Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Katchman, Alexander, Lin Yang, Sergey I. Zakharov, Jared Kushner, Jeffrey Abrams, Bi-Xing Chen, Guoxia Liu, Geoffrey S. Pitt, Henry M. Colecraft, and Steven O. Marx. “Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.” Proceedings of the National Academy of Sciences of the United States of America 114, no. 34 (August 7, 2017): 9194–99. https://doi.org/10.1073/pnas.1706054114.

PMID
28784807
Full Text

Wei, Eric Q., Daniel S. Sinden, Lan Mao, Hailin Zhang, Chuan Wang, and Geoffrey S. Pitt. “Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.” Proc Natl Acad Sci U S A 114, no. 20 (May 16, 2017): E4010–19. https://doi.org/10.1073/pnas.1616393114.

PMID
28461495
Full Text

Wang, Xiangchong, He Tang, Eric Q. Wei, Zhihua Wang, Jing Yang, Rong Yang, Sheng Wang, et al. “Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.” J Mol Cell Cardiol 104 (March 2017): 63–74. https://doi.org/10.1016/j.yjmcc.2017.01.009.

PMID
28119060
Full Text

Yan, Haidun, Chaojian Wang, Steven O. Marx, and Geoffrey S. Pitt. “Calmodulin limits pathogenic Na+ channel persistent current.” J Gen Physiol 149, no. 2 (February 2017): 277–93. https://doi.org/10.1085/jgp.201611721.

PMID
28087622
Full Text

Yang, Jing, Zhihua Wang, Daniel S. Sinden, Xiangchong Wang, Bin Shan, Xiao Yu, Hailin Zhang, Geoffrey S. Pitt, and Chuan Wang. “FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.” Channels (Austin) 10, no. 5 (September 2, 2016): 410–20. https://doi.org/10.1080/19336950.2016.1190055.

PMID
27246624
Full Text

Black, Joshua B., Andrew F. Adler, Hong-Gang Wang, Anthony M. D’Ippolito, Hunter A. Hutchinson, Timothy E. Reddy, Geoffrey S. Pitt, Kam W. Leong, and Charles A. Gersbach. “Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.” Cell Stem Cell 19, no. 3 (September 1, 2016): 406–14. https://doi.org/10.1016/j.stem.2016.07.001.

PMID
27524438
Full Text

Pitt, Geoffrey S., and Seok-Yong Lee. “Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.” Protein Sci 25, no. 9 (September 2016): 1573–84. https://doi.org/10.1002/pro.2960.

PMID
27262167
Full Text

Pages