Medical Oncology

Steven Patierno, PhD

Professor of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Community and Family Medicine
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710
Phone (919) 613-5093
Email address steven.patierno@duke.edu

Patierno's current translational research interests are focused on the genomics molecular biology of cancer disparities, cancer biology, molecular pharmacology and targeted experimental therapeutics to control prostate, breast and lung tumor aggressiveness. He is an internationally recognized expert in cancer control, cancer causation and molecular carcinogenesis, which includes a broad spectrum of laboratory and population level research.   Patierno is also actively engaged in cancer health disparities and healthcare delivery research focused on patient navigation, survivorship, community-based interventions, mHealth, implementation sciences, cancer care economics, and policy.

Education and Training

  • Postdoctoral Training, Norris Comprehensive Cancer, University of Southern California, 1986 - 1988
  • Ph.D., University of Texas Medical School at Houston, 1985
  • B.S., University of Connecticut, 1981

Grants

Publications

Ware, KE, Gupta, S, Eng, J, Foo, W-C, Crawford, L, Austin, G, Puviindran, B, Freedman, J, Patierno, SR, Zhang, T, Corcoran, D, Pierobon, M, Petricoin, E, Somarelli, JA, and Armstong, AJ. "Convergent hormone therapy resistance mediated by stress/dormancy-like pathways in prostate cancer." AACR Special Conference on Prostate Cancer - Advances in Basic, Translational, and Clinical Research. Orlando, FL. December 2, 2017 - December 5, 2017.: AMER ASSOC CANCER RESEARCH, August 1, 2018.

Scholars@Duke

Al Abo, M, Patierno, SR, and Freedman, JA. "Alternative RNA splicing and prostate cancer aggressiveness." AACR Special Conference on Prostate Cancer - Advances in Basic, Translational, and Clinical Research. Orlando, FL. December 2, 2017 - December 5, 2017.: AMER ASSOC CANCER RESEARCH, August 1, 2018.

Scholars@Duke

LaCroix, BL, Patierno, BM, Sullenger, BA, George, DJ, Patierno, SR, and Freedman, JA. "Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer." 10th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Atlanta, GA. September 25, 2017 - September 28, 2017.: AMER ASSOC CANCER RESEARCH, July 1, 2018.

Scholars@Duke

LaCroix, BL, Patierno, BM, Sullenger, BA, George, DJ, Patierno, SR, and Freedman, JA. "Nutritional profiling reveals glutamine-utilizing transaminases as a metabolic vulnerability of TAZ/YAP-driven breast cancer cells." 10th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Atlanta, GA. September 25, 2017 - September 28, 2017.: AMER ASSOC CANCER RESEARCH, July 1, 2018.

Scholars@Duke

Patierno, B, Glover, W, Ribar, T, Kittles, R, Foo, W-C, McCall, S, Huang, J, George, D, Freedman, J, Patierno, S, Wood, K, and Hsu, D. "Establishment of African American prostate cancer patient-derived primary cell lines and xenografts." 10th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Atlanta, GA. September 25, 2017 - September 28, 2017.: AMER ASSOC CANCER RESEARCH, July 1, 2018.

Scholars@Duke

Deveaux, A, Wang, B-D, Lacroix, B, Patierno, B, Zhang, D, Owzar, K, Lee, N, George, D, Freedman, J, and Patierno, S. "Race-related differential splicing of the insulin receptor: A novel target underlying prostate cancer disparities." 10th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. Atlanta, GA. September 25, 2017 - September 28, 2017.: AMER ASSOC CANCER RESEARCH, July 1, 2018.

Scholars@Duke

Freedman, JA, Wang, Y, Li, X, Liu, H, Moorman, PG, George, DJ, Lee, NH, Hyslop, T, Wei, Q, and Patierno, SR. "Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival." Carcinogenesis 39, no. 7 (July 2018): 879-888.

PMID
29726910
Full Text

LeBlanc, TW, Herring, K, Chilcott, J, Bletcher, K, Osaki, M, Manassei, H, Pendergraft, T, Corbett, C, Zafar, Y, Higgins, A, and Patierno, SR. "Development of a digital patient navigation application: Results from subject interviews.": American Society of Clinical Oncology (ASCO), May 20, 2018.

Full Text

LeBlanc, TW, Herring, K, Chilcott, J, Bletcher, K, Osaka, M, Manassei, H, Pendergraft, T, Corbett, C, Zafar, Y, Higgins, A, and Patierno, SR. "Development of a digital patient navigation application: Preliminary results from patient interviews.": American Society of Clinical Oncology (ASCO), March 2018.

Full Text

Wang, B-D, Ceniccola, K, Hwang, S, Andrawis, R, Horvath, A, Freedman, JA, Olender, J, Knapp, S, Ching, T, Garmire, L, Patel, V, Garcia-Blanco, MA, Patierno, SR, and Lee, NH. "Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer." Nature Communications 8 (September 27, 2017): 16161-null.

PMID
28952599
Full Text

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