Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Steinberg, Benjamin A., Zhen Li, Emily C. O’Brien, Jessica Pritchard, Derek S. Chew, T Jared Bunch, Daniel B. Mark, Yelena Nabutovsky, Melissa A. Greiner, and Jonathan P. Piccini. “Atrial fibrillation burden and heart failure: Data from 39,710 individuals with cardiac implanted electronic devices.” Heart Rhythm 18, no. 5 (May 2021): 709–16. https://doi.org/10.1016/j.hrthm.2021.01.021.

PMID
33508517
Full Text

Packer, Douglas L., Jonathan P. Piccini, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, Peter A. Noseworthy, Jeanne E. Poole, et al. “Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.” Circulation 143, no. 14 (April 6, 2021): 1377–90. https://doi.org/10.1161/CIRCULATIONAHA.120.050991.

PMID
33554614
Full Text

Russo, Andrea M., Emily P. Zeitler, Anna Giczewska, Adam P. Silverstein, Hussein R. Al-Khalidi, Yong-Mei Cha, Kristi H. Monahan, et al. “Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results From the CABANA Trial.” Circulation 143, no. 7 (February 16, 2021): 661–72. https://doi.org/10.1161/CIRCULATIONAHA.120.051558.

PMID
33499668
Full Text

Otto, Catherine M., Rick A. Nishimura, Robert O. Bonow, Blase A. Carabello, John P. Erwin, Federico Gentile, Hani Jneid, et al. “2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.” Circulation 143, no. 5 (February 2, 2021): e35–71. https://doi.org/10.1161/CIR.0000000000000932.

PMID
33332149
Full Text

Karády, Júlia, Thomas Mayrhofer, Alexander Ivanov, Borek Foldyna, Michael T. Lu, Maros Ferencik, Amit Pursnani, et al. “Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.” Jama Netw Open 3, no. 12 (December 1, 2020): e2028312. https://doi.org/10.1001/jamanetworkopen.2020.28312.

PMID
33315111
Full Text

Chew, Derek S., Zak Loring, Jatin Anand, Marat Fudim, Angela Lowenstern, Jennifer A. Rymer, Kristin E. D. Weimer, et al. “Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.” Circ Cardiovasc Qual Outcomes 13, no. 12 (December 2020): e007094. https://doi.org/10.1161/CIRCOUTCOMES.120.007094.

PMID
33280436
Full Text

Lewis, Eldrin F., Francisco Ujueta, Gervasio A. Lamas, Rhonda S. Roberts, Daniel B. Mark, Richard L. Nahin, Christine Goertz, Mario Stylianou, and Kerry L. Lee. “Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients.” Cardiovasc Revasc Med 21, no. 11 (November 2020): 1389–95. https://doi.org/10.1016/j.carrev.2020.04.005.

PMID
32303436
Full Text

Escolar, Esteban, Francisco Ujueta, Hwasoon Kim, Daniel B. Mark, Robin Boineau, Richard L. Nahin, Christine Goertz, Kerry L. Lee, Kevin J. Anstrom, and Gervasio A. Lamas. “Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT).” J Diabetes Complications 34, no. 8 (August 2020): 107616. https://doi.org/10.1016/j.jdiacomp.2020.107616.

PMID
32446881
Full Text

Poole, Jeanne E., Brian Olshansky, Daniel B. Mark, Jill Anderson, George Johnson, Anne S. Hellkamp, Linda Davidson-Ray, et al. “Long-Term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT.” J Am Coll Cardiol 76, no. 4 (July 28, 2020): 405–15. https://doi.org/10.1016/j.jacc.2020.05.061.

PMID
32703511
Full Text

Fiuzat, Mona, Justin Ezekowitz, Wendimagegn Alemayehu, Cynthia M. Westerhout, Marco Sbolli, Dario Cani, David J. Whellan, et al. “Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 5, no. 7 (July 1, 2020): 757–64. https://doi.org/10.1001/jamacardio.2020.0640.

PMID
32319999
Full Text

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