Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Christersson, C, Wallentin, L, Andersson, U, Alexander, JH, Alings, M, De Caterina, R, Gersh, BJ, Granger, CB, Halvorsen, S, Hanna, M, Huber, K, Hylek, EM, Lopes, RD, Oh, B-H, and Siegbahn, A. "Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation." Heart (British Cardiac Society) 105, no. 3 (February 2019): 235-242.

PMID
30209126
Full Text

Cocoros, NM, Pokorney, SD, Haynes, K, Garcia, C, Al-Khalidi, HR, Al-Khatib, SM, Archdeacon, P, Goldsack, JC, Harkins, T, Lin, ND, Martin, D, McCall, D, Nair, V, Parlett, L, Temple, R, McMahill-Walraven, C, Granger, CB, and Platt, R. "FDA-Catalyst-Using FDA's Sentinel Initiative for large-scale pragmatic randomized trials: Approach and lessons learned during the planning phase of the first trial." Clinical Trials (London, England) 16, no. 1 (February 2019): 90-97.

PMID
30445835
Full Text

Kochar, A, Al-Khalidi, HR, Doerfler, S, and Granger, CB. "Reply: Delays From First Medical Contact to Revascularization in Patients With ST-Segment Elevation Myocardial Infarction Presenting With Cardiogenic Shock." Jacc. Cardiovascular Interventions 12, no. 1 (January 2019): 107-null. (Letter)

PMID
30621969
Full Text

Granger, CB, Bates, ER, Jollis, JG, Antman, EM, Nichol, G, O'Connor, RE, Gregory, T, Roettig, ML, Peng, SA, Ellrodt, G, Henry, TD, French, WJ, and Jacobs, AK. "Improving Care of STEMI in the United States 2008 to 2012." Journal of the American Heart Association 8, no. 1 (January 2019): e008096-null.

PMID
30596310
Full Text

Thygesen, K, Alpert, JS, Jaffe, AS, Chaitman, BR, Bax, JJ, Morrow, DA, White, HD, and ESC Scientific Document Group, . "Fourth universal definition of myocardial infarction (2018)." European Heart Journal 40, no. 3 (January 2019): 237-269.

PMID
30165617
Full Text

Turakhia, MP, Desai, M, Hedlin, H, Rajmane, A, Talati, N, Ferris, T, Desai, S, Nag, D, Patel, M, Kowey, P, Rumsfeld, JS, Russo, AM, Hills, MT, Granger, CB, Mahaffey, KW, and Perez, MV. "Rationale and design of a large-scale, app-based study to identify cardiac arrhythmias using a smartwatch: The Apple Heart Study." American Heart Journal 207 (January 2019): 66-75.

PMID
30392584
Full Text

Fordyce, CB, Chen, AY, Wang, TY, Lucas, J, Goyal, A, Wong, GC, van Diepen, S, Kontos, MC, Henry, TD, Granger, CB, and Roe, MT. "Patterns of use of targeted temperature management for acute myocardial infarction patients following out-of-hospital cardiac arrest: Insights from the National Cardiovascular Data Registry." American Heart Journal 206 (December 2018): 131-133. (Letter)

PMID
30528916
Full Text

Killu, AM, Granger, CB, and Gersh, BJ. "Risk stratification for stroke in atrial fibrillation: a critique." European Heart Journal (December 2018).

PMID
30508086
Full Text

Limkakeng, AT, and Granger, CB. "In patients with chest pain, HEART Pathway-guided and usual care did not differ for MACE or health care use." Annals of Internal Medicine 169, no. 12 (December 2018): JC69-null.

PMID
30557422
Full Text

Alexander, KP, Brouwer, MA, Mulder, H, Vinereanu, D, Lopes, RD, Proietti, M, Al-Khatib, SM, Hijazi, Z, Halvorsen, S, Hylek, EM, Verheugt, FWA, Alexander, JH, Wallentin, L, Granger, CB, and ARISTOTLE Investigators, . "Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial." American Heart Journal (November 22, 2018).

PMID
30579505
Full Text

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