Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt Street, Durham, NC 27705
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Al-Khatib, SM, Stevenson, WG, Ackerman, MJ, Bryant, WJ, Callans, DJ, Curtis, AB, Deal, BJ, Dickfeld, T, Field, ME, Fonarow, GC, Gillis, AM, Granger, CB, Hammill, SC, Hlatky, MA, Joglar, JA, Kay, GN, Matlock, DD, Myerburg, RJ, and Page, RL. "2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society." Heart Rhythm 15, no. 10 (October 2018): e190-e252.

PMID
29097320
Full Text

Al-Khatib, SM, Stevenson, WG, Ackerman, MJ, Bryant, WJ, Callans, DJ, Curtis, AB, Deal, BJ, Dickfeld, T, Field, ME, Fonarow, GC, Gillis, AM, Granger, CB, Hammill, SC, Hlatky, MA, Joglar, JA, Kay, GN, Matlock, DD, Myerburg, RJ, and Page, RL. "2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society." Journal of the American College of Cardiology 72, no. 14 (October 2018): e91-e220.

PMID
29097296
Full Text

Al-Khatib, SM, Stevenson, WG, Ackerman, MJ, Bryant, WJ, Callans, DJ, Curtis, AB, Deal, BJ, Dickfeld, T, Field, ME, Fonarow, GC, Gillis, AM, Granger, CB, Hammill, SC, Hlatky, MA, Joglar, JA, Kay, GN, Matlock, DD, Myerburg, RJ, and Page, RL. "2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society." Heart Rhythm 15, no. 10 (October 2018): e73-e189.

PMID
29097319
Full Text

Al-Khatib, SM, Stevenson, WG, Ackerman, MJ, Bryant, WJ, Callans, DJ, Curtis, AB, Deal, BJ, Dickfeld, T, Field, ME, Fonarow, GC, Gillis, AM, Granger, CB, Hammill, SC, Hlatky, MA, Joglar, JA, Kay, GN, Matlock, DD, Myerburg, RJ, and Page, RL. "2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society." Journal of the American College of Cardiology 72, no. 14 (October 2018): 1677-1749.

PMID
29097294
Full Text

Lopes, RD, de Barros E Silva, PGM, de Andrade Jesuíno, I, Santucci, EV, Barbosa, LM, Damiani, LP, Nakagawa Santos, RH, Laranjeira, LN, Dall Orto, FTC, Beraldo de Andrade, P, de Castro Bienert, IR, Alexander, JH, Granger, CB, and Berwanger, O. "Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial." Jama Cardiology (September 24, 2018).

PMID
30264159
Full Text

Christersson, C, Wallentin, L, Andersson, U, Alexander, JH, Alings, M, De Caterina, R, Gersh, BJ, Granger, CB, Halvorsen, S, Hanna, M, Huber, K, Hylek, EM, Lopes, RD, Oh, B-H, and Siegbahn, A. "Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation." Heart (British Cardiac Society) (September 12, 2018).

PMID
30209126
Full Text

Green, JB, Hernandez, AF, D'Agostino, RB, Granger, CB, Janmohamed, S, Jones, NP, Leiter, LA, Noronha, D, Russell, R, Sigmon, K, Del Prato, S, and McMurray, JJV. "Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics." American Heart Journal 203 (September 2018): 30-38.

PMID
30015066
Full Text

Kochar, A, Al-Khalidi, HR, Hansen, SM, Shavadia, JS, Roettig, ML, Fordyce, CB, Doerfler, S, Gersh, BJ, Henry, TD, Berger, PB, Jollis, JG, and Granger, CB. "Delays in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction Patients Presenting With Cardiogenic Shock." Jacc. Cardiovascular Interventions 11, no. 18 (September 2018): 1824-1833.

PMID
30236355
Full Text

Shavadia, JS, Roe, MT, Chen, AY, Lucas, J, Fanaroff, AC, Kochar, A, Fordyce, CB, Jollis, JG, Tamis-Holland, J, Henry, TD, Bagai, A, Kontos, MC, Granger, CB, and Wang, TY. "Association Between Cardiac Catheterization Laboratory Pre-Activation and Reperfusion Timing Metrics and Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Report From the ACTION Registry." Jacc. Cardiovascular Interventions 11, no. 18 (September 2018): 1837-1847.

PMID
30236357
Full Text

Vinereanu, D, Wang, A, Mulder, H, Lopes, RD, Jansky, P, Lewis, BS, Gersh, BJ, Avezum, A, Hanna, M, Held, C, Wallentin, L, Granger, CB, and Alexander, JH. "Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease." Heart (British Cardiac Society) 104, no. 15 (August 2018): 1292-1299.

PMID
29352007
Full Text

Pages