Carlos Manuel de Castro, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3872 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address decas003@mc.duke.edu

Clinical research projects have focused on new and innovative treatments for myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, adult leukemias, and lymphomas

In Their Words

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 1988 - 1991
  • Resident, Medicine, University of Texas at Dallas, 1985 - 1988
  • M.D., University of Texas at Dallas, 1985
Weight
-20

Publications

Hudson, Kathryn E., David Rizzieri, Samantha M. Thomas, Thomas W. LeBlanc, Zachary Powell, Louis Diehl, Joseph O. Moore, Carlos DeCastro, and Anne W. Beaven. “Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study..” Br J Haematol 184, no. 4 (February 2019): 647–50. https://doi.org/10.1111/bjh.15138.

PMID
29468651
Full Text

Griffin, Patrick T., Rami S. Komrokji, Carlos M. De Castro, David A. Rizzieri, Magda Melchert, Alan F. List, and Jeffrey E. Lancet. “A multicenter, phase II study of maintenance azacitidine in older patients with acute myeloid leukemia in complete remission after induction chemotherapy..” Am J Hematol 90, no. 9 (September 2015): 796–99. https://doi.org/10.1002/ajh.24087.

PMID
26089240
Full Text

Greenberg, Peter L., Richard M. Stone, Rafael Bejar, John M. Bennett, Clara D. Bloomfield, Uma Borate, Carlos M. De Castro, et al. “Myelodysplastic syndromes, version 2.2015..” J Natl Compr Canc Netw 13, no. 3 (March 2015): 261–72. https://doi.org/10.6004/jnccn.2015.0038.

PMID
25736003
Full Text

Brander, Danielle, David Rizzieri, Jon Gockerman, Louis Diehl, Thomas Charles Shea, Carlos Decastro, Joseph O. Moore, and Anne Beaven. “Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma..” Leuk Lymphoma 54, no. 12 (December 2013): 2627–30. https://doi.org/10.3109/10428194.2013.784969.

PMID
23488610
Full Text

Hillmen, Peter, Petra Muus, Alexander Röth, Modupe O. Elebute, Antonio M. Risitano, Hubert Schrezenmeier, Jeffrey Szer, et al. “Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria..” In Br J Haematol, 162:62–73, 2013. https://doi.org/10.1111/bjh.12347.

PMID
23617322
Full Text

Greenberg, Peter L., Eyal Attar, John M. Bennett, Clara D. Bloomfield, Uma Borate, Carlos M. De Castro, H Joachim Deeg, et al. “Myelodysplastic syndromes: clinical practice guidelines in oncology..” J Natl Compr Canc Netw 11, no. 7 (July 2013): 838–74. https://doi.org/10.6004/jnccn.2013.0104.

PMID
23847220
Full Text

Held, Lauren A., David Rizzieri, Gwynn D. Long, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Mitchell E. Horwitz, Nelson J. Chao, and Cristina Gasparetto. “A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma..” Cancer Invest 31, no. 3 (March 2013): 172–76. https://doi.org/10.3109/07357907.2012.756109.

PMID
23406188
Full Text

Morris, Tod A., Carlos M. DeCastro, Louis F. Diehl, Jon P. Gockerman, Anand S. Lagoo, Zhiguo Li, Joseph O. Moore, David A. Rizzieri, and Arati V. Rao. “Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia..” Leuk Res 37, no. 1 (January 2013): 28–31. https://doi.org/10.1016/j.leukres.2012.09.016.

PMID
23046833
Full Text

Hillmen, P., P. Muus, A. Röth, M. O. Elebute, A. M. Risitano, H. Schrezenmeier, J. Szer, et al. “Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria.” British Journal of Haematology 162, no. 1 (2013): 62–73. https://doi.org/10.1111/bjh.12347.

Full Text

Rao, A. V., D. A. Rizzieri, C. M. DeCastro, L. F. Diehl, A. S. Lagoo, J. O. Moore, and J. P. Gockerman. “Phase I study of dose dense induction and consolidation with gemtuzumab ozogamicin and high dose cytarabine in older adults with AML.” Journal of Geriatric Oncology 3, no. 3 (July 1, 2012): 220–27. https://doi.org/10.1016/j.jgo.2012.02.002.

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