David Bruce Matchar, MD

Professor of Medicine
Director of the Center for Clinical Health Policy Research
Professor of Pathology
Affiliate, Duke Global Health Institute
Member in the Duke Clinical Research Institute
Campus mail Box 102811, DUMC, Durham, NC 27705
Phone (656) 516-2584
Email address david.matchar@duke-nus.edu.sg

My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Key Words: clinical policy, disease management, stroke, decision analysis, clinical guidelines

Education and Training

  • M.D., University of Maryland, College Park, 1980

Publications

Chiu, C-T, Hayward, MD, Chan, A, and Matchar, DB. "Educational differences in the compression of disability incidence in the United States.(Accepted)" Ssm Population Health 7 (April 2019): 100347-null.

PMID
30671529
Full Text

Pua, Y-H, and Matchar, DB. "Physical Performance Predictor Measures in Older Adults With Falls-Related Emergency Department Visits." Journal of the American Medical Directors Association (January 30, 2019).

PMID
30711461
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Yeoh, YS, Koh, GC-H, Tan, CS, Tu, TM, Singh, R, Chang, HM, De Silva, DA, Ng, YS, Ang, YH, Yap, P, Chew, E, Merchant, RA, Yeo, TT, Chou, N, Venketasubramanian, N, Lee, KE, Young, SH, Hoenig, H, Matchar, DB, and Luo, N. "Health-related quality of life loss associated with first-time stroke." Plos One 14, no. 1 (January 28, 2019): e0211493-null.

PMID
30689666
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Lim, KK, Matchar, DB, Chong, JL, Yeo, W, Howe, TS, and Koh, JSB. "Pre-discharge prognostic factors of physical function among older adults with hip fracture surgery: a systematic review." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa (January 15, 2019). (Review)

PMID
30643925
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Ansah, JP, Islam, AM, Koh, V, Ly, V, Kol, H, Matchar, DB, Loun, C, and Loun, M. "Systems modelling as an approach for understanding and building consensus on non-communicable diseases (NCD) management in Cambodia." Bmc Health Services Research 19, no. 1 (January 3, 2019): 2-null.

PMID
30606199
Full Text

Matchar, DB, Ansah, JP, Koh, V, and Whitson, HE. "Trajectories of functional ability over the life course: a conceptual model of the interaction of stressor-induced functional loss and resilience(Accepted)." System Dynamics Review (January 1, 2019).

Full Text

Matchar, DB, Eom, K, Duncan, PW, Lee, M, Sim, R, Sivapragasam, NR, Lien, CT, and Ong, MEH. "A Cost-Effectiveness Analysis of a Randomized Control Trial of a Tailored, Multifactorial Program to Prevent Falls Among the Community-Dwelling Elderly." Archives of Physical Medicine and Rehabilitation 100, no. 1 (January 2019): 1-8.

PMID
30165053
Full Text

Chew, SY, Koh, MS, Loo, CM, Thumboo, J, Shantakumar, S, and Matchar, DB. "Making Clinical Practice Guidelines Pragmatic: How Big Data and Real World Evidence Can Close the Gap." Annals of the Academy of Medicine, Singapore 47, no. 12 (December 2018): 523-527.

PMID
30636269
Scholars@Duke

Tyagi, S, Koh, GC-H, Nan, L, Tan, KB, Hoenig, H, Matchar, DB, Yoong, J, Finkelstein, EA, Lee, KE, Venketasubramanian, N, Menon, E, Chan, KM, De Silva, DA, Yap, P, Tan, BY, Chew, E, Young, SH, Ng, YS, Tu, TM, Ang, YH, Kong, KH, Singh, R, Merchant, RA, Chang, HM, Yeo, TT, Ning, C, Cheong, A, Ng, YL, and Tan, CS. "Healthcare utilization and cost trajectories post-stroke: role of caregiver and stroke factors." Bmc Health Services Research 18, no. 1 (November 22, 2018): 881-null.

PMID
30466417
Full Text

Yeoh, YS, Koh, GC-H, Tan, CS, Lee, KE, Tu, TM, Singh, R, Chang, HM, De Silva, DA, Ng, YS, Ang, YH, Yap, P, Chew, E, Merchant, RA, Yeo, TT, Chou, N, Venketasubramanian, N, Young, SH, Hoenig, H, Matchar, DB, and Luo, N. "Can acute clinical outcomes predict health-related quality of life after stroke: a one-year prospective study of stroke survivors." Health and Quality of Life Outcomes 16, no. 1 (November 21, 2018): 221-null.

PMID
30463574
Full Text

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