Medical Oncology

Steven Patierno, PhD

Professor of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Family Medicine and Community Health
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710
Phone (919) 613-5093
Email address steven.patierno@duke.edu

Patierno's current translational research interests are focused on the genomics molecular biology of cancer disparities, cancer biology, molecular pharmacology and targeted experimental therapeutics to control prostate, breast and lung tumor aggressiveness. He is an internationally recognized expert in cancer control, cancer causation and molecular carcinogenesis, which includes a broad spectrum of laboratory and population level research.   Patierno is also actively engaged in cancer health disparities and healthcare delivery research focused on patient navigation, survivorship, community-based interventions, mHealth, implementation sciences, cancer care economics, and policy.

Education and Training

  • Postdoctoral Training, Norris Comprehensive Cancer, University of Southern California, 1986 - 1988
  • Ph.D., University of Texas Medical School at Houston, 1985
  • B.S., University of Connecticut, 1981

Grants

Publications

Robinson, Timothy J., Jennifer A. Freedman, Muthana Al Abo, April E. Deveaux, Bonnie LaCroix, Brendon M. Patierno, Daniel J. George, and Steven R. Patierno. “Alternative RNA Splicing as a Potential Major Source of Untapped Molecular Targets in Precision Oncology and Cancer Disparities..” Clin Cancer Res 25, no. 10 (May 15, 2019): 2963–68. https://doi.org/10.1158/1078-0432.CCR-18-2445.

PMID
30755441
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Ware, Kathryn E., Santosh Gupta, Jared Eng, Wen-Chi Foo, Lorin Crawford, Garland Austin, Bhairavy Puviindran, et al. “Abstract B038: Convergent hormone therapy resistance mediated by stress/dormancy-like pathways in prostate cancer.” In Poster Presentations  Proffered Abstracts. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.prca2017-b038.

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Al Abo, Muthana, Steven R. Patierno, and Jennifer A. Freedman. “Alternative RNA splicing and prostate cancer aggressiveness..” In Cancer Research, 78:111–12. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

Freedman, Jennifer A., Yanru Wang, Xuechan Li, Hongliang Liu, Patricia G. Moorman, Daniel J. George, Norman H. Lee, Terry Hyslop, Qingyi Wei, and Steven R. Patierno. “Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival..” Carcinogenesis 39, no. 7 (July 3, 2018): 879–88. https://doi.org/10.1093/carcin/bgy062.

PMID
29726910
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LaCroix, Bonnie L., Brendon M. Patierno, Bruce A. Sullenger, Daniel J. George, Steven R. Patierno, and Jennifer A. Freedman. “Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer..” In Cancer Epidemiology Biomarkers & Prevention, 27:46–46. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

LaCroix, Bonnie L., Brendon M. Patierno, Bruce A. Sullenger, Daniel J. George, Steven R. Patierno, and Jennifer A. Freedman. “Nutritional profiling reveals glutamine-utilizing transaminases as a metabolic vulnerability of TAZ/YAP-driven breast cancer cells.” In Cancer Epidemiology Biomarkers & Prevention, 27:148–148. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

Patierno, Brendon, Wayne Glover, Thomas Ribar, Rick Kittles, Wen-Chi Foo, Shannon McCall, Jiaoti Huang, et al. “Establishment of African American prostate cancer patient-derived primary cell lines and xenografts..” In Cancer Epidemiology Biomarkers & Prevention, 27:96–96. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

Deveaux, April, Bi-Dar Wang, Bonnie Lacroix, Brendon Patierno, Dadong Zhang, Kouros Owzar, Norman Lee, Daniel George, Jennifer Freedman, and Steven Patierno. “Race-related differential splicing of the insulin receptor: A novel target underlying prostate cancer disparities.” In Cancer Epidemiology Biomarkers & Prevention, 27:138–39. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

LeBlanc, Thomas William, Kris Herring, Jack Chilcott, Katherine Bletcher, Miya Osaki, Hugo Manassei, Trudy Pendergraft, et al. “Development of a digital patient navigation application: Results from subject interviews..” In Journal of Clinical Oncology, 36:e22146–e22146. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e22146.

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LeBlanc, Thomas William, Kris Herring, Jack Chilcott, Katherine Bletcher, Miya Osaka, Hugo Manassei, Trudy Pendergraft, et al. “Development of a digital patient navigation application: Preliminary results from patient interviews..” In Journal of Clinical Oncology, 36:161–161. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.7_suppl.161.

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