Gastroenterology

Cynthia Ann Moylan, MD

Associate Professor of Medicine
Associate Professor in Pathology
Member of the Duke Cancer Institute
Campus mail 905 S Lasalle St, Gsrb1, DUMC 3256, Durham, NC 27710
Phone (919) 668-0401
Email address cynthia.moylan@duke.edu

My research interests focus on the study of chronic liver disease and primary liver cancer, particularly from nonalcoholic fatty liver disease (NAFLD).  As part of the NAFLD Research Team at Duke, I am investigating the role of epigenetics and genetics on the development of advanced fibrosis from NAFLD.  The long term goal of our research is to develop non-invasive biomarkers to identify those patients at increased risk for cirrhosis and end stage liver disease in order to risk stratify patients as well as to develop better preventative and therapeutic strategies.  

Education and Training

  • Fellow in Gastroenterology, Medicine, Duke University, 2005 - 2009
  • Resident, Medicine, Duke University, 2002 - 2005
  • M.D., University of Miami, 2002

Grants

Publications

Moylan, Cynthia A., Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, et al. “Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children.” Epigenetics, February 21, 2022, 1–16. https://doi.org/10.1080/15592294.2022.2039850.

PMID
35188871
Full Text

Alexopoulos, Anastasia-Stefania, Ryan Duffy, Elizabeth A. Kobe, Jashalynn German, Cynthia A. Moylan, Diana Soliman, Amy S. Jeffreys, Cynthia J. Coffman, and Matthew J. Crowley. “Underrecognition of Nonalcoholic Fatty Liver Disease in Poorly Controlled Diabetes: A Call to Action in Diabetes Care.” J Endocr Soc 5, no. 12 (December 1, 2021): bvab155. https://doi.org/10.1210/jendso/bvab155.

PMID
34755002
Full Text

Fudim, Marat, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, et al. “Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.” J Am Heart Assoc 10, no. 22 (November 16, 2021): e021654. https://doi.org/10.1161/JAHA.121.021654.

PMID
34755544
Full Text

Salah, Husam M., Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, et al. “Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.” Jacc Basic Transl Sci 6, no. 11 (November 2021): 918–32. https://doi.org/10.1016/j.jacbts.2021.07.010.

PMID
34869957
Full Text

Cabezas, Melanie, Alice Parish, Alisha Mavis, Donna Niedzwiecki, Rachel Maguire, Susan Kay Murphy, Anna Mae Diehl, et al. “EVEN MODEST ELEVATIONS IN LIVER FAT ASSOCIATE WITH METABOLIC ABNORMALITIES IN CHILDREN AND MAY INDICATE FUTURE RISK FOR NAFLD AND ASSOCIATED COMPLICATIONS.” In Hepatology, 74:1107A-1108A, 2021.

Scholars@Duke

Wegermann, Kara, Jiamu He, Benjamin Goldstein, Sunny Chung, Joseph Wawrzynski, Tzu-Hao Lee, Jacqueline B. Henson, et al. “ICD CODES INCREASE ACCURACY OF COMPUTABLE PHENOTYPES IN EMR-BASED IDENTIFICATION OF NAFLD.” In Hepatology, 74:1111A-1111A, 2021.

Scholars@Duke

Alexopoulos, Anastasia-Stefania, Matthew J. Crowley, Ying Wang, Cynthia A. Moylan, Cynthia D. Guy, Ricardo Henao, Dawn L. Piercy, et al. “Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.” Hepatology 74, no. 3 (September 2021): 1220–33. https://doi.org/10.1002/hep.31806.

PMID
33724511
Full Text

Hyun, Jeongeun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang, Xiyou Zhou, Raquel Maeso-Díaz, et al. “Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.” J Hepatol 75, no. 3 (September 2021): 623–33. https://doi.org/10.1016/j.jhep.2021.04.033.

PMID
33964370
Full Text

Benhammou, Jihane N., Andrew M. Moon, Joseph R. Pisegna, Feng Su, Philip Vutien, Cynthia A. Moylan, and George N. Ioannou. “Nonalcoholic Fatty Liver Disease Risk Factors Affect Liver-Related Outcomes After Direct-Acting Antiviral Treatment for Hepatitis C.” Dig Dis Sci 66, no. 7 (July 2021): 2394–2406. https://doi.org/10.1007/s10620-020-06457-2.

PMID
32654086
Full Text

Wegermann, Kara, Ayako Suzuki, Alisha M. Mavis, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia A. Moylan. “REPLY.” Hepatology 73, no. 4 (April 2021): 1625. https://doi.org/10.1002/hep.31593.

PMID
33040372
Full Text

Pages