Steven B. Haase, PhD

Professor of Biology
Associate Professor in Medicine
Campus mail 4316 French, Durham, NC 27708
Phone (919) 613-8205
Email address steve.haase@duke.edu

Our group is broadly interested in understanding the biological clock mechanisms that control the timing of events during the cell division cycle. In 2008, the Haase group proposed a new model in which a complex network of sequentially activated transcription factors regulates the precise timing of gene expression during the cell-cycle, and functions as a robust time-keeping oscillator. Greater than a thousand genes are expressed at distinct phases of the cycle, and the control network itself consists of ~20 components, so this dynamical system is far too complex to understand simply by biological intuition. We rely heavily on the expertise of the Harer group (Dept. of Mathematics, Duke University) for the analysis of complex data, and their understanding of dynamical systems.  Using a collection of tools, including molecular genetics, genomics, mathematical models, and statistical inference, our groups aim to understand how the cell division clock works, how it might be perturbed in proliferative diseases such as cancer, and how the clock components might be targeted for new anti-tumor therapies.  Qualitatively, the clock networks that control the yeast cell cycle look much like the networks controlling circadian rhythms in a variety of organisms. More recently, we have been using our experimental and quantitative approaches to investigate the function of circadian clocks, as well as clocks that control the division and development of pathogenic organisms such as P. falciparum and P. vivax, the causative agents of malaria.

Education and Training

  • Ph.D., Stanford University, 1993
  • B.S., Colorado State University, 1985

Publications

Welling, Claire M., David R. Singleton, Steven B. Haase, Christian H. Browning, Brian R. Stoner, Claudia K. Gunsch, and Sonia Grego. “Predictive values of time-dense SARS-CoV-2 wastewater analysis in university campus buildings. (Accepted)” The Science of the Total Environment 835 (August 2022): 155401. https://doi.org/10.1016/j.scitotenv.2022.155401.

PMID
35469858
Full Text

Motta, Francis C., Robert C. Moseley, Bree Cummins, Anastasia Deckard, and Steven B. Haase. “Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes.” Bmc Bioinformatics 23, no. 1 (March 17, 2022): 94. https://doi.org/10.1186/s12859-022-04627-9.

PMID
35300586
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Bryce, Daniel, Robert P. Goldman, Matthew DeHaven, Jacob Beal, Bryan Bartley, Tramy T. Nguyen, Nicholas Walczak, et al. “Round Trip: An Automated Pipeline for Experimental Design, Execution, and Analysis.” Acs Synthetic Biology 11, no. 2 (February 2022): 608–22. https://doi.org/10.1021/acssynbio.1c00305.

PMID
35099189
Full Text

Liu, Andrew Bo, Dan Davidi, Hannah Emily Landsberg, Maria Francesconi, Judy T. Platt, Giang T. Nguyen, Sehyo Yune, et al. “Association of COVID-19 Quarantine Duration and Postquarantine Transmission Risk in 4 University Cohorts.” Jama Network Open 5, no. 2 (February 2022): e220088. https://doi.org/10.1001/jamanetworkopen.2022.0088.

PMID
35212750
Full Text

Moseley, Robert C., Sophia Campione, Bree Cummins, Francis Motta, and Steven B. Haase. “Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline.” Journal of Visualized Experiments : Jove, no. 178 (December 7, 2021). https://doi.org/10.3791/63084.

PMID
34958073
Full Text

Saelens, Joseph W., Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa Konaté, Seidina A. S. Diakité, Karim Traoré, et al. “Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum.” Msphere 6, no. 5 (October 27, 2021): e0075521. https://doi.org/10.1128/mSphere.00755-21.

PMID
34668757
Full Text

Moseley, Robert C., Francis Motta, Gerald A. Tuskan, Steven B. Haase, and Xiaohan Yang. “Inference of Gene Regulatory Network Uncovers the Linkage between Circadian Clock and Crassulacean Acid Metabolism in Kalanchoë fedtschenkoi.” Cells 10, no. 9 (August 27, 2021): 2217. https://doi.org/10.3390/cells10092217.

PMID
34571864
Full Text

Denny, Thomas N., Laura Andrews, Mattia Bonsignori, Kyle Cavanaugh, Michael B. Datto, Anastasia Deckard, C Todd DeMarco, et al. “Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020.” Mmwr Morb Mortal Wkly Rep 69, no. 46 (November 20, 2020): 1743–47. https://doi.org/10.15585/mmwr.mm6946e1.

PMID
33211678
Full Text

Smith, Lauren M., Francis C. Motta, Garima Chopra, J Kathleen Moch, Robert R. Nerem, Bree Cummins, Kimberly E. Roche, et al. “An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum.” Science (New York, N.Y.) 368, no. 6492 (May 2020): 754–59. https://doi.org/10.1126/science.aba4357.

PMID
32409472
Full Text

Cho, Chun-Yi, Christina M. Kelliher, and Steven B. Haase. “The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.” Cell Cycle (Georgetown, Tex.) 18, no. 4 (February 5, 2019): 363–78. https://doi.org/10.1080/15384101.2019.1570655.

PMID
30668223
Full Text

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