Francis Joseph Keefe, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in Psychology andNeuroscience
Professor in Anesthesiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail 2200 W Main St, Suite 340, Durham, NC 27705
Phone (919) 416-3400
Email address keefe003@mc.duke.edu

The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain and disability. The CBT intervention is innovative in that it systematically involves spouses in training in pain coping skills. The second project, tests the long-term effectiveness of a relapse prevention training intervention. This study will feature the use of newly developed daily study methods to analyze the long-term effects of pain coping skills training on daily pain.

In addition, in conjunction with Lara Schanberg of the Department of Medicine we are carrying out a study funded by the Arthritis Foundation that examines the effects of a pain coping skills training regimen for pediatric fibromyalgia patients.

Finally, we are currently gathering pilot data for two new research projects. One project seeks to evaluate the efficacy of a cognitive behavior theapy and education intervention for managing pain in patients having breast cancer and prostate cancer. The second project examines the efficacy of patient controlled compression protocol in the management of pain during mammography.

Education and Training

  • Ph.D., Ohio State University, 1975
  • M.S., Ohio State University, 1973
  • B.A., Bowdoin College, 1971

Publications

Burns, JW, Post, KM, Smith, DA, Porter, LS, Buvanendran, A, Fras, AM, and Keefe, FJ. "Spouse and Patient Beliefs and Perceptions about Chronic Pain: Effects on Couple Interactions and Patient Pain Behavior." The Journal of Pain : Official Journal of the American Pain Society (April 4, 2019).

PMID
30954540
Full Text

Porter, LS, Carson, JW, Olsen, M, Carson, KM, Sanders, L, Jones, L, Westbrook, K, and Keefe, FJ. "Feasibility of a mindful yoga program for women with metastatic breast cancer: results of a randomized pilot study." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer (March 15, 2019).

PMID
30877596
Full Text

Sitlinger, A, Shelby, RA, Van Denburg, AN, White, H, Edmond, SN, Marcom, PK, Bosworth, HB, Keefe, FJ, and Kimmick, GG. "Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer." Journal of Geriatric Oncology 10, no. 2 (March 2019): 317-321.

PMID
30553719
Full Text

Porter, LS, Samsa, G, Steel, JL, Hanson, LC, LeBlanc, TW, Bull, J, Fischer, S, and Keefe, FJ. "Caregiver-guided pain coping skills training for patients with advanced cancer: Background, design, and challenges for the CaringPals study." Clinical Trials (London, England) (February 19, 2019): 1740774519829695-null.

PMID
30782014
Full Text

Bovbjerg, DH, Keefe, FJ, Soo, MS, Manculich, J, Van Denburg, A, Zuley, ML, Ahrendt, GM, Skinner, CS, Edmond, SN, and Shelby, RA. "Persistent breast pain in post-surgery breast cancer survivors and women with no history of breast surgery or cancer: associations with pain catastrophizing, perceived breast cancer risk, breast cancer worry, and emotional distress." Acta Oncologica (Stockholm, Sweden) (February 12, 2019): 1-6.

PMID
30747014
Full Text

Riddle, DL, Keefe, FJ, Ang, DC, Slover, J, Jensen, MP, Bair, MJ, Kroenke, K, Perera, RA, Reed, SD, McKee, D, and Dumenci, L. "Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty: A Multisite Randomized Clinical Trial." The Journal of Bone and Joint Surgery. American Volume 101, no. 3 (February 2019): 218-227.

PMID
30730481
Full Text

Wren, AA, Shelby, RA, Soo, MS, Huysmans, Z, Jarosz, JA, and Keefe, FJ. "Preliminary efficacy of a lovingkindness meditation intervention for patients undergoing biopsy and breast cancer surgery: A randomized controlled pilot study." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer (January 31, 2019).

PMID
30706142
Full Text

Dumenci, L, Perera, RA, Keefe, FJ, Ang, DC, Slover, J, Jensen, MP, and Riddle, DL. "Model-based pain and function outcome trajectory types for patients undergoing knee arthroplasty: a secondary analysis from a randomized clinical trial." Osteoarthritis and Cartilage (January 17, 2019).

PMID
30660721
Full Text

Whitney, CA, Dorfman, CS, Shelby, RA, Keefe, FJ, Gandhi, V, and Somers, TJ. "Reminders of cancer risk and pain catastrophizing: relationships with cancer worry and perceived risk in women with a first-degree relative with breast cancer." Familial Cancer 18, no. 1 (January 2019): 9-18.

PMID
29679190
Full Text

Shelby, RA, Dorfman, CS, Bosworth, HB, Keefe, F, Sutton, L, Owen, L, Corsino, L, Erkanli, A, Reed, SD, Arthur, SS, Somers, T, Barrett, N, Huettel, S, Gonzalez, JM, and Kimmick, G. "Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET)." Contemporary Clinical Trials 76 (January 2019): 120-131.

PMID
30472215
Full Text

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