Feng Gao, MD

Professor Emeritus in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 244 Sands Bldg, Box 102359, Durham, NC 27710
Phone (919) 668-6433
Email address feng.gao@duke.edu

Dr. Feng Gao is Professor of Medicine at Duke University. The Gao laboratory has a long-standing interest in elucidating the origins and evolution of human and simian inmmunodeficiency viruses (HIV and SIV), and in studying HIV/SIV gene function and pathogenic mechanisms from the evolutionary perspective. These studies have led to new strategies to better understand HIV origins,  biology, pathogenesis and drug resistance, and to design new AIDS vaccines.

Education and Training

  • M.D., Harbin Medical University (China), 1984

Publications

Gao, Nan, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, et al. “Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.” Adv Sci (Weinh), March 23, 2022, e2200063. https://doi.org/10.1002/advs.202200063.

PMID
35319830
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Xiao, C., L. Mao, Z. Wang, L. Gao, G. Zhu, J. Su, X. Chen, et al. “SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response.” Iscience 25, no. 3 (March 18, 2022). https://doi.org/10.1016/j.isci.2022.103934.

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Wang, Huaiyu, Pingchao Li, Mo Zhang, Jinpeng Bi, Yizi He, Fangshen Li, Rongzhen Yu, et al. “Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques.” Microb Biotechnol, March 15, 2022. https://doi.org/10.1111/1751-7915.14022.

PMID
35290714
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Yang, Xiao, Mingming Wan, Linjun Cai, Ali Hou, Bo Sun, Yan Zhou, Feng Gao, Weiheng Su, and Chunlai Jiang. “Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells.” Viruses 14, no. 1 (December 29, 2021). https://doi.org/10.3390/v14010049.

PMID
35062253
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Blazkova, Jana, Feng Gao, Manukumar Honnayakanahalli Marichannegowda, J Shawn Justement, Victoria Shi, Emily J. Whitehead, Rachel F. Schneck, et al. “Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.” Nat Med 27, no. 11 (November 2021): 1893–98. https://doi.org/10.1038/s41591-021-01503-6.

PMID
34711975
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Marichannegowda, Manukumar Honnayakanahalli, Michael Mengual, Amit Kumar, Elena E. Giorgi, Joshua J. Tu, David R. Martinez, Ethan O. Romero-Severson, et al. “Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses.” Cell Rep Med 2, no. 7 (July 20, 2021): 100315. https://doi.org/10.1016/j.xcrm.2021.100315.

PMID
34337555
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Kumar, Amit, Elena E. Giorgi, Joshua J. Tu, David R. Martinez, Joshua Eudailey, Michael Mengual, Manukumar Honnayakanahalli Marichannegowda, Russell Van Dyke, Feng Gao, and Sallie R. Permar. “Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers.” Plos Pathog 17, no. 4 (April 2021): e1009478. https://doi.org/10.1371/journal.ppat.1009478.

PMID
33798244
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Hemelaar, Joris, Shanghavie Loganathan, Ramyiadarsini Elangovan, Jason Yun, Leslie Dickson-Tetteh, Shona Kirtley, and Shona WHO-UNAIDS Network for HIV Isolation and Characterization. “Country Level Diversity of the HIV-1 Pandemic between 1990 and 2015.” J Virol 95, no. 2 (December 22, 2020). https://doi.org/10.1128/JVI.01580-20.

PMID
33087461
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Stadtler, Hannah, Elizabeth Wescott, Kelly Hughes, Jerry Chang, Feng Gao, Mary Klotman, and Maria Blasi. “HIV-1 diversity and compartmentalization in urine, semen, and blood.” Medicine (Baltimore) 99, no. 46 (November 13, 2020): e23063. https://doi.org/10.1097/MD.0000000000023063.

PMID
33181671
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Hemelaar, Joris, Ramyiadarsini Elangovan, Jason Yun, Leslie Dickson-Tetteh, Shona Kirtley, Eleanor Gouws-Williams, Peter D. Ghys, and Peter D. WHO-UNAIDS Network for HIV Isolation and Characterisation. “Global and regional epidemiology of HIV-1 recombinants in 1990-2015: a systematic review and global survey.” Lancet Hiv 7, no. 11 (November 2020): e772–81. https://doi.org/10.1016/S2352-3018(20)30252-6.

PMID
33128904
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