Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado Denver, School of Medicine, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado Denver, School of Medicine, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Kelsey, Michelle D., Adam J. Nelson, Jennifer B. Green, Christopher B. Granger, Eric D. Peterson, Darren K. McGuire, and Neha J. Pagidipati. “Guidelines for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: JACC Guideline Comparison.” J Am Coll Cardiol 79, no. 18 (May 10, 2022): 1849–57. https://doi.org/10.1016/j.jacc.2022.02.046.

PMID
35512864
Full Text

De Caterina, Raffaele, Giuseppe Patti, Johan Westerbergh, John Horowitz, Justin A. Ezekowitz, Basil S. Lewis, Renato D. Lopes, et al. “Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial.” Eur Heart J Cardiovasc Pharmacother 8, no. 3 (May 5, 2022): 227–35. https://doi.org/10.1093/ehjcvp/pvaa140.

PMID
33367487
Full Text

Granger, Bradi B., Lisa A. Kaltenbach, Gregg C. Fonarow, Larry A. Allen, David E. Lanfear, Nancy M. Albert, Hussein R. Al-Khalidi, et al. “Health System-Level Performance in Prescribing Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction: Results From the CONNECT-HF Trial.” J Card Fail, April 22, 2022. https://doi.org/10.1016/j.cardfail.2022.03.356.

PMID
35462033
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Granger, Christopher B., Konstantin A. Krychtiuk, and Bernard J. Gersh. “Personalizing Choice of CABG vs PCI for Multivessel Disease: Predictive Model Falls Short.” J Am Coll Cardiol 79, no. 15 (April 19, 2022): 1474–76. https://doi.org/10.1016/j.jacc.2022.02.011.

PMID
35422243
Full Text

Macedo, Ariane Vieira Scarlatelli, Pedro Gabriel Melo de Barros E Silva, Thiago Ceccatto de Paula, Renata Junqueira Moll-Bernardes, Tiago Mendonça Dos Santos, Lilian Mazza, Andre Feldman, et al. “Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial.” Am Heart J 249 (April 8, 2022): 86–97. https://doi.org/10.1016/j.ahj.2022.04.001.

PMID
35405099
Full Text

Russo, Juan J., Andrew T. Yan, Stuart J. Pocock, David Brieger, Ruth Owen, Karolina Andersson Sundell, Akshay Bagai, et al. “Determinants of long-term dual antiplatelet therapy use in post myocardial infarction patients: Insights from the TIGRIS registry.” J Cardiol 79, no. 4 (April 2022): 522–29. https://doi.org/10.1016/j.jjcc.2021.10.024.

PMID
34857432
Full Text

Bhasin, Shalender, A Michael Lincoff, Shehzad Basaria, Douglas C. Bauer, William E. Boden, Glenn R. Cunningham, Deborah Davey, et al. “Effects of long-term testosterone treatment on cardiovascular outcomes in men with hypogonadism: Rationale and design of the TRAVERSE study.” Am Heart J 245 (March 2022): 41–50. https://doi.org/10.1016/j.ahj.2021.11.016.

PMID
34871580
Full Text

Harskamp, Ralf E., Alexander C. Fanaroff, Renato D. Lopes, Daniel M. Wojdyla, Shaun G. Goodman, Laine E. Thomas, Ronald Aronson, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention.” J Am Coll Cardiol 79, no. 5 (February 8, 2022): 417–27. https://doi.org/10.1016/j.jacc.2021.11.035.

PMID
35115097
Full Text

Nelson, Adam J., Emily C. O’Brien, Lisa A. Kaltenbach, Jennifer B. Green, Renato D. Lopes, Caryn G. Morse, Hussein R. Al-Khalidi, et al. “Use of Lipid-, Blood Pressure-, and Glucose-Lowering Pharmacotherapy in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.” Jama Netw Open 5, no. 2 (February 1, 2022): e2148030. https://doi.org/10.1001/jamanetworkopen.2021.48030.

PMID
35175345
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Welsh, Robert C., Payam Dehghani, Renato Lopes, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Stephan Windecker, et al. “Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial.” Open Heart 9, no. 1 (February 2022). https://doi.org/10.1136/openhrt-2021-001892.

PMID
35172988
Full Text

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