Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Januzzi, James L., Tariq Ahmad, Hillary Mulder, Adrian Coles, Kevin J. Anstrom, Kirkwood F. Adams, Justin A. Ezekowitz, et al. “Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction..” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1205–17. https://doi.org/10.1016/j.jacc.2019.06.055.

PMID
31466618
Full Text

Warraich, Haider J., Christopher M. O’Connor, Hongqiu Yang, Bradi B. Granger, Kimberly S. Johnson, Daniel B. Mark, Kevin J. Anstrom, et al. “African Americans With Advanced Heart Failure Are More Likely to Die in a Health Care Facility Than at Home or in Hospice: An Analysis From the PAL-HF Trial..” J Card Fail 25, no. 8 (August 2019): 693–94. https://doi.org/10.1016/j.cardfail.2019.05.013.

PMID
31158470
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Ujueta, Francisco, Ivan A. Arenas, Esteban Escolar, Denisse Diaz, Robin Boineau, Daniel B. Mark, Patrick Golden, et al. “The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT)..” J Diabetes Complications 33, no. 7 (July 2019): 490–94. https://doi.org/10.1016/j.jdiacomp.2019.04.005.

PMID
31101487
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Diepen, Sean van, Rajendra H. Mehta, Jeffrey D. Leimberger, Shaun G. Goodman, Stephen Fremes, Rachael Jankowich, Matthias Heringlake, et al. “Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery..” J Thorac Cardiovasc Surg, June 21, 2019. https://doi.org/10.1016/j.jtcvs.2019.06.020.

PMID
31358329
Full Text

O’Connor, Christopher, Mona Fiuzat, Hillary Mulder, Adrian Coles, Tariq Ahmad, Justin A. Ezekowitz, Kirkwood F. Adams, et al. “Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score..” Eur J Heart Fail 21, no. 6 (June 2019): 770–78. https://doi.org/10.1002/ejhf.1450.

PMID
30919549
Full Text

Fanaroff, Alexander C., Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B. Mark, Redford B. Williams, et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris..” Am J Cardiol 123, no. 9 (May 1, 2019): 1399–1405. https://doi.org/10.1016/j.amjcard.2019.01.036.

PMID
30771861
Full Text

Steinberg, Benjamin A., Paul Dorian, Kevin J. Anstrom, Rachel Hess, Daniel B. Mark, Peter A. Noseworthy, John A. Spertus, and Jonathan P. Piccini. “Patient-Reported Outcomes in Atrial Fibrillation Research: Results of a Clinicaltrials.gov Analysis..” Jacc Clin Electrophysiol 5, no. 5 (May 2019): 599–605. https://doi.org/10.1016/j.jacep.2019.03.008.

PMID
31122382
Full Text

Cowper, Patricia A., J David Knight, Linda Davidson-Ray, Eric D. Peterson, Tracy Y. Wang, Daniel B. Mark, and Daniel B. TRANSLATE‐ACS Investigators. “Acute and 1-Year Hospitalization Costs for Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention: Results From the TRANSLATE-ACS Registry..” J Am Heart Assoc 8, no. 8 (April 16, 2019). https://doi.org/10.1161/JAHA.118.011322.

PMID
30975005
Full Text

Mark, Daniel B., Kevin J. Anstrom, Shubin Sheng, Jonathan P. Piccini, Khaula N. Baloch, Kristi H. Monahan, Melanie R. Daniels, et al. “Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial..” Jama 321, no. 13 (April 2, 2019): 1275–85. https://doi.org/10.1001/jama.2019.0692.

PMID
30874716
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Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Peter A. Noseworthy, et al. “Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial..” Jama 321, no. 13 (April 2, 2019): 1261–74. https://doi.org/10.1001/jama.2019.0693.

PMID
30874766
Full Text

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