Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #301, Durham, NC 27710
Phone (919) 684-8111
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Taylor, SM, Molyneux, ME, Meshnick, SR, and Juliano, JJ. "DOES THIS PATIENT HAVE MALARIA? A META-ANALYSIS OF THE DIAGNOSTIC UTILITY OF CLINICAL FACTORS FOR ENDEMIC AND IMPORTED MALARIA." November 2010.

Scholars@Duke

Rantala, A-M, Taylor, SM, Trottman, PA, Luntamo, M, Mbewe, B, Maleta, K, Kulmala, T, Ashorn, P, and Meshnick, SR. "Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women." Malaria Journal 9 (October 6, 2010): 269-null.

PMID
20925928
Full Text

Taylor, SM, Juliano, JJ, Trottman, PA, Griffin, JB, Landis, SH, Kitsa, P, Tshefu, AK, and Meshnick, SR. "High-throughput pooling and real-time PCR-based strategy for malaria detection." Journal of Clinical Microbiology 48, no. 2 (February 2010): 512-519.

PMID
19940051
Full Text

Taylor, SM, Wolfe, CR, Dixon, TC, Ruch, DS, and Cox, GM. "Wound botulism complicating internal fixation of a complex radial fracture." Journal of Clinical Microbiology 48, no. 2 (February 2010): 650-653.

PMID
20007390
Full Text

Taylor, SM, Juliano, JJ, and Meshnick, SR. "Artemisinin resistance in Plasmodium falciparum malaria." N Engl J Med 361, no. 18 (October 29, 2009): 1807-. (Letter)

PMID
19864681
Full Text

Taylor, SM, Lou, J-Y, and Cox, GM. "Thanks for the memories." Am J Med 122, no. 9 (September 2009): 827-829.

PMID
19699376
Full Text

Juliano, JJ, Taylor, SM, and Meshnick, SR. "Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey?." The Journal of Infectious Diseases 200, no. 1 (July 2009): 5-7.

PMID
19469704
Full Text

Crawford, TC, Smith, WT, Velazquez, EJ, Taylor, SM, Jollis, JG, and Kisslo, J. "Prognostic usefulness of left ventricular thrombus by echocardiography in dilated cardiomyopathy in predicting stroke, transient ischemic attack, and death." Am J Cardiol 93, no. 4 (February 15, 2004): 500-503.

PMID
14969636
Full Text

Taylor, SM, Dolor, RJ, Liu, D, Olsen, MK, and Williams, JW. "Antidepressant therapy in primary care: Does patient preference affect response?." April 2003.

Scholars@Duke

Pages