Francis Joseph Keefe, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in Psychology andNeuroscience
Professor in Anesthesiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail 2200 W Main St, Suite 340, Durham, NC 27705
Phone (919) 416-3400
Email address keefe003@mc.duke.edu

The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain and disability. The CBT intervention is innovative in that it systematically involves spouses in training in pain coping skills. The second project, tests the long-term effectiveness of a relapse prevention training intervention. This study will feature the use of newly developed daily study methods to analyze the long-term effects of pain coping skills training on daily pain.

In addition, in conjunction with Lara Schanberg of the Department of Medicine we are carrying out a study funded by the Arthritis Foundation that examines the effects of a pain coping skills training regimen for pediatric fibromyalgia patients.

Finally, we are currently gathering pilot data for two new research projects. One project seeks to evaluate the efficacy of a cognitive behavior theapy and education intervention for managing pain in patients having breast cancer and prostate cancer. The second project examines the efficacy of patient controlled compression protocol in the management of pain during mammography.

Education and Training

  • Ph.D., Ohio University, 1975
  • M.S., Ohio State University, 1973
  • B.A., Bowdoin College, 1971

Grants

Publications

Burns, John W., Mark P. Jensen, Beverly Thorn, Teresa A. Lillis, James Carmody, Andrea K. Newman, and Francis Keefe. “Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for the treatment of chronic pain: randomized controlled trial.” Pain 163, no. 2 (February 1, 2022): 376–89. https://doi.org/10.1097/j.pain.0000000000002357.

PMID
34074945
Full Text

Scullin, Michael K., Winston E. Jones, Richard Phenis, Samantha Beevers, Sabra Rosen, Kara Dinh, Andrew Kiselica, Francis J. Keefe, and Jared F. Benge. “Using smartphone technology to improve prospective memory functioning: A randomized controlled trial.” J Am Geriatr Soc 70, no. 2 (February 2022): 459–69. https://doi.org/10.1111/jgs.17551.

PMID
34786698
Full Text

Kelleher, Sarah A., Hannah M. Fisher, Joseph G. Winger, Shannon N. Miller, Grace H. Amaden, Tamara J. Somers, Luana Colloca, Hope E. Uronis, and Francis J. Keefe. “Virtual reality for improving pain and pain-related symptoms in patients with advanced stage colorectal cancer: A pilot trial to test feasibility and acceptability.” Palliat Support Care, January 26, 2022, 1–11. https://doi.org/10.1017/S1478951521002017.

PMID
35078545
Full Text

Winger, Joseph G., Katherine Ramos, Sarah A. Kelleher, Tamara J. Somers, Karen E. Steinhauser, Laura S. Porter, Arif H. Kamal, William S. Breitbart, and Francis J. Keefe. “Meaning-Centered Pain Coping Skills Training: A Pilot Feasibility Trial of a Psychosocial Pain Management Intervention for Patients with Advanced Cancer.” J Palliat Med 25, no. 1 (January 2022): 60–69. https://doi.org/10.1089/jpm.2021.0081.

PMID
34388037
Full Text

DeBar, Lynn, Meghan Mayhew, Lindsay Benes, Allison Bonifay, Richard A. Deyo, Charles R. Elder, Francis J. Keefe, et al. “A Primary Care-Based Cognitive Behavioral Therapy Intervention for Long-Term Opioid Users With Chronic Pain : A Randomized Pragmatic Trial.” Ann Intern Med 175, no. 1 (January 2022): 46–55. https://doi.org/10.7326/M21-1436.

PMID
34724405
Full Text

Dorfman, Caroline S., Tamara J. Somers, Rebecca A. Shelby, Joseph G. Winger, Michele L. Patel, Gretchen Kimmick, Linda Craighead, and Francis J. Keefe. “DEVELOPMENT, FEASIBILITY, AND ACCEPTABILITY OF A BEHAVIORAL WEIGHT AND SYMPTOM MANAGEMENT INTERVENTION FOR BREAST CANCER SURVIVORS AND INTIMATE PARTNERS.” J Cancer Rehabil 5 (2022): 7–16. https://doi.org/10.48252/JCR57.

PMID
35253020
Full Text

Somers, Tamara J., James A. Blumenthal, Caroline S. Dorfman, Kim M. Huffman, Sara N. Edmond, Shannon N. Miller, Anava A. Wren, David Caldwell, and Francis J. Keefe. “Effects of a Weight and Pain Management Program in Patients With Rheumatoid Arthritis With Obesity: A Randomized Controlled Pilot Investigation.” J Clin Rheumatol 28, no. 1 (January 1, 2022): 7–13. https://doi.org/10.1097/RHU.0000000000001793.

PMID
34670994
Full Text

Eccleston, Christopher, Francis J. Keefe, and Amanda C. de C Williams. “Basic and applied psychology in PAIN: where we have been and where we are headed.” Pain 162, no. 12 (December 1, 2021): 2785–88. https://doi.org/10.1097/j.pain.0000000000002414.

PMID
34294664
Full Text

Keefe, Francis J., Mark P. Jensen, Amanda C de C. Williams, and Steven Z. George. “The yin and yang of pragmatic clinical trials of behavioral interventions for chronic pain: balancing design features to maximize impact.” Pain, November 29, 2021. https://doi.org/10.1097/j.pain.0000000000002546.

PMID
35027519
Full Text

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