Gregory Alan Taylor, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Associate Research Professor in Immunology
Assistant Research Professor in Immunology
Senior Fellow of the Center for the Study of Aging and Human Development
Campus mail 182 Grecc VA Med Ctr, 508 Fulton St, Durham, NC 27705
Phone (919) 286-0411
Email address gregory.taylor@duke.edu

My lab uses mouse genetic modeling and molecular and cellular techniques to study basic biochemical pathways of relevance to aging biology.

I. Aging is often accompanied by increases in inflammation. A major interest of the lab is how perturbations in the regulation of autophagy and mitochondrial dynamics in cells are linked to inflammation. One project in the lab focuses on a family of interferon-gamma and LPS regulated proteins, the Immunity Related GTPases (IRGs). The lab has shown that mice and cells lacking one of these proteins, Irgm1, have excessive inflammatory responses that are accompanied by decreases in autophagy and mitophagy, and altered cellular metabolism. IRG genes in human (IRGM) have been linked to several inflammatory diseases including Crohn’s disease and sepsis. Current work in the lab focuses on their role in those diseases using bacterial and relevant mouse models.

II. Altered expression of the cytokine Transforming Growth Factor beta (TGF-b) has been linked with a number of aging processes, including stem cell and neural function. TGF-b is consequently a therapeutic target for a number of age-related diseases. The lab is studying a novel regulator of TGF-b expression called P311, which drives TGF-b translation. Mice have been created that lack P311 and are being used to address the role of P311 in a number of physiological processes.

Education and Training

  • Ph.D., Duke University, 1995

Publications

Collazo, C. M., G. S. Yap, G. A. Taylor, and A. Sher. “The IFN-gamma-inducible GTPase (IGTP) is required for in vivo control of Toxoplasma gondii infection in both hematopoeitic and non-hematopoeitic host cells.” Faseb Journal 14, no. 6 (April 20, 2000): A955–A955.

Scholars@Duke

Taylor, G. A., E. Hudson, J. H. Resau, and G. F. Vande Woude. “Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system.” J Biol Chem 275, no. 6 (February 11, 2000): 4215–19. https://doi.org/10.1074/jbc.275.6.4215.

PMID
10660586
Full Text

Taylor, G. A., C. M. Collazo, G. S. Yap, K. Nguyen, T. A. Gregorio, L. S. Taylor, B. Eagleson, et al. “Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.” Proc Natl Acad Sci U S A 97, no. 2 (January 18, 2000): 751–55. https://doi.org/10.1073/pnas.97.2.751.

PMID
10639151
Full Text

Koochekpour, S., M. Jeffers, P. H. Wang, C. Gong, G. A. Taylor, L. M. Roessler, R. Stearman, et al. “The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.” Mol Cell Biol 19, no. 9 (September 1999): 5902–12. https://doi.org/10.1128/MCB.19.9.5902.

PMID
10454537
Full Text

Webb, C. P., G. A. Taylor, M. Jeffers, M. Fiscella, M. Oskarsson, J. H. Resau, and G. F. Vande Woude. “Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.” Oncogene 17, no. 16 (October 22, 1998): 2019–25. https://doi.org/10.1038/sj.onc.1202135.

PMID
9798673
Full Text

Taylor, G. A., M. Jeffers, C. P. Webb, H. M. Koo, M. Anver, K. Sekiguchi, and G. F. Vande Woude. “Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.” Oncogene 17, no. 9 (September 3, 1998): 1179–83. https://doi.org/10.1038/sj.onc.1202004.

PMID
9764829
Full Text

Koochekpour, S., M. Jeffers, S. Rulong, G. Taylor, E. Klineberg, E. A. Hudson, J. H. Resau, and G. F. Vande Woude. “Met and hepatocyte growth factor/scatter factor expression in human gliomas.” Cancer Res 57, no. 23 (December 1, 1997): 5391–98.

PMID
9393765
Scholars@Duke

Taylor, G. A., R. Stauber, S. Rulong, E. Hudson, V. Pei, G. N. Pavlakis, J. H. Resau, and G. F. Vande Woude. “The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.” J Biol Chem 272, no. 16 (April 18, 1997): 10639–45. https://doi.org/10.1074/jbc.272.16.10639.

PMID
9099712
Full Text

Jeffers, M., G. A. Taylor, K. M. Weidner, S. Omura, and G. F. Vande Woude. “Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.” Mol Cell Biol 17, no. 2 (February 1997): 799–808. https://doi.org/10.1128/MCB.17.2.799.

PMID
9001234
Full Text

Thompson, M. J., W. S. Lai, G. A. Taylor, and P. J. Blackshear. “Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.” Gene 174, no. 2 (October 3, 1996): 225–33. https://doi.org/10.1016/0378-1119(96)00084-4.

PMID
8890739
Full Text

Pages