Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Pitt, GS. Preface. July 29, 2016.

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Sun, AY, and Pitt, GS. "Long QT Syndrome and Seizures∗." JACC: Clinical Electrophysiology 2, no. 3 (June 2016): 277-278.

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Matsui, M, and Pitt, GS. "Genetic variants and disease: correlate or cause?." European heart journal 37, no. 18 (May 2016): 1476-1478.

PMID
26419624
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Pablo, JL, Wang, C, Presby, MM, and Pitt, GS. "Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action." Proceedings of the National Academy of Sciences of the United States of America 113, no. 19 (May 2016): E2665-E2674.

PMID
27044086
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Wang, H-G, Zhu, W, Kanter, RJ, Silva, JR, Honeywell, C, Gow, RM, and Pitt, GS. "A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias." Journal of molecular and cellular cardiology 92 (March 2016): 52-62.

PMID
26801742
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Pablo, JL, and Pitt, GS. "Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease." The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 22, no. 1 (February 2016): 19-25. (Review)

PMID
25492945
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Choi, J-I, Wang, C, Thomas, MJ, and Pitt, GS. "α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current." PloS one 11, no. 3 (January 2016): e0152355-.

PMID
27028743
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Zhang, H, Sun, AY, Kim, JJ, Graham, V, Finch, EA, Nepliouev, I, Zhao, G, Li, T, Lederer, WJ, Stiber, JA, Pitt, GS, Bursac, N, and Rosenberg, PB. "STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node." October 2015.

PMID
26424448
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Musa, H, Kline, CF, Sturm, AC, Murphy, N, Adelman, S, Wang, C, Yan, H, Johnson, BL, Csepe, TA, Kilic, A, Higgins, RSD, Janssen, PML, Fedorov, VV, Weiss, R, Salazar, C, Hund, TJ, Pitt, GS, and Mohler, PJ. "SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia." Proceedings of the National Academy of Sciences of the United States of America 112, no. 40 (October 2015): 12528-12533.

PMID
26392562
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Pitt, GS. "Cardiovascular precision medicine: hope or hype?." European heart journal 36, no. 29 (August 2015): 1842-1843.

PMID
26074465
Full Text

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