Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Anwar, Imran J., Isabel DeLaura, Qimeng Gao, Stuart Knechtle, and Jean Kwun. “Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann.” Am J Transplant, February 18, 2022. https://doi.org/10.1111/ajt.17007.

PMID
35181999
Full Text

Song, Shengli, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, and Garnett Kelsoe. “A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines.” Commun Biol 4, no. 1 (November 25, 2021): 1338. https://doi.org/10.1038/s42003-021-02881-w.

PMID
34824350
Full Text

Shaw, Brian I., Vincenzo Villani, Samuel J. Kesseli, Chloe Nobuhara, Mariya L. Samoylova, Dimitrios Moris, Bradley H. Collins, et al. “A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.” J Clin Med 10, no. 23 (November 24, 2021). https://doi.org/10.3390/jcm10235505.

PMID
34884207
Full Text

Schmitz, Robin, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, et al. “C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.” Nat Commun 12, no. 1 (September 15, 2021): 5456. https://doi.org/10.1038/s41467-021-25745-7.

PMID
34526511
Full Text

Jelly, Evan T., Jean Kwun, Robin Schmitz, Alton B. Farris, Zachary A. Steelman, Debra L. Sudan, Stuart J. Knechtle, and Adam Wax. “Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe.” J Biomed Opt 26, no. 9 (September 2021). https://doi.org/10.1117/1.JBO.26.9.096008.

PMID
34561973
Full Text

Kesseli, Samuel J., Jared N. Gloria, Nader Abraham, Samantha E. Halpern, Greta N. Cywinska, Min Zhang, Dimitrios Moris, et al. “Point-of-Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model.” Hepatol Commun 5, no. 9 (September 2021): 1527–42. https://doi.org/10.1002/hep4.1734.

PMID
34510831
Full Text

Olaso, Danae, Miriam Manook, Dimitrios Moris, Stuart Knechtle, and Jean Kwun. “Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient.” J Clin Med 10, no. 16 (August 18, 2021). https://doi.org/10.3390/jcm10163656.

PMID
34441950
Full Text

Halpern, Samantha E., Dimitrios Moris, Brian I. Shaw, Samuel J. Kesseli, Mariya L. Samoylova, Miriam Manook, Robin Schmitz, et al. “Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.” World J Surg 45, no. 5 (May 2021): 1504–13. https://doi.org/10.1007/s00268-020-05943-y.

PMID
33486584
Full Text

Knechtle, Stuart J., Danielle Niedfeldt, Debra Sudan, Annette Jackson, Ian Jamieson, Matthew Hartwig, and Carmelo Milano. “Another Step Toward Becoming a Transplant Community.” Ann Surg 273, no. 4 (April 1, 2021): e149–50. https://doi.org/10.1097/SLA.0000000000004472.

PMID
33086314
Full Text

Schroder, Paul M., Robin Schmitz, Zachary W. Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y. Choi, Miriam Manook, et al. “Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.” Kidney Int 99, no. 1 (January 2021): 161–72. https://doi.org/10.1016/j.kint.2020.08.020.

PMID
32898569
Full Text

Pages