Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978


Jewell, Mark, Marzena Swiderska-Syn, Guanhua Xie, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “MMP9 is a potential mediator of TWEAK-Fn14 signaling in a rodent model of acute alcoholic steatohepatitis.” In Hepatology, 64:836A-836A. WILEY, 2016.


Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. NATURE PUBLISHING GROUP, 2016.


Pereira, Thiago Almeida, Wing-Kin Syn, Frederico Figueiredo Amâncio, Pedro Henrique Diniz Cunha, Julia Fonseca Morais Caporali, Guilherme Vaz de Melo Trindade, Elisângela Trindade Santos, et al. “Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni..” Plos Negl Trop Dis 10, no. 10 (October 2016).

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Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.


Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.


Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.


Swiderska-Syn, Marzena, Guanhua Xie, Gregory A. Michelotti, Mark L. Jewell, Richard T. Premont, Wing-Kin Syn, and Anna Mae Diehl. “Hedgehog regulates yes-associated protein 1 in regenerating mouse liver..” In Hepatology, 64:232–44, 2016.

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Klair, Jagpal Singh, Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine Yates, Aynur Unalp-Arida, et al. “A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease..” Hepatology 64, no. 1 (July 2016): 85–91.

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