Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Abbes, Sarah, Ara Metjian, Alice Gray, Tereza Martinu, Laurie Snyder, Dong-Feng Chen, Matthew Ellis, Gowthami M. Arepally, and Oluwatoyosi Onwuemene. “Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.” Ther Apher Dial 21, no. 5 (October 2017): 441–50. https://doi.org/10.1111/1744-9987.12570.

PMID
28880430
Full Text

Fountain, Eric M., and Gowthami M. Arepally. “Etiology and complications of thrombocytopenia in hospitalized medical patients.” J Thromb Thrombolysis 43, no. 4 (May 2017): 429–36. https://doi.org/10.1007/s11239-016-1467-8.

PMID
28054307
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Lee, Grace M., Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, and Gowthami M. Arepally. “Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies.” Blood Adv 1, no. 11 (April 25, 2017): 644–51. https://doi.org/10.1182/bloodadvances.2017004408.

PMID
29296706
Full Text

Hayes, Vincent, Ian Johnston, Gowthami M. Arepally, Steven E. McKenzie, Douglas B. Cines, Lubica Rauova, and Mortimer Poncz. “Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.” J Clin Invest 127, no. 3 (March 1, 2017): 1090–98. https://doi.org/10.1172/JCI90958.

PMID
28218620
Full Text

Fountain, Eric M., Maggie C. Moses, Lawrence P. Park, Christopher W. Woods, and Gowthami M. Arepally. “Thrombocytopenia in hospitalized patients with severe clostridium difficile infection.” Journal of Thrombosis and Thrombolysis 43, no. 1 (January 2017): 38–42. https://doi.org/10.1007/s11239-016-1423-7.

PMID
27614757
Full Text

Welsby, I. J., E. F. Krakow, J. A. Heit, E. C. Williams, G. M. Arepally, S. Bar-Yosef, D. F. Kong, et al. “The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery.” J Thromb Haemost 15, no. 1 (January 2017): 57–65. https://doi.org/10.1111/jth.13533.

PMID
27714919
Full Text

Khandelwal, Sanjay, Johnson M. Alexandra, C Garren Hester, Michael M. Frank, and Gowthami M. Arepally. “Mechanism of Complement Activation By PF4/ Heparin Complexes.” In Blood, 128:137–137. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.137.137.

Full Text

Khandelwal, Sanjay, Johnson M. Alexandra, Grace M. Lee, and Gowthami M. Arepally. “Novel ELISA-Based Assay for Detection of Complement Activation By PF4/Heparin Complexes.” In Blood, 128:3734–3734. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.3734.3734.

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