Wilton Bryan Williams, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Durham, NC 27710
Phone (919) 660-1546
Email address wilton.williams@duke.edu

Dr. Williams completed a PhD in Biomedical Sciences (Immunology and Microbiology) from the University of Florida and did his postdoctoral work in the laboratory of Dr. Barton Haynes at the Duke Human Vaccine Institute (DHVI).

The key goals of HIV vaccine development are to define the host-virus events during natural HIV infection that lead to the induction of broadly neutralizing antibodies, and to recreate those events with a vaccine. As a junior faculty member in the DHVI, Dr. Williams is further characterizing SHIV non-human primate models for HIV infection, and evaluates B cell responses to HIV-1 vaccination in humans and non-human primates.

Education and Training

  • Ph.D., University of Florida, 2011

Publications

Behrens, Shay, Celia C. LaBranche, Tongqing Zhou, Kevin Wiehe, Mattia Bonsignori, Quentin J. Sattentau, Amanda Eaton, et al. “Germline-targeting and Reverse Engineering to Elicit CH235.12 Lineage bNAbs.” In Aids Research and Human Retroviruses, 34:116–116. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Williams, Wilton Bryan, R Ryan Meyerhoff, Hui Li, Priyamvada Acharya, Guillaume B. E. Stewart-Jones, Kevin Wiehe, Thomas B. Kepler, et al. “Macaque SHIV Induction of 2G12-like Broadly Neutralizing Antibodies.” In Aids Research and Human Retroviruses, 34:38–38. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Li, Hui, Ryan Roark, Shuyi Wang, Fang-Hua Lee, Wenge Ding, Alex Murphy, Juliette Rando, et al. “New SHIV Models of bNAb Elicitation and Env-Ab Coevolution.” In Aids Research and Human Retroviruses, 34:21–21. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Wiehe, Kevin, Todd Bradley, R Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, et al. “Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development..” Cell Host & Microbe 23, no. 6 (June 2018): 759-765.e6. https://doi.org/10.1016/j.chom.2018.04.018.

PMID
29861171
Full Text

Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations..” Nature Communications 8, no. 1 (November 23, 2017). https://doi.org/10.1038/s41467-017-01336-3.

PMID
29170366
Full Text

Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques..” Journal of Virology 91, no. 21 (November 2017). https://doi.org/10.1128/JVI.00923-17.

PMID
28794027
Full Text

Yu, Jae-Sung, Hua-Xin Liao, Jamie Pritchett, Cindy Bowman, Callie Vivian, Robert Parks, Shi-Mao Xia, et al. “Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120..” Journal of Virological Methods 249 (November 2017): 85–93. https://doi.org/10.1016/j.jviromet.2017.08.012.

PMID
28837840
Full Text

Li, Hui, Wilton Williams, Mattia Bonsignori, Shuyi Wang, Wenge Ding, Fang-Hau Lee, Maho Okumura, et al. “Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous Envs.” In Journal of Medical Primatology, 46:174–75. WILEY, 2017.

Scholars@Duke

Li, Hui, Wilton Williams, Mattia Bonsignori, Shuyi Wang, Wenge Ding, Fang-Hau Lee, Maho Okumura, et al. “Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous envs.” In Journal of Medical Primatology, 46:206–7. WILEY, 2017.

Scholars@Duke

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