Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Zheng, Z, Fan, S, Zheng, J, Huang, W, Gasparetto, C, Chao, NJ, Hu, J, and Kang, Y. "Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma." Journal of hematology & oncology 11, no. 1 (February 27, 2018): 29-.

PMID
29482577
Full Text

Piryani, SO, Kam, AYF, Kliassov, EG, Chen, BJ, Spector, NL, Chute, JP, Hsu, DS, Chao, NJ, and Doan, PL. "Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration." Stem cells (Dayton, Ohio) 36, no. 2 (February 2018): 252-264.

PMID
29086459
Full Text

Richardson, PG, Triplett, BM, Ho, VT, Chao, N, Dignan, FL, Maglio, M, and Mohty, M. "Defibrotide sodium for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome." Expert review of clinical pharmacology 11, no. 2 (February 2018): 113-124.

PMID
29301447
Full Text

Guo, M, Chao, NJ, Li, J-Y, Rizzieri, DA, Sun, Q-Y, Mohrbacher, A, Krakow, EF, Sun, W-J, Shen, X-L, Zhan, X-R, Wu, D-P, Liu, L, Wang, J, Zhou, M, Yang, L-H, Bao, Y-Y, Dong, Z, Cai, B, Hu, K-X, Yu, C-L, Qiao, J-H, Zuo, H-L, Huang, Y-J, Sung, AD, Qiao, J-X, Liu, Z-Q, Liu, T-Q, Yao, B, Zhao, H-X, Qian, S-X, Liu, W-W, Forés, R, Duarte, RF, Ai, H-S, and Microtransplantation Interest Group, . "HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group." JAMA oncology 4, no. 1 (January 2018): 54-62.

PMID
28910431
Full Text

Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (December 12, 2017).

PMID
29246821
Full Text

Huang, L-W, Bacon, W, Cirrincione, C, Peterson, B, Long, G, Rizzieri, D, Sullivan, KM, Corbet, K, Horwitz, M, Chao, N, Gasparetto, C, and Tuchman, SA. "Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma." Hematological oncology 35, no. 4 (December 2017): 752-759.

PMID
28105753
Full Text

Huang, W, and Chao, NJ. "Memory T cells: A helpful guard for allogeneic hematopoietic stem cell transplantation without causing graft-versus-host disease." Hematology/oncology and stem cell therapy 10, no. 4 (December 2017): 211-219. (Review)

PMID
28636890
Full Text

Sundaramoorthy, P, Wang, Q, Zheng, Z, Jiao, Y, Chen, BJ, Doan, PL, Chao, NJ, and Kang, Y. "Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice." Stem cell research & therapy 8, no. 1 (November 15, 2017): 263-.

PMID
29141658
Full Text

Poe, JC, Jia, W, Su, H, Anand, S, Rose, JJ, Tata, PV, Suthers, AN, Jones, CD, Kuan, PF, Vincent, BG, Serody, JS, Horwitz, ME, Ho, VT, Pavletic, SZ, Hakim, FT, Owzar, K, Zhang, D, Blazar, BR, Siebel, CW, Chao, NJ, Maillard, I, and Sarantopoulos, S. "An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD." Blood 130, no. 19 (November 2017): 2131-2145.

PMID
28851699
Full Text

Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157.

PMID
28392378
Full Text

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