Wendy P O'Meara, PhD

Associate Professor of Medicine
Associate Research Professor of Global Health
Campus mail Eldoret Kenya, Box 90519, Durham, NC 27710
Phone (919) 681-7711
Email address wendy.omeara@duke.edu

Dr. O'Meara has been working in the field of malaria diagnosis, treatment, and drug resistance since 2004. She is an Associate Professor at Duke University Medical School in the Division of Infectious Diseases, visiting professor at Moi University, and the Co-Field Director of Research for AMPATH.  She has been based full-time in Kenya since 2007.

Dr. O’Meara’s team is interested in improving rational drug use for suspected malaria fevers through expanding the use of diagnostic tools in the community and in health facilities.  As many as 90% of fevers that seek treatment in the formal sector receive antimalarials, and it is estimated that only 20% of those buying antimalarials over-the-counter in the retail sector actually have malaria.  Such overuse poses a significant threat to the continued efficacy of first-line antimalarials. Dr. O’Meara has conducted several randomized controlled trials in western Kenya to test interventions designed to improve the use of information from malaria diagnostic testing in order to target antimalarials to those with confirmed infection. In 2005, she helped to establish the Malaria Diagnostic Centre of Excellence in Kisumu, Kenya.

Recently, she concluded a case-controlled study with colleagues at Moi University that identified the major determinants of insecticide treated bednet failure in western Kenya. Among other results, the study showed that asymptomatically infected household members may be a risk factor for children living in the same household. Current work is extending this observation by leveraging variability in key parasite genes to describe the spatial mixing of malaria infections and track generations of infections from humans to mosquitoes (collaboration with Steve Taylor’s lab).

Dr. O’Meara has experience in marrying innovative spatial techniques with epidemiologic outcomes.  Recent work includes an analysis of health systems factors that contribute to early childhood mortality in sub-Saharan Africa.

Education and Training

  • Ph.D., Massachusetts Institute of Technology, 2003

Publications

O’Meara, Wendy Prudhomme, David Smith, and F Ellis McKenzie. “Potential impact of intermittent preventive treatment for infants on the spread of drug resistant malaria.” American Journal of Tropical Medicine and Hygiene 73, no. 6 (December 1, 2005): 275–275.

Scholars@Duke

Rodríguez-Morales, Alfonso J., Elia Sánchez, Melissa Arria, Miguel Vargas, Carmelina Piccolo, Rosa Colina, and Carlos Franco-Paredes. “White blood cell counts in Plasmodium vivax malaria..” J Infect Dis 192, no. 9 (November 1, 2005): 1675–76. https://doi.org/10.1086/496993.

PMID
16206089
Full Text

McKenzie, F Ellis, Wendy Prudhomme O’Meara, and Chansuda Wongsrichanalai. “Reply to Rodríguez‐Morales et al..” The Journal of Infectious Diseases 192, no. 9 (November 2005): 1676–77. https://doi.org/10.1086/496995.

Full Text

O’Meara, Wendy Prudhomme, F Ellis McKenzie, Alan J. Magill, J Russ Forney, Barnyen Permpanich, Carmen Lucas, Robert A. Gasser, and Chansuda Wongsrichanalai. “Sources of variability in determining malaria parasite density by microscopy..” Am J Trop Med Hyg 73, no. 3 (September 2005): 593–98.

PMID
16172488
Scholars@Duke

O’Meara, Wendy Prudhomme, Joel G. Breman, and F Ellis McKenzie. “Intermittent preventive malaria treatment in Tanzanian infants..” Lancet 366, no. 9485 (August 13, 2005). https://doi.org/10.1016/S0140-6736(05)67092-4.

PMID
16099286
Full Text

O’Meara, Wendy Prudhomme, Joel G. Breman, and F Ellis McKenzie. “The promise and potential challenges of intermittent preventive treatment for malaria in infants (IPTi)..” Malar J 4 (July 20, 2005). https://doi.org/10.1186/1475-2875-4-33.

PMID
16033653
Full Text

McKenzie, F Ellis, Wendy A. Prudhomme, Alan J. Magill, J Russ Forney, Barnyen Permpanich, Carmen Lucas, Robert A. Gasser, and Chansuda Wongsrichanalai. “White blood cell counts and malaria..” J Infect Dis 192, no. 2 (July 15, 2005): 323–30. https://doi.org/10.1086/431152.

PMID
15962228
Full Text

Woolf, P. J., W. Prudhomme, L. Daheron, G. Q. Daley, and D. A. Lauffenburger. “Erratum: Bayesian analysis of signaling networks embryonic stem cell fate decisions (Bioinformatics (2005) vol. 21 (741-753)).” Bioinformatics 21, no. 8 (April 15, 2005). https://doi.org/10.1093/bioinformatics/bti395.

Full Text

Woolf, Peter J., Wendy Prudhomme, Laurence Daheron, George Q. Daley, and Douglas A. Lauffenburger. “Bayesian analysis of signaling networks governing embryonic stem cell fate decisions..” Bioinformatics 21, no. 6 (March 2005): 741–53. https://doi.org/10.1093/bioinformatics/bti056.

PMID
15479714
Full Text

Prudhomme, Wendy A., Keith H. Duggar, and Douglas A. Lauffenburger. “Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix..” Biotechnol Bioeng 88, no. 3 (November 5, 2004): 264–72. https://doi.org/10.1002/bit.20244.

PMID
15486930
Full Text

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