, Palmer, SM, and Granger, CB. "Chronic Obstructive Pulmonary Disease Is Associated With Increased Risk Of Mortality Among Patients With Atrial Fibrillation: Insights From The Aristotle Trial." 2015.

Scholars@Duke

Osho, AA, Castleberry, AW, Snyder, LD, Palmer, SM, Stafford-Smith, M, Lin, SS, Duane Davis, R, and Hartwig, MG. "The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation." Journal of Heart and Lung Transplantation 33, no. 12 (December 1, 2014): 1248-1254.

Full Text

Martinu, T, Gowdy, KM, Nugent, JL, Sun, J, Kinnier, CV, Nelson, ME, Lyes, MA, Kelly, FL, Foster, WM, Gunn, MD, and Palmer, SM. "Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations." American Journal of Respiratory Cell and Molecular Biology 51, no. 6 (December 2014): 810-821.

PMID
24921973
Full Text

Osho, AA, Castleberry, AW, Snyder, LD, Palmer, SM, Stafford-Smith, M, Lin, SS, Duane Davis, R, and Hartwig, MG. "The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 33, no. 12 (December 2014): 1248-1254.

PMID
25107351
Full Text

Smith, PJ, Rivelli, S, Waters, A, Reynolds, J, Hoyle, A, Flowers, M, Davis, RD, Palmer, SM, Mathew, J, Durheim, M, and Blumenthal, JA. "Neurocognitive changes after lung transplantation." Annals of the American Thoracic Society 11, no. 10 (December 2014): 1520-1527.

PMID
25375275
Full Text

Pages