Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Lewis, Eldrin F., Francisco Ujueta, Gervasio A. Lamas, Rhonda S. Roberts, Daniel B. Mark, Richard L. Nahin, Christine Goertz, Mario Stylianou, and Kerry L. Lee. “Differential outcomes with edetate disodium-based treatment among stable post anterior vs. non-anterior myocardial infarction patients.” Cardiovasc Revasc Med, April 7, 2020. https://doi.org/10.1016/j.carrev.2020.04.005.

PMID
32303436
Full Text

Chew, Derek S., Eric Black-Maier, Zak Loring, Peter A. Noseworthy, Douglas L. Packer, Derek V. Exner, Daniel B. Mark, and Jonathan P. Piccini. “Diagnosis-to-Ablation Time and Recurrence of Atrial Fibrillation Following Catheter Ablation: A Systematic Review and Meta-Analysis of Observational Studies.” Circ Arrhythm Electrophysiol 13, no. 4 (April 2020): e008128. https://doi.org/10.1161/CIRCEP.119.008128.

PMID
32191539
Full Text

Goyal, Akash, Neha Pagidipati, C Larry Hill, Brooke Alhanti, James E. Udelson, Michael H. Picard, Patricia A. Pellikka, Udo Hoffmann, Daniel B. Mark, and Pamela S. Douglas. “Clinical and Economic Implications of Inconclusive Noninvasive Test Results in Stable Patients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.” Circ Cardiovasc Imaging 13, no. 4 (April 2020): e009986. https://doi.org/10.1161/CIRCIMAGING.119.009986.

PMID
32268807
Full Text

Litwin, Sheldon E., Adrian Coles, C Larry Hill, Brooke Alhanti, Neha Pagidipati, Kerry L. Lee, Patricia A. Pellikka, et al. “Discordances between predicted and actual risk in obese patients with suspected cardiac ischaemia.” Heart 106, no. 4 (February 2020): 273–79. https://doi.org/10.1136/heartjnl-2018-314503.

PMID
31601728
Full Text

Bonow, Robert O., Daniel B. Mark, and Patrick T. O’Gara. “Coapting Cost and Clinical Outcomes in Transcatheter Intervention for Secondary Mitral Regurgitation.” Circulation 140, no. 23 (December 3, 2019): 1892–94. https://doi.org/10.1161/CIRCULATIONAHA.119.043408.

PMID
31564139
Full Text

Packer, Douglas L., Daniel B. Mark, and Kerry L. Lee. “Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation-Reply.” Jama 322, no. 11 (September 17, 2019): 1106. https://doi.org/10.1001/jama.2019.10688.

PMID
31529005
Full Text

Januzzi, James L., Tariq Ahmad, Hillary Mulder, Adrian Coles, Kevin J. Anstrom, Kirkwood F. Adams, Justin A. Ezekowitz, et al. “Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction.” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1205–17. https://doi.org/10.1016/j.jacc.2019.06.055.

PMID
31466618
Full Text

Panza, Julio A., Alicia M. Ellis, Hussein R. Al-Khalidi, Thomas A. Holly, Daniel S. Berman, Jae K. Oh, Gerald M. Pohost, et al. “Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy.” N Engl J Med 381, no. 8 (August 22, 2019): 739–48. https://doi.org/10.1056/NEJMoa1807365.

PMID
31433921
Full Text

Warraich, Haider J., Christopher M. O’Connor, Hongqiu Yang, Bradi B. Granger, Kimberly S. Johnson, Daniel B. Mark, Kevin J. Anstrom, et al. “African Americans With Advanced Heart Failure Are More Likely to Die in a Health Care Facility Than at Home or in Hospice: An Analysis From the PAL-HF Trial.” J Card Fail 25, no. 8 (August 2019): 693–94. https://doi.org/10.1016/j.cardfail.2019.05.013.

PMID
31158470
Full Text

Pages