Gregory Alan Taylor, PhD

Associate Professor in Medicine
Assistant Research Professor in Immunology
Associate Research Professor in Molecular Genetics and Microbiology
Campus mail 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-0411
Email address gregory.taylor@duke.edu

My lab is interested in innate immune mechanisms that underpin inflammatory processes and resistance to intracellular bacteria and protozoa. For a number of years, we have focused on a family of proteins known as Immunity-Related GTPases (IRG; also known as p47 GTPases), which have been associated with both Crohn’s Disease and resistance to mycobacterial infections in humans. We were among the first to clone IRG genes in the mouse and to define their biochemical activity, cellular localization, and cellular functions, prominent among which is regulation of autophagy. By generating mice that lack certain IRG genes (Irgm1, Irgm3, and Irgd), we have been able to demonstrate the key, but distinct roles that individual IRG proteins play in suppressing inflammation, and in resistance to pathogens such as Salmonella typhimurium, Listeria monocytogenes, and Toxoplasma gondii. We continue to apply a range of biochemical, cellular, and physiological approaches to pinpoint the functions of these and related proteins, with the ultimate goal of generating new therapies for human inflammatory and infectious disease.

Education and Training

  • Ph.D., Duke University, 1995

Publications

Mehto, Subhash, Kautilya Kumar Jena, Parej Nath, Swati Chauhan, Srinivasa Prasad Kolapalli, Saroj Kumar Das, Pradyumna Kumar Sahoo, Ashish Jain, Gregory A. Taylor, and Santosh Chauhan. “The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy..” Mol Cell 73, no. 3 (February 7, 2019): 429-445.e7. https://doi.org/10.1016/j.molcel.2018.11.018.

PMID
30612879
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Coers, Jörn, Hailey M. Brown, Seungmin Hwang, and Gregory A. Taylor. “Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense..” Curr Opin Immunol 54 (October 2018): 93–101. https://doi.org/10.1016/j.coi.2018.06.008.

PMID
29986303
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Rogala, Allison R., Alexi A. Schoenborn, Brian E. Fee, Viviana A. Cantillana, Maria J. Joyce, Raad Z. Gharaibeh, Sayanty Roy, et al. “Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice..” Dis Model Mech 11, no. 2 (February 7, 2018). https://doi.org/10.1242/dmm.031070.

PMID
29361512
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Azzam, Kathleen M., Jennifer H. Madenspacher, Derek W. Cain, Lihua Lai, Kymberly M. Gowdy, Prashant Rai, Kyathanahalli Janardhan, et al. “Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces..” Jci Insight 2, no. 16 (August 17, 2017). https://doi.org/10.1172/jci.insight.91914.

PMID
28814662
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Biering, Scott B., Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, et al. “Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases..” Cell Host Microbe 22, no. 1 (July 12, 2017): 74-85.e7. https://doi.org/10.1016/j.chom.2017.06.005.

PMID
28669671
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Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages..” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.

PMID
28154172
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Greer, Renee L., Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, et al. “Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism..” Nat Commun 7 (November 14, 2016). https://doi.org/10.1038/ncomms13329.

PMID
27841267
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Lin, Xingguang, Jialong Yang, Jinli Wang, Hongxiang Huang, Hong-Xia Wang, Pengcheng Chen, Shang Wang, et al. “mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium..” Sci Rep 6 (October 12, 2016). https://doi.org/10.1038/srep34939.

PMID
27731345
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Pilla-Moffett, Danielle, Matthew F. Barber, Gregory A. Taylor, and Jörn Coers. “Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease..” J Mol Biol 428, no. 17 (August 28, 2016): 3495–3513. https://doi.org/10.1016/j.jmb.2016.04.032.

PMID
27181197
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Klionsky, D. J., K. Abdelmohsen, A. Abe, M. J. Abedin, H. Abeliovich, A. A. Arozena, H. Adachi, et al. “Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356.” Autophagy 12, no. 2 (January 1, 2016). https://doi.org/10.1080/15548627.2016.1147886.

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