Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Goldstein, Sarah A., Jennifer Green, Kurt Huber, Daniel M. Wojdyla, Renato D. Lopes, John H. Alexander, Dragos Vinereanu, Lars Wallentin, Christopher B. Granger, and Sana M. Al-Khatib. “Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial)..” Am J Cardiol, August 7, 2019. https://doi.org/10.1016/j.amjcard.2019.07.046.

PMID
31474328
Full Text

Verheugt, Freek W. A., Jurriën M. Ten Berg, Robert F. Storey, Thomas Cuisset, and Christopher B. Granger. “Antithrombotics: From Aspirin to DOACs in Coronary Artery Disease and Atrial Fibrillation (Part 3/5)..” J Am Coll Cardiol 74, no. 5 (August 6, 2019): 699–711. https://doi.org/10.1016/j.jacc.2019.02.080.

PMID
31277840
Full Text

Tromp, Jasper, Li Shen, Pardeep S. Jhund, Inder S. Anand, Peter E. Carson, Akshay S. Desai, Christopher B. Granger, et al. “Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction..” J Am Coll Cardiol 74, no. 5 (August 6, 2019): 601–12. https://doi.org/10.1016/j.jacc.2019.05.052.

PMID
31370950
Full Text

Shen, Li, Rasmus Rørth, Deborah Cosmi, Søren Lund Kristensen, Mark C. Petrie, Franco Cosmi, Roberto Latini, et al. “Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction..” Eur J Heart Fail 21, no. 8 (August 2019): 974–84. https://doi.org/10.1002/ejhf.1535.

PMID
31271255
Full Text

Bohula, Erin A., Jason N. Katz, Sean van Diepen, Carlos L. Alviar, Vivian M. Baird-Zars, Jeong-Gun Park, Christopher F. Barnett, et al. “Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness..” Jama Cardiol, July 24, 2019. https://doi.org/10.1001/jamacardio.2019.2467.

PMID
31339509
Full Text

Capodanno, Davide, Kurt Huber, Roxana Mehran, Gregory Y. H. Lip, David P. Faxon, Christopher B. Granger, Pascal Vranckx, et al. “Management of Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing PCI: JACC State-of-the-Art Review..” J Am Coll Cardiol 74, no. 1 (July 9, 2019): 83–99. https://doi.org/10.1016/j.jacc.2019.05.016.

PMID
31272556
Full Text

Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin..” J Thromb Thrombolysis 48, no. 1 (July 2019): 27–34. https://doi.org/10.1007/s11239-019-01858-1.

PMID
30972712
Full Text

Shavadia, Jay S., DaJuanicia N. Holmes, Laine Thomas, Eric D. Peterson, Christopher B. Granger, Matthew T. Roe, and Tracy Y. Wang. “Comparative Effectiveness of β-Blocker Use Beyond 3 Years After Myocardial Infarction and Long-Term Outcomes Among Elderly Patients..” Circ Cardiovasc Qual Outcomes 12, no. 7 (July 2019). https://doi.org/10.1161/CIRCOUTCOMES.118.005103.

PMID
31284739
Full Text

Sabin, James E., Noelle M. Cocoros, Crystal J. Garcia, Jennifer C. Goldsack, Kevin Haynes, Nancy D. Lin, Debbe McCall, et al. “Bystander Ethics and Good Samaritanism: A Paradox for Learning Health Organizations..” Hastings Cent Rep 49, no. 4 (July 2019): 18–26. https://doi.org/10.1002/hast.1031.

PMID
31429964
Full Text

Lopes, Renato D., Hwanhee Hong, Ralf E. Harskamp, Deepak L. Bhatt, Roxana Mehran, Christopher P. Cannon, Christopher B. Granger, et al. “Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials..” Jama Cardiol, June 19, 2019. https://doi.org/10.1001/jamacardio.2019.1880.

PMID
31215979
Full Text

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