Christina Eleanor Barkauskas, MD

Assistant Professor of Medicine
Affiliate of the Duke Regeneration Center
Campus mail Box 2629 Med Ctr, Durham, NC 27710
Phone (919) 681-6845
Email address christina.barkauskas@duke.edu

I am a physician-scientist and stem cell biologist focused on understanding the fundamental mechanisms involved in lung injury and repair. I am particularly interested in determining the critical components of the alveolar epithelial stem cell niche and the cellular crosstalk signals that dictate cell identity and behavior during steady state maintenance and repair after injury and infection. I believe this work is fundamental to better understanding the biology of the human lung and the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease that is characterized by relentless scar accumulation in the lung with only minimally effective therapy short of lung transplant.

Through my work, I have developed several areas of expertise which include the following: 1) Development and use of mouse models to genetically manipulate and lineage trace specific cell populations; 2) Isolation and characterization of murine lung cell subpopulations by flow cytometry; 3) Development and use of an ex vivo 3-dimensional organoid assay to study the self-renewal and differentiation of murine alveolar epithelial stem cells and their niche components; 4) Isolation and 3-dimensional culture of alveolar epithelial cells from fresh human lung; 5) Development and analysis of models of experimental lung fibrosis.

Education and Training

  • Advanced Training, Pulmonary & Critical Care Medicine, Duke University School of Medicine, 2011 - 2012
  • Fellowship, Pulmonary& Critical Care Medicine, Duke University School of Medicine, 2009 - 2011
  • Chief Medical Resident, Department Of Medicine, Duke University School of Medicine, 2008 - 2009
  • Fellow in Pulmonary Medicine, Medicine, Duke University, 2007 - 2008
  • Resident, Medicine, Duke University, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004

Publications

Murray, Daniel D., Abdel G. Babiker, Jason V. Baker, Christina E. Barkauskas, Samuel M. Brown, Christina C. Chang, Victoria J. Davey, et al. “Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3).” Clin Trials 19, no. 1 (February 2022): 52–61. https://doi.org/10.1177/17407745211049829.

PMID
34632800
Full Text

ACTIV-3/TICO Bamlanivimab Study Group, James D., Jens D. Lundgren, Birgit Grund, Christina E. Barkauskas, Thomas L. Holland, Robert L. Gottlieb, Uriel Sandkovsky, et al. “Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.” Ann Intern Med 175, no. 2 (February 2022): 234–43. https://doi.org/10.7326/M21-3507.

PMID
34928698
Full Text

Suliman, Hagir B., Zachary Healy, Fabio Zobi, Bryan D. Kraft, Karen Welty-Wolf, Joshua Smith, Christina Barkauskas, and Claude A. Piantadosi. “Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis.” Iscience 25, no. 1 (January 21, 2022): 103535. https://doi.org/10.1016/j.isci.2021.103535.

PMID
34977500
Full Text

Brown, Samuel M., Ithan D. Peltan, Christina Barkauskas, Angela J. Rogers, Virginia Kan, Annetine Gelijns, and B Taylor Thompson. “What Does Acute Respiratory Distress Syndrome Mean during the COVID-19 Pandemic?” Ann Am Thorac Soc 18, no. 12 (December 2021): 1948–50. https://doi.org/10.1513/AnnalsATS.202105-534PS.

PMID
34288834
Full Text

Mummy, David G., Elianna A. Bier, Ziyi Wang, Jennifer Korzekwinski, Lake Morrison, Christina Barkauskas, H Page McAdams, Robert M. Tighe, Bastiaan Driehuys, and Joseph G. Mammarappallil. “Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.” Radiology 301, no. 1 (October 2021): 211–20. https://doi.org/10.1148/radiol.2021204149.

PMID
34313473
Full Text

Murray, Daniel D., Abdel G. Babiker, Jason V. Baker, Christina E. Barkauskas, Samuel M. Brown, Christina C. Chang, Victoria J. Davey, et al. “Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3).” Medrxiv, April 8, 2021. https://doi.org/10.1101/2020.11.08.20227876.

PMID
33215168
Full Text

ACTIV-3/TICO LY-CoV555 Study Group, James D., Jens D. Lundgren, Birgit Grund, Christina E. Barkauskas, Thomas L. Holland, Robert L. Gottlieb, Uriel Sandkovsky, et al. “A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.” N Engl J Med 384, no. 10 (March 11, 2021): 905–14. https://doi.org/10.1056/NEJMoa2033130.

PMID
33356051
Full Text

Wagner, James G., Christina E. Barkauskas, Aaron Vose, Ryan P. Lewandowski, Jack R. Harkema, and Robert M. Tighe. “Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.” Environ Health Perspect 128, no. 11 (November 2020): 117009. https://doi.org/10.1289/EHP7255.

PMID
33253011
Full Text

Soliman, Hesham, Ben Paylor, R Wilder Scott, Dario R. Lemos, ChihKai Chang, Martin Arostegui, Marcela Low, et al. “Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.” Cell Stem Cell 26, no. 3 (March 5, 2020): 459–61. https://doi.org/10.1016/j.stem.2020.01.023.

PMID
32142665
Full Text

Pages