Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Choi, SS, and Diehl, AM. "Alcoholic liver disease." In Handbook of Liver Disease, 109-120. August 24, 2017.

Full Text

Newton, KP, Feldman, HS, Chambers, CD, Wilson, L, Behling, C, Clark, JM, Molleston, JP, Chalasani, N, Sanyal, AJ, Fishbein, MH, Lavine, JE, Schwimmer, JB, and Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . "Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children." The Journal of Pediatrics 187 (August 2017): 141-146.e1.

PMID
28366357
Full Text

Kim, J, Hyun, J, Wang, S, Lee, C, Lee, J-W, Moon, E-Y, Cha, H, Diehl, AM, and Jung, Y. "Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling." Scientific Reports 7, no. 1 (June 19, 2017): 3815-null.

PMID
28630423
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Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Reply to Kim et al." The American Journal of Gastroenterology 112, no. 5 (May 2017): 807-808.

PMID
28469220
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Xie, G, Swiderska-Syn, M, Jewell, ML, Machado, MV, Michelotti, GA, Premont, RT, and Diehl, AM. "Loss of pericyte smoothened activity in mice with genetic deficiency of leptin." Bmc Cell Biology 18, no. 1 (April 20, 2017): 20-null.

PMID
28427343
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Li, J, Roy, S, Kim, Y-M, Li, S, Zhang, B, Love, C, Reddy, A, Rajagopalan, D, Dave, S, Diehl, AM, and Zhuang, Y. "Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors." Journal of Immunology (Baltimore, Md. : 1950) 198, no. 8 (April 2017): 3136-3148.

PMID
28258199
Full Text

Schadde, E, Tsatsaris, C, Swiderska-Syn, M, Breitenstein, S, Urner, M, Schimmer, R, Booy, C, Z'graggen, BR, Wenger, RH, Spahn, DR, Hertl, M, Knechtle, S, Diehl, AM, Schläpfer, M, and Beck-Schimmer, B. "Hypoxia of the growing liver accelerates regeneration." Surgery 161, no. 3 (March 2017): 666-679.

PMID
27436690
Full Text

Ajmera, V, Perito, ER, Bass, NM, Terrault, NA, Yates, KP, Gill, R, Loomba, R, Diehl, AM, Aouizerat, BE, and NASH Clinical Research Network, . "Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 65, no. 1 (January 2017): 65-77.

PMID
27532276
Full Text

Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Lavine, JE, Yates, K, Klair, J, Terrault, NA, Clark, JM, Unalp-Arida, A, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 15, no. 1 (January 2017): 127-131.e2.

PMID
27523635
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Seth, RK, Das, S, Dattaroy, D, Chandrashekaran, V, Alhasson, F, Michelotti, G, Nagarkatti, M, Nagarkatti, P, Diehl, AM, Bell, PD, Liedtke, W, and Chatterjee, S. "TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity." Free radical biology & medicine 102 (January 2017): 260-273.

PMID
27913210
Full Text

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