Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Al-Khatib, SM, Daubert, JP, Anstrom, KJ, Daoud, EG, Gonzalez, M, Saba, S, Jackson, KP, Reece, T, Gu, J, Pokorney, SD, Granger, CB, Hess, PL, Mark, DB, and Stevenson, WG. "Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial." Journal of cardiovascular electrophysiology 26, no. 2 (February 2015): 151-157.

PMID
25332150
Full Text

Zeitler, EP, Hellkamp, AS, Fonarow, GC, Hammill, SC, Curtis, LH, Hernandez, AF, Al-Khalidi, HR, Curtis, JP, Heidenreich, PA, Anstrom, KJ, Peterson, ED, Mark, DB, Hammill, BG, Sanders, GD, and Al-Khatib, SM. "Primary prevention implantable cardioverter-defibrillators and survival in older women." JACC. Heart failure 3, no. 2 (February 2015): 159-167.

PMID
25543969
Full Text

Cowper, PA, Pan, W, Anstrom, KJ, Kaul, P, Wallentin, L, Davidson-Ray, L, Nikolic, E, Janzon, M, Levin, L-Å, Cannon, CP, Harrington, RA, and Mark, DB. "Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study." Journal of the American College of Cardiology 65, no. 5 (February 2015): 465-476.

PMID
25660925
Full Text

Al-Khatib, SM, Daubert, JP, Anstrom, KJ, Daoud, EG, Gonzalez, M, Saba, S, Jackson, KP, Reece, T, Gu, J, Pokorney, SD, Granger, CB, Hess, PL, Mark, DB, and Stevenson, WG. "Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial." Journal of Cardiovascular Electrophysiology 26, no. 2 (January 1, 2015): 151-157.

Full Text

Steinberg, BA, Al-Khatib, SM, Edwards, R, Han, J, Bardy, GH, Bigger, JT, Buxton, AE, Moss, AJ, Lee, KL, Steinman, R, Dorian, P, Hallstrom, A, Cappato, R, Kadish, AH, Kudenchuk, PJ, Mark, DB, Inoue, LYT, and Sanders, GD. "Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials." JACC. Heart failure 2, no. 6 (December 2014): 623-629.

PMID
25306452
Full Text

Cowper, PA, Sheng, S, Anstrom, KJ, Stafford, JA, Lopes, RD, Davidson-Ray, L, Wallentin, L, Phatak, HM, Ansell, J, Dorian, P, Husted, S, McMurray, JJ, Steg, PG, Alexander, JH, Granger, CB, and Mark, DB. "The Cost-Effectiveness of Apixaban versus Warfarin in Patients With Atrial Fibrillation: Insights From the ARISTOTLE Study Group." November 25, 2014.

Scholars@Duke

Patton, KK, Hellkamp, AS, Lee, KL, Mark, DB, Johnson, GW, Anderson, J, Bardy, GH, Poole, JE, and SCD-HeFT Investigators, . "Reply: circadian variations of ventricular arrhythmias and sleep-disordered breathing in HF patients." Journal of the American College of Cardiology 64, no. 18 (November 2014): 1968-1969. (Letter)

PMID
25444153
Full Text

Felker, GM, Ahmad, T, Anstrom, KJ, Adams, KF, Cooper, LS, Ezekowitz, JA, Fiuzat, M, Houston-Miller, N, Januzzi, JL, Leifer, ES, Mark, DB, Desvigne-Nickens, P, Paynter, G, Piña, IL, Whellan, DJ, and O'Connor, CM. "Rationale and design of the GUIDE-IT study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure." JACC. Heart failure 2, no. 5 (October 2014): 457-465.

PMID
25194287
Full Text

Mark, DB, Knight, JD, Velazquez, EJ, Wasilewski, J, Howlett, JG, Smith, PK, Spertus, JA, Rajda, M, Yadav, R, Hamman, BL, Malinowski, M, Naik, A, Rankin, G, Harding, TM, Drew, LA, Desvigne-Nickens, P, and Anstrom, KJ. "Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial." Annals of internal medicine 161, no. 6 (September 2014): 392-399.

PMID
25222386
Full Text

Stewart, RAH, Szalewska, D, She, L, Lee, KL, Drazner, MH, Lubiszewska, B, Kosevic, D, Ruengsakulrach, P, Nicolau, JC, Coutu, B, Choudhary, SK, Mark, DB, Cleland, JGF, Piña, IL, Velazquez, EJ, Rynkiewicz, A, and White, H. "Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass graft surgery or medical therapy: an analysis from the STICH trial (Surgical Treatment for Ischemic Heart Failure)." JACC. Heart failure 2, no. 4 (August 2014): 335-343.

PMID
25023813
Full Text

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