Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Wang, Hong-Gang, Charlotte C. Bavley, Anfei Li, Rebecca M. Jones, Jonathan Hackett, Yared Bayleyen, Francis S. Lee, Anjali M. Rajadhyaksha, and Geoffrey S. Pitt. “Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.150698.

PMID
34156984
Full Text

Joglekar, Anoushka, Andrey Prjibelski, Ahmed Mahfouz, Paul Collier, Susan Lin, Anna Katharina Schlusche, Jordan Marrocco, et al. “A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.” Nat Commun 12, no. 1 (January 19, 2021): 463. https://doi.org/10.1038/s41467-020-20343-5.

PMID
33469025
Full Text

Papa, Arianne, Jared Kushner, Jessica A. Hennessey, Alexander N. Katchman, Sergey I. Zakharov, Bi-Xing Chen, Lin Yang, et al. “Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.” Circulation Research 128, no. 1 (January 2021): 76–88. https://doi.org/10.1161/circresaha.120.317839.

PMID
33086983
Full Text

Wang, Zizun, Sarah H. Vermij, Valentin Sottas, Anna Shestak, Daniela Ross-Kaschitza, Elena V. Zaklyazminskaya, Andy Hudmon, Geoffrey S. Pitt, Jean-Sébastien Rougier, and Hugues Abriel. “Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.” Channels (Austin) 14, no. 1 (December 2020): 268–86. https://doi.org/10.1080/19336950.2020.1805999.

PMID
32815768
Full Text

Abrams, Jeffrey, Daniel Roybal, Nourdine Chakouri, Alexander N. Katchman, Richard Weinberg, Lin Yang, Bi-Xing Chen, et al. “Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.” Jci Insight 5, no. 19 (October 2, 2020). https://doi.org/10.1172/jci.insight.141736.

PMID
32870823
Full Text

Gade, Aravind R., Steven O. Marx, and Geoffrey S. Pitt. “An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.” J Gen Physiol 152, no. 2 (February 3, 2020). https://doi.org/10.1085/jgp.201912434.

PMID
31865383
Full Text

Sinden, Daniel S., Corey D. Holman, Curtis J. Bare, Xiaolu Sun, Aravind R. Gade, David E. Cohen, and Geoffrey S. Pitt. “Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.” Faseb J 33, no. 10 (October 2019): 11579–94. https://doi.org/10.1096/fj.201901178R.

PMID
31339804
Full Text

Cao, Chike, Aaron B. Oswald, Brian A. Fabella, Yinshi Ren, Ramona Rodriguiz, George Trainor, Matthew B. Greenblatt, Matthew J. Hilton, and Geoffrey S. Pitt. “The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.” Bone 125 (August 2019): 160–68. https://doi.org/10.1016/j.bone.2019.05.024.

PMID
31121355
Full Text

Pages