Rheumatology and Immunology

Francis Joseph Keefe, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in Psychology andNeuroscience
Professor in Anesthesiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail 2200 W Main St, Suite 340, Durham, NC 27705
Phone (919) 416-3400
Email address keefe003@mc.duke.edu

The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain and disability. The CBT intervention is innovative in that it systematically involves spouses in training in pain coping skills. The second project, tests the long-term effectiveness of a relapse prevention training intervention. This study will feature the use of newly developed daily study methods to analyze the long-term effects of pain coping skills training on daily pain.

In addition, in conjunction with Lara Schanberg of the Department of Medicine we are carrying out a study funded by the Arthritis Foundation that examines the effects of a pain coping skills training regimen for pediatric fibromyalgia patients.

Finally, we are currently gathering pilot data for two new research projects. One project seeks to evaluate the efficacy of a cognitive behavior theapy and education intervention for managing pain in patients having breast cancer and prostate cancer. The second project examines the efficacy of patient controlled compression protocol in the management of pain during mammography.

Education and Training

  • Ph.D., Ohio University, 1975
  • M.S., Ohio State University, 1973
  • B.A., Bowdoin College, 1971

Grants

Publications

Kelleher, Sarah A., Hannah M. Fisher, Joseph G. Winger, Tamara J. Somers, Hope E. Uronis, Arianna N. Wright, and Francis J. Keefe. “Feasibility, engagement, and acceptability of a behavioral pain management intervention for colorectal cancer survivors with pain and psychological distress: data from a pilot randomized controlled trial.” Support Care Cancer 29, no. 9 (September 2021): 5361–69. https://doi.org/10.1007/s00520-021-06126-8.

PMID
33686520
Full Text

Rini, Christine, Ariana W. K. Katz, Ada Nwadugbo, Laura S. Porter, Tamara J. Somers, and Francis J. Keefe. “Changes in Identification of Possible Pain Coping Strategies by People with Osteoarthritis who Complete Web-based Pain Coping Skills Training.” Int J Behav Med 28, no. 4 (August 2021): 488–98. https://doi.org/10.1007/s12529-020-09938-w.

PMID
33174614
Full Text

Allen, Kelli D., Tyler Beauchamp, Christine Rini, Francis J. Keefe, Kim L. Bennell, Rebecca J. Cleveland, Kimberlea Grimm, et al. “Pilot study of an internet-based pain coping skills training program for patients with systemic Lupus Erythematosus.” Bmc Rheumatol 5, no. 1 (June 17, 2021): 20. https://doi.org/10.1186/s41927-021-00191-6.

PMID
34134788
Full Text

Riddle, Daniel L., James Slover, Francis J. Keefe, Dennis C. Ang, Levent Dumenci, and Robert A. Perera. “Racial Differences in Pain and Function Following Knee Arthroplasty: A Secondary Analysis From a Multicenter Randomized Clinical Trial.” Arthritis Care Res (Hoboken) 73, no. 6 (June 2021): 810–17. https://doi.org/10.1002/acr.24177.

PMID
32144884
Full Text

Carson, James W., Kimberly M. Carson, Maren Olsen, Linda Sanders, Kelly Westbrook, Francis J. Keefe, and Laura S. Porter. “Yoga Practice Predicts Improvements in Day-to-Day Pain in Women With Metastatic Breast Cancer.” J Pain Symptom Manage 61, no. 6 (June 2021): 1227–33. https://doi.org/10.1016/j.jpainsymman.2020.10.009.

PMID
33065208
Full Text

Porter, Laura S., Jennifer L. Steel, Diane L. Fairclough, Thomas W. LeBlanc, Janet Bull, Laura C. Hanson, Stacy Fischer, and Francis J. Keefe. “Caregiver-guided pain coping skills training for patients with advanced cancer: Results from a randomized clinical trial.” Palliat Med 35, no. 5 (May 2021): 952–61. https://doi.org/10.1177/02692163211004216.

PMID
33775175
Full Text

Kelleher, Sarah A., Joseph G. Winger, Hannah M. Fisher, Shannon N. Miller, Shelby D. Reed, Beverly E. Thorn, Bonnie Spring, et al. “Behavioral cancer pain intervention using videoconferencing and a mobile application for medically underserved patients: Rationale, design, and methods of a prospective multisite randomized controlled trial.” Contemp Clin Trials 102 (March 2021): 106287. https://doi.org/10.1016/j.cct.2021.106287.

PMID
33497833
Full Text

Griesemer, Ida, Leslie R. Hausmann, Liubov Arbeeva, Lisa C. Campbell, Crystal W. Cené, Cynthia J. Coffman, Francis J. Keefe, Eugene Z. Oddone, Tamara J. Somers, and Kelli D. Allen. “Discrimination Experiences and Depressive Symptoms among African Americans with Osteoarthritis Enrolled in a Pain Coping Skills Training Randomized Controlled Trial.” J Health Care Poor Underserved 32, no. 1 (2021): 145–55. https://doi.org/10.1353/hpu.2021.0014.

PMID
33678687
Full Text

George, Steven Z., Cynthia J. Coffman, Kelli D. Allen, Trevor A. Lentz, Ashley Choate, Adam P. Goode, Corey B. Simon, et al. “Improving Veteran Access to Integrated Management of Back Pain (AIM-Back): Protocol for an Embedded Pragmatic Cluster-Randomized Trial.” Pain Med 21, no. Suppl 2 (December 12, 2020): S62–72. https://doi.org/10.1093/pm/pnaa348.

PMID
33313728
Full Text

Lawford, Belinda J., Rana S. Hinman, Rachel K. Nelligan, Francis Keefe, Christine Rini, and Kim L. Bennell. “"I Could Do It in My Own Time and When I Really Needed It": Perceptions of Online Pain Coping Skills Training For People With Knee Osteoarthritis.” Arthritis Care Res (Hoboken) 72, no. 12 (December 2020): 1736–46. https://doi.org/10.1002/acr.24093.

PMID
31628723
Full Text

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