Gregory Alan Taylor, PhD

Associate Professor in Medicine
Assistant Research Professor in Immunology
Associate Research Professor in Molecular Genetics and Microbiology
Campus mail 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-0411
Email address gregory.taylor@duke.edu

My lab is interested in innate immune mechanisms that underpin inflammatory processes and resistance to intracellular bacteria and protozoa. For a number of years, we have focused on a family of proteins known as Immunity-Related GTPases (IRG; also known as p47 GTPases), which have been associated with both Crohn’s Disease and resistance to mycobacterial infections in humans. We were among the first to clone IRG genes in the mouse and to define their biochemical activity, cellular localization, and cellular functions, prominent among which is regulation of autophagy. By generating mice that lack certain IRG genes (Irgm1, Irgm3, and Irgd), we have been able to demonstrate the key, but distinct roles that individual IRG proteins play in suppressing inflammation, and in resistance to pathogens such as Salmonella typhimurium, Listeria monocytogenes, and Toxoplasma gondii. We continue to apply a range of biochemical, cellular, and physiological approaches to pinpoint the functions of these and related proteins, with the ultimate goal of generating new therapies for human inflammatory and infectious disease.

Education and Training

  • Ph.D., Duke University, 1995

Publications

Coers, J, Brown, HM, Hwang, S, and Taylor, GA. "Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense." Current Opinion in Immunology 54 (October 2018): 93-101. (Review)

PMID
29986303
Full Text

Rogala, AR, Schoenborn, AA, Fee, BE, Cantillana, VA, Joyce, MJ, Gharaibeh, RZ, Roy, S, Fodor, AA, Sartor, RB, Taylor, GA, and Gulati, AS. "Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice." Disease Models & Mechanisms 11, no. 2 (February 7, 2018).

PMID
29361512
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Biering, SB, Choi, J, Halstrom, RA, Brown, HM, Beatty, WL, Lee, S, McCune, BT, Dominici, E, Williams, LE, Orchard, RC, Wilen, CB, Yamamoto, M, Coers, J, Taylor, GA, and Hwang, S. "Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases." Cell Host & Microbe 22, no. 1 (July 2017): 74-85.e7.

PMID
28669671
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Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of Biological Chemistry 292, no. 11 (March 2017): 4651-4662.

PMID
28154172
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Greer, RL, Dong, X, Moraes, ACF, Zielke, RA, Fernandes, GR, Peremyslova, E, Vasquez-Perez, S, Schoenborn, AA, Gomes, EP, Pereira, AC, Ferreira, SRG, Yao, M, Fuss, IJ, Strober, W, Sikora, AE, Taylor, GA, Gulati, AS, Morgun, A, and Shulzhenko, N. "Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism." Nature Communications 7 (November 14, 2016): 13329-null.

PMID
27841267
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Lin, X, Yang, J, Wang, J, Huang, H, Wang, H-X, Chen, P, Wang, S, Pan, Y, Qiu, Y-R, Taylor, GA, Vallance, BA, Gao, J, and Zhong, X-P. "mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium." Scientific reports 6 (October 12, 2016): 34939-.

PMID
27731345
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Pilla-Moffett, D, Barber, MF, Taylor, GA, and Coers, J. "Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease." Journal of Molecular Biology 428, no. 17 (August 2016): 3495-3513. (Review)

PMID
27181197
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"Erratum." Autophagy 12, no. 2 (February 2016): 443-443.

