Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Levy, WC, Hellkamp, AS, Mark, DB, Poole, JE, Shadman, R, Dardas, TF, Anderson, J, Johnson, G, Fishbein, DP, Lee, KL, Linker, DT, and Bardy, GH. "Improving the Use of Primary Prevention Implantable Cardioverter-Defibrillators Therapy With Validated Patient-Centric Risk Estimates." Jacc. Clinical Electrophysiology 4, no. 8 (August 2018): 1089-1102.

PMID
30139491
Full Text

Bangalore, S, Maron, DJ, Fleg, JL, O'Brien, SM, Herzog, CA, Stone, GW, Mark, DB, Spertus, JA, Alexander, KP, Sidhu, MS, Chertow, GM, Boden, WE, Hochman, JS, and ISCHEMIA-CKD Research Group, . "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design." American Heart Journal 205 (August 2018): 42-52.

PMID
30172098
Full Text

ISCHEMIA Trial Research Group, , Maron, DJ, Hochman, JS, O'Brien, SM, Reynolds, HR, Boden, WE, Stone, GW, Bangalore, S, Spertus, JA, Mark, DB, Alexander, KP, Shaw, L, Berger, JS, Ferguson, TB, Williams, DO, Harrington, RA, and Rosenberg, Y. "International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design." American Heart Journal 201 (July 2018): 124-135.

PMID
29778671
Full Text

Aronson, S. "In Response." Anesthesia and Analgesia 127, no. 1 (July 2018): 317-318.

PMID
29734242
Full Text

Sharma, A, Al-Khatib, SM, Ezekowitz, JA, Cooper, LB, Fordyce, CB, Michael Felker, G, Bardy, GH, Poole, JE, Thomas Bigger, J, Buxton, AE, Moss, AJ, Friedman, DJ, Lee, KL, Steinman, R, Dorian, P, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Peterson, ED, Inoue, LYT, and Sanders, GD. "Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes." European Journal of Heart Failure 20, no. 6 (June 2018): 1031-1038.

PMID
29761861
Full Text

Samad, Z, Shaw, LK, Phelan, M, Glower, DD, Ersboll, M, Toptine, JH, Alexander, JH, Kisslo, JA, Wang, A, Mark, DB, and Velazquez, EJ. "Long-term outcomes of mitral regurgitation by type and severity." American Heart Journal 203 (May 18, 2018): 39-48.

PMID
30015067
Full Text

Packer, DL, Mark, DB, Robb, RA, Monahan, KH, Bahnson, TD, Moretz, K, Poole, JE, Mascette, A, Rosenberg, Y, Jeffries, N, Al-Khalidi, HR, Lee, KL, and CABANA Investigators, . "Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design." American Heart Journal 199 (May 2018): 192-199.

PMID
29754661
Full Text

Katritsis, DG, Mark, DB, and Gersh, BJ. "Revascularization in stable coronary disease: evidence and uncertainties." Nature Reviews. Cardiology (April 13, 2018). (Review)

PMID
29654257
Full Text

Genders, TSS, Coles, A, Hoffmann, U, Patel, MR, Mark, DB, Lee, KL, Steyerberg, EW, Hunink, MGM, Douglas, PS, and CAD Consortium and the PROMISE Investigators, . "The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial." Jacc. Cardiovascular Imaging 11, no. 3 (March 2018): 437-446.

PMID
28624401
Full Text

da Silva, KR, Costa, R, Rodrigues, CG, Schasechter, A, Nobre, MC, Passman, R, and Mark, DB. "Quality of life in patients with implantable cardioverter-defibrillator: systematic review of randomized controlled trials." European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 17, no. 3 (March 2018): 196-206.

PMID
29067836
Full Text

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