Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Halpern, Samantha E., Dimitrios Moris, Brian I. Shaw, Samuel J. Kesseli, Mariya L. Samoylova, Miriam Manook, Robin Schmitz, et al. “Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.” World J Surg 45, no. 5 (May 2021): 1504–13. https://doi.org/10.1007/s00268-020-05943-y.

PMID
33486584
Full Text

Knechtle, Stuart J., Danielle Niedfeldt, Debra Sudan, Annette Jackson, Ian Jamieson, Matthew Hartwig, and Carmelo Milano. “Another Step Toward Becoming a Transplant Community.” Ann Surg 273, no. 4 (April 1, 2021): e149–50. https://doi.org/10.1097/SLA.0000000000004472.

PMID
33086314
Full Text

Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, et al. “Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.” Kidney Int 99, no. 1 (January 2021): 161–72. https://doi.org/10.1016/j.kint.2020.08.020.

PMID
32898569
Full Text

Kapila, Nikhil, Ying Claire Dorsey, Jigesh Shah, Lindsay King, Kadiyala Ravindra, Stuart Knechtle, and Yuval Patel. “Transjugular Intrahepatic Portosystemic Shunt for a Challenging Pregnancy.” Am J Gastroenterol 115, no. 12 (December 2020): 1935. https://doi.org/10.14309/ajg.0000000000000602.

PMID
32221161
Full Text

Dangi, Anil, Shuangjin Yu, Frances T. Lee, Melanie Burnette, Stuart Knechtle, Jean Kwun, and Xunrong Luo. “Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.” Am J Transplant 20, no. 10 (October 2020): 2728–39. https://doi.org/10.1111/ajt.15878.

PMID
32275799
Full Text

Kwun, Jean, and Stuart Knechtle. “Pharmacological approaches to antibody-mediated rejection-Are we getting closer?” Am J Transplant 20, no. 10 (October 2020): 2637–38. https://doi.org/10.1111/ajt.16061.

PMID
32419361
Full Text

Moris, Dimitrios, Brian I. Shaw, Jared Gloria, Samuel J. Kesseli, Mariya L. Samoylova, Robin Schmitz, Miriam Manook, et al. “Textbook Outcomes in Liver Transplantation.” World J Surg 44, no. 10 (October 2020): 3470–77. https://doi.org/10.1007/s00268-020-05625-9.

PMID
32488663
Full Text

Kesseli, Samuel J., Mariya L. Samoylova, Dimitrios Moris, Ashton A. Connor, Robin Schmitz, Brian I. Shaw, Jared N. Gloria, et al. “Outcomes in Kidney Transplantation Between Veterans Affairs and Civilian Hospitals: Considerations in the Context of the MISSION Act.” Ann Surg 272, no. 3 (September 1, 2020): 506–10. https://doi.org/10.1097/SLA.0000000000004119.

PMID
32773623
Full Text

Tamas, James W., Charles Y. Kim, Linnan Tang, Stuart J. Knechtle, and Paul V. Suhocki. “Percutaneous Splenorenal Shunt Creation in a Patient with Chronic Portomesenteric Thrombosis.” J Vasc Interv Radiol 31, no. 9 (September 2020): 1408–9. https://doi.org/10.1016/j.jvir.2020.04.009.

PMID
32868015
Full Text

Kwun, Jean, Jie Li, Clay Rouse, Jae Berm Park, Alton B. Farris, Maragatha Kuchibhatla, Joseph W. Turek, Stuart J. Knechtle, Allan D. Kirk, and M Louise Markert. “Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.” Jci Insight 5, no. 11 (June 4, 2020). https://doi.org/10.1172/jci.insight.129983.

PMID
32352934
Full Text

Pages