David Bruce Matchar, MD

Professor of Medicine
Director of the Center for Clinical Health Policy Research
Professor of Pathology
Affiliate, Duke Global Health Institute
Member in the Duke Clinical Research Institute
Campus mail Box 3230, DUMC, Durham, NC 27710
Email address david.matchar@duke-nus.edu.sg

My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Key Words: clinical policy, disease management, stroke, decision analysis, clinical guidelines

Education and Training

  • M.D., University of Maryland, College Park, 1980

Publications

Lim, KK, Yeo, W, Koh, JSB, Tan, CS, Chong, HC, Zhang, K, Østbye, T, Howe, TS, and Matchar, DB. "The Role of Prefracture Health Status in Physical and Mental Function After Hip Fracture Surgery." Journal of the American Medical Directors Association (July 23, 2018).

PMID
30049543
Full Text

Zhou, K, Vidyarthi, A, Matchar, D, Cheung, YB, Lam, SW, and Ong, M. "The relationship between workload and length of stay in Singapore." Health Policy 122, no. 7 (July 2018): 769-774.

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Malhotra, R, Chei, C-L, Menon, EB, Chow, W-L, Quah, S, Chan, A, Ajay, S, and Matchar, DB. "Trajectories of positive aspects of caregiving among family caregivers of stroke-survivors: the differential impact of stroke-survivor disability." Topics in Stroke Rehabilitation 25, no. 4 (May 2018): 261-268.

PMID
29577825
Full Text

Wong, TH, Nadkarni, NV, Nguyen, HV, Lim, GH, Matchar, DB, Seow, DCC, King, NKK, and Ong, MEH. "One-year and three-year mortality prediction in adult major blunt trauma survivors: a National Retrospective Cohort Analysis." Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 26, no. 1 (April 18, 2018): 28-null.

PMID
29669572
Full Text

Benjamin, EJ, Virani, SS, Callaway, CW, Chamberlain, AM, Chang, AR, Cheng, S, Chiuve, SE, Cushman, M, Delling, FN, Deo, R, de Ferranti, SD, Ferguson, JF, Fornage, M, Gillespie, C, Isasi, CR, Jiménez, MC, Jordan, LC, Judd, SE, Lackland, D, Lichtman, JH, Lisabeth, L, Liu, S, Longenecker, CT, Lutsey, PL, Mackey, JS, Matchar, DB, Matsushita, K, Mussolino, ME, Nasir, K, O'Flaherty, M, Palaniappan, LP, Pandey, A, Pandey, DK, Reeves, MJ, Ritchey, MD, Rodriguez, CJ, Roth, GA, Rosamond, WD, Sampson, UKA, Satou, GM, Shah, SH, Spartano, NL, Tirschwell, DL, Tsao, CW, Voeks, JH, Willey, JZ, Wilkins, JT, Wu, JH, Alger, HM, Wong, SS, Muntner, P, and American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, . "Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association." Circulation 137, no. 12 (March 2018): e67-e492. (Review)

PMID
29386200
Full Text

Ansah, JP, Koh, V, Bayer, S, Harper, P, and Matchar, D. "Healthcare human resource planning." In International Series in Operations Research and Management Science, 515-541. January 1, 2018.

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Chong, JL, and Matchar, DB. "Benefits of Population Segmentation Analysis for Developing Health Policy to Promote Patient-Centred Care." Annals of the Academy of Medicine, Singapore 46, no. 7 (July 2017): 287-289.

PMID
28821893
Scholars@Duke

Matchar, DB, Duncan, PW, Lien, CT, Ong, MEH, Lee, M, Gao, F, Sim, R, and Eom, K. "Randomized Controlled Trial of Screening, Risk Modification, and Physical Therapy to Prevent Falls Among the Elderly Recently Discharged From the Emergency Department to the Community: The Steps to Avoid Falls in the Elderly Study." Archives of physical medicine and rehabilitation 98, no. 6 (June 2017): 1086-1096.

PMID
28202383
Full Text

Ansah, JP, Koh, V, Chiu, C-T, Chei, C-L, Zeng, Y, Yin, Z-X, Shi, X-M, and Matchar, DB. "Projecting the Number of Elderly with Cognitive Impairment in China Using a Multi-State Dynamic Population Model." System Dynamics Review 33, no. 2 (April 2017): 89-111.

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Lv, Y-B, Zhu, P-F, Yin, Z-X, Kraus, VB, Threapleton, D, Chei, C-L, Brasher, MS, Zhang, J, Qian, H-Z, Mao, C, Matchar, DB, Luo, J-S, Zeng, Y, and Shi, X-M. "A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly." Journal of the American Medical Directors Association 18, no. 2 (February 2017): 193.e7-193.e13.

PMID
28126139
Full Text

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