Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt Street, Durham, NC 27705
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017.

PMID
28739198
Full Text

Kristensen, SL, Jhund, PS, Lee, MMY, Køber, L, Solomon, SD, Granger, CB, Yusuf, S, Pfeffer, MA, Swedberg, K, McMurray, JJV, and CHARM Investigators and Committees, . "Prevalence of Prediabetes and Undiagnosed Diabetes in Patients with HFpEF and HFrEF and Associated Clinical Outcomes." Cardiovascular drugs and therapy 31, no. 5-6 (December 2017): 545-549.

PMID
28948430
Full Text

Hirji, SA, Stevens, SR, Shaw, LK, Campbell, EC, Granger, CB, Patel, MR, Sketch, MH, Wang, TY, Ohman, EM, Peterson, ED, and Brennan, JM. "Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non-infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease." American heart journal 194 (December 2017): 116-124.

PMID
29223429
Full Text

Vinereanu, D, Lopes, RD, Mulder, H, Gersh, BJ, Hanna, M, de Barros E Silva, PGM, Atar, D, Wallentin, L, Granger, CB, Alexander, JH, and ARISTOTLE Investigators, . "Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin." Stroke 48, no. 12 (December 2017): 3266-3273.

PMID
29089455
Full Text

Jollis, JG, Al-Khalidi, HR, Roettig, ML, Berger, PB, Corbett, CC, Doerfler, S, Fordyce, CB, Henry, TD, Hollowell, L, Magdon-Ismail, Z, Kochar, A, McCarthy, JJ, Monk, L, O'Brien, PK, Rea, TD, Shavadia, J, Tamis-Holland, J, Wilson, BH, Ziada, KM, and Granger, CB. "Impact of Regionalization of ST Elevation Myocardial Infarction Care on Treatment Times and Outcomes for Emergency Medical Services Transported Patients Presenting to Hospitals with Percutaneous Coronary Intervention: Mission: Lifeline Accelerator-2." Circulation (November 14, 2017).

PMID
29138292
Full Text

Rao, MP, Vinereanu, D, Wojdyla, DM, Alexander, JH, Atar, D, Hylek, EM, Hanna, M, Wallentin, L, Lopes, RD, Gersh, BJ, Granger, CB, and Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial." The American journal of medicine (November 6, 2017).

PMID
29122636
Full Text

Bossard, M, Granger, CB, Tanguay, J-F, Montalescot, G, Faxon, DP, Jolly, SS, Widimsky, P, Niemela, K, Steg, PG, Natarajan, MK, Gao, P, Fox, KAA, Yusuf, S, and Mehta, SR. "Double-Dose Versus Standard-Dose Clopidogrel According to Smoking Status Among Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention." Journal of the American Heart Association 6, no. 11 (November 3, 2017).

PMID
29101117
Full Text

Ebinger, J, Granger, CB, Zhu, A, Chang, A, and Henry, TD. "Idarucizumab since FDA approval: Use in the real-world." American heart journal 193 (November 2017): 93-94. (Letter)

PMID
29129261
Full Text

Fordyce, CB, Hansen, CM, Kragholm, K, Dupre, ME, Jollis, JG, Roettig, ML, Becker, LB, Hansen, SM, Hinohara, TT, Corbett, CC, Monk, L, Nelson, RD, Pearson, DA, Tyson, C, van Diepen, S, Anderson, ML, McNally, B, and Granger, CB. "Association of Public Health Initiatives With Outcomes for Out-of-Hospital Cardiac Arrest at Home and in Public Locations." JAMA cardiology 2, no. 11 (November 2017): 1226-1235.

PMID
28979980
Full Text

Kochar, A, and Granger, CB. "Q Waves at Presentation in Patients With ST-Segment-Elevation Myocardial Infarction: An Underappreciated Marker of Risk." Circulation. Cardiovascular interventions 10, no. 11 (November 2017).

PMID
29146675
Full Text

Pages