Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Bahit, M Cecilia, Christopher B. Granger, John H. Alexander, Hillary Mulder, Daniel M. Wojdyla, Michael Hanna, Shinya Goto, et al. “Regional variation in clinical characteristics and outcomes in patients with atrial fibrillation: Findings from the ARISTOTLE trial.” Int J Cardiol 302 (March 1, 2020): 53–58. https://doi.org/10.1016/j.ijcard.2019.12.060.

PMID
31932116
Full Text

Shavadia, Jay S., Christopher B. Granger, Wendimagegn Alemayehu, Cynthia M. Westerhout, Thomas J. Povsic, Sorin J. Brener, Sean van Diepen, Christopher Defilippi, and Paul W. Armstrong. “High-throughput targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction.” Am Heart J 220 (February 2020): 137–44. https://doi.org/10.1016/j.ahj.2019.09.015.

PMID
31812755
Full Text

Sutter, Joanne S., Yuliya Lokhnygina, James P. Daubert, Tristram Bahnson, Kevin Jackson, Jason I. Koontz, Albert Y. Sun, et al. “Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.” Am Heart J 220 (February 2020): 89–96. https://doi.org/10.1016/j.ahj.2019.11.010.

PMID
31805423
Full Text

Pocock, Stuart J., David Brieger, John Gregson, Ji Y. Chen, Mauricio G. Cohen, Shaun G. Goodman, Christopher B. Granger, et al. “Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.” Clin Cardiol 43, no. 1 (January 2020): 24–32. https://doi.org/10.1002/clc.23283.

PMID
31713893
Full Text

Vora, Amit N., John H. Alexander, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Harald Darius, Stephan Windecker, et al. “Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1960–63. https://doi.org/10.1161/CIRCULATIONAHA.119.043754.

PMID
31553201
Full Text

Windecker, Stephan, Renato D. Lopes, Tyler Massaro, Charlotte Jones-Burton, Christopher B. Granger, Ronald Aronson, Gretchen Heizer, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1921–32. https://doi.org/10.1161/CIRCULATIONAHA.119.043308.

PMID
31557056
Full Text

Black-Maier, Eric, Jonathan P. Piccini, and Christopher B. Granger. “Left atrial appendage closure: A therapy uniquely suited for specific populations of patients with atrial fibrillation.” J Cardiovasc Electrophysiol 30, no. 12 (December 2019): 2968–76. https://doi.org/10.1111/jce.14182.

PMID
31520437
Full Text

Brennan, J Matthew, Lisa Wruck, Michael J. Pencina, Robert M. Clare, Renato D. Lopes, John H. Alexander, Sean O’Brien, et al. “Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.” Am Heart J 218 (December 2019): 110–22. https://doi.org/10.1016/j.ahj.2019.09.002.

PMID
31726314
Full Text

Dewan, Pooja, Rasmus Rørth, Valeria Raparelli, Ross T. Campbell, Li Shen, Pardeep S. Jhund, Mark C. Petrie, et al. “Sex-Related Differences in Heart Failure With Preserved Ejection Fraction.” Circ Heart Fail 12, no. 12 (December 2019): e006539. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006539.

PMID
31813280
Full Text

Perez, Marco V., Kenneth W. Mahaffey, Haley Hedlin, John S. Rumsfeld, Ariadna Garcia, Todd Ferris, Vidhya Balasubramanian, et al. “Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation.” N Engl J Med 381, no. 20 (November 14, 2019): 1909–17. https://doi.org/10.1056/NEJMoa1901183.

PMID
31722151
Full Text

Pages