Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Fanaroff, Alexander C., Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B. Mark, Redford B. Williams, et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris..” Am J Cardiol 123, no. 9 (May 1, 2019): 1399–1405. https://doi.org/10.1016/j.amjcard.2019.01.036.

PMID
30771861
Full Text

Cowper, Patricia A., J David Knight, Linda Davidson-Ray, Eric D. Peterson, Tracy Y. Wang, Daniel B. Mark, and Daniel B. TRANSLATE‐ACS Investigators. “Acute and 1-Year Hospitalization Costs for Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention: Results From the TRANSLATE-ACS Registry..” J Am Heart Assoc 8, no. 8 (April 16, 2019). https://doi.org/10.1161/JAHA.118.011322.

PMID
30975005
Full Text

O’Connor, Christopher, Mona Fiuzat, Hillary Mulder, Adrian Coles, Tariq Ahmad, Justin A. Ezekowitz, Kirkwood F. Adams, et al. “Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score..” European Journal of Heart Failure, March 27, 2019. https://doi.org/10.1002/ejhf.1450.

PMID
30919549
Full Text

Litwin, Sheldon E., Adrian Coles, Neha Pagidipati, Kerry L. Lee, Patricia A. Pellikka, Daniel B. Mark, James E. Udelson, Udo Hoffmann, Pamela S. Douglas, and Pamela S. PROMISE Investigators. “Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial..” Journal of Cardiovascular Computed Tomography, March 27, 2019. https://doi.org/10.1016/j.jcct.2019.03.010.

PMID
30954400
Full Text

Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Peter A. Noseworthy, et al. “Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial..” Jama, March 15, 2019. https://doi.org/10.1001/jama.2019.0693.

PMID
30874766
Full Text

Mark, Daniel B., Kevin J. Anstrom, Shubin Sheng, Jonathan P. Piccini, Khaula N. Baloch, Kristi H. Monahan, Melanie R. Daniels, et al. “Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial..” Jama, March 15, 2019. https://doi.org/10.1001/jama.2019.0692.

PMID
30874716
Full Text

Sharma, Abhinav, Adrian Coles, Nishant K. Sekaran, Neha J. Pagidipati, Michael T. Lu, Daniel B. Mark, Kerry L. Lee, Hussein R. Al-Khalidi, Udo Hoffmann, and Pamela S. Douglas. “Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease..” Journal of the American College of Cardiology 73, no. 8 (March 2019): 893–902. https://doi.org/10.1016/j.jacc.2018.11.056.

PMID
30819356
Full Text

Hochman, Judith S., Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, Karen P. Alexander, Roxy Senior, William E. Boden, et al. “Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial..” Jama Cardiology, February 27, 2019. https://doi.org/10.1001/jamacardio.2019.0014.

PMID
30810700
Full Text

Pagidipati, Neha J., Adrian Coles, Kshipra Hemal, Kerry L. Lee, Rowena J. Dolor, Patricia A. Pellikka, Daniel B. Mark, et al. “Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial..” American Heart Journal 208 (February 2019): 28–36. https://doi.org/10.1016/j.ahj.2018.11.002.

PMID
30529930
Full Text

Daubert, Melissa A., Kirkwood Adams, Eric Yow, Huiman X. Barnhart, Pamela S. Douglas, Susan Rimmer, Casey Norris, et al. “NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF..” Jacc. Heart Failure 7, no. 2 (February 2019): 158–68. https://doi.org/10.1016/j.jchf.2018.10.014.

PMID
30611722
Full Text

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