Carlos Manuel de Castro, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3872 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address decas003@mc.duke.edu

Clinical research projects have focused on new and innovative treatments for myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, adult leukemias, and lymphomas

In Their Words

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 1988 - 1991
  • Resident, Medicine, University of Texas at Dallas, 1985 - 1988
  • M.D., University of Texas at Dallas, 1985

Publications

Hudson, KE, Rizzieri, D, Thomas, SM, LeBlanc, TW, Powell, Z, Diehl, L, Moore, JO, DeCastro, C, and Beaven, AW. "Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study." British Journal of Haematology 184, no. 4 (February 2019): 647-650. (Letter)

PMID
29468651
Full Text

Griffin, PT, Komrokji, RS, De Castro, CM, Rizzieri, DA, Melchert, M, List, AF, and Lancet, JE. "A multicenter, phase II study of maintenance azacitidine in older patients with acute myeloid leukemia in complete remission after induction chemotherapy." American Journal of Hematology 90, no. 9 (September 2015): 796-799.

PMID
26089240
Full Text

Greenberg, PL, Stone, RM, Bejar, R, Bennett, JM, Bloomfield, CD, Borate, U, De Castro, CM, Deeg, HJ, DeZern, AE, Fathi, AT, Frankfurt, O, Gaensler, K, Garcia-Manero, G, Griffiths, EA, Head, D, Klimek, V, Komrokji, R, Kujawski, LA, Maness, LJ, O'Donnell, MR, Pollyea, DA, Scott, B, Shami, PJ, Stein, BL, Westervelt, P, Wheeler, B, Shead, DA, and Smith, C. "Myelodysplastic syndromes, version 2.2015 featured updates to the NCCN guidelines." JNCCN Journal of the National Comprehensive Cancer Network 13, no. 3 (January 1, 2015): 261-272. (Review)

Scholars@Duke

Brander, D, Rizzieri, D, Gockerman, J, Diehl, L, Shea, TC, Decastro, C, Moore, JO, and Beaven, A. "Phase II open label study of the oral vascular endothelial growth factor-receptor inhibitor PTK787/ZK222584 (vatalanib) in adult patients with refractory or relapsed diffuse large B-cell lymphoma." Leukemia & lymphoma 54, no. 12 (December 2013): 2627-2630.

PMID
23488610
Full Text

Greenberg, PL, Attar, E, Bennett, JM, Bloomfield, CD, Borate, U, De Castro, CM, Deeg, HJ, Frankfurt, O, Gaensler, K, Garcia-Manero, G, Gore, SD, Head, D, Komrokji, R, Maness, LJ, Millenson, M, O'Donnell, MR, Shami, PJ, Stein, BL, Stone, RM, Thompson, JE, Westervelt, P, Wheeler, B, Shead, DA, and Naganuma, M. "Myelodysplastic syndromes: clinical practice guidelines in oncology." Journal of the National Comprehensive Cancer Network : Jnccn 11, no. 7 (July 2013): 838-874.

PMID
23847220
Full Text

Held, LA, Rizzieri, D, Long, GD, Gockerman, JP, Diehl, LF, de Castro, CM, Moore, JO, Horwitz, ME, Chao, NJ, and Gasparetto, C. "A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma." Cancer Investigation 31, no. 3 (March 2013): 172-176.

PMID
23406188
Full Text

Hillmen, P, Muus, P, Röth, A, Elebute, MO, Risitano, AM, Schrezenmeier, H, Szer, J, Browne, P, Maciejewski, JP, Schubert, J, Urbano-Ispizua, A, Castro, CD, Socié, G, and Brodsky, RA. "Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria." British Journal of Haematology 162, no. 1 (2013): 62-73.

Full Text

Morris, TA, DeCastro, CM, Diehl, LF, Gockerman, JP, Lagoo, AS, Li, Z, Moore, JO, Rizzieri, DA, and Rao, AV. "Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia." Leuk Res 37, no. 1 (January 2013): 28-31.

PMID
23046833
Full Text

Szer, J, Muus, P, Roeth, A, Elebute, MO, Risitano, AM, Schrezenmeier, H, Maciejewski, JP, Urbano-Ispizua, A, III, DCCM, Socie, G, and Brodsky, RA. "Long-Term Safety of Sustained Eculizumab Treatment in Patients with Paroxysmal Nocturnal Hemoglobinuria." November 16, 2012.

PMID
23617322
Scholars@Duke

Rao, AV, Rizzieri, DA, DeCastro, CM, Diehl, LF, Lagoo, AS, Moore, JO, and Gockerman, JP. "Phase I study of dose dense induction and consolidation with gemtuzumab ozogamicin and high dose cytarabine in older adults with AML." Journal of Geriatric Oncology 3, no. 3 (July 1, 2012): 220-227.

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