Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Katchman, A, Yang, L, Zakharov, SI, Kushner, J, Abrams, J, Chen, B-X, Liu, G, Pitt, GS, Colecraft, HM, and Marx, SO. "Proteolytic cleavage and PKA phosphorylation of α 1C subunit are not required for adrenergic regulation of Ca V 1.2 in the heart." Proceedings of the National Academy of Sciences 114, no. 34 (August 22, 2017): 9194-9199.

Full Text

Pablo, JL, and Pitt, GS. "Divide, multitask, and conquer: Coordination in channel regulation." Channels 11, no. 4 (July 4, 2017): 268-270.

Full Text

Wei, EQ, Sinden, DS, Mao, L, Zhang, H, Wang, C, and Pitt, GS. "Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload." Proceedings of the National Academy of Sciences of the United States of America 114, no. 20 (May 2017): E4010-E4019.

PMID
28461495
Full Text

Wang, X, Tang, H, Wei, EQ, Wang, Z, Yang, J, Yang, R, Wang, S, Zhang, Y, Pitt, GS, Zhang, H, and Wang, C. "Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles." Journal of molecular and cellular cardiology 104 (March 2017): 63-74.

PMID
28119060
Full Text

Yan, H, Wang, C, Marx, SO, and Pitt, GS. "Calmodulin limits pathogenic Na+ channel persistent current." The Journal of general physiology 149, no. 2 (February 2017): 277-293.

PMID
28087622
Full Text

Pitt, GS. "Aview fromthe side-line: A look into the reasons and the genetics involved, for the future of precision Medicine." European Heart Journal 37, no. 47 (December 1, 2016): 3488-3489.

Full Text

Pitt, GS, and Lee, S-Y. "Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins." Protein science : a publication of the Protein Society 25, no. 9 (September 2016): 1573-1584. (Review)

PMID
27262167
Full Text

Yang, J, Wang, Z, Sinden, DS, Wang, X, Shan, B, Yu, X, Zhang, H, Pitt, GS, and Wang, C. "FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner." Channels (Austin, Tex.) 10, no. 5 (September 2016): 410-420.

PMID
27246624
Full Text

Black, JB, Adler, AF, Wang, H-G, D'Ippolito, AM, Hutchinson, HA, Reddy, TE, Pitt, GS, Leong, KW, and Gersbach, CA. "Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells." Cell stem cell 19, no. 3 (September 2016): 406-414.

PMID
27524438
Full Text

Pitt, GS. Ion Channels in Health and Disease. July 29, 2016.

Full Text

Pages