Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Kelton, JG, Warkentin, TE, Moore, JC, Arnold, DM, Nazi, I, Arepally, GM, Roach, JM, and Fier, I. "A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins." J Thromb Haemost 10, no. 7 (July 2012): 1446-1449. (Letter)

PMID
22537227
Full Text

Kasthuri, RS, Glover, SL, Jonas, W, McEachron, T, Pawlinski, R, Arepally, GM, Key, NS, and Mackman, N. "PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI." Blood 119, no. 22 (May 31, 2012): 5285-5293.

PMID
22394597
Full Text

Joglekar, MV, Quintana Diez, PM, Marcus, S, Qi, R, Espinasse, B, Wiesner, MR, Pempe, E, Liu, J, Monroe, DM, and Arepally, GM. "Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH)." Thromb Haemost 107, no. 4 (April 2012): 717-725.

PMID
22318669
Full Text

Lee, G, and Arepally, GM. "Anticoagulation techniques in apheresis: from heparin to citrate and beyond." Journal of clinical apheresis 27, no. 3 (January 2012): 117-125. (Review)

PMID
22532037
Full Text

Andrzejewski, C, Linz, W, Hofmann, J, O'Doherty, U, Robinson, RS, Arepally, GM, and Golden, P. "American Society for Apheresis white paper: considerations for medical staff apheresis medicine physician credentialing and privileging." J Clin Apher 27, no. 6 (2012): 330-335.

PMID
23124963
Full Text

Ortel, TL, Welsby, I, Kong, DF, Heit, JA, Krakow, E, Whitlatch, N, Arepally, GM, Lee, G, Bar-Yosef, S, and Williams, EC. "HIT Antibody Seropositivity and Thromboembolic Events After Cardiac Surgery." November 18, 2011.

Scholars@Duke

Kasthuri, RS, Glover, SL, William, J, Pawlinski, R, Arepally, GM, Key, NS, and Mackman, N. "Induction of tissue factor expression in monocytes by the platelet factor 4/heparin/antibody complex is mediated by MEK1 and pERK1/2." JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 (July 2011): 265-266.

Scholars@Duke

Herold, CI, Gasparetto, C, and Arepally, GM. "Lenalidomide-Associated ITP." Case Rep Hematol 2011 (2011): 638020-.

PMID
22937309
Full Text

Chudasama, SL, Espinasse, B, Hwang, F, Qi, R, Joglekar, M, Afonina, G, Wiesner, MR, Welsby, IJ, Ortel, TL, and Arepally, GM. "Heparin modifies the immunogenicity of positively charged proteins." Blood 116, no. 26 (December 23, 2010): 6046-6053.

PMID
20852126
Full Text

Cuker, A, Arepally, G, Crowther, MA, Rice, L, Datko, F, Hook, K, Propert, KJ, Kuter, DJ, Ortel, TL, Konkle, BA, and Cines, DB. "The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion." J Thromb Haemost 8, no. 12 (December 2010): 2642-2650.

PMID
20854372
Full Text

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