Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #301, Durham, NC 27710
Phone (919) 684-8111
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Rogerson, SJ, Desai, M, Mayor, A, Sicuri, E, Taylor, SM, and van Eijk, AM. "Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. (Accepted)" The Lancet. Infectious diseases 18, no. 4 (April 2018): e107-e118. (Review)

PMID
29396010
Full Text

Miller, RH, Hathaway, NJ, Kharabora, O, Mwandagalirwa, K, Tshefu, A, Meshnick, SR, Taylor, SM, Juliano, JJ, Stewart, VA, and Bailey, JA. "A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity." Malaria journal 16, no. 1 (December 16, 2017): 490-.

PMID
29246158
Full Text

Levitt, B, O'Meara, WP, Langdon, S, and Taylor, SM. "MULTIPLEX BARCODED NEXT-GENERATION SEQUENCING OF MULTICLONAL PLASMODIUM FALCIPARUM GENOTYPES." November 2017.

Scholars@Duke

Patel, JC, Hathaway, NJ, Parobek, CM, Thwai, KL, Madanitsa, M, Khairallah, C, Kalilani-Phiri, L, Mwapasa, V, Massougbodji, A, Fievet, N, Bailey, JA, ter Kuile, FO, Deloron, P, Juliano, JJ, Taylor, SM, Engel, SM, Ndam, NT, and Meshnick, SR. "ASSOCIATION OF SPECIFIC VAR2CSA HAPLOTYPES WITH WORSENED BIRTH OUTCOMES IN WOMEN WITH PLASMODIUM FALCIPARUM PLACENTAL MALARIA IN MALAWI AND BENIN." November 2017.

Scholars@Duke

Patel, JC, Diakite, M, Lesko, CR, Lopera-Mesa, T, Taylor, SM, and Fairhurst, RM. "IMPACT OF ALL-CAUSE ANEMIA ON THE RISK OF FALCIPARUM MALARIA IN MALIAN CHILDREN." November 2017.

Scholars@Duke

Levitt, B, Madanitsa, M, ter Kuile, FO, Thwai, K, Mwapasa, V, Kalilani-Phiri, L, Meshnick, SR, and Taylor, SM. "COMPARATIVE IMPACTS OF ANTENATAL MALARIA PREVENTION STRATEGIES ON PLASMODIUM FALCIPARUM SP-RESISTANCE ALLELES IN MALAWI." November 2017.

Scholars@Duke

Doctor, SM, Liu, Y, Whitesell, A, Thwai, KL, Taylor, SM, Janko, M, Emch, M, Kashamuka, M, Muwonga, J, Tshefu, A, and Meshnick, SR. "Corrigendum to "Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test" [Diagn Microbiol Infect Dis. 2016 May;85(1):16-8. doi: 10.1016/j.Diagmicrobio.2016.01.004. Epub 2016 Jan 9]." Diagnostic microbiology and infectious disease 89, no. 3 (November 2017): 251-.

PMID
28918067
Full Text

Taylor, SM, and Ter Kuile, FO. "Stillbirths: the hidden burden of malaria in pregnancy." The Lancet. Global health 5, no. 11 (November 2017): e1052-e1053.

PMID
28967611
Full Text

Patel, JC, Hathaway, NJ, Parobek, CM, Thwai, KL, Madanitsa, M, Khairallah, C, Kalilani-Phiri, L, Mwapasa, V, Massougbodji, A, Fievet, N, Bailey, JA, Ter Kuile, FO, Deloron, P, Engel, SM, Taylor, SM, Juliano, JJ, Tuikue Ndam, N, and Meshnick, SR. "Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade." Scientific reports 7, no. 1 (August 11, 2017): 7768-.

PMID
28801627
Full Text

Taylor, SM, Madanitsa, M, Thwai, K-L, Khairallah, C, Kalilani-Phiri, L, van Eijk, AM, Mwapasa, V, Ter Kuile, FO, and Meshnick, SR. "Minimal Impact by Antenatal Subpatent Plasmodium falciparum Infections on Delivery Outcomes in Malawian Women: A Cohort Study." The Journal of infectious diseases 216, no. 3 (August 2017): 296-304.

PMID
28658935
Full Text

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