Steve M Taylor, MD

Associate Professor of Medicine
Associate Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #321a, Durham, NC 27710
Phone (919) 684-5815
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina - Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina - Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Band, Gavin, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, et al. “Malaria protection due to sickle haemoglobin depends on parasite genotype.” Nature, December 9, 2021. https://doi.org/10.1038/s41586-021-04288-3.

PMID
34883497
Full Text

Gutman, Julie R., Carole Khairallah, Kasia Stepniewska, Harry Tagbor, Mwayiwawo Madanitsa, Matthew Cairns, Anne Joan L’lanziva, et al. “Intermittent screening and treatment with artemisinin-combination therapy versus intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria in pregnancy: a systematic review and individual participant data meta-analysis of randomised clinical trials.” Eclinicalmedicine 41 (November 2021): 101160. https://doi.org/10.1016/j.eclinm.2021.101160.

PMID
34746720
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Saelens, Joseph W., Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa Konaté, Seidina A. S. Diakité, Karim Traoré, et al. “Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum.” Msphere 6, no. 5 (October 27, 2021): e0075521. https://doi.org/10.1128/mSphere.00755-21.

PMID
34668757
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Sumner, Kelsey M., Elizabeth Freedman, Judith N. Mangeni, Andrew A. Obala, Lucy Abel, Jessie K. Edwards, Michael Emch, et al. “Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya.” Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 73, no. 7 (October 2021): 1176–84. https://doi.org/10.1093/cid/ciab357.

PMID
33904907
Full Text

Weckman, Andrea M., Andrea L. Conroy, Mwayiwawo Madanitsa, Bruno Gnaneswaran, Chloe R. McDonald, Linda Kalilani-Phiri, Jaya Chandna, et al. “Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study.” Plos Medicine 18, no. 9 (September 28, 2021): e1003701. https://doi.org/10.1371/journal.pmed.1003701.

PMID
34582452
Full Text

Meredith, Hannah R., Amy Wesolowski, Diana Menya, Daniel Esimit, Gilchrist Lokoel, Joseph Kipkoech, Betsy Freedman, et al. “Epidemiology of Plasmodium falciparum Infections in a Semi-Arid Rural African Setting: Evidence from Reactive Case Detection in Northwestern Kenya.” Am J Trop Med Hyg 105, no. 4 (August 2, 2021): 1076–84. https://doi.org/10.4269/ajtmh.21-0256.

PMID
34339387
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Sumner, Kelsey M., Judith N. Mangeni, Andrew A. Obala, Elizabeth Freedman, Lucy Abel, Steven R. Meshnick, Jessie K. Edwards, Brian W. Pence, Wendy Prudhomme-O’Meara, and Steve M. Taylor. “Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya.” Elife 10 (July 23, 2021). https://doi.org/10.7554/eLife.68812.

PMID
34296998
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Petersen, Jens E. V., Joseph W. Saelens, Elizabeth Freedman, Louise Turner, Thomas Lavstsen, Rick M. Fairhurst, Mahamadou Diakité, and Steve M. Taylor. “Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes.” Plos Pathog 17, no. 6 (June 2021): e1009659. https://doi.org/10.1371/journal.ppat.1009659.

PMID
34115805
Full Text

Sumner, Kelsey M., Elizabeth Freedman, Lucy Abel, Andrew Obala, Brian W. Pence, Amy Wesolowski, Steven R. Meshnick, Wendy Prudhomme-O’Meara, and Steve M. Taylor. “Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections.” Nat Commun 12, no. 1 (February 10, 2021): 909. https://doi.org/10.1038/s41467-021-21269-2.

PMID
33568678
Full Text

Petersen, Jens E. V., and Steve M. Taylor. “A Thermal Exhaust Port on the Death Star of Plasmodium falciparum-Infected Erythrocytes.” Trends Pharmacol Sci 41, no. 8 (August 2020): 508–11. https://doi.org/10.1016/j.tips.2020.06.005.

PMID
32600921
Full Text

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