Steven Patierno, PhD

Professor of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Family Medicine and Community Health
Core Faculty Member, Duke-Margolis Center for Health Policy
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710
Phone (919) 613-5093
Email address steven.patierno@duke.edu

Patierno's current translational research interests are focused on the genomics molecular biology of cancer disparities, cancer biology, molecular pharmacology and targeted experimental therapeutics to control prostate, breast and lung tumor aggressiveness. He is an internationally recognized expert in cancer control, cancer causation and molecular carcinogenesis, which includes a broad spectrum of laboratory and population level research.   Patierno is also actively engaged in cancer health disparities and healthcare delivery research focused on patient navigation, survivorship, community-based interventions, mHealth, implementation sciences, cancer care economics, and policy.

Education and Training

  • Postdoctoral Training, Norris Comprehensive Cancer, University of Southern California, 1986 - 1988
  • Ph.D., University of Texas Medical School, Houston, 1985
  • B.S., University of Connecticut, 1981

Publications

Fornsaglio, Jamie L., Travis J. O’Brien, and Steven R. Patierno. “Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication.” Mol Cell Biochem 279, no. 1–2 (November 2005): 149–55. https://doi.org/10.1007/s11010-005-8287-z.

PMID
16283524
Full Text

O’Brien, Travis J., Bradford R. Brooks, and Steven R. Patierno. “Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells.” Mol Cell Biochem 279, no. 1–2 (November 2005): 85–95. https://doi.org/10.1007/s11010-005-8225-0.

PMID
16283517
Full Text

Pritchard, Daryl E., Susan Ceryak, Keri E. Ramsey, Travis J. O’Brien, Linan Ha, Jamie L. Fornsaglio, Dietrich A. Stephan, and Steven R. Patierno. “Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.” Mol Cell Biochem 279, no. 1–2 (November 2005): 169–81. https://doi.org/10.1007/s11010-005-8292-2.

PMID
16283527
Full Text

Lugassy, Claire, Stephen E. Vernon, John W. Warner, Carter Q. Le, Michael Manyak, Stephen R. Patierno, and Raymond L. Barnhill. “Angiotropism of human prostate cancer cells: implications for extravascular migratory metastasis.” Bju Int 95, no. 7 (May 2005): 1099–1103. https://doi.org/10.1111/j.1464-410X.2005.05474.x.

PMID
15839940
Full Text

Patierno, S., W. Zellalem, A. Ho, C. Parsons, M. Tonini, and C. Stemini. “Peripheral N-methyl-D-aspartate receptors (NMDA-R) mediate endogenous opioid release induced by abdominal surgery in enteric neurons.” In Gastroenterology, 128:A362–A362, 2005.

Scholars@Duke

Carlisle, D. L., and S. R. Patierno. “Carcinogenesis and molecular genetics.” In Cancer Risk Assessment, 1–15, 2005.

Scholars@Duke

Ha, Linan, Susan Ceryak, and Steven R. Patierno. “Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.” Carcinogenesis 25, no. 11 (November 2004): 2265–74. https://doi.org/10.1093/carcin/bgh242.

PMID
15284180
Full Text

Lugassy, Claire, Hynda K. Kleinman, Jean A. Engbring, Danny R. Welch, John F. Harms, Robyn Rufner, Ghanem Ghanem, Steven R. Patierno, and Raymond L. Barnhill. “Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis.” Am J Pathol 164, no. 4 (April 2004): 1191–98. https://doi.org/10.1016/S0002-9440(10)63207-5.

PMID
15039208
Full Text

Fernandez, Patricia M., Steven R. Patierno, and Frederick R. Rickles. “Tissue factor and fibrin in tumor angiogenesis.” Semin Thromb Hemost 30, no. 1 (February 2004): 31–44. https://doi.org/10.1055/s-2004-822969.

PMID
15034796
Full Text

Pages