Christopher Bull Granger, MD

Professor of Medicine
Professor in the School of Nursing
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt Street, Durham, NC 27705
Phone (919) 668-8900
Email address grang001@mc.duke.edu

Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. I serve as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. I have also studied the effects of genetic variation on heart disease. I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1988 - 1990
  • Chief Medical Resident, Medicine, University of Colorado at Denver, 1987 - 1988
  • Medical Resident, Medicine, University of Colorado at Denver, 1984 - 1987
  • M.D., University of Connecticut, 1984

Publications

Vinereanu, D, Wang, A, Mulder, H, Lopes, RD, Jansky, P, Lewis, BS, Gersh, BJ, Avezum, A, Hanna, M, Held, C, Wallentin, L, Granger, CB, and Alexander, JH. "Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease." Heart (British Cardiac Society) 104, no. 15 (August 2018): 1292-1299.

PMID
29352007
Full Text

Berwanger, O, Nicolau, JC, Carvalho, AC, Jiang, L, Goodman, S, Nicholls, SJ, Parkhomenko, A, Averkov, O, Tajer, C, Malaga, G, Kerr Saraiva, JF, Fonseca, F, Guimaraes, HP, de Barros e Silva, PGM, Damiani, LP, Paisani, DM, Lasagno, CMR, Candido, CT, Valeis, N, Moia, DDF, Piegas, LS, Granger, CB, White, H, and Lopes, RD. "Ticagrelor versus clopidogrel after fibrinolytic therapy in patients with ST-elevation myocardial infarction: Rationale and design of the ticagrelor in patients with ST elevation myocardial infarction treated with thrombolysis (TREAT) trial." American Heart Journal 202 (August 2018): 89-96.

Full Text

Rymer, JA, Tempelhof, MW, Clare, RM, Pieper, KS, Granger, CB, Van de Werf, F, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Lopes, RD, Mahaffey, KW, and Newby, LK. "Discharge timing and outcomes after uncomplicated non-ST-segment elevation acute myocardial infarction." American Heart Journal 201 (July 2018): 103-110.

PMID
29910048
Full Text

Granger, CB, and Kochar, A. "Understanding and Targeting Inflammation in Acute Myocardial Infarction: An Elusive Goal." Journal of the American College of Cardiology 72, no. 2 (July 2018): 199-201.

PMID
29976294
Full Text

Green, JB, Hernandez, AF, D'Agostino, RB, Granger, CB, Janmohamed, S, Jones, NP, Leiter, LA, Noronha, D, Russell, R, Sigmon, K, Del Prato, S, and McMurray, JJV. "Harmony Outcomes: A randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus-Rationale, design, and baseline characteristics." American Heart Journal 203 (June 12, 2018): 30-38.

PMID
30015066
Full Text

Sharma, A, Hijazi, Z, Andersson, U, Al-Khatib, SM, Lopes, RD, Alexander, JH, Held, C, Hylek, EM, Leonardi, S, Hanna, M, Ezekowitz, JA, Siegbahn, A, Granger, CB, and Wallentin, L. "The Use of Biomarkers to Predict Specific Causes of Death in Patients with Atrial Fibrillation: Insights from the ARISTOTLE Trial." Circulation (June 5, 2018).

PMID
29871978
Full Text

Lopes, RD, Vora, AN, Liaw, D, Granger, CB, Darius, H, Goodman, SG, Mehran, R, Windecker, S, and Alexander, JH. "An open-Label, 2 × 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial." American Heart Journal 200 (June 2018): 17-23.

PMID
29898844
Full Text

McCarthy, JJ, Carr, B, Sasson, C, Bobrow, BJ, Callaway, CW, Neumar, RW, Ferrer, JME, Garvey, JL, Ornato, JP, Gonzales, L, Granger, CB, Kleinman, ME, Bjerke, C, and Nichol, G. "Out-of-Hospital Cardiac Arrest Resuscitation Systems of Care: A Scientific Statement From the American Heart Association." Circulation 137, no. 21 (May 22, 2018): e645-e660.

Full Text

Friedman, DJ, and Granger, CB. "Uninterrupted apixaban for atrial fibrillation ablation is a reasonable alternative, but what is the significance of silent cerebral infarctions?." European Heart Journal (May 19, 2018).

PMID
29788351
Full Text

Berwanger, O, Nicolau, JC, Carvalho, AC, Jiang, L, Goodman, SG, Nicholls, SJ, Parkhomenko, A, Averkov, O, Tajer, C, Malaga, G, Saraiva, JFK, Fonseca, FA, De Luca, FA, Guimaraes, HP, de Barros E Silva, PGM, Damiani, LP, Paisani, DM, Lasagno, CMR, Candido, CT, Valeis, N, Moia, DDF, Piegas, LS, Granger, CB, White, HD, Lopes, RD, and TREAT Study Group, . "Ticagrelor vs Clopidogrel After Fibrinolytic Therapy in Patients With ST-Elevation Myocardial Infarction: A Randomized Clinical Trial." Jama Cardiology 3, no. 5 (May 2018): 391-399.

PMID
29525822
Full Text

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