Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Genders, TSS, Coles, A, Hoffmann, U, Patel, MR, Mark, DB, Lee, KL, Steyerberg, EW, Hunink, MGM, Douglas, PS, and CAD Consortium and the PROMISE Investigators, . "The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial." JACC. Cardiovascular imaging 11, no. 3 (March 2018): 437-446.

PMID
28624401
Full Text

Issa, OM, Roberts, R, Mark, DB, Boineau, R, Goertz, C, Rosenberg, Y, Lewis, EF, Guarneri, E, Drisko, J, Magaziner, A, Lee, KL, and Lamas, GA. "Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)." American heart journal 195 (January 2018): 70-77.

PMID
29224648
Full Text

Sze, E, Dunning, A, Loring, Z, Atwater, BD, Chiswell, K, Daubert, JP, Kisslo, JA, Mark, DB, Velazquez, EJ, and Samad, Z. "Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration." The American journal of cardiology 120, no. 11 (December 2017): 1990-1997.

PMID
28958452
Full Text

Mark, DB, and Patel, MR. "Patient-Reported Outcomes in Revascularization Decisions for Left-Main Disease: Sharing the EXCELlence." Journal of the American College of Cardiology 70, no. 25 (December 2017): 3123-3126.

PMID
29097295
Full Text

Lu, MT, Ferencik, M, Roberts, RS, Lee, KL, Ivanov, A, Adami, E, Mark, DB, Jaffer, FA, Leipsic, JA, Douglas, PS, and Hoffmann, U. "Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial." JACC. Cardiovascular imaging 10, no. 11 (November 2017): 1350-1358.

PMID
28412436
Full Text

Zeitler, EP, Al-Khatib, SM, Friedman, DJ, Han, JY, Poole, JE, Bardy, GH, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Dorian, P, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Inoue, LYT, and Sanders, GD. "Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II." November 2017.

PMID
28744959
Full Text

Sharma, A, Sekaran, NK, Coles, A, Pagidipati, NJ, Hoffmann, U, Mark, DB, Lee, KL, Al-Khalidi, HR, Lu, MT, Pellikka, PA, Trong, QA, and Douglas, PS. "Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial." Journal of the American Heart Association 6, no. 11 (October 31, 2017).

PMID
29089344
Full Text

Ladapo, JA, Coles, A, Dolor, RJ, Mark, DB, Cooper, L, Lee, KL, Goldberg, J, Shapiro, MD, Hoffmann, U, and Douglas, PS. "Quantifying sociodemographic and income disparities in medical therapy and lifestyle among symptomatic patients with suspected coronary artery disease: a cross-sectional study in North America." BMJ open 7, no. 9 (September 29, 2017): e016364-.

PMID
28965093
Full Text

Friedman, DJ, Al-Khatib, SM, Zeitler, EP, Han, J, Bardy, GH, Poole, JE, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Steinman, R, Dorian, P, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Inoue, LYT, and Sanders, GD. "New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials." September 2017.

PMID
28888266
Full Text

Lu, MT, Douglas, PS, Udelson, JE, Adami, E, Ghoshhajra, BB, Picard, MH, Roberts, R, Lee, KL, Einstein, AJ, Mark, DB, Velazquez, EJ, Carter, W, Ridner, M, Al-Khalidi, HR, and Hoffmann, U. "Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose." Journal of cardiovascular computed tomography 11, no. 5 (September 2017): 373-382.

PMID
28838846
Full Text

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