Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado Denver, School of Medicine, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado Denver, School of Medicine, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Fanaroff, A. C., R. M. Califf, R. A. Harrington, C. B. Granger, J. J. V. McMurray, M. R. Patel, D. L. Bhatt, et al. “Randomized Trials Versus Common Sense and Clinical Observation: JACC Review Topic of the Week.” Journal of the American College of Cardiology 76, no. 5 (August 4, 2020): 580–89. https://doi.org/10.1016/j.jacc.2020.05.069.

Full Text

Røsjø, H., Z. Hijazi, T. Omland, J. Westerbergh, M. N. Lyngbakken, J. H. Alexander, B. J. Gersh, et al. “Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial.” J Intern Med 288, no. 2 (August 2020): 248–59. https://doi.org/10.1111/joim.13072.

PMID
32350915
Full Text

Berglund, Erik, Lars Wallentin, Jonas Oldgren, Henrik Renlund, John H. Alexander, Christopher B. Granger, Stefan H. Hohnloser, et al. “Effects of apixaban compared with warfarin as gain in event-free time - a novel assessment of the results of the ARISTOTLE trial.” Eur J Prev Cardiol 27, no. 12 (August 2020): 1311–19. https://doi.org/10.1177/2047487319886959.

PMID
31698965
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Brieger, David, Stuart J. Pocock, Stefan Blankenberg, Ji Yan Chen, Mauricio G. Cohen, Christopher B. Granger, Richard Grieve, et al. “Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries.” Int J Cardiol 311 (July 15, 2020): 7–14. https://doi.org/10.1016/j.ijcard.2020.01.070.

PMID
32057476
Full Text

Shavadia, Jay S., Christopher B. Granger, Wendimagegn Alemayehu, Cynthia M. Westerhout, Thomas J. Povsic, Sean Van Diepen, Christopher Defilippi, and Paul W. Armstrong. “Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention.” J Am Heart Assoc 9, no. 13 (July 7, 2020): e016033. https://doi.org/10.1161/JAHA.120.016033.

PMID
32552321
Full Text

Kragholm, Kristian, Carolina Malta Hansen, Matthew E. Dupre, Benjamin Strauss, Clark Tyson, Lisa Monk, David A. Pearson, et al. “Care and outcomes of urban and non-urban out-of-hospital cardiac arrest patients during the HeartRescue Project in Washington state and North Carolina.” Resuscitation 152 (July 2020): 5–15. https://doi.org/10.1016/j.resuscitation.2020.04.030.

PMID
32430288
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McIlvennan, Colleen K., Larry A. Allen, Adam D. Devore, Christopher B. Granger, Lisa A. Kaltenbach, and Bradi B. Granger. “Changes in Care Delivery for Patients With Heart Failure During the COVID-19 Pandemic: Results of a Multicenter Survey.” J Card Fail 26, no. 7 (July 2020): 635–36. https://doi.org/10.1016/j.cardfail.2020.05.019.

PMID
32505814
Full Text

Aulin, Julia, Ziad Hijazi, Agneta Siegbahn, Ulrika Andersson, John H. Alexander, Stuart J. Connolly, Michael D. Ezekowitz, et al. “Serial measurement of interleukin-6 and risk of mortality in anticoagulated patients with atrial fibrillation: Insights from ARISTOTLE and RE-LY trials.” J Thromb Haemost, June 8, 2020. https://doi.org/10.1111/jth.14947.

PMID
32510737
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Geurink, Kyle R., Christopher B. Granger, Lawrence Liao, Neel G. Thomas, Benjamin C. Lindsey, Elizabeth Babin, Natalie Turgeon, Justine Alexander, and Sean D. Pokorney. “A reversal of fortune: A case of cardiovascular collapse following protamine sulfate infusion.” Heartrhythm Case Rep 6, no. 6 (June 2020): 322–24. https://doi.org/10.1016/j.hrcr.2020.02.008.

PMID
32577386
Full Text

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