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Klionsky, DJ, Abdelmohsen, K, Abe, A, Abedin, MJ, Abeliovich, H, Acevedo Arozena, A, Adachi, H, Adams, CM, Adams, PD, Adeli, K, Adhihetty, PJ, Adler, SG, Agam, G, Agarwal, R, Aghi, MK, Agnello, M, Agostinis, P, Aguilar, PV, Aguirre-Ghiso, J, Airoldi, EM, Ait-Si-Ali, S, Akematsu, T, Akporiaye, ET, Al-Rubeai, M, Albaiceta, GM, Albanese, C, Albani, D, Albert, ML, Aldudo, J, Algül, H, Alirezaei, M, Alloza, I, Almasan, A, Almonte-Beceril, M, Alnemri, ES, Alonso, C, Altan-Bonnet, N, Altieri, DC, Alvarez, S, Alvarez-Erviti, L, Alves, S, Amadoro, G, Amano, A, Amantini, C, Ambrosio, S, Amelio, I, Amer, AO, Amessou, M, Amon, A, An, Z, Anania, FA, Andersen, SU, Andley, UP, Andreadi, CK, Andrieu-Abadie, N, Anel, A, Ann, DK, Anoopkumar-Dukie, S, Antonioli, M, Aoki, H, Apostolova, N, Aquila, S, Aquilano, K, Araki, K, Arama, E, Aranda, A, Araya, J, Arcaro, A, Arias, E, Arimoto, H, Ariosa, AR, Armstrong, JL, Arnould, T, Arsov, I, Asanuma, K, Askanas, V, Asselin, E, Atarashi, R, Atherton, SS, Atkin, JD, Attardi, LD, Auberger, P, Auburger, G, Aurelian, L, Autelli, R, Avagliano, L, Avantaggiati, ML, Avrahami, L, Awale, S, Azad, N, Bachetti, T, Backer, JM, Bae, D-H, Bae, J-S, Bae, O-N, Bae, SH, Baehrecke, EH, Baek, S-H, Baghdiguian, S, Bagniewska-Zadworna, A, Bai, H, Bai, J, Bai, X-Y, Bailly, Y, Balaji, KN, Balduini, W, Ballabio, A, Balzan, R, Banerjee, R, Bánhegyi, G, Bao, H, Barbeau, B, Barrachina, MD, Barreiro, E, Bartel, B, Bartolomé, A, Bassham, DC, Bassi, MT, Bast, RC, Basu, A, Batista, MT, Batoko, H, Battino, M, Bauckman, K, Baumgarner, BL, Bayer, KU, Beale, R, Beaulieu, J-F, Beck, GR, Becker, C, Beckham, JD, Bédard, P-A, Bednarski, PJ, Begley, TJ, Behl, C, Behrends, C, Behrens, GM, Behrns, KE, Bejarano, E, Belaid, A, Belleudi, F, Bénard, G, Berchem, G, Bergamaschi, D, Bergami, M, Berkhout, B, Berliocchi, L, Bernard, A, Bernard, M, Bernassola, F, Bertolotti, A, Bess, AS, Besteiro, S, Bettuzzi, S, Bhalla, S, Bhattacharyya, S, Bhutia, SK, Biagosch, C, Bianchi, MW, Biard-Piechaczyk, M, Billes, V, Bincoletto, C, Bingol, B, Bird, SW, Bitoun, M, Bjedov, I, Blackstone, C, Blanc, L, Blanco, GA, Blomhoff, HK, Boada-Romero, E, Böckler, S, Boes, M, Boesze-Battaglia, K, Boise, LH, Bolino, A, Boman, A, Bonaldo, P, Bordi, M, Bosch, J, Botana, LM, Botti, J, Bou, G, Bouché, M, Bouchecareilh, M, Boucher, M-J, Boulton, ME, Bouret, SG, Boya, P, Boyer-Guittaut, M, Bozhkov, PV, Brady, N, Braga, VM, Brancolini, C, Braus, GH, Bravo-San Pedro, JM, Brennan, LA, Bresnick, EH, Brest, P, Bridges, D, Bringer, M-A, Brini, M, Brito, GC, Brodin, B, Brookes, PS, Brown, EJ, Brown, K, Broxmeyer, HE, Bruhat, A, Brum, PC, Brumell, JH, Brunetti-Pierri, N, Bryson-Richardson, RJ, Buch, S, Buchan, AM, Budak, H, Bulavin, DV, Bultman, SJ, Bultynck, G, Bumbasirevic, V, Burelle, Y, Burke, RE, Burmeister, M, Bütikofer, P, Caberlotto, L, Cadwell, K, Cahova, M, Cai, D, Cai, J, Cai, Q, Calatayud, S, Camougrand, N, Campanella, M, Campbell, GR, Campbell, M, Campello, S, Candau, R, Caniggia, I, Cantoni, L, Cao, L, Caplan, AB, Caraglia, M, Cardinali, C, Cardoso, SM, Carew, JS, Carleton, LA, Carlin, CR, Carloni, S, Carlsson, SR, Carmona-Gutierrez, D, Carneiro, LA, Carnevali, O, Carra, S, Carrier, A, Carroll, B, Casas, C, Casas, J, Cassinelli, G, Castets, P, Castro-Obregon, S, Cavallini, G, Ceccherini, I, Cecconi, F, Cederbaum, AI, Ceña, V, Cenci, S, Cerella, C, Cervia, D, Cetrullo, S, Chaachouay, H, Chae, H-J, Chagin, AS, Chai, C-Y, Chakrabarti, G, Chamilos, G, Chan, EY, Chan, MT, Chandra, D, Chandra, P, Chang, C-P, Chang, RC-C, Chang, TY, Chatham, JC, Chatterjee, S, Chauhan, S, Che, Y, Cheetham, ME, Cheluvappa, R, Chen, C-J, Chen, G, Chen, G-C, Chen, G, Chen, H, Chen, JW, Chen, J-K, Chen, M, Chen, M, Chen, P, Chen, Q, Chen, Q, Chen, S-D, Chen, S, Chen, SS-L, Chen, W, Chen, W-J, Chen, WQ, Chen, W, Chen, X, Chen, Y-H, Chen, Y-G, Chen, Y, Chen, Y, Chen, Y, Chen, Y-J, Chen, Y-Q, Chen, Y, Chen, Z, Chen, Z, Cheng, A, Cheng, CH, Cheng, H, Cheong, H, Cherry, S, Chesney, J, Cheung, CHA, Chevet, E, Chi, HC, Chi, S-G, Chiacchiera, F, Chiang, H-L, Chiarelli, R, Chiariello, M, Chieppa, M, Chin, L-S, Chiong, M, Chiu, GN, Cho, D-H, Cho, S-G, Cho, WC, Cho, Y-Y, Cho, Y-S, Choi, AM, Choi, E-J, Choi, E-K, Choi, J, Choi, ME, Choi, S-I, Chou, T-F, Chouaib, S, Choubey, D, Choubey, V, Chow, K-C, Chowdhury, K, Chu, CT, Chuang, T-H, Chun, T, Chung, H, Chung, T, Chung, Y-L, Chwae, Y-J, Cianfanelli, V, Ciarcia, R, Ciechomska, IA, Ciriolo, MR, Cirone, M, Claerhout, S, Clague, MJ, Clària, J, Clarke, PG, Clarke, R, Clementi, E, Cleyrat, C, Cnop, M, Coccia, EM, Cocco, T, Codogno, P, Coers, J, Cohen, EE, Colecchia, D, Coletto, L, Coll, NS, Colucci-Guyon, E, Comincini, S, Condello, M, Cook, KL, Coombs, GH, Cooper, CD, Cooper, JM, Coppens, I, Corasaniti, MT, Corazzari, M, Corbalan, R, Corcelle-Termeau, E, Cordero, MD, Corral-Ramos, C, Corti, O, Cossarizza, A, Costelli, P, Costes, S, Cotman, SL, Coto-Montes, A, Cottet, S, Couve, E, Covey, LR, Cowart, LA, Cox, JS, Coxon, FP, Coyne, CB, Cragg, MS, Craven, RJ, Crepaldi, T, Crespo, JL, Criollo, A, Crippa, V, Cruz, MT, Cuervo, AM, Cuezva, JM, Cui, T, Cutillas, PR, Czaja, MJ, Czyzyk-Krzeska, MF, Dagda, RK, Dahmen, U, Dai, C, Dai, W, Dai, Y, Dalby, KN, Dalla Valle, L, Dalmasso, G, D'Amelio, M, Damme, M, Darfeuille-Michaud, A, Dargemont, C, Darley-Usmar, VM, Dasarathy, S, Dasgupta, B, Dash, S, Dass, CR, Davey, HM, Davids, LM, Dávila, D, Davis, RJ, Dawson, TM, Dawson, VL, Daza, P, de Belleroche, J, de Figueiredo, P, de Figueiredo, RCBQ, de la Fuente, J, De Martino, L, De Matteis, A, De Meyer, GR, De Milito, A, De Santi, M, de Souza, W, De Tata, V, De Zio, D, Debnath, J, Dechant, R, Decuypere, J-P, Deegan, S, Dehay, B, Del Bello, B, Del Re, DP, Delage-Mourroux, R, Delbridge, LM, Deldicque, L, Delorme-Axford, E, Deng, Y, Dengjel, J, Denizot, M, Dent, P, Der, CJ, Deretic, V, Derrien, B, Deutsch, E, Devarenne, TP, Devenish, RJ, Di Bartolomeo, S, Di Daniele, N, Di Domenico, F, Di Nardo, A, Di Paola, S, Di Pietro, A, Di Renzo, L, DiAntonio, A, Díaz-Araya, G, Díaz-Laviada, I, Diaz-Meco, MT, Diaz-Nido, J, Dickey, CA, Dickson, RC, Diederich, M, Digard, P, Dikic, I, Dinesh-Kumar, SP, Ding, C, Ding, W-X, Ding, Z, and Dini, L et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." Autophagy 12, no. 1 (January 2016): 1-222.

PMID
26799652
Full Text

Murray, HW, Mitchell-Flack, M, Taylor, GA, and Ma, X. "IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver." Experimental parasitology 157 (October 2015): 103-109.

PMID
26208780
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