Gregory Alan Taylor, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Associate Research Professor in Immunology
Assistant Research Professor in Immunology
Senior Fellow of the Center for the Study of Aging and Human Development
Campus mail 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-0411
Email address gregory.taylor@duke.edu

My lab uses mouse genetic modeling and molecular and cellular techniques to study basic biochemical pathways of relevance to aging biology.

I. Aging is often accompanied by increases in inflammation. A major interest of the lab is how perturbations in the regulation of autophagy and mitochondrial dynamics in cells are linked to inflammation. One project in the lab focuses on a family of interferon-gamma and LPS regulated proteins, the Immunity Related GTPases (IRGs). The lab has shown that mice and cells lacking one of these proteins, Irgm1, have excessive inflammatory responses that are accompanied by decreases in autophagy and mitophagy, and altered cellular metabolism. IRG genes in human (IRGM) have been linked to several inflammatory diseases including Crohn’s disease and sepsis. Current work in the lab focuses on their role in those diseases using bacterial and relevant mouse models.

II. Altered expression of the cytokine Transforming Growth Factor beta (TGF-b) has been linked with a number of aging processes, including stem cell and neural function. TGF-b is consequently a therapeutic target for a number of age-related diseases. The lab is studying a novel regulator of TGF-b expression called P311, which drives TGF-b translation. Mice have been created that lack P311 and are being used to address the role of P311 in a number of physiological processes.

Education and Training

  • Ph.D., Duke University, 1995

Publications

Liu, Zhen, Huifang M. Zhang, Ji Yuan, Travis Lim, Alhousseynou Sall, Gregory A. Taylor, and Decheng Yang. “Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.” Cell Microbiol 10, no. 9 (September 2008): 1787–1800. https://doi.org/10.1111/j.1462-5822.2008.01165.x.

PMID
18452580
Full Text

Sun, Yan-Gang, Yong-Jing Gao, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A. Taylor, and Zhou-Feng Chen. “Involvement of P311 in the affective, but not in the sensory component of pain.” Mol Pain 4 (June 12, 2008): 23. https://doi.org/10.1186/1744-8069-4-23.

PMID
18549486
Full Text

Coers, Jörn, Isaac Bernstein-Hanley, David Grotsky, Iana Parvanova, Jonathan C. Howard, Gregory A. Taylor, William F. Dietrich, and Michael N. Starnbach. “Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.” J Immunol 180, no. 9 (May 1, 2008): 6237–45. https://doi.org/10.4049/jimmunol.180.9.6237.

PMID
18424746
Full Text

Feng, Carl G., David C. Weksberg, Gregory A. Taylor, Alan Sher, and Margaret A. Goodell. “The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.” Cell Stem Cell 2, no. 1 (January 10, 2008): 83–89. https://doi.org/10.1016/j.stem.2007.10.007.

PMID
18371424
Full Text

Henry, Stanley C., Xiaojou Daniell, Maanasa Indaram, John F. Whitesides, Gregory D. Sempowski, David Howell, Tim Oliver, and Gregory A. Taylor. “Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).” J Immunol 179, no. 10 (November 15, 2007): 6963–72. https://doi.org/10.4049/jimmunol.179.10.6963.

PMID
17982087
Full Text

Taylor, Gregory A., Carl G. Feng, and Alan Sher. “Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).” Microbes Infect 9, no. 14–15 (November 2007): 1644–51. https://doi.org/10.1016/j.micinf.2007.09.004.

PMID
18023232
Full Text

Bafica, Andre, Carl G. Feng, Helton C. Santiago, Julio Aliberti, Allen Cheever, Karen E. Thomas, Gregory A. Taylor, Stefanie N. Vogel, and Alan Sher. “The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.” J Immunol 179, no. 8 (October 15, 2007): 5514–22. https://doi.org/10.4049/jimmunol.179.8.5514.

PMID
17911638
Full Text

Bernstein-Hanley, Isaac, Jörn Coers, Zarine R. Balsara, Gregory A. Taylor, Michael N. Starnbach, and William F. Dietrich. “The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.” Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14092–97. https://doi.org/10.1073/pnas.0603338103.

PMID
16959883
Full Text

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