Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin..” J Thromb Thrombolysis 48, no. 1 (July 2019): 27–34. https://doi.org/10.1007/s11239-019-01858-1.

PMID
30972712
Full Text

Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin..” J Thromb Thrombolysis 48, no. 1 (July 2019): 27–34. https://doi.org/10.1007/s11239-019-01858-1.

PMID
30972712
Full Text

Berwanger, Otavio, Renato D. Lopes, Diogo D. F. Moia, Francisco A. Fonseca, Lixin Jiang, Shaun G. Goodman, Stephen J. Nicholls, et al. “Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With Fibrinolysis: TREAT Trial..” J Am Coll Cardiol 73, no. 22 (June 11, 2019): 2819–28. https://doi.org/10.1016/j.jacc.2019.03.011.

PMID
30898608
Full Text

Berwanger, Otavio, Renato D. Lopes, Diogo D. F. Moia, Francisco A. Fonseca, Lixin Jiang, Shaun G. Goodman, Stephen J. Nicholls, et al. “Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With Fibrinolysis: TREAT Trial..” J Am Coll Cardiol 73, no. 22 (June 11, 2019): 2819–28. https://doi.org/10.1016/j.jacc.2019.03.011.

PMID
30898608
Full Text

Shavadia, Jay S., Abhinav Sharma, Xiangqiong Gu, James Neaton, Laurie DeLeve, David Holmes, Phillip Home, Robert H. Eckel, Paul B. Watkins, and Christopher B. Granger. “Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program..” Clin Trials 16, no. 3 (June 2019): 253–62. https://doi.org/10.1177/1740774519836766.

PMID
30880443
Full Text

Shavadia, Jay S., Abhinav Sharma, Xiangqiong Gu, James Neaton, Laurie DeLeve, David Holmes, Phillip Home, Robert H. Eckel, Paul B. Watkins, and Christopher B. Granger. “Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program..” Clin Trials 16, no. 3 (June 2019): 253–62. https://doi.org/10.1177/1740774519836766.

PMID
30880443
Full Text

Diener, Hans-Christoph, Ralph L. Sacco, J Donald Easton, Christopher B. Granger, Richard A. Bernstein, Shinichiro Uchiyama, Jörg Kreuzer, et al. “Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source..” N Engl J Med 380, no. 20 (May 16, 2019): 1906–17. https://doi.org/10.1056/NEJMoa1813959.

PMID
31091372
Full Text

Diener, Hans-Christoph, Ralph L. Sacco, J Donald Easton, Christopher B. Granger, Richard A. Bernstein, Shinichiro Uchiyama, Jörg Kreuzer, et al. “Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source..” N Engl J Med 380, no. 20 (May 16, 2019): 1906–17. https://doi.org/10.1056/NEJMoa1813959.

PMID
31091372
Full Text

Hohnloser, Stefan H., Marat Fudim, John H. Alexander, Daniel M. Wojdyla, Justin A. Ezekowitz, Michael Hanna, Dan Atar, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight..” Circulation 139, no. 20 (May 14, 2019): 2292–2300. https://doi.org/10.1161/CIRCULATIONAHA.118.037955.

PMID
30773022
Full Text

Hohnloser, Stefan H., Marat Fudim, John H. Alexander, Daniel M. Wojdyla, Justin A. Ezekowitz, Michael Hanna, Dan Atar, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight..” Circulation 139, no. 20 (May 14, 2019): 2292–2300. https://doi.org/10.1161/CIRCULATIONAHA.118.037955.

PMID
30773022
Full Text

Pages