Gregory Alan Taylor, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Associate Research Professor in Immunology
Assistant Research Professor in Immunology
Senior Fellow of the Center for the Study of Aging and Human Development
Campus mail 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-0411
Email address gregory.taylor@duke.edu

My lab uses mouse genetic modeling and molecular and cellular techniques to study basic biochemical pathways of relevance to aging biology.

I. Aging is often accompanied by increases in inflammation. A major interest of the lab is how perturbations in the regulation of autophagy and mitochondrial dynamics in cells are linked to inflammation. One project in the lab focuses on a family of interferon-gamma and LPS regulated proteins, the Immunity Related GTPases (IRGs). The lab has shown that mice and cells lacking one of these proteins, Irgm1, have excessive inflammatory responses that are accompanied by decreases in autophagy and mitophagy, and altered cellular metabolism. IRG genes in human (IRGM) have been linked to several inflammatory diseases including Crohn’s disease and sepsis. Current work in the lab focuses on their role in those diseases using bacterial and relevant mouse models.

II. Altered expression of the cytokine Transforming Growth Factor beta (TGF-b) has been linked with a number of aging processes, including stem cell and neural function. TGF-b is consequently a therapeutic target for a number of age-related diseases. The lab is studying a novel regulator of TGF-b expression called P311, which drives TGF-b translation. Mice have been created that lack P311 and are being used to address the role of P311 in a number of physiological processes.

Education and Training

  • Ph.D., Duke University, 1995

Publications

Dockterman, Jacob, Brian E. Fee, Gregory A. Taylor, and Jörn Coers. “Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii.” Infect Immun 89, no. 11 (October 15, 2021): e0020221. https://doi.org/10.1128/IAI.00202-21.

PMID
34338548
Full Text

Rai, Prashant, Kyathanahalli S. Janardhan, Julie Meacham, Jennifer H. Madenspacher, Wan-Chi Lin, Peer W. F. Karmaus, Jennifer Martinez, et al. “IRGM1 links mitochondrial quality control to autoimmunity.” Nat Immunol 22, no. 3 (March 2021): 312–21. https://doi.org/10.1038/s41590-020-00859-0.

PMID
33510463
Full Text

Huang, Hsin-I, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, et al. “Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.” In Front Immunol, 12:661290, 2021. https://doi.org/10.3389/fimmu.2021.661290.

PMID
33995384
Full Text

Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham D. Wallace, Anthony S. Piro, Sarah Luoma, et al. “Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.” Embo Rep 21, no. 11 (November 5, 2020): e50830. https://doi.org/10.15252/embr.202050830.

PMID
33124745
Full Text

Norona, Johana, Petya Apostolova, Dominik Schmidt, Rebekka Ihlemann, Nadine Reischmann, Gregory Taylor, Natalie Köhler, et al. “Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.” Blood 136, no. 12 (September 2020): 1442–55. https://doi.org/10.1182/blood.2020005957.

PMID
32542357
Full Text

Kongsomboonvech, Angel K., Felipe Rodriguez, Anh L. Diep, Brandon M. Justice, Brayan E. Castallanos, Ana Camejo, Debanjan Mukhopadhyay, et al. “Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.” Plos Pathog 16, no. 8 (August 2020): e1008327. https://doi.org/10.1371/journal.ppat.1008327.

PMID
32853276
Full Text

Taylor, Gregory A., Hsin-I Huang, Brian E. Fee, Nourhan Youssef, Mark L. Jewell, Viviana Cantillana, Alexi A. Schoenborn, et al. “Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.” Plos Pathog 16, no. 5 (May 2020): e1008553. https://doi.org/10.1371/journal.ppat.1008553.

PMID
32453761
Full Text

Mehto, Subhash, Kautilya Kumar Jena, Parej Nath, Swati Chauhan, Srinivasa Prasad Kolapalli, Saroj Kumar Das, Pradyumna Kumar Sahoo, Ashish Jain, Gregory A. Taylor, and Santosh Chauhan. “The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.” Mol Cell 73, no. 3 (February 7, 2019): 429-445.e7. https://doi.org/10.1016/j.molcel.2018.11.018.

PMID
30612879
Full Text

Rommereim, Leah M., Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, and David J. Bzik. “Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells.” Front Immunol 10 (2019): 2104. https://doi.org/10.3389/fimmu.2019.02104.

PMID
31555296
Full Text

Coers, Jörn, Hailey M. Brown, Seungmin Hwang, and Gregory A. Taylor. “Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense.” Curr Opin Immunol 54 (October 2018): 93–101. https://doi.org/10.1016/j.coi.2018.06.008.

PMID
29986303
Full Text

Pages