Steven B. Haase, PhD

Associate Professor of Biology
Associate Professor in Medicine
Campus mail 4316 French, Durham, NC 27708
Phone (919) 613-8205
Email address steve.haase@duke.edu

Our group is broadly interested in understanding the biological clock mechanisms that control the timing of events during the cell division cycle. In 2008, the Haase group proposed a new model in which a complex network of sequentially activated transcription factors regulates the precise timing of gene expression during the cell-cycle, and functions as a robust time-keeping oscillator. Greater than a thousand genes are expressed at distinct phases of the cycle, and the control network itself consists of ~20 components, so this dynamical system is far too complex to understand simply by biological intuition. We rely heavily on the expertise of the Harer group (Dept. of Mathematics, Duke University) for the analysis of complex data, and their understanding of dynamical systems.  Using a collection of tools, including molecular genetics, genomics, mathematical models, and statistical inference, our groups aim to understand how the cell division clock works, how it might be perturbed in proliferative diseases such as cancer, and how the clock components might be targeted for new anti-tumor therapies.  Qualitatively, the clock networks that control the yeast cell cycle look much like the networks controlling circadian rhythms in a variety of organisms. More recently, we have been using our experimental and quantitative approaches to investigate the function of circadian clocks, as well as clocks that control the division and development of pathogenic organisms such as P. falciparum and P. vivax, the causative agents of malaria.

Education and Training

  • Ph.D., Stanford University, 1993
  • B.S., Colorado State University at Fort Collins, 1985

Publications

Cho, Chun-Yi, Christina M. Kelliher, and Steven B. Haase. “The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle..” Cell Cycle (Georgetown, Tex.) 18, no. 4 (February 5, 2019): 363–78. https://doi.org/10.1080/15384101.2019.1570655.

PMID
30668223
Full Text

Kelliher, Christina M., Matthew W. Foster, Francis C. Motta, Anastasia Deckard, Erik J. Soderblom, M Arthur Moseley, and Steven B. Haase. “Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae..” Mol Biol Cell 29, no. 22 (November 1, 2018): 2644–55. https://doi.org/10.1091/mbc.E18-04-0255.

PMID
30207828
Full Text

Moseley, Robert C., Ritesh Mewalal, Francis Motta, Gerald A. Tuskan, Steve Haase, and Xiaohan Yang. “Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant Kalanchoë fedtschenkoi and a Model C3 Photosynthesis Plant Arabidopsis thaliana..” Frontiers in Plant Science 9 (January 2018). https://doi.org/10.3389/fpls.2018.01757.

PMID
30546378
Full Text

Kelliher, Christina M., and Steven B. Haase. “Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans..” Current Genetics 63, no. 5 (October 2017): 803–11. https://doi.org/10.1007/s00294-017-0688-5.

PMID
28265742
Full Text

Cho, Chun-Yi, Francis C. Motta, Christina M. Kelliher, Anastasia Deckard, and Steven B. Haase. “Reconciling conflicting models for global control of cell-cycle transcription..” Cell Cycle (Georgetown, Tex.) 16, no. 20 (October 2017): 1965–78. https://doi.org/10.1080/15384101.2017.1367073.

PMID
28934013
Full Text

Kelliher, Christina M., Adam R. Leman, Crystal S. Sierra, and Steven B. Haase. “Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans..” Plos Genetics 12, no. 12 (December 5, 2016). https://doi.org/10.1371/journal.pgen.1006453.

PMID
27918582
Full Text

McGoff, Kevin A., Xin Guo, Anastasia Deckard, Christina M. Kelliher, Adam R. Leman, Lauren J. Francey, John B. Hogenesch, Steven B. Haase, and John L. Harer. “The Local Edge Machine: inference of dynamic models of gene regulation..” Genome Biology 17, no. 1 (October 19, 2016). https://doi.org/10.1186/s13059-016-1076-z.

PMID
27760556
Full Text

Perea, Jose A., Anastasia Deckard, Steve B. Haase, and John Harer. “SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data..” Bmc Bioinformatics 16 (August 16, 2015). https://doi.org/10.1186/s12859-015-0645-6.

PMID
26277424
Full Text

Bristow, Sara L., Adam R. Leman, Laura A. Simmons Kovacs, Anastasia Deckard, John Harer, and Steven B. Haase. “Checkpoints couple transcription network oscillator dynamics to cell-cycle progression..” Genome Biology 15, no. 9 (September 5, 2014). https://doi.org/10.1186/s13059-014-0446-7.

PMID
25200947
Full Text

Pages