Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Gunaratne, Ruwan, James Frederiksen, Nabil K. Thalji, Michelle D. Ho, Gowthami M. Arepally, Rodney M. Camire, and Bruce A. Sullenger. “RNA Aptamer Against FXa Synergizes with FXa Catalytic Site Inhibitors to Effectively and Reversibly Anticoagulate Blood in an Ex Vivo Oxygenator Circuit.” In Blood, 128:3823–3823. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.3823.3823.

Full Text

Cines, Douglas B., Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, et al. “Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.” Blood Adv 1, no. 1 (November 29, 2016): 62–74. https://doi.org/10.1182/bloodadvances.2016000877.

PMID
29296696
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Khandelwal, Sanjay, and Gowthami M. Arepally. “Immune pathogenesis of heparin-induced thrombocytopenia.” Thromb Haemost 116, no. 5 (October 28, 2016): 792–98. https://doi.org/10.1160/TH16-01-0074.

PMID
27465274
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Khandelwal, Sanjay, Grace M. Lee, C Garren Hester, Mortimer Poncz, Steven E. McKenzie, Bruce S. Sachais, Lubica Rauova, et al. “The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).” Blood 128, no. 14 (October 6, 2016): 1789–99. https://doi.org/10.1182/blood-2016-04-709634.

PMID
27412887
Full Text

Fountain, Eric M., and Gowthami M. Arepally. “THROMBOCYTOPENIA IN HOSPITALIZED NON-ICU PATIENTS.” American Journal of Hematology 91, no. 9 (September 1, 2016): E401–E401.

Scholars@Duke

Metjian, Ara, Yvette Tanhehco, Phu Pham Huy, Nicole A. Aqui, Vijay Bhoj, Oluwatoyosi Onwuemene, Marisa Marques, and Gowthami M. Arepally. “The Thrombotic Microangiopathy Registry of North America.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Fountain, Eric, and Gowthami M. Arepally. “Thrombocytopenia in Hospitalized Non-ICU Patients.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Lee, Grace M., Manali Joglekar, Sanjay Khandelwal, Rui Qi, Lubica Rauova, and Gowthami M. Arepally. “Characterization of Human and Murine Anti-Protamine/Heparin Antibodies.” In Blood, 126:3461–3461. American Society of Hematology, 2015. https://doi.org/10.1182/blood.v126.23.3461.3461.

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Cai, Zheng, Serge V. Yarovoi, Zhiqiang Zhu, Lubica Rauova, Vincent Hayes, Tatiana Lebedeva, Qun Liu, et al. “Atomic description of the immune complex involved in heparin-induced thrombocytopenia.” Nat Commun 6 (September 22, 2015): 8277. https://doi.org/10.1038/ncomms9277.

PMID
26391892
Full Text

Pages