Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Sharma, A, Coles, A, Sekaran, NK, Pagidipati, NJ, Lu, MT, Mark, DB, Lee, KL, Al-Khalidi, HR, Hoffmann, U, and Douglas, PS. "Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease." Journal of the American College of Cardiology 73, no. 8 (March 2019): 893-902.

PMID
30819356
Full Text

Hochman, JS, Reynolds, HR, Bangalore, S, O'Brien, SM, Alexander, KP, Senior, R, Boden, WE, Stone, GW, Goodman, SG, Lopes, RD, Lopez-Sendon, J, White, HD, Maggioni, AP, Shaw, LJ, Min, JK, Picard, MH, Berman, DS, Chaitman, BR, Mark, DB, Spertus, JA, Cyr, DD, Bhargava, B, Ruzyllo, W, Wander, GS, Chernyavskiy, AM, Rosenberg, YD, Maron, DJ, and ISCHEMIA Research Group, . "Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial." Jama Cardiology (February 27, 2019).

PMID
30810700
Full Text

Fanaroff, AC, Prather, K, Brucker, A, Wojdyla, D, Davidson-Ray, L, Mark, DB, Williams, RB, Barefoot, J, Weisz, G, Ben-Yehuda, O, Stone, GW, Ohman, EM, and Alexander, KP. "Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris." The American Journal of Cardiology (February 7, 2019).

PMID
30771861
Full Text

Pagidipati, NJ, Coles, A, Hemal, K, Lee, KL, Dolor, RJ, Pellikka, PA, Mark, DB, Patel, MR, Litwin, SE, Daubert, MA, Shah, SH, Hoffmann, U, Douglas, PS, and PROMISE Investigators, . "Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial." American Heart Journal 208 (February 2019): 28-36.

PMID
30529930
Full Text

Daubert, MA, Adams, K, Yow, E, Barnhart, HX, Douglas, PS, Rimmer, S, Norris, C, Cooper, L, Leifer, E, Desvigne-Nickens, P, Anstrom, K, Fiuzat, M, Ezekowitz, J, Mark, DB, O'Connor, CM, Januzzi, J, and Felker, GM. "NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF." Jacc. Heart Failure 7, no. 2 (February 2019): 158-168.

PMID
30611722
Full Text

Jang, JJ, Bhapkar, M, Coles, A, Vemulapalli, S, Fordyce, CB, Lee, KL, Udelson, JE, Hoffmann, U, Tardif, J-C, Jones, WS, Mark, DB, Sorrell, VL, Espinoza, A, Douglas, PS, Patel, MR, and PROMISE Investigators, . "Predictive Model for High-Risk Coronary Artery Disease." Circulation. Cardiovascular Imaging 12, no. 2 (February 2019): e007940-null.

PMID
30712364
Full Text

Mark, DB, Cowper, PA, Anstrom, KJ, Sheng, S, Daniels, MR, Knight, JD, Baloch, KN, Davidson-Ray, L, Fiuzat, M, Januzzi, JL, Whellan, DJ, Piña, IL, Ezekowitz, JA, Adams, KF, Cooper, LS, O'Connor, CM, and Felker, GM. "Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure." Journal of the American College of Cardiology 72, no. 21 (November 2018): 2551-2562.

PMID
30466512
Full Text

Mentz, RJ, O'Connor, CM, Granger, BB, Yang, H, Patel, CB, Steinhauser, KE, Fiuzat, M, Johnson, KS, Anstrom, KJ, Dodson, GC, Taylor, DH, Mark, DB, Tulsky, JA, and Rogers, JG. "Palliative care and hospital readmissions in patients with advanced heart failure: Insights from the PAL-HF trial." October 2018.

PMID
30100051
Full Text

Samad, Z, Shaw, LK, Phelan, M, Glower, DD, Ersboll, M, Toptine, JH, Alexander, JH, Kisslo, JA, Wang, A, Mark, DB, and Velazquez, EJ. "Long-term outcomes of mitral regurgitation by type and severity." American Heart Journal 203 (September 2018): 39-48.

PMID
30015067
Full Text

Levy, WC, Hellkamp, AS, Mark, DB, Poole, JE, Shadman, R, Dardas, TF, Anderson, J, Johnson, G, Fishbein, DP, Lee, KL, Linker, DT, and Bardy, GH. "Improving the Use of Primary Prevention Implantable Cardioverter-Defibrillators Therapy With Validated Patient-Centric Risk Estimates." Jacc. Clinical Electrophysiology 4, no. 8 (August 2018): 1089-1102.

PMID
30139491
Full Text

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