Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Heidenreich, P. A., B. Bozkurt, D. Aguilar, L. A. Allen, J. J. Byun, M. M. Colvin, A. Deswal, et al. “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.” Journal of Cardiac Failure 28, no. 5 (May 1, 2022): e1–167. https://doi.org/10.1016/j.cardfail.2022.02.010.

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Mark, Daniel B., John A. Spertus, Robert Bigelow, Sophia Anderson, Melanie R. Daniels, Kevin J. Anstrom, Khaula N. Baloch, et al. “Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA.” Circulation 145, no. 17 (April 26, 2022): 1294–1307. https://doi.org/10.1161/CIRCULATIONAHA.121.057363.

PMID
35259918
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Bahnson, Tristram D., Anna Giczewska, Daniel B. Mark, Andrea M. Russo, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, et al. “Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial.” Circulation 145, no. 11 (March 15, 2022): 796–804. https://doi.org/10.1161/CIRCULATIONAHA.121.055297.

PMID
34933570
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Chew, Derek S., Patricia A. Cowper, Hussein Al-Khalidi, Kevin J. Anstrom, Melanie R. Daniels, Linda Davidson-Ray, Yanhong Li, et al. “Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial.” Circulation 145, no. 11 (March 15, 2022): 819–28. https://doi.org/10.1161/CIRCULATIONAHA.121.056276.

PMID
35044802
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Zhang, Lili, Devvora Olalere, Thomas Mayrhofer, Daniel O. Bittner, Hamed Emami, Nina M. Meyersohn, Stefan B. Puchner, et al. “Differences in Cardiovascular Risk, Coronary Artery Disease, and Cardiac Events Between Black and White Individuals Enrolled in the PROMISE Trial.” Jama Cardiol 7, no. 3 (March 1, 2022): 259–67. https://doi.org/10.1001/jamacardio.2021.5340.

PMID
34935857
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Nanna, Michael G., Sreekanth Vemulapalli, Christopher B. Fordyce, Daniel B. Mark, Manesh R. Patel, Hussein R. Al-Khalidi, Michelle Kelsey, et al. “The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.” Am Heart J 245 (March 2022): 136–48. https://doi.org/10.1016/j.ahj.2021.12.004.

PMID
34953768
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Granger, Bradi B., James A. Tulsky, Brystana G. Kaufman, Robert M. Clare, Kevin Anstrom, Daniel B. Mark, Kimberly A. Johnson, et al. “Polypharmacy in Palliative Care for Advanced Heart Failure: The PAL-HF Experience.” J Card Fail 28, no. 2 (February 2022): 334–38. https://doi.org/10.1016/j.cardfail.2021.08.021.

PMID
34628013
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Ezekowitz, Justin A., Wendimagegn Alemayehu, Sarah Rathwell, Andrew D. Grant, Mona Fiuzat, David J. Whellan, Tariq Ahmad, et al. “The influence of comorbidities on achieving an N-terminal pro-b-type natriuretic peptide target: a secondary analysis of the GUIDE-IT trial.” Esc Heart Fail 9, no. 1 (February 2022): 77–86. https://doi.org/10.1002/ehf2.13692.

PMID
34784657
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Chew, Derek S., Zhen Li, Benjamin A. Steinberg, Emily O’Brien, Jessica Pritchard, T Jared Bunch, Daniel B. Mark, et al. “Association between economic and arrhythmic burden of paroxysmal atrial fibrillation in patients with cardiac implanted electronic devices.” Am Heart J 244 (February 2022): 116–24. https://doi.org/10.1016/j.ahj.2021.11.006.

PMID
34800369
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Tobin, Rachel S., Marc D. Samsky, Maragatha Kuchibhatla, Christopher M. O’Connor, Mona Fiuzat, Haider J. Warraich, Kevin J. Anstrom, et al. “Race Differences in Quality of Life following a Palliative Care Intervention in Patients with Advanced Heart Failure: Insights from the Palliative Care in Heart Failure Trial.” J Palliat Med 25, no. 2 (February 2022): 296–300. https://doi.org/10.1089/jpm.2021.0220.

PMID
34851740
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