Daphne Ruth Friedman, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 508 Fulton Street (111g), Durham VA Medical Center, Durham, NC 27705
Phone (919) 286-6944
Email address daphne.friedman@duke.edu

My area of expertise is in leukemias and lymphomas, including Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. My research interests are focused on improving treatment options for patients with hematologic malignancies, through laboratory and clinical research.  I am also a staff physician at the Durham VA Medical Center, and am deeply committed to expanding treatment options for veterans, including working on clinical trials for multiple myeloma, prostate cancer, and lung cancer at the Durham VA.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 2005 - 2008
  • Medical Resident, Medicine, University of Maryland, College Park, 2002 - 2005
  • M.D., University of Maryland, College Park, 2002

Publications

Weinberg, J Brice, Danielle M. Brander, Dale J. Christensen, and Daphne R. Friedman. “Post-translational regulation could be determine functional differences between SET alpha and beta isoform - Response to Cristóbal et al..” Br J Haematol 186, no. 4 (August 2019). https://doi.org/10.1111/bjh.15934.

PMID
31044417
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Brander, Danielle M., Daphne R. Friedman, Alicia D. Volkheimer, Dale J. Christensen, Laura Z. Rassenti, Thomas J. Kipps, Eross Guadalupe, et al. “SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia..” British Journal of Haematology 184, no. 4 (February 2019): 605–15. https://doi.org/10.1111/bjh.15677.

PMID
30443898
Full Text

Friedman, Daphne R., Eross Guadalupe, Alicia Volkheimer, Joseph O. Moore, and J Brice Weinberg. “Clinical outcomes in chronic lymphocytic leukaemia associated with expression of CD5, a negative regulator of B-cell receptor signalling..” Br J Haematol 183, no. 5 (December 2018): 747–54. https://doi.org/10.1111/bjh.15632.

PMID
30407619
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Chanfreau, Catherine, Kristine E. Lynch, Ji Won Chang, Daniel J. Becker, Daphne R. Friedman, Donna R. Rivera, Scott L. DuVall, and Julie A. Lynch. “Chronic myeloid leukemia among veterans from 2006 to 2015: Trends in utilization of tyrosine kinase inhibitors.” In Pharmacoepidemiology and Drug Safety, 27:102–3. WILEY, 2018.

Scholars@Duke

Friedman, Daphne R., Eross Guadeloupe, Alicia Volkheimer, and J Brice Weinberg. “Surface CD5 Protein Risk Stratifies Chronic Lymphocytic Leukemia.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.

Scholars@Duke

Friedman, Daphne R., Alexander B. Sibley, Kouros Owzar, Kari G. Chaffee, Susan Slager, Neil E. Kay, Curtis A. Hanson, et al. “Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study..” Am J Hematol 91, no. 7 (July 2016): 687–91. https://doi.org/10.1002/ajh.24376.

PMID
27037726
Full Text

Holohan, Brody, Moriah M. Hagiopian, Tsung-Po Lai, Ejun Huang, Daphne R. Friedman, Woodring E. Wright, and Jerry W. Shay. “Perifosine as a potential novel anti-telomerase therapy..” Oncotarget 6, no. 26 (September 8, 2015): 21816–26. https://doi.org/10.18632/oncotarget.5200.

PMID
26307677
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Vakkalanka, Swaroop, Kumar V. Penmetsa, Dawn Chasse, Youwei Chen, Srikant Viswanadha, Daphne R. Friedman, and J Brice Weinberg. “Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro..” In Drug Discovery. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.hemmal14-a24.

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Friedman, Daphne Ruth, Tiffany Stewart, Eross Guadalupe, Danielle M. Brander, David S. Pisetsky, and J Brice Weinberg. “Pan-caspase peptide inhibitor to induce primary chronic lymphocytic leukemia (CLL) cell death through a non-apoptotic and non-necroptotic mechanism..” In Journal of Clinical Oncology, 33:e13536–e13536. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13536.

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