David Bruce Matchar, MD

Professor of Medicine
Director of the Center for Clinical Health Policy Research
Professor of Pathology
Affiliate, Duke Global Health Institute
Member in the Duke Clinical Research Institute
Campus mail Box 3230, DUMC, Durham, NC 27710
Email address david.matchar@duke-nus.edu.sg

My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Key Words: clinical policy, disease management, stroke, decision analysis, clinical guidelines

Education and Training

  • M.D., University of Maryland, College Park, 1980

Publications

Matchar, DB, Duncan, PW, Lien, CT, Ong, MEH, Lee, M, Gao, F, Sim, R, and Eom, K. "Randomized Controlled Trial of Screening, Risk Modification, and Physical Therapy to Prevent Falls Among the Elderly Recently Discharged From the Emergency Department to the Community: The Steps to Avoid Falls in the Elderly Study." Archives of physical medicine and rehabilitation 98, no. 6 (June 2017): 1086-1096.

PMID
28202383
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Lv, Y-B, Zhu, P-F, Yin, Z-X, Kraus, VB, Threapleton, D, Chei, C-L, Brasher, MS, Zhang, J, Qian, H-Z, Mao, C, Matchar, DB, Luo, J-S, Zeng, Y, and Shi, X-M. "A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly." Journal of the American Medical Directors Association 18, no. 2 (February 2017): 193.e7-193.e13.

PMID
28126139
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Matchar, DB, Ansah, JP, Bayer, S, and Hovmand, P. "Simulation modeling for primary care planning in Singapore." January 17, 2017.

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Ansah, JP, Koh, V, Qureshi, MA, and Matchar, DB. "Modeling to inform long-term care policy and planning for an aging society." In Understanding Complex Systems, 183-224. January 1, 2017.

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Zhou, K, Vidyarthi, AR, Wong, CH, and Matchar, D. "Where to go if not the hospital? Reviewing geriatric bed utilization in an acute care hospital in Singapore." Geriatrics & Gerontology International (2017).

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Wong, N, Chua, SJT, Gao, F, Sim, STR, Matchar, D, Wong, SLA, Yeo, KK, Tan, WCJ, and Chin, CT. "The effect of a nurse-led telephone-based care coordination program on the follow-up and control of cardiovascular risk factors in patients with coronary artery disease." International journal for quality in health care : journal of the International Society for Quality in Health Care 28, no. 6 (December 2016): 758-763.

PMID
27621081
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Tian, Y, Hassmiller Lich, K, Osgood, ND, Eom, K, and Matchar, DB. "Linked Sensitivity Analysis, Calibration, and Uncertainty Analysis Using a System Dynamics Model for Stroke Comparative Effectiveness Research." Medical decision making : an international journal of the Society for Medical Decision Making 36, no. 8 (November 2016): 1043-1057.

PMID
27091379
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Bee, YM, Batcagan-Abueg, APM, Chei, C-L, Do, YK, Haaland, B, Goh, S-Y, Lee, PC, Chiam, PPS, Ho, ETL, and Matchar, DB. "A Smartphone Application to Deliver a Treat-to-Target Insulin Titration Algorithm in Insulin-Naive Patients With Type 2 Diabetes: A Pilot Randomized Controlled Trial." Diabetes care 39, no. 10 (October 2016): e174-e176. (Letter)

PMID
27506223
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Matchar, DB, Chei, C-L, Yin, Z-X, Koh, V, Chakraborty, B, Shi, X-M, and Zeng, Y. "Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey." The journals of gerontology. Series A, Biological sciences and medical sciences 71, no. 10 (October 2016): 1363-1368.

PMID
27412894
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Phibbs, CS, Love, SR, Jacobson, AK, Edson, R, Su, P, Uyeda, L, Matchar, DB, and writing for the THINRS Executive Committee and Site Investigators, . "At-Home Versus In-Clinic INR Monitoring: A Cost-Utility Analysis from The Home INR Study (THINRS)." Journal of General Internal Medicine 31, no. 9 (September 2016): 1061-1067.

PMID
27234663
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