Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Escolar, Esteban, Francisco Ujueta, Hwasoon Kim, Daniel B. Mark, Robin Boineau, Richard L. Nahin, Christine Goertz, Kerry L. Lee, Kevin J. Anstrom, and Gervasio A. Lamas. “Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT).” J Diabetes Complications 34, no. 8 (August 2020): 107616. https://doi.org/10.1016/j.jdiacomp.2020.107616.

PMID
32446881
Full Text

Poole, Jeanne E., Brian Olshansky, Daniel B. Mark, Jill Anderson, George Johnson, Anne S. Hellkamp, Linda Davidson-Ray, et al. “Long-Term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT.” J Am Coll Cardiol 76, no. 4 (July 28, 2020): 405–15. https://doi.org/10.1016/j.jacc.2020.05.061.

PMID
32703511
Full Text

Fiuzat, Mona, Justin Ezekowitz, Wendimagegn Alemayehu, Cynthia M. Westerhout, Marco Sbolli, Dario Cani, David J. Whellan, et al. “Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 5, no. 7 (July 1, 2020): 757–64. https://doi.org/10.1001/jamacardio.2020.0640.

PMID
32319999
Full Text

Chew, Derek S., Elissa Rennert-May, Eldon Spackman, Daniel B. Mark, and Derek V. Exner. “Cost-Effectiveness of Extended Electrocardiogram Monitoring for Atrial Fibrillation After Stroke: A Systematic Review.” Stroke 51, no. 7 (July 2020): 2244–48. https://doi.org/10.1161/STROKEAHA.120.029340.

PMID
32498661
Full Text

Poole, Jeanne E., Tristram D. Bahnson, Kristi H. Monahan, George Johnson, Hoss Rostami, Adam P. Silverstein, Hussein R. Al-Khalidi, et al. “Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial.” J Am Coll Cardiol 75, no. 25 (June 30, 2020): 3105–18. https://doi.org/10.1016/j.jacc.2020.04.065.

PMID
32586583
Full Text

Diepen, Sean van, Rajendra H. Mehta, Jeffrey D. Leimberger, Shaun G. Goodman, Stephen Fremes, Rachael Jankowich, Matthias Heringlake, et al. “Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery.” J Thorac Cardiovasc Surg 159, no. 6 (June 2020): 2302-2309.e6. https://doi.org/10.1016/j.jtcvs.2019.06.020.

PMID
31358329
Full Text

Spertus, John A., Philip G. Jones, David J. Maron, Daniel B. Mark, Sean M. O’Brien, Jerome L. Fleg, Harmony R. Reynolds, et al. “Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.” N Engl J Med 382, no. 17 (April 23, 2020): 1619–28. https://doi.org/10.1056/NEJMoa1916374.

PMID
32227754
Full Text

Spertus, John A., Philip G. Jones, David J. Maron, Sean M. O’Brien, Harmony R. Reynolds, Yves Rosenberg, Gregg W. Stone, et al. “Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1408–19. https://doi.org/10.1056/NEJMoa1916370.

PMID
32227753
Full Text

Maron, David J., Judith S. Hochman, Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, William E. Boden, Bernard R. Chaitman, et al. “Initial Invasive or Conservative Strategy for Stable Coronary Disease.” N Engl J Med 382, no. 15 (April 9, 2020): 1395–1407. https://doi.org/10.1056/NEJMoa1915922.

PMID
32227755
Full Text

Goyal, Akash, Neha Pagidipati, C Larry Hill, Brooke Alhanti, James E. Udelson, Michael H. Picard, Patricia A. Pellikka, Udo Hoffmann, Daniel B. Mark, and Pamela S. Douglas. “Clinical and Economic Implications of Inconclusive Noninvasive Test Results in Stable Patients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.” Circulation. Cardiovascular Imaging 13, no. 4 (April 9, 2020): e009986. https://doi.org/10.1161/circimaging.119.009986.

PMID
32268807
Full Text

Pages