Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Sinden, Daniel S., Corey D. Holman, Curtis J. Bare, Xiaolu Sun, Aravind R. Gade, David E. Cohen, and Geoffrey S. Pitt. “Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity..” Faseb J 33, no. 10 (October 2019): 11579–94. https://doi.org/10.1096/fj.201901178R.

PMID
31339804
Full Text

Cao, Chike, Aaron B. Oswald, Brian A. Fabella, Yinshi Ren, Ramona Rodriguiz, George Trainor, Matthew B. Greenblatt, Matthew J. Hilton, and Geoffrey S. Pitt. “The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear..” Bone 125 (August 2019): 160–68. https://doi.org/10.1016/j.bone.2019.05.024.

PMID
31121355
Full Text

Yang, Lin, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I. Zakharov, Bi-Xing Chen, Zunaira Shuja, et al. “Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking..” J Clin Invest 129, no. 2 (February 1, 2019): 647–58. https://doi.org/10.1172/JCI123878.

PMID
30422117
Full Text

Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Hong-Gang Wang, Stephan Frangakis, et al. “The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction..” J Clin Invest 128, no. 11 (November 1, 2018): 4843–55. https://doi.org/10.1172/JCI95945.

PMID
30153110
Full Text

Sanders, Stephan J., Arthur J. Campbell, Jeffrey R. Cottrell, Rikke S. Moller, Florence F. Wagner, Angie L. Auldridge, Raphael A. Bernier, et al. “Progress in Understanding and Treating SCN2A-Mediated Disorders..” Trends Neurosci 41, no. 7 (July 2018): 442–56. https://doi.org/10.1016/j.tins.2018.03.011.

PMID
29691040
Full Text

Cao, Chike, Yinshi Ren, Adam S. Barnett, Anthony J. Mirando, Douglas Rouse, Se Hwan Mun, Kyung-Hyun Park-Min, et al. “Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss..” Jci Insight 2, no. 22 (November 16, 2017). https://doi.org/10.1172/jci.insight.95512.

PMID
29202453
Full Text

Katchman, Alexander, Lin Yang, Sergey I. Zakharov, Jared Kushner, Jeffrey Abrams, Bi-Xing Chen, Guoxia Liu, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx. “Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart..” Proc Natl Acad Sci U S A 114, no. 34 (August 22, 2017): 9194–99. https://doi.org/10.1073/pnas.1706054114.

PMID
28784807
Full Text

Wei, Eric Q., Daniel S. Sinden, Lan Mao, Hailin Zhang, Chuan Wang, and Geoffrey S. Pitt. “Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload..” Proc Natl Acad Sci U S A 114, no. 20 (May 16, 2017): E4010–19. https://doi.org/10.1073/pnas.1616393114.

PMID
28461495
Full Text

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