Cynthia Ann Moylan, MD

Assistant Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 905 S Lasalle St, Gsrb1, DUMC 3256, Durham, NC 27710
Phone (919) 668-0401
Email address cynthia.moylan@duke.edu

My research interests focus on the study of chronic liver disease and primary liver cancer, particularly from nonalcoholic fatty liver disease (NAFLD).  As part of the NAFLD Research Team at Duke, I am investigating the role of epigenetics and genetics on the development of advanced fibrosis from NAFLD.  The long term goal of our research is to develop non-invasive biomarkers to identify those patients at increased risk for cirrhosis and end stage liver disease in order to risk stratify patients as well as to develop better preventative and therapeutic strategies.  

Education and Training

  • Fellow in Gastroenterology, Medicine, Duke University, 2005 - 2009
  • Resident, Medicine, Duke University, 2002 - 2005
  • M.D., University of Miami, 2002

Publications

Moylan, CA, and Abdelmalek, MF. "Nonalcoholic Fatty Liver Disease with Cirrhosis Increases Familial Risk for Advanced Fibrosis." Hepatology (Baltimore, Md.) (March 13, 2018).

PMID
29534302
Full Text

Patel, YA, Gifford, EJ, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, D, Choi, SS, Moylan, CA, and Hunt, CM. "Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration." Alimentary pharmacology & therapeutics 47, no. 2 (January 2018): 268-278.

PMID
29115682
Full Text

Li, X, Moylan, CA, Baker, SS, Liu, W, Baker, RD, Murphy, SK, Abdelmalek, MF, Zhu, R, Diehl, AM, and Zhu, L. "Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis." October 2017.

Scholars@Duke

Wegermann, K, Moylan, CA, Zheng, J, Abdelmalek, MF, Chow, S-C, Guy, CD, Diehl, AM, and Suzuki, A. "Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD)." October 2017.

Scholars@Duke

Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

Patel, YA, Gifford, E, Glass, LM, McNeil, R, Turner, MJ, Han, B, Provenzale, DT, Choi, SS, Moylan, CA, and Hunt, CM. "Diet/exercise programs are used by only one in five severely obese patients with biopsy-defined Nonalcoholic Fatty Liver Disease (NAFLD) advanced fibrosis in the Veterans Health Administration (VHA)." October 2017.

Scholars@Duke

Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Reply to Kim et al." The American journal of gastroenterology 112, no. 5 (May 2017): 807-808.

PMID
28469220
Full Text

Moylan, CA, Giraldo, RH, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool." April 2017.

Full Text

Mwinyi, J, Boström, AE, Pisanu, C, Murphy, SK, Erhart, W, Schafmayer, C, Hampe, J, Moylan, C, and Schiöth, HB. "NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition." Biochimica et biophysica acta 1862, no. 3 (March 2017): 314-323.

PMID
27993651
Full Text

Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis." The American journal of gastroenterology 111, no. 11 (November 2016): 1591-1598.

PMID
27644736
Full Text

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