Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Khandelwal, Sanjay, Grace M. Lee, C Garren Hester, Mortimer Poncz, Steven E. McKenzie, Bruce S. Sachais, Lubica Rauova, et al. “The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).” Blood 128, no. 14 (October 6, 2016): 1789–99. https://doi.org/10.1182/blood-2016-04-709634.

PMID
27412887
Full Text

Fountain, Eric M., and Gowthami M. Arepally. “THROMBOCYTOPENIA IN HOSPITALIZED NON-ICU PATIENTS.” American Journal of Hematology 91, no. 9 (September 1, 2016): E401–E401.

Scholars@Duke

Metjian, Ara, Yvette Tanhehco, Phu Pham Huy, Nicole A. Aqui, Vijay Bhoj, Oluwatoyosi Onwuemene, Marisa Marques, and Gowthami M. Arepally. “The Thrombotic Microangiopathy Registry of North America.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Fountain, Eric, and Gowthami M. Arepally. “Thrombocytopenia in Hospitalized Non-ICU Patients.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Lee, Grace M., Manali Joglekar, Sanjay Khandelwal, Rui Qi, Lubica Rauova, and Gowthami M. Arepally. “Characterization of Human and Murine Anti-Protamine/Heparin Antibodies.” In Blood, 126:3461–3461. American Society of Hematology, 2015. https://doi.org/10.1182/blood.v126.23.3461.3461.

Full Text

Cai, Zheng, Serge V. Yarovoi, Zhiqiang Zhu, Lubica Rauova, Vincent Hayes, Tatiana Lebedeva, Qun Liu, et al. “Atomic description of the immune complex involved in heparin-induced thrombocytopenia.” Nat Commun 6 (September 22, 2015): 8277. https://doi.org/10.1038/ncomms9277.

PMID
26391892
Full Text

Joglekar, M., S. Khandelwal, D. B. Cines, M. Poncz, L. Rauova, and G. M. Arepally. “Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.” J Thromb Haemost 13, no. 8 (August 2015): 1416–27. https://doi.org/10.1111/jth.13003.

PMID
25960020
Full Text

Joglekar, Manali V., Sanjay Khandelwal, Mortimer Poncz, Lubica Rauova, and Gowthami M. Arepally. “Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Cai, Zheng, Serge V. Yarovoi, Zhiquiang Zhu, Lubica Rauova, Tatiana Lebedeva, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines, and Mark I. Greene. “Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT).” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Pages