Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Writing Committee Members, Y Joseph, Catherine M. Otto, Rick A. Nishimura, Robert O. Bonow, Blase A. Carabello, John P. Erwin, Federico Gentile, et al. “2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.” J Thorac Cardiovasc Surg 162, no. 2 (August 2021): e183–353. https://doi.org/10.1016/j.jtcvs.2021.04.002.

PMID
33972115
Full Text

Thomas, Kevin L., Hussein R. Al-Khalidi, Adam P. Silverstein, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Daniel B. Mark, Douglas L. Packer, and Douglas L. CABANA Investigators. “Ablation Versus Drug Therapy for Atrial Fibrillation in Racial and Ethnic Minorities.” J Am Coll Cardiol 78, no. 2 (July 13, 2021): 126–38. https://doi.org/10.1016/j.jacc.2021.04.092.

PMID
34238436
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Writing Committee Members, Y Joseph, Steve R. Ommen, Seema Mital, Michael A. Burke, Sharlene M. Day, Anita Deswal, Perry Elliott, et al. “2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.” J Thorac Cardiovasc Surg 162, no. 1 (July 2021): e23–106. https://doi.org/10.1016/j.jtcvs.2021.04.001.

PMID
33926766
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Kaufman, Brystana G., Bradi B. Granger, Jie-Lena Sun, Gillian Sanders, Donald H. Taylor, Daniel B. Mark, Haider Warraich, et al. “The Cost-Effectiveness of Palliative Care: Insights from the PAL-HF Trial.” J Card Fail 27, no. 6 (June 2021): 662–69. https://doi.org/10.1016/j.cardfail.2021.02.019.

PMID
33731305
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Steinberg, Benjamin A., Zhen Li, Emily C. O’Brien, Jessica Pritchard, Derek S. Chew, T Jared Bunch, Daniel B. Mark, Yelena Nabutovsky, Melissa A. Greiner, and Jonathan P. Piccini. “Atrial fibrillation burden and heart failure: Data from 39,710 individuals with cardiac implanted electronic devices.” Heart Rhythm 18, no. 5 (May 2021): 709–16. https://doi.org/10.1016/j.hrthm.2021.01.021.

PMID
33508517
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Rettmann, Maryam E., David R. Holmes, Kristi H. Monahan, Jerome F. Breen, Tristram D. Bahnson, Daniel B. Mark, Jeanne E. Poole, et al. “Treatment-Related Changes in Left Atrial Structure in Atrial Fibrillation: Findings From the CABANA Imaging Substudy.” Circ Arrhythm Electrophysiol 14, no. 5 (May 2021): e008540. https://doi.org/10.1161/CIRCEP.120.008540.

PMID
33848199
Full Text

Packer, Douglas L., Jonathan P. Piccini, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, Peter A. Noseworthy, Jeanne E. Poole, et al. “Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.” Circulation 143, no. 14 (April 6, 2021): 1377–90. https://doi.org/10.1161/CIRCULATIONAHA.120.050991.

PMID
33554614
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Wan, Luxi, Marc D. Samsky, Christopher M. O’Connor, Amanda Stebbins, Brooke Alhanti, Haider J. Warraich, Kimberly S. Johnson, et al. “Patterns of Change in Individual Domains of the Kansas City Cardiomyopathy Questionnaire With a Palliative Care Intervention for Patients With Advanced Heart Failure: Insights from PAL-HF.” J Card Fail, February 26, 2021. https://doi.org/10.1016/j.cardfail.2021.02.007.

PMID
33647475
Full Text

Russo, Andrea M., Emily P. Zeitler, Anna Giczewska, Adam P. Silverstein, Hussein R. Al-Khalidi, Yong-Mei Cha, Kristi H. Monahan, et al. “Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results From the CABANA Trial.” Circulation 143, no. 7 (February 16, 2021): 661–72. https://doi.org/10.1161/CIRCULATIONAHA.120.051558.

PMID
33499668
Full Text

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