Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Jewell, Mark, Marzena Swiderska-Syn, Guanhua Xie, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “MMP9 is a potential mediator of TWEAK-Fn14 signaling in a rodent model of acute alcoholic steatohepatitis.” In Hepatology, 64:836A-836A. WILEY, 2016.

Scholars@Duke

Jewell, Mark, Marzena Swiderska-Syn, Guanhua Xie, Gamze Karaca, Richard T. Premont, and Anna Mae Diehl. “MMP9 is a potential mediator of TWEAK-Fn14 signaling in a rodent model of acute alcoholic steatohepatitis.” In Hepatology, 64:836A-836A. WILEY, 2016.

Scholars@Duke

Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.

Scholars@Duke

Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. NATURE PUBLISHING GROUP, 2016.

Scholars@Duke

Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.

Scholars@Duke

Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. NATURE PUBLISHING GROUP, 2016.

Scholars@Duke

Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.

Scholars@Duke

Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.

Scholars@Duke

Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.

Scholars@Duke

Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.

Scholars@Duke

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